Faculty Profiles - EKUNI Daisuke

Papers - EKUNI Daisuke

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Experimental periodontitis induces gene expression of proinflammatory cytokines in liver and white adipose tissues in obesity. Reviewed International journal

Yasumasa Endo, Takaaki Tomofuji, Daisuke Ekuni, Koichiro Irie, Tetsuji Azuma, Naofumi Tamaki, Tatsuo Yamamoto, Manabu Morita

Journal of Periodontology Vol.81 ( No.4 ) 520 - 526 2010.4

Effects of periodontitis on aortic insulin resistance in an obese rat model. Reviewed International journal

Daisuke Ekuni, Takaaki Tomofuji, Koichiro Irie, Kenta Kasuyama, Michihiro Umakoshi, Tetsuji Azuma, Naofumi Tamaki, Toshihiro Sanbe, Yasumasa Endo, Tatsuo Yamamoto, Takashi Nishida, Manabu Morita

Laboratory Investigation; a Journal of Technical Methods and Pathology Vol.90 ( No.3 ) 348 - 359 2010.1

Language：English Publishing type：Research paper (scientific journal)

The combination of obesity and its associated risk factors, such as insulin resistance and inflammation, results in the development of atherosclerosis. However, the effects of periodontitis on atherosclerosis in an obese body remain unclear. The aim of the study was to investigate the effects of ligature-induced periodontitis in Zucker fatty rats on initiation of atherosclerosis by evaluating aortic insulin resistance. Zucker fatty rats (n=24) were divided into two groups. In the periodontitis group, periodontitis was ligature-induced for 4 weeks, whereas the control group was left unligated. After the 4-week experimental period, descending aorta was used for measuring the levels of lipid deposits, immunohistochemical analysis, and evaluation of gene expression. Levels of serum C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-alpha), and insulin were also measured. Rats in the periodontitis group had significantly enhanced lipid deposits in the aorta, but not in the control group. Expression of suppressor of cytokine signaling 3, vascular cell adhesion molecule 1, reactive oxygen species, nitrotyrosine, and endothelin-1 in the periodontitis group was more intense than that in the control group. Significantly decreased levels of phosphatidylinositol 3-kinase (Pi3k) catalytic beta-polypeptide (Pi3kcb), Pi3kp85, and insulin receptor substrate 1 and 2 were observed in the periodontitis group. Levels of serum CRP and TNF-alpha were significantly increased in the periodontitis group. Under insulin-stimulated conditions, aorta in the periodontitis group altered the Akt phosphorylation. Periodontitis in obesity induced the initial stage of atherosclerosis and disturbed aortic insulin signaling.

DOI： 10.1038/labinvest.2009.141

PubMed

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Relationship between periodontitis and hepatic abnormalities in young adults. Reviewed International journal

Furuta M, Ekuni D, Yamamoto T, Irie K, Koyama R, Sanbe T, Yamanaka R, Morita M, Kuroki K, Tobe K

Acta odontologica Scandinavica 68 ( 1 ) 27 - 33 2010.1

Imbalance of oxidative/anti-oxidative status induced by periodontitis is involved in apoptosis of rat submandibular glands. Reviewed International journal

Daisuke Ekuni, Yasumasa Endo, Koichiro Irie, Tetsuji Azuma, Naofumi Tamaki, Takaaki Tomofuji, Manabu Morita

Archives of Oral Biology Vol.55 ( No.2 ) 170 - 176 2009.12

Preventive effects of a cocoa-enriched diet on gingival oxidative stress in experimental periodontitis. Reviewed International journal

Takaaki Tomofuji, Daisuke Ekuni, Koichiro Irie, Tetsuji Azuma, Yasumasa Endo, Naofumi Tamaki, Toshihiro Sanbe, Jun Murakami, Tatsuo Yamamoto, Manabu Morita

Journal of Periodontology Vol.80 ( No.11 ) 1799 - 1808 2009.11

Modified IOTNを用いた不正咬合の基準設定 pilot study

村上隆, 江國大輔, 古田美智子, 山城隆

日本矯正歯科学会大会プログラム・抄録集 68回 152 - 152 2009.11

メインテナンス期の歯周病患者における咬合力と歯周状態の関係について

竹内倫子, 山本龍生, 江國大輔, 森田学

口腔衛生学会雑誌 59 ( 5 ) 609 - 609 2009.10

メインテナンス期の歯周病患者において咬合力は予後因子となりうる

竹内倫子, 山本龍生, 江國大輔, 森田学

口腔衛生学会雑誌 59 ( 4 ) 327 - 327 2009.8

岡山大学病院における頭頸部癌チーム医療と予防歯科の関わり

山中玲子, 水川展吉, 山本龍生, 小山玲子, 古田美智子, 江國大輔, 西川悟郎, 岡崎惠子, 志茂加代子, 羽川操, 森田学

岡山歯学会雑誌 28 ( 1 ) 90 - 90 2009.6

Vitamin C intake attenuates the degree of experimental atherosclerosis induced by periodontitis in the rat by decreasing oxidative stress. Reviewed International journal

Daisuke Ekuni, Takaaki Tomofuji, Toshihiro Sanbe, Koichiro Irie, Tetsuji Azuma, Takayuki Maruyama, Naofumi Tamaki, Jun Murakami, Susumu Kokeguchi, Tatsuo Yamamoto

Archives of Oral Biology Vol.54 ( No.5 ) 495 - 502 2009.3

Validity of a questionnaire for periodontitis screening of Japanese employees. Reviewed International journal

Tatsuo Yamamoto, Reiko Koyama, Naofumi Tamaki, Takayuki Maruyama, Takaaki Tomofuji, Daisuke Ekuni, Reiko Yamanaka, Tetsuji Azuma, Manabu Morita

Journal of Occupational Health Vol.51 ( No.2 ) 137 - 143 2009.2

Effects of improvement in periodontal inflammation by toothbrushing on serum lipopolysaccharide concentration and liver injury in rats. Reviewed International journal

Takaaki Tomofuji, Daisuke Ekuni, Toshihiro Sanbe, Tetsuji Azuma, Naofumi Tamaki, Takayuki Maruyama, Tatsuo Yamamoto, Tatsuo Watanabe, Mutsumi Miyauchi, Takashi Takata

Acta Odontologica Scandinavica Vol.67 ( No.4 ) 200 - 205 2009

Effects of vitamin C intake on gingival oxidative stress in rat periodontitis. Reviewed International journal

Takaaki Tomofuji, Daisuke Ekuni, Toshihiro Sanbe, Koichiro Irie, Tetsuji Azuma, Takayuki Maruyama, Naofumi Tamaki, Jun Murakami, Susumu Kokeguchi, Tatsuo Yamamoto

Free Radical Biology and Medicine Vol.46 ( No.2 ) 163 - 168 2008.10

Language：English Publishing type：Research paper (scientific journal)

Increased levels of oxidative stress due to excessive production of reactive oxygen species are involved in the pathogenesis of periodontitis. Studies suggest a negative association between plasma vitamin C level and the severity of periodontitis. We hypothesized that increases in plasma vitamin C levels after vitamin C intake might clinically reduce gingival oxidative stress in a rat periodontitis model. A ligature was placed around rat mandibular molars for 4 weeks to induce periodontitis, and the rats were then given drinking water with or without 1 g/L vitamin C for 2 weeks after the ligature was removed. The periodontitis-induced rats showed a 149% increase in 8-hydroxydeoxyguanosine level and a 40% decrease in reduced:oxidized glutathione ratio in gingival tissue. Vitamin C intake induced a 175% increase in plasma vitamin C level, resulting in an improvement in the gingival 8-hydroxydeoxyguanosine level (decreased) and in the reduced:oxidized glutathione ratio (increased). Furthermore, in ligature-induced periodontitis lesions, gene expression encoding inflammation, including interleukin-1 alpha and interleukin-1 beta, was more than twofold down-regulated by vitamin C intake. The results suggest that systemic administration of vitamin C could be clinically beneficial in improving periodontitis-induced oxidative stress by down-regulating inflammatory gene expression.

DOI： 10.1016/j.freeradbiomed.2008.09.040

PubMed

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小学生における食習慣と咬合力・咬合接触面積の関係

古田美智子, 山中玲子, Akhter Rahena, 小山玲子, 友藤孝明, 江國大輔, 玉木直文, 東哲司, 山本龍生, 岸本悦央

口腔衛生学会雑誌 58 ( 5 ) 557 - 557 2008.10

新入生の歯科健診とアンケート評価 (第2報)歯周病のスクリーニング検査としてのアンケートの有効性

古田美智子, 江國大輔, 入江浩一郎, 小山玲子, 三部俊博, 山中玲子, アクター・ラヘナ, 山本龍生, 森田学

口腔衛生学会雑誌 58 ( 4 ) 343 - 343 2008.8

新入生の歯科健診とアンケート評価 (第1報)新入生の口腔内状態とアンケート結果の概要

江國大輔, 古田美智子, 入江浩一郎, 小山玲子, 三部俊博, 山中玲子, アクター・ラヘナ, 山本龍生, 森田学

口腔衛生学会雑誌 58 ( 4 ) 342 - 342 2008.8

Oxidative damage of rat liver induced by ligature-induced periodontitis and chronic ethanol consumption. Reviewed International journal

Takaaki Tomofuji, Toshihiro Sanbe, Daisuke Ekuni, Tetsuji Azuma, Koichiro Irie, Takayuki Maruyama, Naofumi Tamaki, Tatsuo Yamamoto

Archives of Oral Biology Vol.53 ( No.12 ) 1113 - 1118 2008.7

非外科的歯周治療後のメインテナンス期におけるホープレス歯の予後調査

江國大輔, 山本龍生, 竹内倫子

日本歯周病学会会誌 50 ( 春季特別 ) 183 - 183 2008.4

Retrospective study of teeth of poor prognosis during maintenance following non-surgical periodontal treatment

Ekuni Daisuke, Yamamoto Tatsuo, Takeuchi Noriko

Program and Abstracts of Annual Meeting of the Japanese Society of Periodontology 2008 95 - 95 2008

Relationship between periodontal status and levels of oxidative stress and antioxidant potential in plasma

Maruyama Takayuki, Tamaki Naofumi, Tomofuji Takaaki, Ekuni Daisuke, Yamanaka Reiko, Takeuchi Noriko, Yamamoto Tatsuo

Program and Abstracts of Annual Meeting of the Japanese Society of Periodontology 2008 52 - 52 2008

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