研究者詳細 - 松尾　俊彦

論文 - 松尾　俊彦

分割表示 141 件中 121 - 140 件目／全件表示 >>

The incidence and pathology of conjunctival ulceration in Behçet's syndrome. 査読

Matsuo T, Itami M, Nakagawa H, Nagayama M

The British journal of ophthalmology 86 ( 2 ) 140 - 143 2002年2月

Two cases of ocular injury due to air-bag activation

F. Nonaka, M. Nagayama, T. Matsuo, F. Shiraga, H. Ohtsuki

Japanese Journal of Clinical Ophthalmology 55 ( 2 ) 158 - 162 2001年

記述言語：日本語掲載種別：研究論文（学術雑誌）

We observed two cases of ocular injury due to air-bag activation. Both the cases were wearing a seat-belt at the time of injury. One was a 62-year-old male who was seated at the passenger seat in the front row. His left eye showed corneal endothelial damage, iridodialysis, lens luxation and vitreous hemorrhage. Traumatic macular hole was found after the second surgery two weeks after the injury. The final visual acuity of 0.05. The corneal endothelial cell population per mm3 was 1,547 right and 2,012 left. The other was a 62-year-old male driver. His left eye showed corneal erosion, corneal endothelial damage, commotio retinae and macular edema. The visual acuity improved to 0.9 one month after injury. The corneal endothelial cell population was 2,915 right and 1,447 left. These two cases showed that the left eye was more severely affected than the right and that corneal endothelial damage was an outstanding feature.

A novel gene (retinovin) expressed selectively in the early stage of chick retinal development 査読

M Itami, T Matsuo, H Ohtsuki

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 276 ( 1 ) 12 - 15 2000年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：ACADEMIC PRESS INC

To understand molecular mechanisms of retinal development, genes expressed selectively only in the early stage of retinal development were isolated by subtractive hybridization based on suppression polymerase chain reaction. The retina has no layered structure in 7-day chick embryos, in contrast with the fully developed multilayered structure of neurons in 15-day embryos. The subtraction between cDNA derived from retinal tissues at these different stages, followed by repeat rounds of 5'-RACE (rapid amplification of cDNA ends) and 3'-RACE, led to isolation of a novel gene with an open reading frame encoding a putative protein with 753 amino acids. Its specific expression in the 7-day embryonic retina was confirmed by Northern blot analysis. The gene, named "retinovin," would be used as a marker for identifying retinal stem cells present at the early stage of retinal development. (C) 2000 Academic Press.

Identification of ingrowth site of idiopathic subfoveal choroidal neovascularization by indocyanine green angiography 査読

Fumio Shiraga, Chieko Shiragami, Toshihiko Matsuo, Shiho Yokoe, Ippei Takasu, Hiroshi Ohtsuki

Ophthalmology 107 ( 3 ) 600 - 607 2000年3月

記述言語：英語掲載種別：研究論文（学術雑誌）

Purpose: This study aimed to determine whether indocyanine green (ICG) angiography is useful to identify the ingrowth site of idiopathic choroidal neovascularization (CNV), which can predict visual outcomes after surgical removal of idiopathic CNV. Design: Consecutive, observational case series. Participants: Twenty-six patients with idiopathic subfoveal CNV, of whom six underwent submacular surgery. Intervention: Indocyanine green videoangiography with a scanning laser ophthalmoscope. Main Outcome Measures: We studied ICG videoangiographic images of choroidal neovascular membranes from the early phase to the late phase with special attention to abnormal findings, which can indicate the ingrowth site of CNV. Results: Early ICG angiography demonstrated distinct neovascular vessels in 24 of the 26 patients (92%). Hypofluorescent rims continuously or intermittently surrounded neovascular membranes on late ICG angiograms in 21 of the 26 patients (81%). In 22 of the 26 patients (85%), ICG angiography demonstrated hypofluorescent areas within the CNV. These hypofluorescent areas frequently became ring shaped in the middle to late phase of the ICG angiography. In 14 of 16 patients (88%) with CNV larger than half a disc area, the filling of neovascular vessels appeared from the inside of the hypofluorescent areas and branched out toward the surrounding hyperfluorescent membrane in the early phase. In all six patients who underwent surgical removal of CNV, ICG videoangiography showed these hypofluorescent areas from which neovascular vessels emanated. Three of the four surgical patients, in whom hypofluorescent areas or central fluorescent areas surrounded by ring-shaped hypofluorescence were extrafoveal or juxtafoveal, had a best postoperative visual acuity of 20/60 or better. In contrast, both surgical patients with subfoveal hypofluorescent areas had a best postoperative visual acuity of 20/70 or worse. Conclusions: Although further observations are needed, ICG angiography may be a useful adjunct in the identification of the ingrowth site of idiopathic CNV, which can predict visual outcomes after surgery. (C) 2000 by the American Academy of Ophthalmology.

DOI： 10.1016/S0161-6420(99)00126-8

Risk for ocular attacks following phacoemulsification and intraocular lens implantation in patients of Behcet disease

M. Takahashi, T. Matsuo, A. Yamaoka, H. Kuwada, H. Ohtsuki, Y. Inoue, K. Egi

Japanese Journal of Clinical Ophthalmology 54 ( 8 ) 1499 - 1502 2000年

記述言語：日本語掲載種別：研究論文（学術雑誌）

We reviewed 16 eyes of 12 patients with Behcet disease who underwent intraocular implantation for complicated cataract. The incidence of acute ocular attack during the first postoperative year was significantly higher in longstanding cases and in patients who received surgery within 6 months after the last attack. The incidence of acute ocular attack was independent on the extraocular manifestations or sysemic mediation Cataract surgery did not induce more frequent ocular attacks. Postoperative visual acuity improved in all the eyes. Severe intra- or postoperative complications were absent throughout. The findings show that cataract surgery in patients of Behcet disease is relatively safe when performed 6 months or more after the last ocular attack.

Surgical treatment of submacular hemorrhage associated with idiopathic polypoidal choroidal vasculopathy 査読

Fumio Shiraga, Toshihiko Matsuo, Shiho Yokoe, Ippei Takasu, Toshio Okanouchi, Hiroshi Ohtsuki, Hans E. Grossniklaus

American Journal of Ophthalmology 128 ( 2 ) 147 - 154 1999年8月

記述言語：英語掲載種別：研究論文（学術雑誌）

PURPOSE: To report the visual outcome of surgical treatment of submacular hemorrhage associated with idiopathic polypoidal choroidal vasculopathy. METHODS: Eight eyes of eight consecutive patients with thick submacular hemorrhages associated with idiopathic polypoidal choroidal vasculopathy were treated with pars plana vitrectomy and tissue plasminogen activator-assisted removal of subretinal blood (December 1995 to September 1997) or intravitreal 100% sulfur hexafluoride gas injection without tissue plasminogen activator (October 1997 to March 1998). RESULTS: Postoperatively, laser treatment was performed for active polypoidal lesions outside the foveal avascular zone in four eyes. A retinal pigment epithelial tear was seen outside the foveal avascular zone in three eyes, and one eye developed a retinal detachment. The best-corrected visual acuity improved (by 3 or more lines) or stabilized in seven of the eight eyes. Four eyes had a final best- corrected visual acuity of 20/40 or better, and three eyes had a final best- corrected visual acuity of 20/50 to 20/200. In one eye, the visual acuity decreased from 20/100 to 20/500 because of the development of a subfoveal neovascular membrane. The membrane was excised, and histologic examination showed fibrovascular tissue between the retina and retinal pigment epithelium (type 2 pattern). CONCLUSIONS: Surgical intervention may be of benefit in eyes with submacular hemorrhage associated with idiopathic polypoidal choroidal vasculopathy.

DOI： 10.1016/S0002-9394(99)00078-1

A novel gene (oculomedin) induced by mechanical stretching in human trabecular cells of the eye 査読

Yukiko Sato, Toshihiko Matsuo, Hiroshi Ohtsuki

Biochemical and Biophysical Research Communications 259 ( 2 ) 349 - 351 1999年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Academic Press Inc.

To understand molecular mechanisms underlying the response to pressure in human trabecular cells of the eye, genes induced by cyclic mechanical stretching were isolated by subtractive hybridization assisted by polymerase chain reaction. A novel gene containing an Alu repetitive element in the 5' untranslated region was identified, and its expression was confirmed by Northern blot analysis to be stretch-specific in trabecular cells. The gene was also expressed in the retina, but not in the other tissues, including the brain. The gene encoded a putative small protein with 44 amino acids, which showed homology with neuromedin K. The putative novel protein was named as 'oculomedin,' and would be used as a candidate gene for glaucoma.

DOI： 10.1006/bbrc.1999.0797

Choroidal abnormalities in Behçet disease observed by simultaneous indocyanine green and fluorescein angiography with scanning laser ophthalmoscopy. 査読国際誌

T Matsuo, Y Sato, F Shiraga, C Shiragami, Y Tsuchida

Ophthalmology 106 ( 2 ) 295 - 300 1999年2月

記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVE: To examine choroidopathy in patients with Behçet disease. DESIGN: Prospective clinical study. PARTICIPANTS: Thirty-three patients (63 eyes) with Behçet disease. INTERVENTION: Patients underwent simultaneous indocyanine green (ICG) and fluorescein angiography with a double detector of scanning laser ophthalmoscopy. MAIN OUTCOME MEASURES: Angiographic findings recorded on videotapes were evaluated. The relation of angiographic findings with systemic activity and aqueous inflammation was also analyzed. RESULTS: Fluorescein angiography showed leakage in varying degrees from retinal vessels in 30 patients (53 eyes, 84%). The ICG angiographic findings were choroidal vascular wall staining in 16 eyes (25%), hyperfluorescent spots in 42 eyes (66%) and hypofluorescent plaques in 22 eyes (35%), both of which were not evident with fluorescein, leakage from choroidal vessels in 3 eyes (5%), and irregular filling of choriocapillaris in 11 eyes (17%). These findings did not have a statistically significant correlation with the presence or absence of aqueous inflammation or oral aphthous ulcerations. CONCLUSIONS: The patients with Behçet disease showed choroidal abnormalities, which could be revealed only by ICG angiography, but not with funduscopy or fluorescein angiography. Simultaneous ICG and fluorescein angiography would be useful for examining choroidal lesions in Behçet disease.

Choroidal lesions in sarcoidosis evaluated by indocyanine green angiography

M. Itami, T. Matsuo, C. Shiragami, F. Shiraga, Y. Sato, H. Ohtsuki

Japanese Journal of Clinical Ophthalmology 53 ( 4 ) 641 - 644 1999年

記述言語：日本語掲載種別：研究論文（国際会議プロシーディングス）

We studied 21 eyes of 11 patients of systemic sarcoidosis by simultaneous fluorescein and indocyanine green (ICG) angiography using a scanning laser ophthalmoscope. We paid particular attention to choroidal abnormalities. ICG angiographic findings, which were not evident on fluorescein angiogram, included moth-eaten or patchy areas of hypofluorescence, hyperfluorescente dots, staining of choroidal vascular wall, and reduced number of choroidal vessels. The moth-eaten hypofluorescence was more frequent in eyes with extensive leakage of fluorescein from retinal vessels than in those with less leakage. These findings illustrate the value of simultaneous fluorescein and ICG angiography in assessing the choroidal lesions and in evaluating the activity of sarcoidosis in the choroid.

Transplanted and repopulated retinal pigment epithelial cells on damaged Bruch's membrane in rabbits. 国際誌

C Shiragami, T Matsuo, F Shiraga, N Matsuo

The British journal of ophthalmology 82 ( 9 ) 1056 - 62 1998年9月

記述言語：英語掲載種別：研究論文（学術雑誌）

AIMS: The authors studied how artificially damaged Bruch's membrane influenced growth and differentiation of transplanted embryonic retinal pigment epithelial (RPE) cells and of host RPE cells in rabbits. METHODS: Embryonic RPE cells obtained from pigmented rabbits were transplanted into the subretinal space of adult albino rabbits. The host RPE was removed with a silicone cannula, and Bruch's membrane was damaged by scratching with a microhooked 27 gauge needle under the detached retina in closed vitrectomy. The transplantation sites were examined 3, 7, and 14 days after surgery by light and electron microscopy. RESULTS: Varying degrees of damage in Bruch's membrane were observed. Pigmented and hypopigmented RPE cells showed a normal polarity and tight junctions were seen at the sites of mild to moderate damage 3-7 days after the surgery. In contrast, fibroblast-like cells with no such features of RPE cells formed multiple layers at the sites of severe damage involving the full thickness of Bruch's membrane and the choriocapillaris even 14 days after the surgery. Without transplantation, host RPE cells repopulated the damaged areas in the same way as transplanted RPE cells. CONCLUSIONS: Transplanted embryonic RPE cells as well as host RPE cells grew and differentiated on the moderately damaged Bruch's membrane, while the severely damaged Bruch's membrane did not allow differentiation of RPE cells although these cells could grow and cover the damaged areas.

Bovine trabecular cells produce TIMP-1 and MMP-2 in response to mechanical stretching 査読

Y Okada, T Matsuo, H Ohtsuki

JAPANESE JOURNAL OF OPHTHALMOLOGY 42 ( 2 ) 90 - 94 1998年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：ELSEVIER SCIENCE INC

Bovine trabecular cells in growth phase were exposed to cyclic mechanical stretching of the bottom of a culture dish at a cycle of 30 seconds for 72 hours, The stretched cells produced significantly larger amounts of metalloproteinase-2 (MMP-2) and tissue inhibitor of metalloproteinase-1 (TIMP-1) after 72 hours, compared with cells in nonstretched control. In contrast, TIMP-2 and MMP-9 levels were not influenced by mechanical stretching. Trabecular cells would modify extracellular matrix in response to such mechanical stimuli as bending of trabecular meshwork or aqueous flow by the production of TIMP-1 and MMP-2. (C) 1998 Japanese Ophthalmological Society.

Aqueous vascular endothelial growth factor increases in anterior segment ischemia in rabbits 査読

T Tanaka, T Matsuo, H Ohtsuki

JAPANESE JOURNAL OF OPHTHALMOLOGY 42 ( 2 ) 85 - 89 1998年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：ELSEVIER SCIENCE INC

Both long posterior ciliary arteries were occluded or the three extraocular muscles were tenotomized to produce anterior segment ischemia in rabbits, and the aqueous levels of vascular endothelial growth factor (VEGF) were measured. The occlusion of both long posterior ciliary arteries led to clinical and histological anterior segment ischemia in varying degrees. The aqueous VEGF levels increased significantly compared with controls on all days examined (Mann-Whitney U test: day 1, P = 0.0039; day 4, P = 0.0065; day 7, P = 0.0039; day 14, P = 0.0104), while the levels at days 7 and 14 decreased significantly compared with those at day 4 (Wilcoxon signed-rank test; day 4 to day 7 and day 4 to day 14, P = 0.0464). In contrast, tenotomy of the three extraocular muscles resulted in no histological changes. The VEGF levels increased significantly compared with controls at day 1 and day 4 after surgery (Mann-Whitney U test: day 1 and day 4, P = 0.0104), while the levels at day 14 decreased significantly compared with those at day 1 (Wilcoxon signed-rank test, P = 0.0499). Aqueous VEGF levels represent the severity of anterior segment ischemia and could be used as an indicator for the extent of ischemia. (C) 1998 Japanese Ophthalmological Society.

Geographic choroiditis and retinal vasculitis in rheumatoid arthritis 査読

Toshihiko Matsuo, Ikuya Masuda, Nobuhiko Matsuo

Japanese Journal of Ophthalmology 42 ( 1 ) 51 - 55 1998年1月

記述言語：英語掲載種別：研究論文（学術雑誌）

A 37-year-old man developed geographic choroiditis and retinal vasculitis in the left eye while taking 3.5 mg/day oral prednisolone for rheumatoid arthritis. The choroidal lesions stopped growing when the dose of prednisolone was increased to 60 mg/day, while its tapering resulted in the recurrence and enlargement of the choroidal lesions to the macula. The patient experienced further recurrence twice in the following year. Indocyanine green angiography demonstrated the obstruction of choroidal arteries in addition to the complete obstruction of the choriocapillaris in a fresh lesion. This case was the first to have geographic choroiditis on the background of a systemic inflammatory disease.

DOI： 10.1016/S0021-5155(97)00102-0

Metastasis to the iris in squamous cell lung cancer 査読

Akio Hiraki, Hiroshi Ueoka, Toshihiko Matsuo, Tomio Nakagawa, Tadashi Yoshino, Katsuyuki Kiura, Masahiro Tabata, Katsuyoshi Sakae, Yuji Ohtsuki, Yoshio Hiraki, Mine Harada

International Journal of Clinical Oncology 3 ( 3 ) 186 - 190 1998年

記述言語：英語掲載種別：研究論文（学術雑誌）

A 72-year-old Japanese woman, suffering from squamous cell lung cancer with brain metastasis, underwent 2 courses of combination chemotherapy, consisting of cisplatin and vindesine. Although both the primary tumor and the brain metastasis regressed markedly, she developed left ocular pain with blurred vision. An abnormal mass was found in the left iris, and cytologic examination of the aqueous aspirate revealed a few malignant cells, which, when examined by electron microscopy, were considered to be derived from squamous cell carcinoma of the lung.

DOI： 10.1007/BF02489914

A case of atypical Treacher-Collins syndrome

Hirotake Fujiwara, Michio Sugihara, Toshihiko Matsuo, Miki Nouso, Satoshi Hasebe, Hiroshi Ohtsuki

Folia Ophthalmologica Japonica 48 ( 9 ) 1154 - 1157 1997年9月

記述言語：日本語掲載種別：研究論文（学術雑誌）

We report a 15 month-old male with atypical Treacher-Collins syndrome, who presented with strabismus due to hyperexotropia of the right eye. The diagnosis was based on findings of micrognathia, lowness and hypoplasia of bilateral external ears, conductive deafness, ventricular extrasystole, nursing difficulty, abnormal arrangement of the teeth and mental retardation. Magnetic resonance imaging showed hyperplasia of the cartilage involving the left trochlea and osteo-hyperplasia of the right internal ear
moreover, increased fatty tissue was found between the inner wall and medial rectus muscle of the left orbit. These findings suggest mild dysplasia of the orbital bone. The mechanism of strabismus remains unknown, but this orbital deformity could cause malposition of the eye.

Bilateral iridocyclitis with retinal capillaritis in juveniles 査読

T. Matsuo, N. Matsuo

Ophthalmology 104 ( 6 ) 939 - 944 1997年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Elsevier Inc.

Purpose: The authors present clinical features of 18 juvenile patients with a new type of uveitis termed bilateral iridocyclitis with retinal capillaritis (BIRC). Methods: The authors reviewed medical records of 18 consecutive patients who showed bilateral iridocyclitis with retinal capillary leakage but no systemic manifestations during an 11-year period from January 1985 to December 1995. Results: Twelve of the 18 patients were female and the age at onset ranged from 9 to 17 years old. All patients had many cells in the anterior chamber and anterior vitreous, together with mutton fat keratic precipitates. Fluorescein angiography showed leakage from the optic disc and retinal capillaries, mainly in the midperiphery, which corresponded to retinal cloudiness. Macular edema was minimal, and all patients maintained good vision. The inflammation responded well to topical, oral, and intravenous administration of corticosteroids, the choice of which was based on the extent of retinal inflammation. Human leukocyte antigen (HLA)-DR6 and HLA-Cw7 were associated significantly with the presence of BIRC (chi square test, P &lt
0.0001). Conclusions: Bilateral retinal capillaritis affecting capillaries in various areas of the retina and overlying retinal cloudiness with no distinct lesions are unique to these patients. Fluorescein angiography is essential for diagnosis of BIRC.

DOI： 10.1016/S0161-6420(97)30203-6

Abducens nerve palsy in a case under treatment with systemic interferon

M. Hosogi, S. Hasebe, T. Matsuo, H. Ohtsuki

Japanese Journal of Clinical Ophthalmology 51 ( 7 ) 1357 - 1360 1997年

記述言語：日本語掲載種別：研究論文（学術雑誌）

A 42-year-old male developed right abducens nerve palsy. He had been under treatment with systemic interferon- α for chronic hepatitis C since 17 days before. The abducens palsy rapidly improved after discontinuation of interferon. Diplopia disappeared one month after discontinuation. Neurological examinations including magnetic resonance imaging failed to identify the cause of abducens palsy. This case illustrates that oculomotor narve palsy is a liability in patients under treatment with systemic interferon.

Insufficiency of accommodation and convergence in whiplash injuries

Y. Tsutsui, T. Matsuo, K. Hasebe, H. Ohtsuki, N. Matsuo

Japanese Journal of Clinical Ophthalmology 49 ( 4 ) 775 - 778 1995年

記述言語：日本語掲載種別：研究論文（学術雑誌）

We reviewed 7 patients with insufficiency of convergence and accommodation secondary to blunt trauma to the head and neck, or whiplash injury, during the past 10-year period. Accommodation was reduced in all the 7 patients, convergence was normal in 3, weakened in 3 and absent in 2. Subjective symptoms improved in all cases by wearing convex lenses for near and/or base in prisms. The state of insufficiency of convergence and acommodation persisted throughout. Convergence and accommodation insufficiency has to be suspected when patients present with ophthalmological complaints after whiplash injuries.

ANOMALOUS POSTERIOR INSERTION OF MEDIAL RECTUS MUSCLE SIMULATING CONGENITAL OCULOMOTOR PALSY 査読

M OKANO, T MATSUO, H KONISHI, S HASEBE, Y TADOKORO, H OHTSUKI

JAPANESE JOURNAL OF OPHTHALMOLOGY 34 ( 3 ) 275 - 279 1990年

Familial hypo-retinol-binding proteinemia found in a child with keratomalacia 査読

T. Matsuo, N. Matsuo, F. Shiraga, N. Koide

Journal of Japanese Ophthalmological Society 92 ( 4 ) 694 - 698 1988年

記述言語：日本語掲載種別：研究論文（学術雑誌）

Retinol-binding protein (RBP) is a plasma protein with a molecular weight of 21,000 synthesized in the hepatocytes, binds with retinol (vitamin A), and transports it to peripheral tissues. Keratomalacia is caused by deficiency of vitamin A itself and/or protein-calorie malnutrition in the latter of which production of RBP is inhibited. We found for the first time familial hypo-retinol-binding proteinemia in a child at an age of 19 months who developed keratomalacia during measles infection in spite of good nourishment. The patient, her sister and mother showed persistent low levels, about half the normal levels of retinol and RBP which were unresponsive to oral vitamin A and protein diet. But they had normal liver function tests, normal levels of the other serum proteins, lipids, and fat-soluble vitamins. This hypo-retinol binding proteinemia was thought to predispose the child to develop keratomalacia during measles. The family members involved would be heterozygous for the normal gene and the defective gene of RBP.

　前のページ - 次のページ　

1
2
3
4
5
6
7
8