Faculty Profiles - Uchiyama Jumpei

MISC - Uchiyama Jumpei

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Commonly identified phage-derived genes among the genomes of Rodentibacter pneumotropicus isolates

池郁生, 佐々木啓, 内山淳平, 豊田敦

日本ウイルス学会学術集会プログラム・予稿集(Web) 70th 2023

細菌感染症創薬に向けた「次世代型抗菌酵素」の創出

内山淳平, 内山伊代, 福田憲, 玉井栄治, 金丸周司, 萩谷英大, 松下治

微生物シンポジウム講演要旨集 35th 2023

ピロリ菌を除菌可能な食べれる人工抗菌酵素剤の研究開発

内山淳平

研究報告書三島海雲記念財団 [編] ( 60 ) 1 - 4 2023

牛伝染性リンパ腫ウイルスの不顕性感染に関する乳牛の消化管の揮発性脂肪酸および細菌叢の横断的調査

鈴木武人, 村上裕信, 内山淳平, 佐藤礼一郎, 内山伊代, 小方雅也, 曽川一幸, 石田大歩, 松下治, 長井誠

日本ワンヘルスサイエンス学会年次学術集会抄録集(Web) 7th 2023

食肉加工におけるEnterococcus faecalisに特異的なファージエンドライシンの殺菌効果

小方雅也, 田邊奏, 三嶋花, 内山淳平, 田原口智士, 水野谷航, 竹田志郎

日本食品科学工学会大会講演集 70th 2023

腸内細菌を介した酸素ナノバブル水による抗腫瘍作用

永根大幹, 鈴木利美奈, 水垣ひなの, 丹羽智瑛, 内山淳平, 稲波修, 赤羽英夫, 安井博宣, 山下匡

日本生化学会大会プログラム・講演要旨集 95回 2P - 273 2022.11

腸内細菌を介した酸素ナノバブル水による抗腫瘍作用

永根大幹, 鈴木利美奈, 水垣ひなの, 丹羽智瑛, 内山淳平, 稲波修, 赤羽英夫, 安井博宣, 山下匡

日本生化学会大会プログラム・講演要旨集 95回 2P - 273 2022.11

分娩後子宮捻転を発症した乳牛の子宮内細菌叢解析

風間啓, 内山淳平, 恩田賢

日本獣医学会学術集会講演要旨集 165回 [HL1P - 01] 2022.9

健常犬の糞便中から分離した乳酸菌AZABU株はヒト単球細胞をM2bマクロファージに分化誘導する

安田伊武希, 金木真央, 竹田志郎, 内山淳平, 福山朋季

日本獣医学会学術集会講演要旨集 165回 [J2A - 02] 2022.9

イヌにおける胆嚢の常在細菌叢の存在の検討と肝疾患に関連した細菌叢解析

経田真梨菜, 根尾櫻子, 内山伊代, 内山淳平, 村上裕信, 島綾香, 茅沼秀樹, 横山大希, 高木哲, 金井詠一, 久末正晴, 葛原早瑛

日本獣医学会学術集会講演要旨集 165回 [HS1P - 15] 2022.9

分娩後子宮捻転を発症した乳牛の子宮内細菌叢解析

風間啓, 内山淳平, 恩田賢

日本獣医学会学術集会講演要旨集 165回 [HL1P - 01] 2022.9

健常犬の糞便中から分離した乳酸菌AZABU株はヒト単球細胞をM2bマクロファージに分化誘導する

安田伊武希, 金木真央, 竹田志郎, 内山淳平, 福山朋季

日本獣医学会学術集会講演要旨集 165回 [J2A - 02] 2022.9

イヌにおける胆嚢の常在細菌叢の存在の検討と肝疾患に関連した細菌叢解析

経田真梨菜, 根尾櫻子, 内山伊代, 内山淳平, 村上裕信, 島綾香, 茅沼秀樹, 横山大希, 高木哲, 金井詠一, 久末正晴, 葛原早瑛

日本獣医学会学術集会講演要旨集 165回 [HS1P - 15] 2022.9

Helicobacter pylori株の長期凍結保存(Long-term cryopreservation of Helicobacter pylori strains)

Hayashi Shunji, Uchiyama Jumpei, Yokota Kenji, Shimomura Hirofumi

日本ヘリコバクター学会学術集会プログラム・抄録集 28回 185 - 185 2022.6

Ozone water as a potential preventive and therapeutic option for periodontal disease in dogs

Tomoki Fukuyama, Kaneki Mao, Oohira Chiharu, Uchiyama Jumpei, Ano Tetsuya

Proceedings for Annual Meeting of The Japanese Pharmacological Society 95 2-O-090 2022

Language：Japanese Publisher：Japanese Pharmacological Society

Periodontal disease, which is majorly caused by Porphyromonas gulae, is extremely common in dogs, and is associated with serious systemic diseases such as kidney failure, heart disease and immune disorder. Ozon water is ozone-gas-dissolved water, which has antimicrobial activity by oxidizing molecules. However, both therapeutic and preventive effects of ozone water for periodontal disease in dogs are still unclear. We herein examined the antibacterial and anti-inflammatory effects of ozone water in vitro using P. gulae. Our results indicated that treatment of ozone water significantly inhibited the growth of P. gulae until 24h post ozone water treatment as compared to purified water treatment. Ozone water also showed the anti-inflammatory effects in P. gulae-infected human gingival epithelial cells (Ca9-22). Secretions of IL-1β and TNFα were significantly suppressed by ozone water treatment compared to the treatment of purified water. As IL-1β and TNFα activate the osteoclast and finally promote bone resorption in the oral cavity, our findings imply the potential therapeutic and preventive effects of ozone water in canine periodontal disease. We are currently investigating the in vivo preventive and therapeutic effects of ozone water in dogs.

DOI： 10.1254/jpssuppl.95.0_2-o-090

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Potential therapeutic effects of ozone water on pyoderma and atopic dermatitis in dogs

Kaneki Mao, Takahashi Miyu, Uchiyama Jumpei, Ano Tetsuya, Fukuyama Tomoki

Proceedings for Annual Meeting of The Japanese Pharmacological Society 95 1-SS-64 2022

Language：Japanese Publisher：Japanese Pharmacological Society

Ozone water is currently utilized for antibacterial and antiviral purposes under the pandemic of COVID-19 due to its strong oxidation effect without safety problems. Therefore, clinical applications of ozone water for cutaneous diseases such as atopic dermatitis (AD) and pyoderma are expected recently. The aim of this project is to apply the ozone water for AD and pyoderma in dogs. We here examined the antibacterial effects of ozone water using staphylococci in in vitro setting, and anti-allergic effects of ozone water in AD mouse model.

We first examined the bactericidal effect of ozone water on resident staphylococci on skin. Staphylococcus aureus, which is an exacerbating factor in human AD, and S. lentus collected from AD mouse model was treated with ozone water and the number of bacteria was determined. Our findings indicated that ozone water showed a significant bactericidal effect against both staphylococcal species . We are currently investigating the efficacy of ozone water against staphylococci isolated from AD and pyoderma dogs. In vivo experiment with AD mouse model is also underway to look for the therapeutic effects of ozone water with impact on inflammatory and itch responses.

DOI： 10.1254/jpssuppl.95.0_1-ss-64

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白内障術後眼内炎に対するバクテリオファージによる発症予防効果の検討

岸本達真, 石田わか, 中島勇魚, 鈴木崇, 内山淳平, 松崎茂展, 福田憲, 山城健児

日本眼感染症学会・日本眼炎症学会・日本コンタクトレンズ学会総会・日本涙道・涙液学会プログラム・講演抄録集 58th-55th-64th-10th 2022

純血種柴犬を使用したアトピー性皮膚炎に関連した口腔・糞便細菌叢の特徴付け

内山淳平, 大隅尊史, 水上圭二郎, 福山朋季, 島綾香, 海野朝香, 内山伊代, 宇根有美, 村上裕信, 阪口雅弘, 阪口雅弘

日本ワンヘルスサイエンス学会年次学術集会抄録集(Web) 6th 2022

Microbiome analysis of bovine uterine, aiming to creation of novel technology improving low fertility

内山淳平, 八木沢拓也, 片桐成二

食肉に関する助成研究調査成果報告書 40 2022

Topical treatment with high concentration of ozone water ameliorates inflammatory responses and breakdown of the cutaneous barrier in a mouse model of atopic dermatitis through antibacterial effect toward staphylococci

Kaneki Mao, Ohira Chiharu, Takahashi Miyu, Uchiyama Jumpei, Ano Tetsuya, Fukuyama Tomoki

Proceedings for Annual Meeting of The Japanese Pharmacological Society 96 2-B-P-170 2022

Language：Japanese Publisher：Japanese Pharmacological Society

We focus on the ozone water to develop a novel treatment approach for staphylococci related inflammatory skin diseases. In the 95th Annual Meeting of the Japanese Pharmacological Society, we reported the anti-allergic and anti-microbial effect of 3 mg/L ozone water in a mouse model of atopic dermatitis (AD) and staphylococci, however, its effect was far from clinical application. The aim of this study is to evaluate the anti-microbial and anti-inflammatory property of high concentration (11 mg/L) of ozone water to advance our project. Ozone water showed a significant bactericidal effect against Staphylococcus aureus, S. pseudintermedius and S. lentus. Furthermore, S. pseudintermedius induced IL-1β and IL-6 secretion in human epidermal keratinocytes was significantly inhibited by pre-treatment of ozone water. In vivo experiment with a mouse model of AD, significant improvement of AD symptoms and trans epidermal water loss were also found in an ozone water treatment group. Surprisingly, local immune reactions such as type II conventional dendritic cells, effector helper T cells, and IgE-produced B cells are also regulated by ozone water application. Our findings strongly suggest that topical treatment with high concentration of ozone water significantly ameliorated AD symptoms through antibacterial effect toward staphylococci.

DOI： 10.1254/jpssuppl.96.0_2-b-p-170

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