研究者詳細 - 片岡　隆浩

論文 - 片岡　隆浩

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Comparative Effects of Radon Inhalation According to Mouse Strain and Cisplatin Dose in a Cisplatin-induced Renal Damage Model

Sasaoka, Kaori, Kataoka, Takahiro, Kanzaki, Norie, Kobashi, Yusuke, Sakoda, Akihiro, Ishimori, Yuu, Yamaoka, Kiyonori

PAKISTAN JOURNAL OF ZOOLOGY 50 ( 3 ) 1157 - 1170 2018年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：ZOOLOGICAL SOC PAKISTAN

Cisplatin (CDDP) is widely used for treating solid cancers; however, it induces nephrotoxicity caused by oxidative stress. Here, we investigated whether radon inhalation has different effects against CDDP-induced renal injury in two mouse strains differing in radiosensitivity, and determined the appropriate dose of CDDP combined with radon inhalation for highly radiosensitive mice. CDDP was administered at 20 mg/kg weight to C57BL/6J and BALB/c mice after radon inhalation at 1000 Bq/m(3) and 2000 Bq/m(3) for 24 h. Radon inhalation had a slight positive effect against CDDP toxicity in C57BL/6J mice with respect to improved hair condition, whereas radon inhalation exacerbated CDDP-induced toxicity in BALB/c mice, such as a decrease in hair condition, higher creatinine levels, and decreased antioxidant contents (catalase and glutathione). When BALB/c mice were treated with a lower dose of CDDP (15 mg/kg) after 1000 Bq/m(3) radon inhalation, the creatinine level was reduced and the superoxide dismutase content was increased, suggesting that this combination might have a protective effect against the CDDP-induced renal damage. The supportive effect of radon inhalation shows its good potential as a candidate treatment to alleviate CDDP-induced renal damage in veterinary medicine.

DOI： 10.17582/journal.pjz/2018.50.3.1157.1170

Pressure dependence of X-rays produced by an LiTaO3 single crystal over a wide range of pressure

Katsumi Hanamoto, Takahiro Kataoka, Kiyonori Yamaoka

Applied Radiation and Isotopes 135 40 - 42 2018年5月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Elsevier Ltd

The energy spectra of X-rays produced by an LiTaO3 single crystal have been measured at the pressures of 8 × 10−4−4 Pa. The energy spectra showed that the endpoint energy steadily increased with decrease of pressure at 2–4 Pa and gradually decreased with decrease of pressure at 0.1–2 Pa, and became almost constant below 0.1 Pa. The amount of X-rays steadily increased with decrease of pressure at 2–4 Pa and almost saturated below 0.5 Pa. The change of X-rays produced by the LiTaO3 single crystal was compared with the previous works and discussed in relation to the distance between the crystal surface and the target.

DOI： 10.1016/j.apradiso.2018.01.019

ラドン吸入による抗酸化機能の亢進と抗酸化ビタミン摂取との複合効果に関する研究動向査読

片岡隆浩, 山岡聖典

放射線生物研究 53 ( 3 ) 211 - 222 2018年

記述言語：日本語出版者・発行元：放射線生物研究会

ラドン療法には疼痛性・呼吸器・消化器などの疾患に対し症状緩和の効果があることが、臨床試験に結果に基づき報告されている。また、我々は動物実験などにより、これら症状緩和のメカニズムには抗酸化機能などの生体防御機能の亢進が関与していることも明らかにしてきた。本稿では、この内、ラドン吸入による抗酸化機能の亢進と、これと抗酸化ビタミン摂取の複合効果に関して、我々の得た研究成果を中心に概説する。すなわち、マウスにおいて四塩化炭素(CCl4)誘導障害の抑制の程度から、肝臓では1000Bq/m3または2000Bq/m3のラドンを24時間吸入させた場合と500mg/kg体重アスコルビン酸または300mg/kg体重α-トコフェロールの摂取が、腎臓では2000Bq/m3のラドンを24時間吸入と300〜500mg/kg体重α-トコフェロール摂取が、それぞれ等しい効果であった。また、スナネズミにおいて一過性脳虚血に伴う海馬CAl領域の細胞損傷の抑制の程度から、2000Bq/m3のラドンを24時間吸入と500mg/kg体重アスコルビン酸摂取が等しい効果であった。他方、急性アルコール性マウス肝障害に対し、ラドン吸入とアスコルビン酸またはα-トコフェロールの摂取の併用に複合的な抑制があった。また、神経障害性マウス疼痛に対し、ラドン吸入とプレガバリン摂取の併用には相加効果があった。以上の所見などから、ラドン吸入は多くの臓器・組織において抗酸化機能を亢進し、多くの活性酸素由来の疾患の通常治療との併用により効果を高めることが示唆できた。(著者抄録)

Knowledge discovery of suppressive effect of disease and increased anti-oxidative function by low-dose radiation using self-organizing map

Norie Kanzaki, Takahiro Kataoka, Yusuke Kobashi, Yuto Yunoki, Tsuyoshi Ishida, Akihiro Sakoda, Yuu Ishimori, Kiyonori Yamaoka

RADIOISOTOPES 67 ( 2 ) 43 - 57 2018年

Image quality of the coronary angiography with noise reduction technology to decrease the radiation dose

Masayuki Kumashiro, Takahiro Kataoka, Shinobu Yokota, Shinobu Nakagawa, Keisuke Otsuki, Nobuyuki Miyake, Shinji Osumi, Kiyonori Yamaoka

Acta Medica Okayama 72 ( 2 ) 153 - 164 2018年

心臓カテーテル検査およびPCIにおける雑音低減技術を用いた患者と術者の被ばく低減効果

熊代正行, 片岡隆浩, 横田忍, 中川忍, 清川文秋, 光井英樹, 大角真司, 山岡聖典

日本診療放射線技師会誌 65 ( 5 ) 31 - 40 2018年

Radon inhalation induces manganese-superoxide dismutase in mouse brain via nuclear factor-κB activation

Takahiro Kataoka, Reo Etani, Norie Kanzaki, Yusuke Kobashi, Yuto Yunoki, Tsuyoshi Ishida, Akihiro Sakoda, Yuu Ishimori, Kiyonori Yamaoka

Journal of Radiation Research 58 ( 6 ) 887 - 893 2017年11月

Protective effects of hot spring water drinking and radon inhalation on ethanol-induced gastric mucosal injury in mice

Reo Etani, Takahiro Kataoka, Norie Kanzaki, Akihiro Sakoda, Hiroshi Tanaka, Yuu Ishimori, Fumihiro Mitsunobu, Takehito Taguchi, Kiyonori Yamaoka

JOURNAL OF RADIATION RESEARCH 58 ( 5 ) 614 - 625 2017年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：OXFORD UNIV PRESS

Radon therapy using radon (Rn-222) gas is classified into two types of treatment: inhalation of radon gas and drinking water containing radon. Although short- or long-term intake of spa water is effective in increasing gastric mucosal blood flow, and spa water therapy is useful for treating chronic gastritis and gastric ulcer, the underlying mechanisms for and precise effects of radon protection against mucosal injury are unclear. In the present study, we examined the protective effects of hot spring water drinking and radon inhalation on ethanol-induced gastric mucosal injury in mice. Mice inhaled radon at a concentration of 2000 Bq/m(3) for 24 h or were provided with hot spring water for 2 weeks. The activity density of Rn-222 ranged from 663 Bq/l (start point of supplying) to 100 Bq/l (end point of supplying). Mice were then orally administered ethanol at three concentrations. The ulcer index (UI), an indicator of mucosal injury, increased in response to the administration of ethanol; however, treatment with either radon inhalation or hot spring water inhibited the elevation in the UI due to ethanol. Although no significant differences in antioxidative enzymes were observed between the radon-treated groups and the non-treated control groups, lipid peroxide levels were significantly lower in the stomachs of mice pre-treated with radon or hot spring water. These results suggest that hot spring water drinking and radon inhalation inhibit ethanol-induced gastric mucosal injury.

DOI： 10.1093/jrr/rrx021

Measurements of radon activity concentration in mouse tissues and organs

Yuu Ishimori, Hiroshi Tanaka, Akihiro Sakoda, Takahiro Kataoka, Kiyonori Yamaoka, Fumihiro Mitsunobu

RADIATION AND ENVIRONMENTAL BIOPHYSICS 56 ( 2 ) 161 - 165 2017年5月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SPRINGER

The purpose of this study is to investigate the biokinetics of inhaled radon, radon activity concentrations in mouse tissues and organs were determined after mice had been exposed to about 1 MBq/m(3) of radon in air. Radon activity concentrations in mouse blood and in other tissues and organs were measured with a liquid scintillation counter and with a well-type HP Ge detector, respectively. Radon activity concentration in mouse blood was 0.410 +/- 0.016 Bq/g when saturated with 1 MBq/m(3) of radon activity concentration in air. In addition, average partition coefficients obtained were 0.74 +/- 0.19 for liver, 0.46 +/- 0.13 for muscle, 9.09 +/- 0.49 for adipose tissue, and 0.22 +/- 0.04 for other organs. With these results, a value of 0.414 for the blood-to-air partition coefficient was calculated by means of our physiologically based pharmacokinetic model. The time variation of radon activity concentration in mouse blood during exposure to radon was also calculated. All results are compared in detail with those found in the literature.

DOI： 10.1007/s00411-017-0682-9

Analysis of liver damage from radon, X-ray, or alcohol treatments in mice using a self-organizing map

Norie Kanzaki, Takahiro Kataoka, Reo Etani, Kaori Sasaoka, Akihiro Kanagawa, Kiyonori Yamaoka

JOURNAL OF RADIATION RESEARCH 58 ( 1 ) 33 - 40 2017年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：OXFORD UNIV PRESS

In our previous studies, we found that low-dose radiation inhibits oxidative stress-induced diseases due to increased antioxidants. Although these effects of low-dose radiation were demonstrated, further research was needed to clarify the effects. However, the analysis of oxidative stress is challenging, especially that of low levels of oxidative stress, because antioxidative substances are intricately involved. Thus, we proposed an approach for analysing oxidative liver damage via use of a self-organizing map (SOM)-a novel and comprehensive technique for evaluating hepatic and antioxidative function. Mice were treated with radon inhalation, irradiated with X-rays, or subjected to intraperitoneal injection of alcohol. We evaluated the oxidative damage levels in the liver from the SOM results for hepatic function and antioxidative substances. The results showed that the effects of low-dose irradiation (radon inhalation at a concentration of up to 2000 Bq/m(3), or X-irradiation at a dose of up to 2.0 Gy) were comparable with the effect of alcohol administration at 0.5 g/kg bodyweight. Analysis using the SOM to discriminate small changes was made possible by its ability to 'learn' to adapt to unexpected changes. Moreover, when using a spherical SOM, the method comprehensively examined liver damage by radon, X-ray, and alcohol. We found that the types of liver damage caused by radon, X-rays, and alcohol have different characteristics. Therefore, our approaches would be useful as a method for evaluating oxidative liver damage caused by radon, X-rays and alcohol.

DOI： 10.1093/jrr/rrw083

Pressure dependence of X-rays produced by an LiTaO3 single crystal at the pressures of 1-20 Pa

Katsumi Hanamoto, Takahiro Kataoka, Kiyonori Yamaoka

APPLIED RADIATION AND ISOTOPES 116 134 - 137 2016年10月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：PERGAMON-ELSEVIER SCIENCE LTD

The energy spectra of X-rays produced by an LiTaO3 single crystal have been measured at pressures of 1-20 Pa. The energy spectra showed that the endpoint energy and the amount of X-rays gradually increased with the decrease of pressure at 5-8 Pa and abruptly increased around 4 Pa and below. A maximum endpoint energy of 70 keV was obtained using the LiTaO3 single crystal with 5 mm thickness at a pressure of 3 Pa. The change of X-rays produced by the LiTaO(3)single crystal was discussed in relation to the breakdown potential at the pressures. (C) 2016 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.apradiso.2016.08.003

Difference in the action mechanism of radon inhalation and radon hot spring water drinking in suppression of hyperuricemia in mice

Reo Etani, Takahiro Kataoka, Norie Kanzaki, Akihiro Sakoda, Hiroshi Tanaka, Yuu Ishimori, Fumihiro Mitsunobu, Kiyonori Yamaoka

JOURNAL OF RADIATION RESEARCH 57 ( 3 ) 250 - 257 2016年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：OXFORD UNIV PRESS

Although radon therapy is indicated for hyperuricemia, the underlying mechanisms of action have not yet been elucidated in detail. Therefore, we herein examined the inhibitory effects of radon inhalation and hot spring water drinking on potassium oxonate (PO)-induced hyperuricemia in mice. Mice inhaled radon at a concentration of 2000 Bq/m(3) for 24 h or were given hot spring water for 2 weeks. Mice were then administrated PO at a dose of 500 mg/kg. The results obtained showed that serum uric acid levels were significantly increased by the administration of PO. Radon inhalation or hot spring water drinking significantly inhibited elevations in serum uric acid levels through the suppression of xanthine oxidase activity in the liver. Radon inhalation activated anti-oxidative functions in the liver and kidney. These results suggest that radon inhalation inhibits PO-induced hyperuricemia by activating anti-oxidative functions, while hot spring water drinking may suppress PO-induced elevations in serum uric acid levels through the pharmacological effects of the chemical compositions dissolved in it.

DOI： 10.1093/jrr/rrw014

Possible applications of radon therapy in veterinary care for oxidative stress-induced kidney damage

Kaori Sasaoka, Takahiro Kataoka, Norie Kanzaki, Kiyonori Yamaoka

Free Radicals and Health 61 - 74 2016年1月

掲載種別：論文集(書籍)内論文

Oxidative stress in the body is considered an imbalance between the production and removal of reactive oxygen species (ROS). Ischemic acute renal failure, chronic renal failure, uremia, glomerulonephritis, and diabetic nephropathy are ROS-related diseases. In the veterinary field, a few studies of chronic kidney failure related to oxidative stress have been reported. Radon therapy has been used in Japan and Europe, and has been shown to have beneficial effects on ROS-related diseases such as bronchial asthma, arteriosclerosis, osteoarthritis, and pain-related diseases. We have demonstrated that radon inhalation increases antioxidative functions in kidney, and inhibits oxidative stress-induced kidney damage in animals. In addition, radon exposure systems for pets have already been developed. Therefore, we review the possible applications of radon therapy in veterinary care for oxidative stress-induced kidney damage.

Activation of Antioxidative Functions by Radon Inhalation Enhances the Mitigation Effects of Pregabalin on Chronic Constriction Injury-Induced Neuropathic Pain in Mice

Takahiro Kataoka, Shunsuke Horie, Reo Etani, Norie Kanzaki, Kaori Sasaoka, Yusuke Kobashi, Katsumi Hanamoto, Kiyonori Yamaoka

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY 2016 2016年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：HINDAWI LTD

Radon inhalation brings pain relief for chronic constriction injury- (CCI-) induced neuropathic pain in mice due to the activation of antioxidative functions, which is different from the mechanism of the pregabalin effect. In this study, we assessed whether a combination of radon inhalation and pregabalin administration is more effective against neuropathic pain than radon or pregabalin only. Mice were treated with inhaled radon at a concentration of 1,000 Bq/m(3) for 24 hours and pregabalin administration after CCI surgery. In mice treated with pregabalin at a dose of 3 mg/kg weight, the 50% paw withdrawal threshold of mice treated with pregabalin or radon and pregabalin was significantly increased, suggesting pain relief. The therapeutic effects of radon inhalation or the combined effects of radon and pregabalin (3 mg/kg weight) were almost equivalent to treatment with pregabalin at a dose of 1.4 mg/kg weight or 4.1 mg/kg weight, respectively. Radon inhalation and the combination of radon and pregabalin increased antioxidant associated substances in the paw. The antioxidant substances increased much more in radon inhalation than in pregabalin administration. These findings suggested that the activation of antioxidative functions by radon inhalation enhances the pain relief of pregabalin and that this combined effect is probably an additive effect.

DOI： 10.1155/2016/9853692

Radon inhalation suppresses nephropathy in streptozotocin-induced type-1 diabetic mice

Yuichi Nishiyama, Takahiro Kataoka, Keiko Yamato, Reo Etani, Takehito Taguchi, Kiyonori Yamaoka

JOURNAL OF NUCLEAR SCIENCE AND TECHNOLOGY 53 ( 6 ) 909 - 915 2016年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：TAYLOR & FRANCIS LTD

In this study, we investigated the suppressive effects of radon inhalation against nephropathy in C57BL/6J mice with type-1 diabetes induced by intraperitoneal injection of streptozotocin (50 mg/kg weight, given five times). Four weeks after diabetes induction, the diabetic mice were continuously treated with inhaled radon-222 of 2000 Bq/m(3) or air only (sham) for four weeks. The results showed that radon inhalation did not affect type-1 diabetic symptoms such as body weight loss, hyperglycemia, and hypoinsulinemia. However, diabetic mice treated with radon showed lower urinary albumin excretion and fibrotic change in renal glomeruli compared with diabetic mice not treated with radon. Furthermore, renal superoxide dismutase activity and glutathione content were significantly higher in diabetic mice treated with radon than in diabetic mice not treated with radon. These findings suggested that radon inhalation enhanced renal antioxidants activities, resulting in the suppression of diabetic nephropathy. This study may contribute to the development of a novel approach in the treatment of nephropathy for diabetic patients.

DOI： 10.1080/00223131.2015.1078751

Study on Antidepressant-Like Effects of Radon Inhalation on Forced Swim Induced Depression in Mice

Keiko Yamato, Takahiro Kataoka, Yuichi Nishiyama, Yuji Takata, Reo Etani, Kiyonori Yamaoka

RADIOISOTOPES 65 ( 12 ) 493 - 506 2016年

Evaluating the protective effects of radon inhalation or ascorbic acid treatment after transient global cerebral ischemic injury in gerbils

Takahiro Kataoka, Reo Etani, Norie Kanzaki, Kaori Sasaoka, Yusuke Kobashi, Katsumi Hanamoto, Takehito Taguchi, Kiyonori Yamaoka

JOURNAL OF NUCLEAR SCIENCE AND TECHNOLOGY 53 ( 11 ) 1681 - 1685 2016年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：TAYLOR & FRANCIS LTD

In this study, we compared the protective effects of radon inhalation and ascorbic acid administration on transient global cerebral ischemic injury in gerbils. Gerbils were treated with radon inhalation (2000 Bq/m(3), 24 hours) or ascorbic acid (100, 300, or 500mg/kg body weight). Then, transient global cerebral ischemia was induced by bilateral occlusion of the common carotid artery. Results showed that the number of damaged neurons was significantly increased in gerbils that underwent ischemia compared with that in control gerbils. However, the number of damaged neurons in gerbils treated with radon or 500mg/kg of ascorbic acid before ischemia was significantly lower than gerbils who were subjected to ischemia without any pretreatment, and the protective effects of radon inhalation were similar to the effects of administering 500mg/kg ascorbic acid. The levels of superoxide dismutase (SOD) and total glutathione (t-GSH) in brain tissue were increased to a similar extent by pretreatment with radon inhalation or 500mg/kg of ascorbic acid. These findings suggested that radon inhalation has a protective antioxidative effect against transient global cerebral ischemic injury similar to 500mg/kg ascorbic acid treatment.

DOI： 10.1080/00223131.2016.1198731

Combined effects of radon inhalation and antioxidant vitamin administration on acute alcohol-induced hepatopathy in mice

Reo Etani, Takahiro Kataoka, Yuichi Nishiyama, Yuji Takata, Kiyonori Yamaoka

JOURNAL OF NUCLEAR SCIENCE AND TECHNOLOGY 52 ( 12 ) 1512 - 1518 2015年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：TAYLOR & FRANCIS LTD

It has been reported that radon inhalation activates antioxidative functions in liver and has an antioxidative effect against hepatopathy similar to that of the antioxidative effects of ascorbic acid (VC) or -tocopherol (VE). In this study, we examined the combined effects of radon inhalation and antioxidant vitamin administration on acute alcohol-induced hepatopathy in mice. ICR mice were subjected to intraperitoneal (i.p.) administration of alcohol after pretreating with air only (sham) or radon at a concentration of approximately 2000 Bq/m(3) for 24 hours and i.p. administration of VC (300 mg/kg body weight) or VE (300 mg/kg body weight). In mice injected with alcohol, the combined radon and antioxidant vitamins treatment significantly decreased the activities of glutamic oxaloacetic transaminase in serum compared to not only the alcohol-administered group (sham group), but also the radon inhalation with alcohol administration group or the vitamin and alcohol administration group. In addition, radon inhalation significantly increased the antioxidant level, in such as the catalase activity and the total glutathione content in liver compared to the sham group. These results suggested that the combined radon and antioxidant vitamin treatment could effectively inhibit alcohol-induced hepatopathy in mice without any antagonizing action.

DOI： 10.1080/00223131.2015.1014875

The possible applications of radon inhalation treatment as antioxidant therapy for hepatopathy

Takahiro Kataoka, Akihiro Sakoda, Reo Etani, Yuu Ishimori, Fumihiro Mitsunobu, Kiyonori Yamaoka

Radon: Geology, Environmental Impact and Toxicity Concerns 133 - 148 2015年1月

掲載種別：論文集(書籍)内論文

The possibility of antioxidant therapy has been reported for several diseases such as ischemic stroke. The therapy could also be applied for diseases caused by reactive oxygen species (ROS). It has been reported that ROS or free radicals may cause various types of hepatopathy, including alcoholic liver disease. Low dose (0.5 Gy) X- or γ- irradiation activates the antioxidative functions of the mouse liver and inhibits ROS- or free radical-induced hepatopathy. Radon therapy is performed mainly for pain-related diseases in Japan and Europe. Several clinical studies have been reported, but the possible mechanisms of the beneficial effects remain unknown. Recently, we have reported that the possible mechanism of radon therapy is the activation of antioxidative functions following radon inhalation. For example, radon inhalation inhibits and alleviates chronic constriction injury induced pain or inflammatory pain in mice due to the activation of antioxidative functions. In addition, although hepatopathy is not the main indication for radon therapy, our recent studies suggested that radon inhalation inhibits hepatopathy caused by ROS or free radicals. In this chapter, based on experiments with mice, we reviewed the possible applications of radon inhalation as an antioxidant therapy for hepatopathy from the viewpoints of recent antioxidant therapy, hepatopathy induced by ROS or free radicals, and the beneficial effects of radon inhalation for hepatopathy.

三朝ラドン温泉の健康効果に関する最近の研究動向

片岡隆浩, 迫田晃弘, 恵谷玲央, 石森有, 光延文裕, 山岡聖典

温泉科学 64 ( 4 ) 380 - 387 2015年

記述言語：日本語出版者・発行元：(一社)日本温泉科学会

岡山大学病院三朝医療センターではラドン温泉を活用したラドン療法が実施されており、適応症として例えば変性性関節症に伴う疼痛がある。臨床試験による実証報告例は多くあるものの、なぜ有効であるかのメカニズムの解明に関する研究報告例は少ない。本稿では、放射能効果の観点から近年得られた筆者らのラドン健康効果の研究成果を中心に概説した。すなわち、小動物用ラドン吸入装置を開発し、三朝医療センターに隣接した三朝ラドン効果研究施設内に設置した。これを用い、例えば、マウス諸臓器中の抗酸化酵素活性のラドン濃度・吸入時間の依存性について検討した。その結果、多くの臓器でsuperoxide dismutase(SOD)活性が増加したことから、ラドン吸入は抗酸化機能を亢進させることがわかった。また、streptozotocin(STZ)誘導マウスI型糖尿病の症状緩和について検討した。その結果、ラドン吸入による膵臓中の抗酸化機能の亢進に伴い膵島の酸化ストレスが緩和されることでインスリンの分泌機能の低下が抑制され、I型糖尿病が緩和することもわかった。以上の所見などから、ラドン吸入は抗酸化機能などを亢進させ活性酸素由来の疾患の症状を緩和するメカニズムの一端が明らかにできた。(著者抄録)

その他リンク： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2015&ichushi_jid=J00191&link_issn=&doc_id=20150513080001&doc_link_id=%2Ffd5onsen%2F2015%2F006404%2F003%2F0380-0387%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Ffd5onsen%2F2015%2F006404%2F003%2F0380-0387%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

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