研究者詳細 - 片岡　隆浩

論文 - 片岡　隆浩

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トロンの生体作用とラドンとの比較に関する研究査読

山岡聖典, 片岡隆浩

74 87 - 89 2025年2月

ラドン温泉療法の適応症とそのメカニズムに関する最近の研究動向査読

片岡隆浩, 迫田晃弘, 神﨑訓枝, 光延文裕, 山岡聖典

日本温泉気候物理医学会雑誌 88 ( 2 ) 1 - 16 2024年11月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：日本温泉気候物理医学会

早期公開
三朝（鳥取県）の温泉療法は，バドガスタイン（オーストリア）やモンタナ（アメリカ）の坑道療法とともにラドン療法（特にラドン高濃度熱気浴療法）として世界的に有名である．ラドン療法の適応症には，活性酸素種に起因する呼吸器・疼痛・消化器・慢性変性・老年性などに関わる様々な疾患が含まれるが，その多くは経験的処方に基づいている．このため，筆者らはラドンと子孫核種に関連した被ばくの主要経路の特定や体内挙動の実験的・数理的な検討を行い，吸入などにより生じる生体反応と組織・臓器吸収線量との関係をより定量的に評価し，適応症に関わるメカニズムの解明と新たな探索の基礎研究を進めてきた．その結果，メカニズムとしては，ラドン吸入により生じる少量の酸化ストレスに伴う一連の適度な生理刺激作用に関して解明されつつある．すなわち，抗酸化・免疫調節・損傷修復機能の亢進，抗炎症・ホルモン分泌・循環代謝の促進，アポトーシス・熱ショックタンパク質の誘導などである．また，新たな適応症として，炎症性・神経障害性疼痛，炎症性浮腫，胃粘膜損傷，潰瘍性大腸炎，高尿酸血症，1型糖尿病，肝・腎障害，一過性脳虚血発作，うつ病などの可能性が示唆される．さらに，ラドン吸入と抗酸化剤や治療剤との併用による疾患の抑制効果に関して，いずれもその効果を高めることが示唆される．副作用の強い薬剤に対して減薬効果が期待できるため，通常の治療に対するラドン療法の併用効果の更なる臨床的検証が求められる．

DOI： 10.11390/onki.2363

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Effect of Radon Inhalation on Murine Brain Proteins: Investigation Using Proteomic and Multivariate Analyses 査読

Shota Naoe, Ayumi Tanaka, Norie Kanzaki, Reiju Takenaka, Akihiro Sakoda, Takaaki, Miyaji, Kiyonori Yamaoka, Takahiro Kataoka

Acta Medica Okayama 78 ( 5 ) 387 - 399 2024年10月

Association between Radon Hot Spring Bathing and Health Conditions: A Cross-Sectional Study in Misasa, Japan 査読

Takahiro Kataoka, Hiroshi Habu, Ayumi Tanaka, Shota Naoe, Kaito Murakami, Yuki Fujimoto, Ryohei Yukimine, Soshi Takao, Fumihiro Mitsunobu, Takashi Yorifuji, Kiyonori Yamaoka

77 ( 4 ) 387 - 394 2023年8月

Effects of low-dose/high-dose-rate X-irradiation on oxidative stress in organs following forced swim test and its combined effects on alcohol-induced liver damage in mice 査読

Shota Naoe, Yuki Fujimoto, Kaito Murakami, Ryohei Yukimine, Ayumi Tanaka, Kiyonori Yamaoka, Takahiro Kataoka

Journal of Radiation Research 64 ( 4 ) 635 - 643 2023年5月

担当区分：最終著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Oxford University Press (OUP)

Abstract

The liver’s susceptibility to oxidative stress after a combination of forced swim test (FST) and low-dose-rate γ-irradiation has been observed. Therefore, this study aims to clarify the effects of low-dose (0.1 and 0.5 Gy)/high-dose-rate (1.2 Gy/min) irradiation on combined oxidative stressors—liver damage associated with FST and alcohol administration. In addition, the effects of similar irradiation on FST-induced immobility, which induces psychomotor retardation, and antioxidative effects on the brain, lungs, liver and kidneys were investigated, and the results were compared with those of a similar previous study that utilized low-dose-rate irradiation. Low-dose/high-dose-rate (especially 0.5 Gy) irradiation temporarily worsened liver antioxidant function and hepatic function with FST- and alcohol administration-related oxidative damage; however, the damages improved soon after. In addition, the increase in total glutathione content in the liver contributed to the early improvement of hepatic functions. However, pre-irradiation did not suppress immobility during the FST. The results also suggested that the effects of low-dose/high-dose-rate irradiation on the antioxidant functions of each organ after the FST were different from those of low-dose/low-dose-rate irradiation. Overall, this study provides further insights into the effects of low-dose irradiation on exposure to a combination of different oxidative stressors. It will also contribute to the elucidation of dose rate effects on oxidative stress in the low-dose irradiation range.

DOI： 10.1093/jrr/rrad030

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Changes in Sulfur Metabolism in Mouse Brains Following Radon Inhalation 査読

Norie Kanzaki, Akihiro Sakoda, Takahiro Kataoka, Lue Sun, Hiroshi Tanaka, Iwao Ohtsu, Kiyonori Yamaoka

International Journal of Environmental Research and Public Health 19 ( 17 ) 10750 - 10750 2022年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：MDPI AG

Therapy using hot springs, including the high-level radioactive gas “radon”, is traditionally conducted as an alternative treatment for various diseases. Oxidative-stress-related diseases are inhibited by the enhancement of antioxidative functions following radon inhalation. We have reported that radon inhalation increased the level of anti-oxidants, such as glutathione (G-SH), in the brain and had a protective antioxidative effect against transient global cerebral ischemic injury. However, no studies have yet revealed the changes in G-SH associated substances after radon inhalation. In this study, we comprehensively analyzed several metabolites, focusing on G-SH. Mice were exposed to radon at concentrations of 200, 2000, or 20,000 Bq/m3 for 1, 3, or 10 days. We detected 27 metabolites in the mouse brains. The result showed that the L-methionine levels increased, whereas the levels of urea, glutathione, and sulfite ion decreased under any condition. Although the ratio of G-SH to oxidized glutathione (GS-SG) decreased, glutathione monosulfide (G-S-SH) and cysteine monosulfide (Cys-S-SH) increased after radon inhalation. G-S-SH and Cys-S-SH can produce a biological defense against the imbalance of the redox state at very low-dose irradiation following radon inhalation because they are strong scavengers of reactive oxygen species. Additionally, we performed an overall assessment of high-dimensional data and showed some specific characteristics. We showed the changes in metabolites after radon inhalation using partial least squares-discriminant analysis and self-organizing maps. The results showed the health effects of radon, especially the state of sulfur-related metabolites in mouse brains under the exposure conditions for radon therapy.

DOI： 10.3390/ijerph191710750

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Immunomodulatory Effects of Radon Inhalation on Lipopolysaccharide-Induced Inflammation in Mice 査読

Takahiro Kataoka, Shota Naoe, Kaito Murakami, Yuki Fujimoto, Ryohei Yukimine, Ayumi Tanaka, Kiyonori Yamaoka

International Journal of Environmental Research and Public Health 19 ( 17 ) 10632 - 10632 2022年8月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：MDPI AG

Typical indications for radon therapy include autoimmune diseases such as rheumatoid arthritis (RA). We had previously reported that radon inhalation inhibits Th17 immune responses in RA mice by activating Th1 and Th2 immune responses. However, there are no reports on how radon inhalation affects the activated Th1 and Th17 immune responses, and these findings may be useful for identifying new indications for radon therapy. Therefore, in this study, we investigated the effect of radon inhalation on the lipopolysaccharide (LPS)-induced inflammatory response, focusing on the expression of related cytokines and antioxidant function. Male BALB/c mice were exposed to 2000 Bq/m3 radon for one day. Immediately after radon inhalation, LPS was administered intraperitoneally at 1.0 mg/kg body weight for 4 h. LPS administration increased the levels of Th1- and Th17-prone cytokines, such as interleukin-2, tumor necrosis factor-α, and granulocyte-macrophage colony-stimulating factor, compared to no treatment control (sham). However, these effects were suppressed by radon inhalation. IL-10 levels were significantly increased by LPS administration, with or without radon inhalation, compared to sham. However, radon inhalation did not inhibit oxidative stress induced by LPS administration. These findings suggest that radon inhalation has immunomodulatory but not antioxidative functions in LPS-induced injury.

DOI： 10.3390/ijerph191710632

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Potential inhibitory effects of low-dose thoron inhalation and ascorbic acid administration on alcohol-induced hepatopathy in mice 査読

Takahiro Kataoka, Tsuyoshi Ishida, Shota Naoe, Norie Kanzaki, Akihiro Sakoda, Hiroshi Tanaka, Fumihiro Mitsunobu, Kiyonori Yamaoka

Journal of Radiation Research 63 ( 5 ) 719 - 729 2022年7月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Oxford University Press (OUP)

Abstract

Although thoron inhalation exerts antioxidative effects in several organs, there are no reports on whether it inhibits oxidative stress-induced damage. In this study, we examined the combined effects of thoron inhalation and ascorbic acid (AA) administration on alcohol-induced liver damage. Mice were subjected to thoron inhalation at 500 or 2000 Bq/m3 and were administered 50% ethanol (alcohol) and 300 mg/kg AA. Results showed that although alcohol administration increased the levels of glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) in the serum, the combination of thoron inhalation (500 Bq/m3) and AA administration 24 h after alcohol administration effectively inhibited alcohol-induced liver damage. The combination of thoron inhalation (500 Bq/m3) and AA administration 24 h after alcohol administration increased catalase (CAT) activity. Alcohol administration significantly decreased glutathione (GSH) levels in the liver. The GSH content in the liver after 2000 Bq/m3 thoron inhalation was lower than that after 500 Bq/m3 thoron inhalation. These findings suggest that the combination of thoron inhalation at 500 Bq/m3 and AA administration has positive effects on the recovery from alcohol-induced liver damage. The results also suggested that thoron inhalation at 500 Bq/m3 was more effective than that at 2000 Bq/m3, possibly because of the decrease in GSH content in the liver. In conclusion, the combination of thoron inhalation at 500 Bq/m3 and AA administration promoted an early recovery from alcohol-induced liver damage.

DOI： 10.1093/jrr/rrac046

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A simple method for estimating the potential of the pyroelectric crystal surface 査読

Katsumi Hanamoto, Takahiro Kataoka, Kiyonori Yamaoka

Applied Radiation and Isotopes 185 110230 - 110230 2022年7月

Radon Solubility and Diffusion in the Skin Surface Layer

Akihiro Sakoda, Tsuyoshi Ishida, Norie Kanzaki, Hiroshi Tanaka, Takahiro Kataoka, Fumihiro Mitsunobu, Kiyonori Yamaoka

International Journal of Environmental Research and Public Health 19 ( 13 ) 7761 - 7761 2022年6月

掲載種別：研究論文（学術雑誌）出版者・発行元：MDPI AG

In specific situations such as bathing in a radon spa, where the radon activity concentration in thermal water is far higher than that in air, it has been revealed that radon uptake via skin can occur and should be considered for more precise dose evaluation. The primary aim of the present study was to numerically demonstrate the distribution as well as the degree of diffusion of radon in the skin, with a focus on its surface layer (i.e., stratum corneum). We developed a biokinetic model that included diffusion theory at the stratum corneum, and measured radon solubility in that tissue layer as a crucial parameter. The implementation of the model suggested that the diffusion coefficient in the stratum corneum was as low as general radon-proof sheets. After a 20-min immersion in water, the simulated depth profile of radon in the skin showed that the radon activity concentration at the top surface skin layer was approximately 103 times higher than that at the viable skin layer. The information on the position of radon as a radiation source would contribute to special dose evaluation where specific target cell layers are assumed for the skin.

DOI： 10.3390/ijerph19137761

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Confirmation of efficacy, elucidation of mechanism, and new search for indications of radon therapy

Kiyonori Yamaoka, Takahiro Kataoka

Journal of Clinical Biochemistry and Nutrition 70 ( 2 ) 87 - 92 2022年

Mechanisms of action of radon therapy on cytokine levels in normal mice and rheumatoid arthritis mouse model 査読

Takahiro Kataoka, Shota Naoe, Kaito Murakami, Ryohei Yukimine, Yuki Fujimoto, Norie Kanzaki, Akihiro Sakoda, Fumihiro Mitsunobu, Kiyonori Yamaoka

Journal of Clinical Biochemistry and Nutrition 70 ( 2 ) 154 - 159 2022年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：The Society for Free Radical Research Japan

The typical indication of radon therapy is rheumatoid arthritis. Although there are several reports that radon therapy has regulation effects on Th17 cells, there has been no study reporting that radon inhalation affects the immune balance among Th1, Th2, and Th17. The purpose of this study is to examine the cytokine changes after radon inhalation. BALB/c mice inhaled radon at 2,000 Bq/m3 for 2 or 4 weeks. SKG/Jcl mice inhaled radon at 2,000 Bq/m3 for 4 weeks after zymosan administration. The results showed that radon inhalation for 4 weeks activated the immune response of Th1, Th2, and Th17. Moreover, the balance among them was not lost by radon inhalation. Radon inhalation for 4 weeks decreased superoxide dismutase activity and increased catalase activity in spleen. These findings suggest that an imbalance of oxidative stress may contribute to activate the immune response. Although zymosan administration activated Th17 immune response and decreased Th1 and Th2 immune response in SKG/Jcl mice, most cytokines related to Th1, Th2, and Th17 approached the normal level by radon inhalation. These findings suggested that radon inhalation has a different action between SKG/Jcl mice and normal BABL/c mice. This may indicate that radon inhalation has an immunomodulation function.

DOI： 10.3164/jcbn.21-91

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Radon inhalation decreases DNA damage induced by oxidative stress in mouse organs via the activation of antioxidative functions 査読

Takahiro Kataoka, Hina Shuto, Shota Naoe, Junki Yano, Norie Kanzaki, Akihiro Sakoda, Hiroshi Tanaka, Katsumi Hanamoto, Fumihiro Mitsunobu, Hiroaki Terato, Kiyonori Yamaoka

Journal of Radiation Research 62 ( 5 ) 861 - 867 2021年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Oxford University Press (OUP)

<title>Abstract</title>
Radon inhalation decreases the level of lipid peroxide (LPO); this is attributed to the activation of antioxidative functions. This activation contributes to the beneficial effects of radon therapy, but there are no studies on the risks of radon therapy, such as DNA damage. We evaluated the effect of radon inhalation on DNA damage caused by oxidative stress and explored the underlying mechanisms. Mice were exposed to radon inhalation at concentrations of 2 or 20 kBq/m3 (for one, three, or 10 days). The 8-hydroxy-2′-deoxyguanosine (8-OHdG) levels decreased in the brains of mice that inhaled 20 kBq/m3 radon for three days and in the kidneys of mice that inhaled 2 or 20 kBq/m3 radon for one, three or 10 days. The 8-OHdG levels in the small intestine decreased by approximately 20–40% (2 kBq/m3 for three days or 20 kBq/m3 for one, three or 10 days), but there were no significant differences in the 8-OHdG levels between mice that inhaled a sham treatment and those that inhaled radon. There was no significant change in the levels of 8-oxoguanine DNA glycosylase, which plays an important role in DNA repair. However, the level of Mn-superoxide dismutase (SOD) increased by 15–60% and 15–45% in the small intestine and kidney, respectively, following radon inhalation. These results suggest that Mn-SOD probably plays an important role in the inhibition of oxidative DNA damage.

DOI： 10.1093/jrr/rrab069

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Dosimetry of radon progeny deposited on skin in air and thermal water

Akihiro Sakoda, Yuu Ishimori, Norie Kanzaki, Hiroshi Tanaka, Takahiro Kataoka, Fumihiro Mitsunobu, Kiyonori Yamaoka

Journal of Radiation Research 62 ( 4 ) 634 - 644 2021年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Oxford University Press (OUP)

<title>Abstract</title>
It is held that the skin dose from radon progeny is not negligibly small and that introducing cancer is a possible consequence under normal circumstances as there are a number of uncertainties in terms of related parameters such as activity concentrations in air and water, target cells in skin, skin covering materials, and deposition velocities. An interesting proposal has emerged in that skin exposure to natural radon-rich thermal water as part of balneotherapy can produce an immune response to induce beneficial health effects. The goal of this study was to obtain generic dose coefficients with a focus on the radon progeny deposited on the skin in air or water in relation to risk or treatment assessments. We thus first estimated the skin deposition velocities of radon progeny in air and thermal water based on data from the latest human studies. Skin dosimetry was then performed under different assumptions regarding alpha-emitting source position and target cell (i.e. basal cells or Langerhans cells). Furthermore, the impact of the radon progeny deposition on effective doses from all exposure pathways relating to ‘radon exposure’ was assessed using various possible scenarios. It was found that in both exposure media, effective doses from radon progeny inhalation are one to four orders of magnitude higher than those from the other pathways. In addition, absorbed doses on the skin can be the highest among all pathways when the radon activity concentrations in water are two or more orders of magnitude higher than those in air.

DOI： 10.1093/jrr/rrab030

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The Effects of Low-Dose-Rate γ-irradiation on Forced Swim Test-Induced Immobility and Oxidative Stress in Mice

Tetsuya Nakada, Takahiro Kataoka, Takaharu Nomura, Hina Shuto, Junki Yano, Shota Naoe, Katsumi Hanamoto, Kiyonori Yamaoka

Acta Medica Okayama 75 ( 2 ) 169 - 175 2021年4月

記述言語：英語掲載種別：研究論文（学術雑誌）

The forced swim test (FST) induces immobility in mice. Low-dose (high-dose-rate) X-irradiation inhibits FSTinduced immobility in mice due to its antioxidative function. We evaluated the effects of low-dose γ-irradiation at a low-dose-rate on the FST-induced depletion of antioxidants in mouse organs. Mice received whole-body low-dose-rate (0.6 or 3.0 mGy/h) of low-dose γ-irradiation for 1 week, followed by daily FSTs (5 days). The immobility rate on day 2 compared to day 1 was significantly lower in the 3.0 mGy/h irradiated mice than in sham irradiated mice. The FST significantly decreased the catalase (CAT) activity and total glutathione (t-GSH) content in the brain and kidney, respectively. The superoxide dismutase (SOD) activity and t-GSH content in the liver of the 3.0 mGy/h irradiated mice were significantly lower than those of the non-FST-treated mice. The CAT activity in the lungs of mice exposed to 3.0 mGy/h γ-irradiation was higher than that of non-FST treated mice and mice treated with FST. However, no significant differences were observed in the levels of these antioxidant markers between the sham and irradiated groups except for the CAT activity in lungs. These findings suggest that the effects of low-dose-rate and low-dose γ-irradiation on FST are highly organ-dependent.

DOI： 10.18926/AMO/61896

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Evaluation of the redox state in mouse organs following radon inhalation

Takahiro Kataoka, Norie Kanzaki, Akihiro Sakoda, Hina Shuto, Junki Yano, Shota Naoe, Hiroshi Tanaka, Katsumi Hanamoto, Hiroaki Terato, Fumihiro Mitsunobu, Kiyonori Yamaoka

Journal of Radiation Research 62 ( 2 ) 206 - 216 2021年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Oxford University Press (OUP)

<title>Abstract</title>
Radon inhalation activates antioxidative functions in mouse organs, thereby contributing to inhibition of oxidative stress-induced damage. However, the specific redox state of each organ after radon inhalation has not been reported. Therefore, in this study, we evaluated the redox state of various organs in mice following radon inhalation at concentrations of 2 or 20 kBq/m3 for 1, 3 or 10 days. Scatter plots were used to evaluate the relationship between antioxidative function and oxidative stress by principal component analysis (PCA) of data from control mice subjected to sham inhalation. The results of principal component (PC) 1 showed that the liver and kidney had high antioxidant capacity; the results of PC2 showed that the brain, pancreas and stomach had low antioxidant capacities and low lipid peroxide (LPO) content, whereas the lungs, heart, small intestine and large intestine had high LPO content but low antioxidant capacities. Furthermore, using the PCA of each obtained cluster, we observed altered correlation coefficients related to glutathione, hydrogen peroxide and LPO for all groups following radon inhalation. Correlation coefficients related to superoxide dismutase in organs with a low antioxidant capacity were also changed. These findings suggested that radon inhalation could alter the redox state in organs; however, its characteristics were dependent on the total antioxidant capacity of the organs as well as the radon concentration and inhalation time. The insights obtained from this study could be useful for developing therapeutic strategies targeting individual organs.

DOI： 10.1093/jrr/rraa129

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Comparison of antioxidative effects between radon and thoron inhalation in mouse organs 国際誌

Yusuke Kobashi, Takahiro Kataoka, Norie Kanzaki, Tsuyoshi Ishida, Akihiro Sakoda, Hiroshi Tanaka, Yuu Ishimori, Fumihiro Mitsunobu, Kiyonori Yamaoka

Radiation and Environmental Biophysics 59 ( 3 ) 473 - 482 2020年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Springer Science and Business Media LLC

Radon therapy has been traditionally performed globally for oxidative stress-related diseases. Many researchers have studied the beneficial effects of radon exposure in living organisms. However, the effects of thoron, a radioisotope of radon, have not been fully examined. In this study, we aimed to compare the biological effects of radon and thoron inhalation on mouse organs with a focus on oxidative stress. Male BALB/c mice were randomly divided into 15 groups: sham inhalation, radon inhalation at a dose of 500 Bq/m3 or 2000 Bq/m3, and thoron inhalation at a dose of 500 Bq/m3 or 2000 Bq/m3 were carried out. Immediately after inhalation, mouse tissues were excised for biochemical assays. The results showed a significant increase in superoxide dismutase and total glutathione, and a significant decrease in lipid peroxide following thoron inhalation under several conditions. Additionally, similar effects were observed for different doses and inhalation times between radon and thoron. Our results suggest that thoron inhalation also exerts antioxidative effects against oxidative stress in organs. However, the inhalation conditions should be carefully analyzed because of the differences in physical characteristics between radon and thoron.

DOI： 10.1007/s00411-020-00843-0

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その他リンク： http://link.springer.com/article/10.1007/s00411-020-00843-0/fulltext.html

X-Irradiation at 0.5 Gy after the forced swim test reduces forced swimming-induced immobility in mice

Takahiro Kataoka, Hina Shuto, Junki Yano, Shota Naoe, Tsuyoshi Ishida, Tetsuya Nakada, Keiko Yamato, Katsumi Hanamoto, Takaharu Nomura, Kiyonori Yamaoka

Journal of Radiation Research 61 ( 4 ) 517 - 523 2020年7月

掲載種別：研究論文（学術雑誌）出版者・発行元：Oxford University Press (OUP)

<title>Abstract</title>
The forced swim test (FST) is a screening model for antidepressant activity; it causes immobility and induces oxidative stress. We previously reported that radon inhalation has antidepressant-like effects in mice potentially through the activation of antioxidative functions upon radon inhalation. This study aimed to investigate the effect of prior and post low-dose X-irradiation (0.1, 0.5, 1.0 and 2.0 Gy) on FST-induced immobility and oxidative stress in the mouse brain, and the differences, if any, between the two. Mice received X-irradiation before or after the FST repeatedly for 5 days. In the post-FST-irradiated group, an additional FST was conducted 4 h after the last irradiation. Consequently, animals receiving prior X-irradiation (0.1 Gy) had better mobility outcomes than sham-irradiated mice; however, their levels of lipid peroxide (LPO), an oxidative stress marker, remained unchanged. However, animals that received post-FST X-irradiation (0.5 Gy) had better mobility outcomes and their LPO levels were significantly lower than those of the sham-irradiated mice. The present results indicate that 0.5 Gy X-irradiation after FST inhibits FST-induced immobility and oxidative stress in mice.

DOI： 10.1093/jrr/rraa022

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Basic study on enhancement of antioxidant function by Low-dose irradiation in mouse brain and its combined effect with ascorbic acid 査読

Takahiro Kataoka, Yuto Yunoki, Norie Kanzaki, Kaori Sasaoka, Yusuke Kobashi, Tsuyoshi Ishida, Katsumi Hanamoto, Kiyonori Yamaoka

Radioisotopes 69 ( 2 ) 45 - 53 2020年

Reduction of radiation exposure in patients and cardiologists using a noise reduction technique in cardiac catheterization and percutaneous coronary intervention

Masayuki Kumashiro, Takahiro Kataoka, Shinobu Yokota, Shinobu Nakagawa, Fumiaki Kiyokawa, Hideki Mitsui, Shinji Osumi, Kiyonori Yamaoka

Journal of JART 66 45 - 57 2019年

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