Faculty Profiles - EKUNI Daisuke

Papers - EKUNI Daisuke

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大学生における歯科に関する知識、歯科に関する知識の情報源及び口腔保健行動との関連:前向きコホート研究 Reviewed

福原大樹, 江國大輔, 片岡広太, 田畑綾乃, 内田瑶子, 外山直樹, 米田俊樹, 杉浦嘉雄, イスラム・モハマド・モニルル, 佐保輝, 森田学

岡山歯学会雑誌 38 ( 2 ) 93 - 93 2019.12

Structural equation modeling to detect predictors of oral health-related quality of life among Japanese university students: a prospective cohort study. International journal

Hikari Saho, Daisuke Ekuni, Kota Kataoka, Ayano Taniguchi-Tabata, Naoki Toyama, Yoshio Sugiura, Md Monirul Islam, Yoshiaki Iwasaki, Manabu Morita

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation 28 ( 12 ) 3213 - 3224 2019.12

Quasi-Randomized Trial of Effects of Perioperative Oral Hygiene Instruction on Inpatients with Heart Diseases Using a Behavioral Six-Step Method. International journal

Chie Omori, Daisuke Ekuni, Yumiko Ohbayashi, Minoru Miyake, Manabu Morita

International journal of environmental research and public health 16 ( 21 ) 2019.11

舌口唇運動機能は身体フレイルに関連する

竹内倫子, 江國大輔, 田畑綾乃, 外山直樹, 森田学

日本公衆衛生学会総会抄録集 78回 231 - 231 2019.10

Influence of Occupational Stress and Coping Style on Periodontitis among Japanese Workers: A Cross-Sectional Study. International journal

Md Monirul Islam, Daisuke Ekuni, Toshiki Yoneda, Aya Yokoi, Manabu Morita

International journal of environmental research and public health 16 ( 19 ) 2019.9

Incidence of the Acute Symptom of Chronic Periodontal Disease in Patients Undergoing Supportive Periodontal Therapy: A 5-Year Study Evaluating Climate Variables. International journal

Hikari Saho, Noriko Takeuchi, Daisuke Ekuni, Manabu Morita

International journal of environmental research and public health 16 ( 17 ) 2019.8

Change in tongue pressure and the related factors after esophagectomy: a short-term, longitudinal study.

Aya Yokoi, Daisuke Ekuni, Reiko Yamanaka, Hironobu Hata, Yasuhiro Shirakawa, Manabu Morita

Esophagus : official journal of the Japan Esophageal Society 16 ( 3 ) 300 - 308 2019.7

Relationship between acetaldehyde concentration in mouth air and characteristics of microbiota of tongue dorsum in Japanese healthy adults: a cross-sectional study. International journal

Aya Yokoi, Daisuke Ekuni, Hironobu Hata, Mayu Yamane-Takeuchi, Takayuki Maruyama, Reiko Yamanaka, Manabu Morita

Journal of applied oral science : revista FOB 27 e20180635 2019.6

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: Acetaldehyde, associated with consumption of alcoholic beverages, is known to be a carcinogen and to be related to the tongue dorsum. The aim of this study was to investigate the relationship between acetaldehyde concentration in mouth air and bacterial characteristics on the tongue dorsum. METHODOLOGY: Thirty-nine healthy volunteers participated in the study. Acetaldehyde concentrations in mouth air were evaluated by a high-sensitivity semiconductor gas sensor. A 16S rRNA gene sequencing technique was used to compare microbiomes between two groups, focusing on the six samples with the highest acetaldehyde concentrations (HG) and the six samples with lowest acetaldehyde concentrations (LG). RESULTS: Acetaldehyde concentration increased in correlation with the increase in bacterial count (p=0.048). The number of species observed in the oral microbiome of the HG was higher than that in the oral microbiome of the LG (p=0.011). The relative abundances of Gemella sanguinis, Veillonella parvula and Neisseria flavescens in the oral microbiome of the HG were higher than those in the oral microbiome of the LG (p<0.05). CONCLUSION: Acetaldehyde concentration in mouth air was associated with bacterial count, diversity of microbiome, and relative abundance of G. sanguinis, V. parvula, and N. flavescens.

DOI： 10.1590/1678-7757-2018-0635

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Relationship between acetaldehyde concentration in mouth air and characteristics of microbiota of tongue dorsum in Japanese healthy adults: a cross-sectional study. Reviewed International journal

Yokoi A, Ekuni D, Hata H, Yamane-Takeuchi M, Maruyama T, Yamanaka R, Morita M

Journal of applied oral science : revista FOB 27 e20180635 2019.6

Serum microRNAs and chronic periodontitis: A case-control study. Reviewed International journal

Yoneda T, Tomofuji T, Ekuni D, Azuma T, Maruyama T, Fujimori K, Sugiura Y, Morita M

Archives of oral biology 101 57 - 63 2019.5

光線力学療法を併用した歯周治療によって歯周状態が改善した一症例

江國大輔, 中島千穂, 森田学

口腔衛生学会雑誌 69 ( 2 ) 98 - 105 2019.4

幼児における保育環境とう蝕発生との関係

横井彩, 竹内倫子, 江國大輔, 森田学

口腔衛生学会雑誌 69 ( 増刊 ) 205 - 205 2019.4

The level of salivary lactate dehydrogenase as an indicator of the association between gingivitis and related factors in Japanese university students.

Ayano Taniguchi-Tabata, Daisuke Ekuni, Tetsuji Azuma, Toshiki Yoneda, Mayu Yamane-Takeuchi, Kota Kataoka, Hirofumi Mizuno, Hisataka Miyai, Yoshiaki Iwasaki, Manabu Morita

Journal of oral science 61 ( 1 ) 133 - 139 2019.3

Detection of Salivary miRNAs Reflecting Chronic Periodontitis: A Pilot Study. International journal

Kohei Fujimori, Toshiki Yoneda, Takaaki Tomofuji, Daisuke Ekuni, Tetsuji Azuma, Takayuki Maruyama, Hirofumi Mizuno, Yoshio Sugiura, Manabu Morita

Molecules (Basel, Switzerland) 24 ( 6 ) 2019.3

Language：English Publishing type：Research paper (scientific journal)

The purpose of this cross-sectional pilot study was to find salivary microRNAs (miRNAs) reflecting periodontal condition in chronic periodontitis. One hundred and twenty chronic periodontitis patients (mean age, 68.4 years) participated in the study, from whom unstimulated whole saliva was collected. A multiphase study was conducted to explore salivary miRNAs as biomarkers of periodontitis. At first, a polymerase chain reaction (PCR) array was performed to compare salivary miRNAs profiles in no and mild (no/mild) and severe periodontitis patients. Next, the relative expression of salivary miRNAs on individual samples was assessed by real-time reverse transcription-PCR. The numbers (%) of patients were 26 (21.6%, no/mild), 58 (48.3%, moderate) and 36 (30.0%, severe), respectively. Among 84 miRNAs, only the relative expression of hsa-miR-381-3p in the severe periodontitis group was significantly higher than that of the no/mild periodontitis group (p < 0.05). Among the 120 patients, there was also a significant correlation between the relative expression of hsa-miR-381-3p and the mean probing pocket depth (PPD) (r = 0.181, p < 0.05). Salivary hsa-miR-381-3p was correlated with periodontitis condition in chronic periodontitis patients.

DOI： 10.3390/molecules24061034

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Detection of Salivary miRNAs Reflecting Chronic Periodontitis: A Pilot Study. Reviewed International journal

Fujimori K, Yoneda T, Tomofuji T, Ekuni D, Azuma T, Maruyama T, Mizuno H, Sugiura Y, Morita M

Molecules (Basel, Switzerland) 24 ( 6 ) 2019.3

Awareness of Clenching and Underweight are Risk Factors for Onset of Crowding in Young Adults: A Prospective 3-Year Cohort Study. International journal

Naoki Toyama, Daisuke Ekuni, Ayano Taniguchi-Tabata, Kota Kataoka, Mayu Yamane-Takeuchi, Kohei Fujimori, Terumasa Kobayashi, Daiki Fukuhara, Koichiro Irie, Tetsuji Azuma, Yoshiaki Iwasaki, Manabu Morita

International journal of environmental research and public health 16 ( 5 ) 2019.2

Relationship Between Renal Dysfunction and Oral Mucositis in Patients Undergoing Concurrent Chemoradiotherapy for Pharyngeal Cancer: A Retrospective Cohort Study. Reviewed

Mizuno H, Miyai H, Yokoi A, Kobayashi T, Inabu C, Maruyama T, Ekuni D, Mizukawa N, Kariya S, Nishizaki K, Kimata Y, Morita M

In vivo (Athens, Greece) 33 ( 1 ) 183 - 189 2019.1

Association among secondhand smoke exposure, sleep quality, and prevalence of sleep bruxism in Japanese young adults: A cross-sectional study

Naoki Toyama, Daisuke Ekuni, Ayano Taniguchi-Tabata, Toshiki Yoneda, Kota Kataoka, Aya Yokoi, Yoko Uchida, Daiki Fukuhara, Hikari Saho, Islam Monirul, Nanami Sawada, Yukiho Nakashima, Yoshiaki Iwasaki, Manabu Morita

TOBACCO INDUCED DISEASES 17 26 - 27 2019

Relationship Between Renal Dysfunction and Oral Mucositis in Patients Undergoing Concurrent Chemoradiotherapy for Pharyngeal Cancer: A Retrospective Cohort Study. International journal

Hirofumi Mizuno, Hisataka Miyai, Aya Yokoi, Terumasa Kobayashi, Chiaki Inabu, Takayuki Maruyama, Daisuke Ekuni, Nobuyoshi Mizukawa, Shin Kariya, Kazunori Nishizaki, Yoshihiro Kimata, Manabu Morita

In vivo (Athens, Greece) 33 ( 1 ) 183 - 189 2019

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND/AIM: The aim of this retrospective cohort study was to investigate the association between renal dysfunction (RD) and the development of oral mucositis (OM) in patients undergoing concurrent chemoradiotherapy (CCRT) for pharyngeal cancer including radiation to the oral cavity. PATIENTS AND METHODS: Of 130 patients diagnosed as having pharyngeal cancer who received CCRT at the Okayama University Hospital Head and Neck Cancer Center, 44 were finally selected. RESULTS: During the observation period, 24 (54.5%) patients experienced severe OM (grade 3). The Cox proportional hazards regression model demonstrated that RD (hazard ratio(HR)=2.45, 95% confidence interval(CI)=1.067-6.116, p=0.035) and nasopharynx/oropharynx as center of the irradiated area (HR=2.56, 95% CI=1.072-5.604, p=0.034) were significantly associated with the incidence of severe OM (grade 3). CONCLUSION: In patients with pharyngeal cancer treated with CCRT including radiation to the oral cavity, RD at baseline can be a risk factor for developing severe OM.

DOI： 10.21873/invivo.11457

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New oral hygiene care regimen reduces postoperative oral bacteria count and number of days with elevated fever in ICU patients with esophageal cancer.

Hirofumi Mizuno, Shinsuke Mizutani, Daisuke Ekuni, Ayano Tabata-Taniguchi, Takayuki Maruyama, Aya Yokoi, Chie Omori, Kazuyoshi Shimizu, Hiroshi Morimatsu, Yasuhiro Shirakawa, Manabu Morita

Journal of oral science 60 ( 4 ) 536 - 543 2018.12

Language：English Publishing type：Research paper (scientific journal)

Using a controlled pre/post study design, we investigated the effects of professional mechanical cleaning of the oral cavity with benzethonium chloride, interdental brushes, and hydrogen peroxide on the number of oral bacteria and postoperative complications among esophageal cancer patients in an intensive care unit. Before surgery, 44 patients with esophageal cancer were recruited at Okayama Hospital from January through August 2015. The control group (n = 23) received routine oral hygiene care in the intensive care unit. The intervention group (n = 21) received intensive interdental cleaning with benzethonium chloride solution and tongue cleaning with hydrogen peroxide. The number of oral bacteria on the tongue surface and plaque index were significantly lower in the intervention group than in the control group on postoperative days 1 and 2 (P < 0.05). Additionally, the number of days with elevated fever during a 1-week period was significantly lower in the intervention group than in the control group (P = 0.037). As compared with routine oral hygiene, a new oral hygiene regimen comprising benzethonium chloride, interdental brushes, and hydrogen peroxide significantly reduced the number of oral bacteria and days with elevated fever in patients with esophageal cancer.

DOI： 10.2334/josnusd.17-0381

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