研究者詳細 - 馬場　健児

論文 - 馬場　健児

分割表示 142 件中 101 - 120 件目／全件表示 >>

重症心奇形を合併したbiliary atresia splenic malformation(BASM)の1例

尾山貴徳, 野田卓男, 納所洋, 谷本光隆, 栄徳隆裕, 馬場健児, 大月審一, 小谷恭弘, 新井禎彦, 笠原真悟, 佐野俊二, 吉田龍一, 楳田祐三, 八木孝仁

日本小児外科学会雑誌 53 ( 2 ) 342 - 342 2017年4月

Intracoronary Cardiac Progenitor Cells in Single Ventricle Physiology The PERSEUS (Cardiac Progenitor Cell Infusion to Treat Univentricular Heart Disease) Randomized Phase 2 Trial 査読

Shuta Ishigami, Shinichi Ohtsuki, Takahiro Eitoku, Daiki Ousaka, Maiko Kondo, Yoshihiko Kurita, Kenta Hirai, Yosuke Fukushima, Kenji Baba, Takuya Goto, Naohiro Horio, Junko Kobayashi, Yosuke Kuroko, Yasuhiro Kotani, Sadahiko Arai, Tatsuo Iwasaki, Shuhei Sato, Shingo Kasahara, Shunji Sano, Hidemasa Oh

CIRCULATION RESEARCH 120 ( 7 ) 1162 - + 2017年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：LIPPINCOTT WILLIAMS & WILKINS

Rationale: Patients with single ventricle physiology are at high risk of mortality resulting from ventricular dysfunction. The preliminary results of the phase 1 trial showed that cardiosphere-derived cells (CDCs) may be effective against congenital heart failure.Objective: To determine whether intracoronary delivery of autologous CDCs improves cardiac function in patients with single ventricle physiology.Methods and Results: We conducted a phase 2 randomized controlled study to assign in a 1: 1 ratio 41 patients who had single ventricle physiology undergoing stage 2 or 3 palliation to receive intracoronary infusion of CDCs 4 to 9 weeks after surgery or staged reconstruction alone (study A). The primary outcome measure was to assess improvement in cardiac function at 3-month follow-up. Four months after palliation, controls had an alternative option to receive late CDC infusion on request (study B). Secondary outcomes included ventricular function, heart failure status, somatic growth, and health-related quality of life after a 12-month observation. At 3 months, the absolute changes in ventricular function were significantly greater in the CDC-treated group than in the controls (+ 6.4% [SD, 5.5] versus + 1.3% [SD, 3.7]; P= 0.003). In study B, a late CDC infusion in 17 controls increased the ventricular function at 3 months compared with that at baseline (38.8% [SD, 7.7] versus 34.8% [SD, 7.4]; P< 0.0001). At 1 year, overall CDC infusion was associated with improved ventricular function (41.4% [SD, 6.6] versus 35.0% [SD, 8.2]; P< 0.0001) and volumes (P< 0.001), somatic growth (P< 0.0001) with increased trophic factors production, such as insulin-like growth factor-1 and hepatocyte growth factor, and quality of life, along with a reduced heart failure status (P< 0.0001) and cardiac fibrosis (P= 0.014) relative to baseline.Conclusions: Intracoronary infusion of CDCs after staged palliation favorably affected cardiac function by reverse remodeling in patients with single ventricle physiology. This impact may improve heart failure status, somatic growth, and quality of life in patients and reduce parenting stress for their families.

DOI： 10.1161/CIRCRESAHA.116.310253

Web of Science

researchmap

複雑心奇形を有する成人先天性心疾患患者に対するCatheter Intervention

馬場健児, 大月審一, 近藤麻衣子, 栗田佳彦, 栄徳隆裕, 重光祐輔, 平井健太, 福嶋遙佑, 岩崎達雄, 笠原真悟

日本成人先天性心疾患学会雑誌 6 ( 1 ) 118 - 118 2017年1月

A staged decompression of right ventricle allows growth of right ventricle and subsequent biventricular repair in patients with pulmonary atresia and intact ventricular septum 査読

Yasuhiro Kotani, Shingo Kasahara, Yasuhiro Fujii, Takahiro Eitoku, Kenji Baba, Shin-ichi Otsuki, Yosuke Kuroko, Sadahiko Arai, Shunji Sano

EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY 50 ( 2 ) 298 - 303 2016年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：OXFORD UNIV PRESS INC

To achieve the growth of right-sided heart structures, our choice of the first palliation for patients with pulmonary atresia and intact ventricular septum (PA-IVS) includes a modified Blalock-Taussig shunt (BTS) with pulmonary valvotomy. We sought to analyse the impact of the first palliation on the growth of right-sided heart structures and factors associated with a choice of definitive surgical procedure.Fifty patients with PA-IVS who underwent a staged surgical approach from 1991 to 2012 were retrospectively reviewed.Right ventricular (RV)-coronary artery fistulas were seen in 42% of patients at the time of birth. All 50 patients had a modified BTS with pulmonary valvotomy. Six patients died after the first palliation or inter-stage. Thirty patients achieved a biventricular repair (BVR group), 6 patients had a 1 + 1/2 ventricular repair (1 + 1/2V group) and 5 patients had a Fontan completion (Fontan group). After modified BTS with pulmonary valvotomy, tricuspid valve z-score did not increase in any of the group (BVR: pre -2.79 vs post -2.24, 1 + 1/2V: pre -5.25 vs post -6.69, Fontan: pre -6.82 vs post -7.94). Normalized RV end-diastolic volume increased only in BVR group after modified BTS with pulmonary valvotomy (BVR: pre 32% vs post 64%, 1 + 1/2V: pre 43% vs post 42%, Fontan: pre 29% vs post 32%). Major RV-coronary artery fistula was a strong factor with proceeding single-ventricle palliation [BVR: 4/30 (13%) patients, 1 + 1/2V: 1/6 (17%) and Fontan: 4/5 (80%)].Tricuspid valve growth was not obtained by modified BTS with pulmonary valvotomy; therefore, tricuspid valve size at birth appeared to be a predictor for achieving BVR. Proportionate RV growth was seen only in patients who achieved BVR. However, RV growth was not seen in patients having 1 + 1/2 ventricular repair. Major RV-coronary artery fistula was a strong predictor for proceeding single-ventricle palliation.

DOI： 10.1093/ejcts/ezw124

Web of Science

researchmap

機能的単心室における冠動脈バルーン閉鎖下心筋幹細胞注入の実際

栄徳隆裕, 馬場健児, 近藤麻衣子, 栗田佳彦, 福嶋遥佑, 平井健太, 大月審一, 石上修大, 佐野俊二, 王英正

Journal of JPIC 1 ( 1 ) 13 - 19 2016年8月

記述言語：日本語出版者・発行元：(一社)日本先天性心疾患インターベンション学会

背景:心筋再生医療は,成人を対象としたものがほとんどで小児を対象とした臨床研究は極めて少ない.また当院で実施した小児の機能的単心室症に対する自己心臓内幹細胞移植の際に我々が行っている冠動脈バルーン閉鎖下心筋幹細胞注入の小児におけるまとまった報告は少ない.方法:岡山大学病院において冠動脈バルーン閉鎖下心筋幹細胞注入による自己心臓内幹細胞移植が第1相試験として2011年1月から2012年12月までに左心低形成症候群患者を対象に7例,また第2相試験として2013年7月から2015年3月までに機能的単心室症患者を対象に34例,合計41例に行われた.小児に対する冠動脈バルーン閉鎖下心筋幹細胞注入の手技,有害事象に関して検討を行った.結果:対象41例の自己心臓内幹細胞移植時の年齢と体重はそれぞれ中央値33ヵ月,10.1kgであった.冠動脈バルーン閉鎖下心筋幹細胞注入時に心電図上ST変化,血圧低下,脈拍低下,冠動脈攣縮を認めたが,いずれも一過性であり,重篤な合併症を認めず,全例で安全に手技を完遂できた.結語:冠動脈バルーン閉鎖下心筋幹細胞注入は機能的単心室症を有する小児においても安全に施行可能である.(著者抄録)

researchmap

Norwood-Sano procedure RingedとNon-ringed RV-PA conduitの比較(Norwood-Sano Procedure:Ringed vs Non-Ringed RV-PA conduit)

栄徳隆裕, 馬場健児, 近藤麻衣子, 栗田佳彦, 福嶋遥佑, 重光祐輔, 平井健太, 大月審一, 佐野俊二, 笠原真悟, 小谷恭弘

日本小児循環器学会雑誌 32 ( Suppl.1 ) s1 - 185 2016年7月