Faculty Profiles - Uchiyama Jumpei

MISC - Uchiyama Jumpei

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ファージ・ルネッサンスファージ発見から100年たった今ファージを利用した細菌検出黄色ブドウ球菌検出ファージクロマト法の開発

松井秀仁, 内山淳平, 津田愛美, 松崎茂展, 花木秀明

日本細菌学雑誌 71 ( 1 ) 54 - 54 2016.2

緑膿菌PAO1株とファージKPP22の短期間進化的軍拡競走の解析

那須川忠弥, 内山淳平, 鈴木仁人, 宮田玲奈, 山口琴絵, 内山伊代, 阪口義彦, 柴山恵吾, 阪口雅弘, 松崎茂展

日本細菌学雑誌 71 ( 1 ) 92 - 92 2016.2

ファージ・ルネッサンスファージ発見から100年たった今活性型ピロリ菌ファージKHP30の特徴付けとその潜伏感染性の解析(Phage renaissance: 100 years have passed since phage discovery Characterization of active Helicobacter pylori phage KHP30, and analysis of its latent infection)

内山淳平, 内山伊代, 竹内啓晃, 阪口義彦, 阪口雅弘, 松崎茂展

日本細菌学雑誌 71 ( 1 ) 53 - 53 2016.2

Helicobacter pylori ファージとそのゲノム

内山淳平, 竹内啓晃, 松崎茂展

Helicobacter Research 20 50 - 54 2016

Machining Speed of Small Curved Holes using Electrochemical Machining

UCHIYAMA Mitsuo, KUROSAWA Keita, SUZUKI Junpei

Journal of The Japan Society of Electrical Machining Engineers 50 ( 123 ) 36 - 42 2016

Language：Japanese Publisher：Japan Society of Electrical Machining Engineers

This paper describes the design optimization of the structure of a tool for producing curved holes by electrochemical machining and the results of machining experiments. Curved holes can be machined using a flexible tool that can be curved by the hole being processed by the tool itself. The tool for producing small holes of less than 6 mm diameter has a simple structure composed of a flexible tube and a columnar electrode tip. A tool device equipped with an ultrasonic vibration function was designed and fabricated to remove the sludge from the curved face of the hole during machining. Machining tests showed that the machining speed was able to exceed the target value of 1mm/min.

DOI： 10.2526/jseme.50.36

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Other Link： http://id.ndl.go.jp/bib/027253454

細菌感染症における診断法と治療法の開発:バクテリオファージの利用

内山淳平, 松井秀仁, 阪口義彦, 花木秀明, 松崎茂展, 阪口雅弘

日本獣医学会学術集会講演要旨集 158回 182 - 182 2015.8

イヌにおける新規口腔内常在細菌の同定と全ゲノム配列解析

平山隆一郎, 平山隆一郎, 鈴木仁人, 内山淳平, 松井真理, 鈴木里和, 柴山恵吾, 阪口雅弘, 木内明男

日本獣医学会学術集会講演要旨集 158回 313 - 313 2015.8

眼感染症に対するファージ療法の研究開発および臨床応用への問題点

福田憲, 石田わか, 内山淳平, 松崎茂展, 福島敦樹

日本獣医学会学術集会講演要旨集 158回 183 - 183 2015.8

食物有害反応を示す犬における卵白アレルゲンに対するIgE反応性の検討

島倉秀勝, 齋藤拓, 藤村正人, 岡本憲明, 内山淳平, 阪口雅弘

日本獣医学会学術集会講演要旨集 158回 401 - 401 2015.8

Evaluation of the lubrication mechanism at various rotation speeds and granule filling levels in a container mixer using a thermal effusivity sensor Reviewed International journal

Jumpei Uchiyama, Shigeru Aoki

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY 41 ( 7 ) 1172 - 1181 2015.7

Language：English Publisher：TAYLOR & FRANCIS LTD

To research the detailed mechanism of the lubrication process using the thermal effusivity sensor, the relationships of the lubrication progress with the pattern of powder flow, the rotation speed and the filling level were investigated. The thermal effusivity profile was studied as a function of the number of rotations at various rotation speeds. It was observed that at lower rotation speeds, the profiles of the lubrication progress were almost the same, regardless of the rotation speed. In this region, the highest speed was defined as the critical rotation speed (CRS), which was found to be one of the important factors. The CRS had close relations with avalanche flow in the blender. The first and the second phases were observed in the lubrication process. The first phase was influenced by the CRS and the filling level in the blender. The second phase was influenced by the rotation speed. The mechanism of two-phase process was proposed as a macro progression of the dispersion of the lubricant (first phase) and micro progression of the coating of the powder particles with lubricant (second phase). The accurate monitoring by the thermal effusivity sensor was able to help a better understanding in the lubrication process.

DOI： 10.3109/03639045.2014.935394

ファージ尾部タンパクを用いた黄色ブドウ球菌検出方法の開発

松井秀仁, 崔龍洙, 花木秀明, 内山淳平, 松崎茂展

日本化学療法学会雑誌 63 ( Suppl.A ) 170 - 170 2015.5

New Approach to Evaluate the Lubrication Process in Various Granule Filling Levels and Rotating Mixer Sizes Using a Thermal Effusivity Sensor Reviewed

Jumpei Uchiyama, Shigeru Aoki, Yoshifumi Uemoto

CHEMICAL & PHARMACEUTICAL BULLETIN 63 ( 3 ) 164 - 179 2015.3

Language：English Publisher：PHARMACEUTICAL SOC JAPAN

The principles of thermal effusivity are applied to an understanding of the detailed mechanisms of the lubrication process in a rotating mixer. The relationships and impact of the lubrication process by the pattern of powder flow, the filling level, and the rotating mixer size were investigated. Thermal effusivity profiles of the lubrication process, as obtained, indicate that lubrication is a two-phase process. The intersection point of the first and second phases (IPFS) is influenced by changing the filling level, thus changing the resulting number of avalanche flows created. The slope of the second phase (SSP) is influenced by the relationship between the number and the length of avalanche flows. Understanding this difference between the first and second phases is important to successfully evaluate the impact of proposed changes in the lubrication process. From this knowledge, a predictive model of the lubrication profile can be generated to allow an evaluation of proposed changes to the lubrication process. This model allows estimation of the lubrication profile at different filling levels and in different rotating mixer sizes. In this study, the actual lubrication profile almost coincides with the model predicted lubrication profile. Based on these findings, it is assumed that lubrication profiles at a commercial scale can be predicted from data generated at the laboratory scale. Further, it is assumed that changes in the filling level can also be estimated from the laboratory or current data.

DOI： 10.1248/cpb.c14-00634

B型ボツリヌス菌のボツリヌス毒素遺伝子をコードするプラスミド解析(Analysis of botulinum neurotoxin type B6 gene-encoding plasmid in Clostridium botulinum type B)

阪口義彦, 内山淳平, 細見晃司, 幸田知子, 松崎茂展, 小椋義俊, 林哲也, 林俊治, 小崎俊司, 向本雅郁

日本細菌学雑誌 70 ( 1 ) 178 - 178 2015.2

各種ファージに対する黄色ブドウ球菌受容体の解析

内山淳平, 黒川健児, 坂口義彦, 内山(竹村)伊代, 氏原隆子, 村上雅尚, 大畑雅典, 松崎茂展

日本細菌学雑誌 70 ( 1 ) 215 - 215 2015.2

緑膿菌感染症に対するファージ療法と化学療法の併用療法の可能性検討

重久立, 内山淳平, 宮田怜奈, 山口琴絵, 内山伊代, 阪口義彦, 氏原隆子, 大畑雅典, 松崎茂展

日本細菌学雑誌 70 ( 1 ) 198 - 198 2015.2

クライオ電子顕微鏡による新規大型黄色ブドウ球菌バクテリオファージS6の構造解析

宮崎直幸, 内山淳平, 松崎茂展, 村田和義

日本生化学会大会(Web) 87回 [2P - 130] 2014.10

Genomic and phylogenetic traits of Staphylococcus phages S25-3 and S25-4 (family Myoviridae, genus Twort-like viruses) Reviewed

Iyo Takemura-Uchiyama, Jumpei Uchiyama, Shin Ichiro Kato, Takako Ujihara, Masanori Daibata, Shigenobu Matsuzaki

Annals of Microbiology 64 ( 3 ) 1453 - 1456 2014.9

Publisher：Springer

The genomes of Staphylococcus phages S25-3 and S25-4 (family Myoviridae, genus Twort-like viruses) were sequenced and analyzed from an evolutionary perspective. The genome-based phylogeny and genome analyses of phages S25-3 and S25-4 showed that they had diverged evolutionarily from the majority of this viral genus based on the presence of mobile genetic elements, i.e., a putative transposase and the homing endonuclease I-MsaI. These results suggest that genetic elements such as transposases and homing endonucleases are likely to be involved with the evolution of some Twort-like phages, including phages S25-3 and S25-4. © 2013 Springer-Verlag Berlin Heidelberg and the University of Milan.

DOI： 10.1007/s13213-013-0762-2

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最先端医療・福祉の科学ファージ吸着分子を利用した簡易迅速細菌検出技術

内山淳平, 松井秀仁, 内山(竹村)伊代, 渡辺茂, 花木秀明, 松崎茂展

化学工業 65 ( 8 ) 588 - 595 2014.8

ファージ吸着分子を利用した簡易迅速細菌検査技術 Invited

内山淳平, 松井秀仁, 内山(竹村)伊代, 渡辺茂, 花木秀明, 松﨑茂展

化学工業 65 ( 8 ) 12 - 19 2014.8

Evaluation of risk and benefit in thermal effusivity sensor for monitoring lubrication process in pharmaceutical product manufacturing Reviewed

Jumpei Uchiyama, Yoshiteru Kato, Yoshifumi Uemoto

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY 40 ( 8 ) 999 - 1004 2014.8

Language：English Publisher：TAYLOR & FRANCIS LTD

In the process design of tablet manufacturing, understanding and control of the lubrication process is important from various viewpoints. A detailed analysis of thermal effusivity data in the lubrication process was conducted in this study. In addition, we evaluated the risk and benefit in the lubrication process by a detailed investigation. It was found that monitoring of thermal effusivity detected mainly the physical change of bulk density, which was changed by dispersal of the lubricant and the coating powder particle by the lubricant. The monitoring of thermal effusivity was almost the monitoring of bulk density, thermal effusivity could have a high correlation with tablet hardness. Moreover, as thermal effusivity sensor could detect not only the change of the conventional bulk density but also the fractional change of thermal conductivity and thermal capacity, two-phase progress of lubrication process could be revealed. However, each contribution of density, thermal conductivity, or heat capacity to thermal effusivity has the risk of fluctuation by formulation. After carefully considering the change factor with the risk to be changed by formulation, thermal effusivity sensor can be a useful tool for monitoring as process analytical technology, estimating tablet hardness and investigating the detailed mechanism of the lubrication process.

DOI： 10.3109/03639045.2013.795581

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