研究者詳細 - 馬場　健児

論文 - 馬場　健児

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Intracoronary Autologous Cardiac Progenitor Cell Transfer in Patients With Hypoplastic Left Heart Syndrome (TICAP) : A Prospective Phase 1 Controlled Trial 査読

Ishigami Shuta, Ohtsuki Shinichi, Tarui Suguru, Ousaka Daiki, Eitoku Takahiro, Kondo Maiko, Okuyama Michihiro, Kobayashi Junko, Baba Kenji, Arai Sadahiko, Kawabata Takuya, Yoshizumi Ko, Tateishi Atsushi, Kuroko Yosuke, Iwasaki Tatsuo, Sato Shuhei, Kasahara Shingo, Sano Shunji, Oh Hidemasa

Circulation Research 116 ( 4 ) 653 - 664 2015年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Lippincott Williams & Wilkins

RATIONALE: Hypoplastic left heart syndrome (HLHS) remains a lethal congenital cardiac defect. Recent studies have suggested that intracoronary administration of autologous cardiosphere-derived cells (CDCs) may improve ventricular function. OBJECTIVE: The aim of this study was to test whether intracoronary delivery of CDCs is feasible and safe in patients with hypoplastic left heart syndrome. METHODS AND RESULTS: Between January 5, 2011, and January 16, 2012, 14 patients (1.8±1.5 years) were prospectively assigned to receive intracoronary infusion of autologous CDCs 33.4±8.1 days after staged procedures (n=7), followed by 7 controls with standard palliation alone. The primary end point was to assess the safety, and the secondary end point included the preliminary efficacy to verify the right ventricular ejection fraction improvements between baseline and 3 months. Manufacturing and intracoronary delivery of CDCs were feasible, and no serious adverse events were reported within the 18-month follow-up. Patients treated with CDCs showed right ventricular ejection fraction improvement from baseline to 3-month follow-up (46.9%±4.6% to 52.1%±2.4%; P=0.008). Compared with controls at 18 months, cardiac MRI analysis of CDC-treated patients showed a higher right ventricular ejection fraction (31.5%±6.8% versus 40.4%±7.6%; P=0.049), improved somatic growth (P=0.0005), reduced heart failure status (P=0.003), and lower incidence of coil occlusion for collaterals (P=0.007). CONCLUSIONS: Intracoronary infusion of autologous CDCs seems to be feasible and safe in children with hypoplastic left heart syndrome after staged surgery. Large phase 2 trials are warranted to examine the potential effects of cardiac function improvements and the long-term benefits of clinical outcomes.

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適応拡大の意義とFenestration、failed Fontan Failing Fontan患者に対するFenestration作製の有用性について

栗田佳彦, 大月審一, 栄徳隆裕, 近藤麻衣子, 馬場健児, 森島恒雄, 佐野俊二, 笠原慎吾, 岩崎達雄, 戸田雄一郎

日本小児循環器学会雑誌 30 ( Suppl. ) s127 - s127 2014年6月

胎児診断に基く周産期治療左心低形成症候群high risk症例の周産期、周術期計画胎児診断からのアプローチ

近藤麻衣子, 大月審一, 馬場健児, 大野直幹, 栗田佳彦, 栄徳隆裕, 佐野俊二, 篠原真悟, 岩崎達雄, 戸田雄一郎, 清水一好

日本小児循環器学会雑誌 30 ( Suppl. ) s154 - s154 2014年6月

"Reverse Blalock-Taussig shunt": application in single ventricle hybrid palliation 査読

The Journal of Thoracic Cardiovascular Surgery 2013年8月

LVOTOを伴うTGAに対するPulmonary root translocationの有用性について

栄徳隆裕, 大月審一, 馬場健児, 大野直幹, 近藤麻衣子, 栗田佳彦, 小寺亜矢, 佐野俊二, 笠原真悟, 岩崎達雄, 戸田雄一郎

日本小児循環器学会雑誌 29 ( Suppl. ) s284 - s284 2013年6月

当院での術中肺静脈stent症例についての検討

栗田佳彦, 大月審一, 小寺亜矢, 栄徳隆裕, 近藤麻衣子, 大野直幹, 馬場健児, 森島恒雄, 佐野俊二, 笠原慎吾, 岩崎達夫

日本小児循環器学会雑誌 29 ( Suppl. ) s158 - s158 2013年6月

両側肺動脈banding後Norwood手術と初回Norwood手術との肺動脈の成長に関する比較検討

馬場健児, 大月審一, 岡本吉生, 大野直幹, 近藤麻衣子, 栗田佳彦, 栄徳隆裕, 岩崎達雄, 笠原真悟, 佐野俊二, 森島恒雄

日本小児循環器学会雑誌 29 ( Suppl. ) s159 - s159 2013年6月

複雑心奇形におけるDrug Eluting Stentの応用

近藤麻衣子, 大月審一, 馬場健児, 岡本吉生, 大野直幹, 栗田佳彦, 栄徳隆裕, 小寺亜矢, 佐野俊二, 笠原真悟, 岩崎達雄

日本小児循環器学会雑誌 29 ( Suppl. ) s299 - s299 2013年6月

胎児不整脈により胎児水腫を認めた3例

小寺亜矢, 大月審一, 馬場健児, 大野直幹, 岡本吉生, 栗田佳彦, 近藤麻衣子, 栄徳隆裕, 森島恒雄, 佐野俊二

日本小児循環器学会雑誌 29 ( Suppl. ) s235 - s235 2013年6月

Fate of the ductal stent after hybrid palliation for hypoplastic left heart syndrome 査読

The Annals of Thoracic Surgery 2013年5月

心臓カテーテル検査中に重度の不整脈を生じた症例の後方視的検討

栄徳隆裕, 大月審一, 馬場健児, 岡本吉生, 近藤麻衣子, 栗田佳彦, 小寺亜矢, 森島恒雄

日本小児科学会雑誌 117 ( 3 ) 646 - 646 2013年3月

Fontan手術適応症例の肺動静脈瘻に対する治療介入

小寺亜矢, 大月審一, 馬場健児, 岡本吉生, 近藤麻衣子, 栗田佳彦, 栄徳隆裕, 森島恒雄, 佐野俊二

日本小児科学会雑誌 117 ( 2 ) 400 - 400 2013年2月

Hybrid versus Norwood strategies for single-ventricle palliation. 招待査読国際誌

Kenji Baba, Yasuhiro Kotani, Devin Chetan, Rajiv R Chaturvedi, Kyong-Jin Lee, Lee N Benson, Lars Grosse-Wortmann, Glen S Van Arsdell, Christopher A Caldarone, Osami Honjo

Circulation 126 ( 11 Suppl 1 ) S123-31 2012年9月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Hybrid and Norwood strategies differ substantially in terms of stage II palliative procedures. We sought to compare these strategies with an emphasis on survival and reintervention after stage II and subsequent Fontan completion. METHODS AND RESULTS: Of 110 neonates with functionally single-ventricle physiology who underwent stage I palliation between 2004 and 2010, 75 (69%) infants (Norwood, n=43; hybrid, n=32) who subsequently underwent stage II palliation were studied. Survival and reintervention rates after stage II palliation, anatomic and physiologic variables at pre-Fontan assessment, and Fontan outcomes were compared between the groups. Predictors for reintervention were analyzed. Freedom from death/transplant after stage II palliation was equivalent between the groups (Norwood, 80.4% versus hybrid, 85.6% at 3 years, P=0.66). Hybrid patients had a higher pulmonary artery (PA) reintervention rate (P=0.003) and lower Nakata index at pre-Fontan evaluation (P=0.015). Aortic arch and atrioventricular valve reinterventions were not different between the groups. Ventricular end-diastolic pressure, mean PA pressure, and ventricular function were equivalent at pre-Fontan assessment. There were no deaths after Fontan completion in either group (Norwood, n=25, hybrid, n=14). CONCLUSIONS: Survival after stage II palliation and subsequent Fontan completion is equivalent between the groups. The hybrid group had a higher PA reintervention rate and smaller PA size. Both strategies achieved adequate physiology for Fontan completion. Evolution of the hybrid strategy requires refinement to provide optimal PA growth.

PubMed

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小児心臓手術後の急性腎障害(AKI)におけるpRIFLE criteriaの予測クレアチニンクリアランスを用いた診断と尿量を用いた診断の比較

杉本健太郎, 戸田雄一郎, 岩崎達雄, 清水一好, 金澤伴幸, 石井典子, 森田潔, 笠原真悟, 佐野俊二, 馬場健児, 大月審一

日本小児循環器学会雑誌 28 ( Suppl. ) s257 - s257 2012年6月