研究者詳細 - 片岡　隆浩

論文 - 片岡　隆浩

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Recent Studies on Anti-inflammatory Effects of Radon Inhalation in Mice

Norie Kanzaki, Takahiro Kataoka, Reo Etani, Kiyonori Yamaoka

Inflammation & Cell Signaling 1 ( 6 ) 1 - 5 2015年

Radon Inhalation Protects Against Transient Global Cerebral Ischemic Injury in Gerbils

Takahiro Kataoka, Reo Etani, Yuji Takata, Yuichi Nishiyama, Atsushi Kawabe, Masayuki Kumashiro, Takehito Taguchi, Kiyonori Yamaoka

INFLAMMATION 37 ( 5 ) 1675 - 1682 2014年10月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SPRINGER/PLENUM PUBLISHERS

Although brain disorders are not the main indication for radon therapy, our previous study suggested that radon inhalation therapy might mitigate brain disorders. In this study, we assessed whether radon inhalation protects against transient global cerebral ischemic injury in gerbils. Gerbils were treated with inhaled radon at a concentration of 2,000 Bq/m(3) for 24 h. After radon inhalation, transient global cerebral ischemia was induced by bilateral occlusion of the common carotid artery. Results showed that transient global cerebral ischemia induced neuronal damage in hippocampal CA1, and the number of damaged neurons was significantly increased compared with control. However, radon treatment inhibited ischemic damage. Superoxide dismutase (SOD) activity in the radon-treated gerbil brain was significantly higher than that in sham-operated gerbils. These findings suggested that radon inhalation activates antioxidative function, especially SOD, thereby inhibiting transient global cerebral ischemic injury in gerbils.

DOI： 10.1007/s10753-014-9896-z

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Effects of cream containing ultralow volume radionuclides on carrageenan-induced inflammatory paw edema in mice

Takahiro Kataoka, Yuji Takata, Reo Etani, Yuichi Nishiyama, Atsushi Kawabe, Katsumi Hanamoto, Takehito Taguchi, Kiyonori Yamaoka

Biochemistry & Physiology 3 ( 2 ) 1 - 5 2014年

Absorbed doses of lungs from radon retained in airway lumens of mice and rats

Akihiro Sakoda, Yuu Ishimori, Kiyonori Yamaoka, Takahiro Kataoka, Fumihiro Mitsunobu

RADIATION AND ENVIRONMENTAL BIOPHYSICS 52 ( 3 ) 389 - 395 2013年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SPRINGER

This paper provides absorbed doses arising from radon gas in air retained in lung airway lumens. Because radon gas exposure experiments often use small animals, the calculation was performed for mice and rats. For reference, the corresponding computations were also done for humans. Assuming that radon concentration in airway lumens is the same as that in the environment, its progeny's production in and clearance from airways were simulated. Absorbed dose rates were obtained for three lung regions and the whole lung, considering that secretory and basal cells are sensitive to radiation. The results showed that absorbed dose rates for all lung regions and whole lung generally increase from mice to rats to humans. For example, the dose rates for the whole lung were 25.4 in mice, 41.7 in rats, and 59.9 pGy (Bq m(-3))(-1) h(-1) in humans. Furthermore, these values were also compared with lung dose rates from two other types of exposures, that is, due to inhalation of radon or its progeny, which were already reported. It was confirmed that the direct inhalation of radon progeny in the natural environment, which is known as a cause of lung cancer, results in the highest dose rates for all species. Based on the present calculations, absorbed dose rates of the whole lung from radon gas were lower by a factor of about 550 (mice), 200 (rats), or 70 (humans) than those from radon progeny inhalation. The calculated dose rate values are comparatively small. Nevertheless, the present study is considered to contribute to our understanding of doses from inhalation of radon and its progeny.

DOI： 10.1007/s00411-013-0478-5

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Preventive and curative effects of radon inhalation on chronic constriction injury-induced neuropathic pain in mice

K. Yamato, T. Kataoka, Y. Nishiyama, T. Taguchi, K. Yamaoka

EUROPEAN JOURNAL OF PAIN 17 ( 4 ) 480 - 492 2013年4月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：WILEY-BLACKWELL

Background Radon therapy is clinically useful for the treatment of pain-related diseases. However, there have been no studies regarding the effects of radon inhalation on neuropathic pain. In this study, we aimed to determine whether radon inhalation actually induced a remission of neuropathic pain and improved the quality of life. Methods First, we investigated the antinociceptive effects of radon inhalation in the chronic constriction injury (CCI) model of neuropathic pain. We evaluated pain behaviour in mice before and after CCI surgery, using von Frey test. Pretreated mice received CCI surgery immediately after 24-h inhalation of radon at background (BG) concentration (c. 19Bq/m3), or at a concentration of 1000 or 2000Bq/m3, and post-treated mice inhaled similar levels of radon 2 days after CCI surgery. Results CCI surgery induced mechanical allodynia and hyperalgesia on a plantar surface of mice, as assessed using von Frey test, and 2000Bq/m3 radon inhalation alleviated hyperalgesic conditions 2237% compared to BG level concentration. Concurrently, CCI surgery increased norepinephrine (NE), tumour necrosis factor-alpha (TNF-) and nitric oxide (NO) concentrations in plasma, and leukocyte migration in paws. Furthermore, CCI-induced neuropathy reduced superoxide dismutase (SOD) activity. Treatment with radon inhalation, specifically at a concentration of 2000Bq/m3, produced antinociceptive effects, i.e., lowered plasma TNF-, NE and NO levels and restored SOD activity, as well as pain-related behaviour. Conclusions This study showed that inhalation of 2000Bq/m3 radon prevented and alleviated CCI-induced neuropathic pain in mice.

DOI： 10.1002/j.1532-2149.2012.00210.x

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Antinociceptive Effects of Radon Inhalation on Formalin-Induced Inflammatory Pain in Mice

Keiko Yamato, Takahiro Kataoka, Yuichi Nishiyama, Takehito Taguchi, Kiyonori Yamaoka

INFLAMMATION 36 ( 2 ) 355 - 363 2013年4月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SPRINGER/PLENUM PUBLISHERS

Radon therapy is clinically useful for the treatment of inflammatory diseases. The mechanisms of pain relief remain to be fully elucidated. In this study, we investigated the antinociceptive effects of radon inhalation in a mouse model of formalin-induced inflammatory pain. Immediately, after radon inhalation at a concentration of background level (ca. 19 Bq/m(3)), 1,000 or 2,000 Bq/m(3) for 24 h, 1.35 % formalin (0.5 % formaldehyde in saline, 20 mu l) was subcutaneously injected into the hind paw of mice, and we measured licking response time. Radon inhalation inhibited the second phase of response in formalin test. Formalin administration induced nociception and increased tumor necrosis factor alpha (TNF-alpha) and nitric oxide (NO) levels in serum and leukocyte migration in paws. Concurrently, formalin injection decreased antioxidative functions. Radon inhalation produced antinociceptive effects, i.e., lowered serum TNF-alpha and NO levels, and restored antioxidative functions. The results showed that radon inhalation inhibited formalin-induced inflammatory pain.

DOI： 10.1007/s10753-012-9554-2

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Suppression of streptozotocin-induced type-1 diabetes in mice by radon inhalation

Y. Nishiyama, T. Kataoka, J. Teraoka, A. Sakoda, H. Tanaka, Y. Ishimori, F. Mitsunobu, T. Taguchi, K. Yamaoka

Physiological Research 62 ( 1 ) 57 - 66 2013年

記述言語：英語掲載種別：研究論文（学術雑誌）

We examined the protective effect of radon inhalation on streptozotocin (STZ)-induced type-1 diabetes in mice. Mice inhaled radon at concentrations of 1000, 2500, and 5500 Bq/m3 for 24 hours before STZ administration. STZ administration induced characteristics of type-1 diabetes such as hyperglycemia and hypoinsulinemia
however, radon inhalation at doses of 1000 and 5500 Bq/m3 significantly suppressed the elevation of blood glucose in diabetic mice. Serum insulin was significantly higher in mice pre-treated with radon at a dose of 1000 Bq/m3 than in mice treated with a sham. In addition, superoxide dismutase activities and total glutathione contents were significantly higher and lipid peroxide was significantly lower in mice pre-treated with radon at doses of 1000 and 5500 Bq/m3 than in mice treated with a sham. These results were consistent with the result that radon inhalation at 1000 and 5500 Bq/m3 suppressed hyperglycemia. These findings suggested that radon inhalation suppressed STZ-induced type-1 diabetes through the enhancement of antioxidative functions in the pancreas. © 2013 Institute of Physiology v.v.i., Academy of Sciences of the Czech Republic, Prague, Czech Republic.

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ラドンの健康影響に関する一考察ラドン療法の効果と機構に関する最近の研究動向

西山祐一, 片岡隆浩, 山岡聖典

日本原子力学会和文論文誌 12 ( 4 ) 267 - 276 2013年

ラドン療法に関する最近の研究動向-鎮痛効果に着目して-

大和恵子, 片岡隆浩, 西山祐一, 山岡聖典

放射線生物研究 48 ( 1 ) 66 - 81 2013年

記述言語：日本語出版者・発行元：放射線生物研究会

ラドン療法は、疼痛性疾患・呼吸器疾患・消化器疾患・代謝性疾患などに対し改善効果があるとされている。しかし、これまでにラドン療法による改善効果について科学的に実証したデータは少なく、その機構の詳細な解明も必要とされている。適応症のうち欧州では特に効果度の高いとされる疼痛性疾患に対する治療が盛んに行われ、臨床試験により持続的な疼痛の軽減や鎮痛薬服用量の減少などが明らかにされつつある。筆者らも動物実験により、ラドン吸入による疼痛の軽減やこれを示す関連物質の変化などを明らかにしている。本稿では、このラドン療法に伴う鎮痛効果に関して、欧州における最近の研究動向や筆者らによる神経障害性疼痛・炎症性疼痛・炎症性浮腫などの緩和効果に関する研究について概説する。(著者抄録)

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Study of Antioxidative Effects and Anti-inflammatory Effects in Mice due to Low-dose X-irradiation or Radon Inhalation

Journal of Radiation Research 54 ( 4 ) 587 - 596 2013年

Comparative study on the inhibitory effects of antioxidant vitamins and radon on carbon tetrachloride-induced hepatopathy

Takahiro Kataoka, Yuichi Nishiyama, Keiko Yamato, Junichi Teraoka, Yuji Morii, Akihiro Sakoda, Yuu Ishimori, Takehito Taguchi, Kiyonori Yamaoka

JOURNAL OF RADIATION RESEARCH 53 ( 6 ) 830 - 839 2012年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：OXFORD UNIV PRESS

We have previously reported that radon inhalation activates anti-oxidative functions and inhibits carbon tetrachloride (CCl4)-induced hepatopathy. It has also been reported that antioxidant vitamins can inhibit CCl4-induced hepatopathy. In the current study, we examined the comparative efficacy of treatment with radon, ascorbic acid and alpha-tocopherol on CCl4-induced hepatopathy. Mice were subjected to intraperitoneal injection of CCl4 after inhaling approximately 1000 or 2000 Bq/m(3) radon for 24 h, or immediately after intraperitoneal injection of ascorbic acid (100, 300, or 500 mg/kg bodyweight) or alpha-tocopherol (100, 300, or 500 mg/kg bodyweight). We estimated the inhibitory effects on CCl4-induced hepatopathy based on hepatic function-associated parameters, oxidative damage-associated parameters and histological changes. The results revealed that the therapeutic effects of radon inhalation were almost equivalent to treatment with ascorbic acid at a dose of 500 mg/kg or alpha-tocopherol at a dose of 300 mg/kg. The activities of superoxide dismutase, catalase, and glutathione peroxidase in the liver were significantly higher in mice exposed to radon than in mice treated with CCl4 alone. These findings suggest that radon inhalation has an anti-oxidative effect against CCl4-induced hepatopathy similar to the anti-oxidative effects of ascorbic acid or alpha-tocopherol due to the induction of anti-oxidative functions.

DOI： 10.1093/jrr/rrs057

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Lung dosimetry of inhaled radon progeny in mice

Akihiro Sakoda, Yuu Ishimori, Kosuke Fukao, Kiyonori Yamaoka, Takahiro Kataoka, Fumihiro Mitsunobu

RADIATION AND ENVIRONMENTAL BIOPHYSICS 51 ( 4 ) 425 - 442 2012年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SPRINGER

Biological response of exposure to radon progeny has long been investigated, but there are only few studies in which absorbed doses in lungs of laboratory animals were estimated. The present study is the first attempt to calculate the doses of inhaled radon progeny for mice. For reference, the doses for rats and humans were also computed with the corresponding models. Lung deposition of particles, their clearance, and energy deposition of alpha particles to sensitive tissues were systematically simulated. Absorbed doses to trachea and bronchi, bronchioles and terminal bronchioles, alveolar-interstitial regions, and whole lung were first provided as a function of monodisperse radon progeny particles with an equilibrium equivalent radon concentration of 1 Bq m(-3) (equilibrium factor, 0.4 and unattached fraction, 0.01). Based on the results, absorbed doses were then calculated for (1) a reference mine condition and (2) a condition previously used for animal experiments. It was found that the whole lung doses for mice, rats, and humans were 34.8, 20.7, and 10.7 nGy (Bq m(-3))(-1) h(-1) for the mine condition, respectively, while they were 16.9, 9.9, and 6.5 nGy (Bq m(-3))(-1) h(-1) for the animal experimental condition. In both cases, the values for mice are about 2 times higher than those for rats, and about 3 times higher than those for humans. Comparison of our data on rats and humans with those published in the literature shows an acceptable agreement, suggesting the validity of the present modeling for mice. In the future, a more sophisticated dosimetric study of inhaled radon progeny in mice would be desirable to demonstrate how anatomical, physiological, and environmental parameters can influence absorbed doses.

DOI： 10.1007/s00411-012-0431-z

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Radioactivity of Pb-210 in Japanese cigarettes and radiation dose from smoking inhalation

A. Sakoda, K. Fukao, A. Kawabe, T. Kataoka, K. Hanamoto, K. Yamaoka

RADIATION PROTECTION DOSIMETRY 150 ( 1 ) 109 - 113 2012年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：OXFORD UNIV PRESS

It is well known that cigarette tobaccos contain naturally occurring radioactive nuclides such as Pb-210 and Po-210. In many countries, the radioactivity of tobaccos has been measured to estimate the effective dose from smoking inhalation. The present study covered 24 cigarette brands including the top 20 of sales in Japan between April 2008 and March 2009. The activity concentrations of Pb-210 were measured by gamma-ray spectrometry, and then those of its progeny (Po-210) were evaluated assuming the radioactive equilibrium between the two nuclides. Their concentrations were in the range of 214 mBq cigarette(1) with an arithmetic mean of 83 mBq cigarette(1). The annual committed effective doses were also calculated, based on the scenario that a smoker consumes 20 cigarettes a day. The average doses from Pb-210 and Po-210 inhalations were 229 and 6827 Sv y(1), respectively.

DOI： 10.1093/rpd/ncr364

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Protective Effects of Radon Inhalation on Carrageenan-Induced Inflammatory Paw Edema in Mice

Takahiro Kataoka, Junichi Teraoka, Akihiro Sakoda, Yuichi Nishiyama, Keiko Yamato, Mayuko Monden, Yuu Ishimori, Takaharu Nomura, Takehito Taguchi, Kiyonori Yamaoka

INFLAMMATION 35 ( 2 ) 713 - 722 2012年4月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SPRINGER/PLENUM PUBLISHERS

We assessed whether radon inhalation inhibited carrageenan-induced inflammation in mice. Carrageenan (1% v/v) was injected subcutaneously into paws of mice that had or had not inhaled approximately 2,000 Bq/m(3) of radon for 24 h. Radon inhalation significantly increased superoxide dismutase (SOD) and catalase activities and significantly decreased lipid peroxide levels in mouse paws, indicating that radon inhalation activates antioxidative functions. Carrageenan administration induced paw edema and significantly increased tumor necrosis factor-alpha (TNF-alpha) and nitric oxide in serum. However, radon inhalation significantly reduced carrageenan-induced paw edema. Serum TNF-alpha levels were lower in the radon-treated mice than in sham-treated mice. In addition, SOD and catalase activities in paws were significantly higher in the radon-treated mice than in the sham-treated mice. These findings indicated that radon inhalation had anti-inflammatory effects and inhibited carrageenan-induced inflammatory paw edema.

DOI： 10.1007/s10753-011-9364-y

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Study on effects of thoron and thermal treatment for aging-related diseases in humans

Y. Aoyama, T. Kataoka, Sh. Nakagawa, A. Sakoda, Y. Ishimori, F. Mitsunobu, K. Yamaoka

IRANIAN JOURNAL OF RADIATION RESEARCH 9 ( 4 ) 221 - 229 2012年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：IJRR-IRANIAN JOURNAL RADIATION RES

Background: The aim of this study was to analyze the effects of thoron and thermal treatment for aging-related diseases in humans. Materials and Methods: All subjects inhaled thoron with a high concentration (about 4900 Bq/m(3)) for 2 weeks. Blood pressures were measured and blood samples were collected after each treatment 1, 2 and 3 weeks after the first treatment. Results: The alpha-atrial natriuretic peptide level of the rheumatoid arthritis group was increased and the blood pressure was significantly decreased. Superoxide dismutase activity of rheumatoid arthritis group was significantly increased by treatment. In addition, thoron and thermal treatment significantly enhanced the concanavalin A-induced mitogen response and increased the level of CD4-positive cells; it decreased the level of CD8-positive cells. The results suggest that thoron and thermal treatment activates antioxidative function. Furthermore, these findings suggest that thoron and thermal treatment prevents diabetic ketoacidosis and contributes to the prevention of aging-related diseases. Conclusion: Thoron and thermal therapy may be part of the mechanism for the alleviation of diabetes mellitus and rheumatoid arthritis. Iran. J. Radiat. Res., 2012; 9(4): 221-229

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Pressure dependence of X-rays produced by an LiTaO3 single crystal at low pressures

Katsumi Hanamoto, Atsushi Kawabe, Akihiro Sakoda, Takahiro Kataoka, Mari Okada, Kiyonori Yamaoka

NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT 669 ( 21 ) 66 - 69 2012年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：ELSEVIER SCIENCE BV

The energy spectra of X-rays produced by an LiTaO3 single crystal have been measured at pressures of 5-50 Pa. The energy spectra showed that the amount of X-rays increased exponentially and the endpoint energy of the spectra increased linearly with the decrease of pressure at pressures of 10-25 Pa. A maximum endpoint energy of about 22 key was obtained using an LiTaO3 single crystal with 0.5 mm thickness at the pressure of 10 Pa. The maximum energy produced by the present experimental setup was estimated assuming that the LiTaO3 single crystal forms a parallel-plate capacitor. The estimated energy reasonably agreed with the energy obtained. The pressure dependence of the endpoint energy was discussed in relation to the breakdown potential at low pressures. (C) 2011 Elsevier B.V. All rights reserved.

DOI： 10.1016/j.nima.2011.12.028

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Inhibitory Effects of Prior Low-dose X-irradiation on Cold-induced Brain Injury in Mouse

Masaaki Yoshimoto, Takahiro Kataoka, Teruaki Toyota, Takehito Taguchi, Kiyonori Yamaoka

INFLAMMATION 35 ( 1 ) 89 - 97 2012年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SPRINGER/PLENUM PUBLISHERS

We examined the inhibitory effects of low-dose X-irradiation on mouse brain tissue with cold-induced injury by comparing tissue samples from three groups of mice: control, sham-irradiated cold-exposed, and X-ray-irradiated (0.5 Gy) cold-exposed mice. The water content in brain increased significantly in the sham-irradiated group following the cold-induced injury relative to the control group. However, water content in brain tissue from the X-ray-irradiated group was significantly lower than that from the sham-irradiated group. Levels of antioxidants, such as superoxide dismutase and glutathione, in brain tissue from the X-ray-irradiated group were higher than those from the sham-irradiated group. Moreover, the cold injury-induced cell death, particularly apoptosis, while low-dose irradiation inhibited cell death, especially among glial cells, but not numeral cells. These findings suggest that prior low-dose X-irradiation activated antioxidant function and inhibited cold-induced brain injury.

DOI： 10.1007/s10753-011-9293-9

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Comparative study on the inhibitory effects of α-tocopherol and radon on carbon tetrachloride-induced renal damage

Takahiro Kataoka, Keiko Yamato, Yuichi Nishiyama, Yuji Morii, Reo Etani, Yuji Takata, Katsumi Hanamoto, Atsuishi Kawabe, Akihiro Sakoda, Yuu Ishimori, Takehito Taguchi, Kiyonori Yamaoka

Renal Failure 34 ( 9 ) 1181 - 1187 2012年

Activation of bio-defense system by low-dose irradiation or radon inhalation and its applicable possibility for treatment of diabetes and hepatopathy

Takahiro Kataoka, Kiyonori Yamaoka

ISRN Endocrinology 2012 1 - 11 2012年

ラドン吸入がペットの健康改善に及ぼす効果に関する基礎的検討

片岡隆浩, 徳永力三, 迫田晃弘, 川辺睦, 花元克巳, 山岡聖典

RADIOISOTOPES 61 ( 1 ) 1 - 8 2012年

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