研究者詳細 - 片岡　隆浩

論文 - 片岡　隆浩

分割表示 86 件中 61 - 80 件目／全件表示 >>

Effects of pre and post radon inhalation on carbon tetrachloride-induced oxidative damage in mouse organs

Yuichi Nishiyama, Takahiro Kataoka, Junichi Teraoka, Akihiro Sakoda, Yuu Ishimori, Kiyonori Yamaoka

RADIOISOTOPES 61 ( 5 ) 231 - 241 2012年

Inhibitory Effects of Pretreatment with Radon on Acute Alcohol-Induced Hepatopathy in Mice

Teruaki Toyota, Takahiro Kataoka, Yuichi Nishiyama, Takehito Taguchi, Kiyonori Yamaoka

MEDIATORS OF INFLAMMATION 2012 ( Article ID 382801 ) 1 - 10 2012年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：HINDAWI PUBLISHING CORPORATION

We previously reported that radon inhalation activates antioxidative functions in the liver and inhibits carbon tetrachloride-induced hepatopathy in mice. In addition, it has been reported that reactive oxygen species contribute to alcohol-induced hepatopathy. In this study, we examined the inhibitory effects of radon inhalation on acute alcohol- induced hepatopathy in mice. C57BL/6J mice were subjected to intraperitoneal injection of 50% alcohol (5 g/kg bodyweight) after inhaling approximately 4000 Bq/m(3) radon for 24 h. Alcohol administration significantly increased the activities of glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT) in serum, and the levels of triglyceride and lipid peroxide in the liver, suggesting acute alcohol- induced hepatopathy. Radon inhalation activated antioxidative functions in the liver. Furthermore, pretreatment with radon inhibited the depression of hepatic functions and antioxidative functions. These findings suggested that radon inhalation activated antioxidative functions in the liver and inhibited acute alcohol- induced hepatopathy in mice.

DOI： 10.1155/2012/382801

Suppression of Dextran Sulfate Sodium-Induced Colitis in Mice by Radon Inhalation

Yuichi Nishiyama, Takahiro Kataoka, Keiko Yamato, Takehito Taguchi, Kiyonori Yamaoka

MEDIATORS OF INFLAMMATION 2012 ( Article ID 239617 ) 1 - 11 2012年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：HINDAWI LTD

The enhanced release of reactive oxygen species from activated neutrophils plays important role in the pathogenesis of inflammatory bowel disease. We previously reported that radon inhalation activates antioxidative functions in various organs of mice. In this study, we examined the protective effects of radon inhalation on dextran sulfate sodium- (DSS) induced colitis in mice which were subjected to DSS for 7 days. Mice were continuously treated with air only (sham) or radon at a concentration of 2000 Bq/m(3) from a day before DSS administration to the end of colitis induction. In the results, radon inhalation suppressed the elevation of the disease activity index score and histological damage score induced by DSS. Based on the changes in tumor necrosis factor-alpha in plasma and myeloperoxidase activity in the colon, it was shown that radon inhalation suppressed DSS-induced colonic inflammation. Moreover, radon inhalation suppressed lipid peroxidation of the colon induced by DSS. The antioxidant level (superoxide dismutase and total glutathione) in the colon after DSS administration was significantly higher in mice treated with radon than with the sham. These results suggested that radon inhalation suppressed DSS-induced colitis through the enhancement of antioxidative functions in the colon.

DOI： 10.1155/2012/239617

Radon Inhalation Protects Mice from Carbon-Tetrachloride-Induced Hepatic and Renal Damage

Takahiro Kataoka, Yuichi Nishiyama, Teruaki Toyota, Masaaki Yoshimoto, Akihiro Sakoda, Yuu Ishimori, Yutaka Aoyama, Takehito Taguchi, Kiyonori Yamaoka

INFLAMMATION 34 ( 6 ) 559 - 567 2011年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SPRINGER/PLENUM PUBLISHERS

We assessed whether radon inhalation provided protection from carbon tetrachloride (CCl4)-induced hepatic and renal damage in mice. Mice were subjected to intraperitoneal injection of CCl4 after inhaling approximately 18 kBq/m(3) radon for 6 h. Radon inhalation significantly increased total glutathione (t-GSH) content and glutathione peroxidase (GPx) activity in the liver and kidney. Injection of CCl4 was associated with significantly higher levels of glutamic oxaloacetic transaminase (GOT) and alkaline phosphatase (ALP) activity and creatinine level in serum, and pretreatment with radon significantly decreased the GOT and ALP activity and creatinine level associated with CCl4 injection, suggesting that radon inhalation alleviates CCl4-induced hepatic and renal damage. The t-GSH contents and GPx activity in the liver and kidney of animals pretreated with radon were significantly higher than those of the CCl4-only group. These findings suggested that radon inhalation activated antioxidative functions and inhibited CCl4-induced hepatic and renal damage in mice.

DOI： 10.1007/s10753-010-9263-7

Study of the Response of Superoxide Dismutase in Mouse Organs to Radon Using a New Large-scale Facility for Exposing Small Animals to Radon

Takahiro Kataoka, Akihiro Sakoda, Yuu Ishimori, Teruaki Toyota, Yuichi Nishiyama, Hiroshi Tanaka, Fumihiro Mitsunobu, Kiyonori Yamaoka

JOURNAL OF RADIATION RESEARCH 52 ( 6 ) 775 - 781 2011年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：JAPAN RADIATION RESEARCH SOC

We examined dose dependent or dose rate dependent changes of superoxide dismutase (SOD) activity using a new large-scale facility for exposing small animals to radon. Mice were exposed to radon at a concentration of 250, 500, 1000, 2000, or 4000 Bq/m(3) for 0.5, 1, 2, 4, or 8 days. When mice were exposed to radon at 2000 day.Bq/m(3), activation of SOD activities in plasma, liver, pancreas, heart, thymus, and kidney showed dose rate effects. Our results also suggested that continuous exposure to radon increased SOD activity, but SOD activity transiently returned to normal levels at around 2 days. Moreover, we classified the organs into four groups (1. plasma, brain, lung; 2. heart, liver, pancreas, small intestine; 3. kidney, thymus; 4. stomach) based on changes in SOD activity. Thymus had the highest responsiveness and stomach had lowest. These data provide useful baseline measurements for future studies on, radon effects.

DOI： 10.1269/jrr.10072

PERFORMANCE OF THE FIRST JAPANESE LARGE-SCALE FACILITY FOR RADON INHALATION EXPERIMENTS WITH SMALL ANIMALS

Yuu Ishimori, Fumihiro Mitsunobu, Kiyonori Yamaoka, Hiroshi Tanaka, Takahiro Kataoka, Akihiro Sakoda

RADIATION PROTECTION DOSIMETRY 146 ( 1-3 ) 31 - 33 2011年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：OXFORD UNIV PRESS

A radon test facility for small animals was developed in order to increase the statistical validity of differences of the biological response in various radon environments. This paper illustrates the performances of that facility, the first large-scale facility of its kind in Japan. The facility has a capability to conduct approximately 150 mouse-scale tests at the same time. The apparatus for exposing small animals to radon has six animal chamber groups with five independent cages each. Different radon concentrations in each animal chamber group are available. Because the first target of this study is to examine the in vivo behaviour of radon and its effects, the major functions to control radon and to eliminate thoron were examined experimentally. Additionally, radon progeny concentrations and their particle size distributions in the cages were also examined experimentally to be considered in future projects.

DOI： 10.1093/rpd/ncr100

STUDIES ON POSSIBILITY FOR ALLEVIATION OF LIFESTYLE DISEASES BY LOW-DOSE IRRADIATION OR RADON INHALATION

Takahiro Kataoka, Akihiro Sakoda, Masaaki Yoshimoto, Shinya Nakagawa, Teruaki Toyota, Yuichi Nishiyama, Keiko Yamato, Yuu Ishimori, Atsushi Kawabe, Katsumi Hanamoto, Takehito Taguchi, Kiyonori Yamaoka

RADIATION PROTECTION DOSIMETRY 146 ( 1-3 ) 360 - 363 2011年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：OXFORD UNIV PRESS

Our previous studies showed the possibility that activation of the antioxidative function alleviates various oxidative damages, which are related to lifestyle diseases. Results showed that, low-dose X-ray irradiation activated superoxide dismutase and inhibits oedema following ischaemia-reperfusion. To alleviate ischaemia-reperfusion injury with transplantation, the changes of the antioxidative function in liver graft using low-dose X-ray irradiation immediately after exenteration were examined. Results showed that liver grafts activate the antioxidative function as a result of irradiation. In addition, radon inhalation enhances the antioxidative function in some organs, and alleviates alcohol-induced oxidative damage of mouse liver. Moreover, in order to determine the most effective condition of radon inhalation, mice inhaled radon before or after carbon tetrachloride (CCl(4)) administration. Results showed that radon inhalation alleviates CCl(4)-induced hepatopathy, especially prior inhalation. It is highly possible that adequate activation of antioxidative functions induced by low-dose irradiation can contribute to preventing or reducing oxidative damages, which are related to lifestyle diseases.

DOI： 10.1093/rpd/ncr189

An Assessment of Radioactivity Levels of Pb-210 and K-40 in Tobacco and Radiation Exposure from Smoking

Tomohiro Nagamatsu, Akihiro Sakoda, Takahiro Kataoka, Toshiro Ono, Kiyonori Yamaoka

ACTA MEDICA OKAYAMA 65 ( 2 ) 91 - 95 2011年4月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：OKAYAMA UNIV MED SCHOOL

No research has been conducted on the radiation influence of tobacco on the alimentary system, although there have been some previous works on the respiratory system. In this study, the radioactive concentrations of Pb-210 and K-40 in a cigarette sample were first measured. The transfer factors of the nuclides from tobacco into smoke and solution (saliva and/or alcohol) were then examined. Moreover, the radiation doses from smoke inhalation were also evaluated. The radioactive concentrations of Pb-210 and K-40 in the cigarette tobacco were 0.01 and 0.3 Bq/cigarette. Since this Pb-210 activity and the Po-210 activity previously reported for the same sample were comparable, it can be concluded that there was a radioactive equilibrium between the 2 nuclides. The observed transfer factor of Pb-210 (12%) into smoke was almost the same as that of K-40 (15%), whereas the reported value for Po-210 (60%) was significantly higher. The radiation doses due to inhalation of cigarette smoke varied from organ to organ, depending on the organotropic properties of the nuclide. For example, the kidneys, respiratory tract, and spleen showed relatively high doses from Pb-210 and Po-210. The leaching rates indicated an inconsistent tendency related to solution types. This result could suggest that alcohol drinking, which is common in smokers, does not especially enhance the leaching characteristics.

DOI： 10.18926/AMO/45267

A comparative study on effect of continuous radon inhalation on several-time acute alcohol-induced oxidative damages of liver and brain in mouse

Takahiro Kataoka, Akihiro Sakoda, Masaaki Yoshimoto, Teruaki Toyota, Yuki, Yamamoto, Yuu Ishimori, Katsumi Hanamoto, Atsushi Kawabe, Fumihiro Mitsunobu, Kiyonori Yamaoka

Radiation Safety Management 10 ( 1 ) 1 - 7 2011年

Applicability and performance of an imaging plate at subzero temperatures

Akihiro Sakoda, Yuu Ishimori, Katsumi Hanamoto, Atsushi Kawabe, Takahiro Kataoka, Tomohiro Nagamatsu, Kiyonori Yamaoka

APPLIED RADIATION AND ISOTOPES 68 ( 10 ) 2013 - 2015 2010年10月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：PERGAMON-ELSEVIER SCIENCE LTD

The performance of imaging plates (IPs) has not been studied at temperatures lower than 0 degrees C. In the present study, an IP was irradiated with gamma rays emitted from the mineral monazite at temperatures between -80 and 30 degrees C to determine its fundamental properties. The IP response as a function of irradiation time was found to be linear, suggesting that the IP works properly at low temperatures. Fading, an effect which should be considered at temperatures of more than 0 degrees C, was not observed at -30 and 80 degrees C. Furthermore, the fading-corrected PSL value of the IP irradiated at 80 degrees C was lower than at other temperatures (30.5 and -30 degrees C). This can be explained by thermostimulated luminescence (TSL). Since the only intensive TSL peak in the temperature range from -80 to 30 degrees C is present at about -43 degrees C, some of the electrons trapped at F centers recombine with holes through the process of TSL before the stored radiation image is read out at room temperature. This finding suggests that the apparent sensitivity of the IP is lower at -80 degrees C although it is similar to sensitivities between -30 and 30 degrees C. This low sensitivity should be corrected to perform quantitative measurements. (C) 2010 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.apradiso.2010.03.020

Physiologically Based Pharmacokinetic Modeling of Inhaled Radon to Calculate Absorbed Doses in Mice, Rats, and Humans

Akihiro Sakoda, Yuu Ishimori, Atsushi Kawabe, Takahiro Kataoka, Katsumi Hanamoto, Kiyonori Yamaoka

JOURNAL OF NUCLEAR SCIENCE AND TECHNOLOGY 47 ( 8 ) 731 - 738 2010年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：TAYLOR & FRANCIS LTD

This is the first report to provide radiation doses, arising from inhalation of radon itself, in mice and rats. To quantify absorbed doses to organs and tissues in mice, rats, and humans, we computed the behavior of inhaled radon in their bodies on the basis of a physiologically based pharmacokinetic (PBPK) model. It was assumed that radon dissolved in blood entering the gas exchange compartment is transported to any tissue by the blood circulation to be instantaneously distributed according to a tissue/blood partition coefficient. The calculated concentrations of radon in the adipose tissue and red bone marrow following its inhalation were much higher than those in the others, because of the higher partition coefficients. Compared with a previous experimental data for rats and model calculation for humans, the present calculation was proved to be valid. Absorbed dose rates to organs and tissues were estimated to be within the range of 0.04-1.4 nGy (Bq m(-3))(-1) day(-1) for all the species. Although the dose rates are not so high, it may be better to pay attention to the dose to the red bone marrow from the perspective of radiation protection. For more accurate dose assessment, it is necessary to update tissue/blood partition coefficients of radon that strongly govern the result of the PBPK modeling.

DOI： 10.1080/18811248.2010.9711649

First model of the effect of grain size on radon emanation

Akihiro Sakoda, Katsumi Hanamoto, Yuu Ishimori, Takahiro Kataoka, Atsushi Kawabe, Kiyonori Yamaoka

APPLIED RADIATION AND ISOTOPES 68 ( 6 ) 1169 - 1172 2010年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：PERGAMON-ELSEVIER SCIENCE LTD

The present model represents an improvement on previous models of radon emanation from soil by incorporating soil grain size in addition to moisture. Monte Carlo simulation was employed in the calculation since it was difficult to mathematically express the radon emanation fraction for the present soil model. Grain size is one of the most important factors in describing the properties of soil. Grain size was demonstrated to affect the radon emanation fraction, depending on moisture content. Although the emanation fraction is generally considered to be proportional to grain size, the result of the model calculation suggested that the effect of grain size is not so simple. This study should serve as an initial step toward improving the modeling of this radon emanation. (C) 2010 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.apradiso.2009.11.070

Differences of natural radioactivity and radon emanation fraction among constituent minerals of rock or soil

Akihiro Sakoda, Yuichi Nishiyama, Katsumi Hanamoto, Yuu Ishimori, Yuki Yamamoto, Takahiro Kataoka, Atsushi Kawabe, Kiyonori Yamaoka

APPLIED RADIATION AND ISOTOPES 68 ( 6 ) 1180 - 1184 2010年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：PERGAMON-ELSEVIER SCIENCE LTD

We examined differences in the radioactive characteristics among the main minerals forming granite materials. Using a non-toxic high-density agent, minerals were separated from rock (granite-gneiss) and soil (weathered granite) samples. The natural radioactivity ((238)U and (226)Ra) and radon emanation fraction of the minerals were then studied by gamma-ray spectrometry. The radon emanation fractions (27-43%) of the minerals from the soil were much higher than those (0.6-4.6%) of the rock minerals. Additionally, the emanation fractions differed greatly among the minerals separated from both the bulk rock and soil. These results were discussed in terms of the differences of surface area and radium distribution in the mineral grains. It was noticeable that a higher emanation fraction than expected for quartz was commonly observed in the rock and soil samples. We then estimated the contribution of each constituent mineral to the total radon exhalation from the bulk samples. The result depended not only on the radon emanation fraction, but also on the (226)Ra activity and the mineral content. Furthermore, using the obtained data, we also discussed the effect of grain size on radon emanation and why this has been reported to vary markedly in previous studies. (C) 2010 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.apradiso.2009.12.036

Experimental and modeling studies of grain size and moisture content effects on radon emanation

Akihiro Sakoda, Yuu Ishimori, Katsumi Hanamoto, Takahiro Kataoka, Atsushi Kawabe, Kiyonori Yamaoka

RADIATION MEASUREMENTS 45 ( 2 ) 204 - 210 2010年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：PERGAMON-ELSEVIER SCIENCE LTD

Some models have already been developed to explain the effect of moisture content on the radon emanation fraction of soil. For this purpose, "microscopic" soil models, which are easy to deal with mathematically but cannot take grain size into consideration, have been designed. These previous models consist basically of two opposite grain surfaces and pores between the grains. In the present study, in order to study the effect of not only moisture content but also grain size, we present a simple modeling approach based on two "macroscopic" soil models: (1) a single-grain model and (2) a multiple-grain model. The latter model represents a configuration of spherical grains packed in a simple cubic structure. Based on these soil models and general assumptions, the radon emanation fraction was calculated as a function of grain size or moisture content by Monte Carlo simulation. The results for the multiple-grain model show that the radon emanation fraction is markedly increased with grain sizes ranging from 10 to 100 inn and reaches a constant value of 50% when moisture content is 0% and the radium is uniformly distributed on the grain surface. Moreover, a drastic increase is seen at smaller grain sizes with increasing moisture content. From these results, we concluded that the calculation of radon emanation depends greatly on the pore size between a Ra-bearing grain and a neighboring grain. The validity of the model was also evaluated by comparison to experimental data. (C) 2010 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.radmeas.2010.01.010

Development of a radon test facility for small animals

Yuu Ishimori, Fumihiro Mitsunobu, Kiyonori Yamaoka, Hiroshi Tanaka, Takahiro Kataoka, Akihiro Sakoda

保健物理 45 ( 1 ) 65 - 71 2010年

小動物病院におけるX線撮影に伴う放射線診療従事者の実効線量評価

川辺睦, 山田一孝, 花元克巳, 迫田晃弘, 片岡隆浩, 山岡聖典

動物臨床医学 19 ( 4 ) 113 - 117 2010年

記述言語：日本語出版者・発行元：動物臨床医学会

獣医療でX線撮影を実施するにあたっては，獣医療診療従事者等（獣医師および動物看護師，以下従事者等とする）による用手保定が必要になることが多い。このため，多くの検査で遠隔操作が可能な人間医療より従事者等の被ばくが高くなる可能性がある。しかしながら，これまでわが国における従事者等の被ばくに関する報告はほとんど見あたらず，正確な実態をつかめないのが現状である。また，体幹部防護衣を着用した従事者等は不均等被ばくの様態を呈し，測定基本部位のみのモニタリングでは実効線量を過小評価するおそれがある。そこで本研究では，一般的なX線撮影を用手保定法により行うときの従事者等の被ばくを，体幹部防護衣着用の前提で実効線量により評価した。その結果，90 kV，4 mAsで体厚20 cm程度の動物を撮影するときの従事者等の実効線量は約2.4 μSvとなり，1週間につき160回程度の撮影で年間の線量限度に達する見込みであることがわかった。

DOI： 10.11252/dobutsurinshoigaku.19.113

Basic Study on Active Changes in Biological Function of Mouse Liver Graft in Cold Storage after Low-Dose X-Irradiation

Takahiro Kataoka, Masaaki Yoshimoto, Shinya Nakagawa, Yuko Mizuguchi, Takehito Taguchi, Kiyonori Yamaoka

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION 45 ( 2 ) 219 - 226 2009年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：JOURNAL CLINICAL BIOCHEMISTRY & NUTRITION

We previously reported that low-dose X-irradiation alleviates ischemia-reperfusion injury such as mouse paw edema. In this study, we examined active changes in the biological function of mouse liver grafts in cold storage after low-dose X-irradiation. Mouse livers were sham-irradiated or were irradiated with 0.25, 0.5, 1.0, or 5.0 Gy of X-ray and stored for 4, 8, 24, or 48 h in preservation or saline solution. The results show that storage for 24 h in saline solution after 0.5 Gy irradiation significantly increased the activity of superoxide dismutase (SOD) and catalase. Following storage for 4, 8, or 48 h in preservation solution, lipid peroxide levels of the 0.5 Gy irradiated group were significantly lower than those of the sham irradiated group. Following storage for 24 h in preservation solution, the activity of SOD and catalase of the 1.0 Gy irradiated group were significantly higher than those of the sham irradiated group. Hepatocytes stored in saline solution were vacuolated. However, no vacuole formation was observed in hepatocytes stored in preservation solution. These findings suggest that low-dose irradiation significantly activates antioxidative functions of liver grafts. Moreover, the dose at which enhancement of antioxidative function occurs in livers stored in preservation solution, which contains glutathione, is significantly higher than that in saline solution.

DOI： 10.3164/jcbn.09-06

No different sensitivity in terms of whole-body irradiation between normal and acatalasemic mice

Shinya Nakagawa, Takahiro Kataoka, Yuko Mizuguchi, Masaaki Yoshimoto, Akihiro Sakoda, Takaharu Nomura, Da-Hong Wang, Atsushi Kawabe, Takehito Taguchi, Kiyonori Yamaoka

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION 43 ( 1 ) 41 - 49 2008年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：JOURNAL CLINICAL BIOCHEMISTRY & NUTRITION

To elucidate the radiosensitivity of an acatalasemic mouse, we examined the time and dose-dependency in the survival rates, the lymphocytes and the intestinal epithelial cells, and the antioxidant function after 3.0 to 12.0 Gy whole body irradiation. Results showed that no significant differences between acatalasemic mice and normal mice were observed in the survival rates and the histological changes in spleens and small intestine after each irradiation. The catalase activities in livers and spleens of acatalasemic mice were significantly lower than those of normal mice and the glutathione peroxidase activity in livers of acatalasemic mice was significantly higher than that of normal mice. At 10 days after 6.0 Gy irradiation, the catalase activities in livers of acatalasemic and normal mice and that in spleens of normal mice significantly decreased compared with no-irradiation control, and there were no differences between those catalase activities. The total glutathione content in acatalasemic mice was significantly higher than that in normal mice at 10 days after 6.0 Gy irradiation. These findings suggested that the radiosensitivity of acatalasemic mice in terms of whole body irradiation doesn't significantly differ from that of normal mice, probably due to compensated sufficient contents of glutathione peroxidase and total glutathione in acatalasemic mice.

DOI： 10.3164/jcbn.2008042

ラドン吸入試作装置によるマウス諸臓器中の抗酸化機能の亢進に関する研究.

中川慎也, 片岡隆浩, 迫田晃弘, 石森有, 花元克巳, 山岡聖典

RADIOISOTOPES 57 ( 4 ) 241 - 251 2008年

Inhibitory effects of prior low-dose X-irradiation on ischemia-reperfusion injury in mouse paw

Takahiro Kataoka, Yuko Mizuguchi, Masaaki Yoshimoto, Takehito Taguchi, Kiyonori Yamaoka

JOURNAL OF RADIATION RESEARCH 48 ( 6 ) 505 - 513 2007年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：OXFORD UNIV PRESS

We have reported that low-dose, unlike high-dose, irradiation enhanced antioxidation function and reduced oxidative damage. On the other hand, ischemia-reperfusion injury is induced by reactive oxygen species. In this study, we examined the inhibitory effects of prior low-dose X-irradiation on ischemia-reperfusion injury in mouse paw. BALB/c mice were irradiated by sham or 0.5 Gy of X-ray. At 4 hrs after irradiation, the left hind leg was bound 10 times with a rubber ring for 0.5, 1, or 2 hrs and the paw thickness was measured. Results show that the paw swelling thickness by ischemia for 0.5 hr was lower than that for 2 hrs. At I hr after reperfusion from ischemia for I hr, superoxide dismutase activity in serum was increased in those mice which received 0.5 Gy irradiation and in the case of the ischemia for 0.5 or I hr, the paw swelling thicknesses were inhibited by 0.5 Gy irradiation. In addition, interstitial edema in those mice which received 0.5 Gy irradiation was less than that in the mice which underwent by sham irradiation. These findings suggest that the ischemia-reperfusion injury is inhibited by the enhancement of antioxidation function by 0.5 Gy irradiation.

DOI： 10.1269/jrr.07060

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