研究者詳細 - 松尾　俊彦

論文 - 松尾　俊彦

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MDSをともない、経過中に涙丘と骨髄浸潤をきたした芽球性形質細胞様樹状細胞腫瘍の1例

濱田利久, 鈴木大介, 竹島千夏, 三宅智子, 杉生真帆, 松尾俊彦, 岩月啓氏

日本皮膚悪性腫瘍学会学術大会プログラム・抄録集 27回 121 - 121 2011年6月

Optical coherence tomographic parameters as objective signs for visual acuity in patients with retinitis pigmentosa, future candidates for retinal prostheses 査読

Miho Tamaki, Toshihiko Matsuo

Journal of Artificial Organs 14 ( 2 ) 140 - 150 2011年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Springer Tokyo

To find optical coherence tomographic parameters related with visual acuity, and, thus, which might be used as objective signs to predict visual acuity after future treatment, for example retinal prosthesis implantation, 86 eyes of 45 consecutive patients with retinitis pigmentosa, who showed no macular diseases, underwent optical coherence tomography to measure macular retinal thickness and peripapillary retinal nerve fiber layer (RNFL) thickness, and to obtain horizontal cross-sectional images at the fovea for observation of the inner segment/outer segment (IS/OS) junction line. Best-corrected visual acuity was significantly better either in the right eyes or in the left eyes with greater retinal thickness of all four quadrants of the macular area in the inner ring, encompassing 1-3 mm from the foveal center (P\\0.05, Spearman rank correlation test), and also with the presence of the IS/OS line at the fovea (P\\0.0001, Wilcoxon-Kruskal-Wallis rank sum test). Retinal average thickness in the posterior pole covering the 6 9 6 mm square area was positively correlated with peripapillary RNFLaverage thickness either in the right eyes or in the left eyes (P\\0.05). The average thickness of the peripapillary RNFLbecame significantly less with age (P\\0.05), but was not related with visual acuity. Macular retinal thickness and the presence of the IS/OS line, but not peripapillary RNFLthickness, could serve as objective signs for better visual acuity in retinitis pigmentosa. The macular retinal thickness might be used as an objective predictor to choose patients with retinitis pigmentosa who would be expected to gain vision after retinal prosthesis implantation. © The Japanese Society for Artificial Organs 2011.

DOI： 10.1007/s10047-011-0557-9

Erratum: Optical coherence tomographic parameters as objective signs for visual acuity in patients with retinitis pigmentosa, future candidates for retinal prostheses (Journal of Artificial Organs (2011) 14, (140-150) DOI: 10.1007/s10047-011-0557-9) 査読

Miho Tamaki, Toshihiko Matsuo

Journal of Artificial Organs 14 ( 4 ) 385 2011年

脈絡膜黒色腫の病期、再発診断におけるFDG-PET/CTの初期経験

荻野裕香, 奥村能啓, 佐藤修平, 新家崇義, 原田聡介, 檜垣文代, 宗田由子, 山本岳玄, 加藤勝也, 郷原英夫, 平木隆夫, 三村秀文, 加地充昌, 松尾俊彦, 金澤右

日本医学放射線学会秋季臨床大会抄録集 46回 S530 - S530 2010年8月

Immunoglobulin G4 (IgG4)-positive or -negative ocular adnexal benign lymphoid lesions in relation to systemic involvement. 査読

Matsuo T, Ichimura K, Sato Y, Tanimoto Y, Kiura K, Kanazawa S, Okada T, Yoshino T

Journal of clinical and experimental hematopathology : JCEH 50 ( 2 ) 129 - 142 2010年

記述言語：英語出版者・発行元：The Japanese Society for Lymphoreticular Tissue Research

The purpose of this study is to determine the relationship of ocular adnexal benign or reactive lymphoid hyperplasia, including orbital pseudotumor, with immunoglobulin G4 (IgG4)-related diseases. Medical charts of 9 consecutive patients with ocular adnexal benign lymphoid lesions, seen in the Department of Ophthalmology, Okayama University Hospital, were reviewed, and pathological sections were restained immunohistochemically for IgG4-, IgG-, and CD138-positive plasma cells. The diagnosis of IgG4-positive lesions was based on 10 or more IgG4-positive plasma cells in a high-power field and greater than 40% ratios of IgG4-positive plasma cells/CD138-positive plasma cells and IgG4-positive plasma cells/IgG-positive plasma cells. IgG4-positive lesions were determined as absent in 5 patients (4 with bilateral lacrimal/orbital lesions and one with a unilateral conjunctival lesion), none of whom showed systemic manifestations. In contrast, IgG4-positive lesions were present in 4 patients (3 with bilateral lacrimal/orbital lesions and one with a unilateral lacrimal/orbital lesion), who showed systemic manifestations : one with Hashimoto thyroiditis, one with IgG4-positive bilateral interstitial lung disease and hepatic inflammatory pseudotumor, one with bilateral interstitial lung disease, and one with systemic lymphadenopathy and antiphospholipid syndrome. In conclusion, IgG4-positive ocular adnexal benign lymphoid lesions might be used as a benchmark for the probable presence of other systemic lymphoid lesions.

DOI： 10.3960/jslrt.50.129

その他リンク： http://search.jamas.or.jp/link/ui/2011254628

A case of aplasia of inferior rectus muscle

Tomoko Watanabe, Toshihiko Matsuo, Takashi Furuse, Satoshi Hasebe, Toshihiro Yanagawa, Toshinari Shimizu, Hiroshi Ohtsuki

Japanese Journal of Clinical Ophthalmology 62 ( 8 ) 1309 - 1314 2008年8月

記述言語：日本語掲載種別：研究論文（国際会議プロシーディングス）

Purpose : To report a case of aplasia of inferior rectus muscle detected at an advanced age. Case : A 73-year-old female had superior displacement of her right eye since birth that exacerbated recently. Findings : Her corrected visual acuity was 0.1 right and 0.8 left. The right eye was displaced superior-temporally at the primary position. Ocular motility was restricted in 5 directions except superiorly, presented with exacerbation of superior displacement of her right eye. Magnetic resonance imaging (MRI) showed absence of inferior rectus muscle in the right eye, atrophy of superior rectus and levator muscle, and constriction in the posterior portion of medical rectus muscle. There was no polymorphism of ARIX and PHOX2B genes. Transposition of horizontal muscles in the right eye resulted in alignment in the primary position and improved right visual acuity to 0.7. Reported Cases : There are 16 cases of aplasia of inferior rectus muscle reported in Japan. The series comprised 4 males, 8 females, and unknown in 4 cases. Associated lesion included microcornea, nanophthalmos, displaced pupil, and choroidal coloboma. Conclusion : Aplasia of inferior rectus muscle is a possibility when limitation in downward gaze is present. Forced duction test and MRI are useful adjunct diagnostic modalities.

Different histopathological types of orbital lymphoma 16 years after systemic follicular lymphoma: immunohistochemical and immunogenetic analyses of two cases. 査読

Matsuo T, Ichimura K, Shinagawa K, Yoshino T

Journal of clinical and experimental hematopathology : JCEH 48 ( 1 ) 17 - 24 2008年4月

記述言語：英語出版者・発行元：The Japanese Society for Lymphoreticular Tissue Research

The purpose of this study is to show that the histopathological type of an orbital lymphoma can differ from the systemic follicular lymphoma that precedes it. A 44-year-old man (Patient #1) and a 50-year-old man (Patient #2) presented with generalized lymphadenopathy due to grade 1 follicular lymphoma proven on lymph node biopsy. Patient #1 was followed without treatment for 16 years when he developed a right orbital mass. Patient #2 underwent several courses of combination chemotherapy as well as radiation but relapsed. The second biopsy of the lymph node nine years later showed the same histopathological type of follicular lymphoma. He developed an orbital mass on the right side 16 years after the initial presentation. In Patient #1, excisional biopsy of the orbital masses showed extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). In Patient #2, biopsy revealed the orbital mass to be T-cell/histiocyte-rich diffuse large B-cell lymphoma. In Patient #1, when comparing the original lymph node biopsy to the orbital biopsy obtained years later, no evidence for clonality was noted by polymerase chain reaction. In Patient #2, the amplification by polymerase chain reaction of the immunoglobulin heavy chain gene rearrangement in the lymph node lesion and the orbital lesion gave rise to a single discrete band with the same DNA sequence except for five nucleotide changes, indicating the same clonality in the presence of genomic changes. In conclusion, orbital lymphomas can occur as a second lymphoma with a different histopathological type in the long-term follow-up of systemic lymphomas. The original and subsequent lymphomatous lesions may or may not share neoplastic cell clonality and all genomics. [J Clin Exp Hematopathol 48(1) : 17-24, 2008]

DOI： 10.3960/jslrt.48.17

その他リンク： http://search.jamas.or.jp/link/ui/2008264833

Clinical features, ARIX and PHOX2B nucleotide changes in three families with congenital superior oblique muscle palsy 査読

Sayuri Imai, Toshihiko Matsuo, Emi Itoshima, Hiroshi Ohtsuki

ACTA MEDICA OKAYAMA 62 ( 1 ) 45 - 53 2008年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：OKAYAMA UNIV MED SCHOOL

We analyzed nucleotide changes in 3 genes, ARIX, PHOX2B, and KIF21A, in 6 patients of 3 families with congenital superior oblique muscle palsy. Three exons of ARIX, 3 exons of PHOX2B, and exons 8, 20, and 21 of KIF21A were amplified by polymerase chain reaction from genomic DNA isolated from the peripheral blood. The DNA fragments were directly sequenced in both directions. In 2 different families, a heterozygous nucleotide change, ARIX 153G > A, in the 5'-untranslated region was found in common between a father and daughter with muscle palsy and between a mother and daughter with muscle palsy (Family No. I and No. 3). In the other family (Family No. 2), a heterozygous 15-nucleotide deletion, PHOX2B 1124del15, resulting in loss of 5 alanine residues in the alanine repeat of the protein, was found in the daughter with muscle palsy and her father with normal traits, but was not found in the mother with muscle palsy. No KIF21A nucleotide change was found in any patients. The ARIX 153G > A polymorphism might be a genetic risk factor for the development of congenital superior oblique muscle palsy.

DOI： 10.18926/AMO/30985

[Vision engineering--photoelectric dye-based retinal prostheses: Okayama University model]. 査読

Matsuo T

Brain and nerve = Shinkei kenkyu no shinpo 59 ( 4 ) 331 - 338 2007年4月

Vision engineering - Photoelectric dye-based retinal prostheses: Okayama university model 査読

Toshihiko Matsuo

Brain and Nerve 59 ( 4 ) 331 - 338 2007年4月

記述言語：日本語掲載種別：研究論文（学術雑誌）

Patients with retinitis pigmentosa lose photoreceptor cells by genetic abnormalities and hence become blind. Neurons such as bipolar cells and ganglion cells still remain alive even in the retina of these patients, and ganglion cells send axons to the brain as the optic nerve. The replacement of dead photoreceptor cells with something artificial is the basic concept of retinal prostheses. The remaining retinal neurons can be stimulated by either electric current or electric potential. Photodiode array and electrode array are two main ways to stimulate retinal neurons as retinal prostheses. These retinal prostheses have problems such as low sensitivity and requiring outer electric sources (batteries). To overcome the problems, we are developing photoelectric dye-based retinal prostheses which absorb light and convert photon energy to electric potentials. The prototype, photoelectric dye-coupled polyethylene film, could generate intracellular calcium elevation in photoreceptor-lacking retinal tissues and also in cultured retinal neurons. The photoelectric dye-based retinal prostheses are thin and soft, and therefore, a sheet of the film in a large size, corresponding to wide visual field, can be inserted into the vitreous and then to the subretinal space through a small opening by rolling up the film. After the production control and the quality control have been established, clinical trials of the photoelectric dye-based retinal prostheses would be planned in concordance with the Drugs and Medical Devices Law to prove the safety and the efficacy.

A low-vision-care viewpoint of cataract surgery for patients with retinitis pigmentosa

Noriko Morimoto, Toshihiko Matsuo, Hiroshi Ohtsuki

Folia Ophthalmologica Japonica 58 ( 3 ) 153 - 157 2007年3月

記述言語：日本語掲載種別：研究論文（学術雑誌）

Purpose : To evaluate the outcomes and patient satisfaction with cataract surgery in patients with retinitis pigmentosa (RP). Methods : A retrospective review was conducted of the medical records of 12 patients (21 eyes) with RP who underwent cataract surgery at Okayama University Hospital between June 2004 and March 2006, and the patients were interviewed regarding their satisfaction with the surgery. Results : Best-corrected visual acuity improved in 17 eyes. Regarding complications, aftercataract, anterior capsular contraction, and temporary elevation of intraocular pressure occurred in 7, 1, and 1 patients, respectively. Subjective improvement in visual acuity, visual field, photophobia, ability to read and write, mobility, activities of daily life, and social life were noted in 10, 2, 4, 7, 6, 10, and 1 patients, respectively. All patients regarded the decision to undergo surgery as a good one. Conclusions : In this study, patients with RP were satisfied with their visual acuities and abilities to perform activities of daily living after cataract surgery, and we considered complications of this surgery to be minor. These results show that when patients are well informed before giving consent to the surgery, satisfaction with the results of surgery will be high. Cataract surgery should be performed before the patient's quality of life declines.

Detection of strabismus and amblyopia in 1.5-and 3-year-old children by a preschool vision-screening program in Japan 査読

Toshihiko Matsuo, Chie Matsuo, Hiroaki Matsuoka, Keiko Kio

ACTA MEDICA OKAYAMA 61 ( 1 ) 9 - 16 2007年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：OKAYAMA UNIV MED SCHOOL

All children at the age of 1.5 and 3 years in Japan undergo physical, mental, and developmental checkups including dental, eye, and hearing examinations. The vision-screening program consists of 3 steps: questionnaires and home visual acuity testing as the first step (only for 3-year-old children), visual acuity testing by nurses and inspection by medical officers at regional Health Centers as the second step, and detailed examinations by ophthalmologists as the third step. This study aims to reveal the prevalence of strabismus and amblyopia as obtained from data in the vision-screening program. The final diagnoses made by ophthalmologists and sent back to the Health Centers in Okayama City were reviewed to elucidate the prevalence of strabismus, amblyopia, refractive errors, and other diseases in 1.5- and 3-year-old children in Okayama City in 5 years from 2000 to 2004. Of approximately 6,500-6,900 total children, 83.7-86.8% at 1.5 years old and 77.8-81.9% at 3 years old were brought to the Health Centers. The rates of strabismus were 0.01-0.12% at 1.5 years old and 0.20-0.34% at 3 years old, while the rates of amblyopia were 0% at 1.5 years old and 0.13-0.18 % at 3 years old. The higher rates of strabismus at 3 years old were attributed mainly to the increase of exotropia and intermittent exotropia. In conclusions, the prevalence of strabismus was different between 1.5- and 3-year-old children. The vision-screening program in Japan functions to detect strabismus and amblyopia.

DOI： 10.18926/AMO/32910

Prostaglandins F-2 alpha and E-2 in aqueous humor of patients with cataract surgery 査読

T Matsuo

JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS 20 ( 2 ) 101 - 106 2004年4月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：MARY ANN LIEBERT INC PUBL

To understand the role of prostaglandins F-2alpha, and E-2 in aqueous humor under the normal condition, their concentrations were measured by enzyme immunoassay in aqueous fluid obtained from either eye of 60 patients during cataract surgery and correlated with clinical factors as the age and intraocular pressure. The concentrations of prostaglandin F-2alpha in the aqueous of all patients were below the level of detection. The concentrations of prostaglandin E-2 in the aqueous were below the level of detection in 37 patients while ranged from 9 to 48 pg/mL (median, 31) in 23 patients. The levels of prostaglandin E-2 did not have correlation with the age of the patients or the intraocular pressure of the eyes. In conclusions, the concentrations of prostaglandin E-2 were apparently higher than the concentrations of prostaglandin F-2alpha in the aqueous. This study could not prove the relationship between prostaglandin levels and the intraocular pressure or the age.

DOI： 10.1089/108076804773710768

ARIX gene polymorphisms in patients with congenital superior oblique muscle palsy 査読

Y Jiang, T Matsuo, H Fujiwara, S Hasebe, H Ohtsuki, T Yasuda

BRITISH JOURNAL OF OPHTHALMOLOGY 88 ( 2 ) 263 - 267 2004年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：B M J PUBLISHING GROUP

Aim: To identify ARIX gene polymorphisms in patients with congenital superior oblique muscle palsy and to find the relation between the ARIX gene and congenital superior oblique muscle palsy.
Methods: The three exons of the ARIX gene were sequenced by genomic DNA amplification with polymerase chain reaction (PCR) and direct sequencing in 15 patients with superior oblique muscle palsy (13 with congenital and two with acquired palsy) and 54 normal individuals. PCR products cloned into plasmids were also sequenced. A family with father and a daughter each having congenital superior oblique muscle palsy was also involved in this study.
Results: Four patients with congenital superior oblique muscle palsy carried heterozygous nucleotide changes in the ARIX gene. One patient with the absence of the superior oblique muscle had T7C in the 5'-UTR of the exon 1 and C-44A in the promoter region, both of which were located on the same strand. Another unrelated patient with congenital superior oblique muscle palsy had C76G in the 5'-UTR of the exon 1 and C-9A in the promoter region on the same strand. G153A in the 5'-UTR of exon 1 was found in common in two affected members of a family with congenital superior oblique muscle palsy. This G153A in the 5'-UTR of exon 1 was also present in four unrelated normal individuals. No other heterozygous nucleotide changes were found in normal individuals.
Conclusions: The nucleotide change (G153A) in the 5'-UTR of exon 1 co-segregated with congenital superior oblique muscle palsy in one family. Four other nucleotide changes in the exon 1 or the promoter region were found only in patients with congenital superior oblique muscle palsy. These nucleotide polymorphisms may be one of the risk factors for the development of congenital superior oblique muscle palsy.

DOI： 10.1136/bjo2003.021527

A Simple Method for Screening Photoelectric Dyes towards Their Use for Retinal Prostheses 査読

Toshihiko Matsuo

Acta Medica Okayama 57 ( 5 ) 257 - 260 2003年10月

記述言語：英語掲載種別：研究論文（学術雑誌）

Photoelectric dyes absorb light and convert photon energy to electric potentials. To test whether these dyes could be used for retinal prostheses, a simple in vitro screening system was developed. Retinal neurons were cultured from the eyes of chick embryos at the 10-day embryonic stage, at which time no retinal photoreceptor cells have yet developed. Intracellular calcium elevation was observed with Fluo-4 in cultured retinal neurons before and after photoelectric dye was applied at varying concentrations to the culture medium. Five of 7 photoelectric dyes tested in this in vitro system induced intracellular calcium elevation in cultured chick retinal neurons. The intracellular calcium elevation generated by the 5 photoelectric dyes was blocked by extracellular calcium depletion in the case of all 5 dyes, and, except for one dye, by the presence of voltage-gated calcium channel blockers. The photoelectric dyes absorbed light under an inverted microscope and stimulated retinal neurons. This simple in vitro system allows the screening of photoelectric dyes which can be used for retinal prostheses.

Clinical correlations of aggrecan in the resected medial rectus muscle of patients with intermittent exotropia 査読

T Yamane, T Matsuo, S Hasebe, H Ohtsuki

ACTA MEDICA OKAYAMA 57 ( 4 ) 199 - 204 2003年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：OKAYAMA UNIV MED SCHOOL

The purpose of this study was to elucidate the role of extracellular matrix components such as aggrecan, fibronectin, and laminin in the extraocular muscle of patients with strabismus. Resected tissues of the medial rectus muscle of 47 patients with intermittent exotropia obtained during recession-resection surgery were frozen under liquid nitrogen and pulverized by a Freezer/Mill to solubilize the tissue for enzyme immunoassay. The total amounts of aggrecan, fibronectin, and laminin in the resected tissue were correlated with clinical data of patients such as age, exodeviation, and refractive error. The amount of aggrecan decreased significantly with the advance of age (P < 0.0001, Spearman rank correlation test), while the amount of laminin or fibronectin had no correlation with age. Patients with basic type intermittent exotropia showed larger, although not significantly, amounts of aggrecan than those with convergence insufficiency type (P = 0.0538, Mann-Whitney U-test). The amount of aggrecan may be related to motor aspects of intermittent exotropia.

DOI： 10.18926/AMO/32803

Genome-wide search for strabismus susceptibility loci 査読

H Fujiwara, T Matsuo, M Sato, T Yamane, M Kitada, S Hasebe, H Ohtsuki

ACTA MEDICA OKAYAMA 57 ( 3 ) 109 - 116 2003年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：OKAYAMA UNIV MED SCHOOL

The purpose of this study was to search for chromosomal susceptibility loci for comitant strabismus. Genomic DNA was isolated from 10 mL blood taken from each member of 30 nuclear families in which 2 or more siblings are affected by either esotropia or exotropia. A genome-wide search was performed with amplification by polymerase chain reaction of 400 markers in microsatellite regions with similar to10 cM resolution. For each locus, non-parametric affected sib-pair analysis and nonparametric linkage analysis for multiple pedigrees (Genehunter software, http://linkage. rockefeller.edu/soft/) were used to calculate multipoint lod scores and non-parametric linkage (NPL) scores, respectively. In sib-pair analysis, lod scores showed basically flat lines with several peaks of 0.25 on all chromosomes. In non-parametric linkage analysis for multiple pedigrees, NPL scores showed one peak as high as 1.34 on chromosomes 1, 2, 4, 7, 10, 15, and 16, while 2 such peaks were found on chromosomes 3, 9, 11, 12, 18, and 20. Non-parametric linkage analysis for multiple pedigrees of 30 families with comitant strabismus suggested a number of chromosomal susceptibility loci. Our ongoing study involving a larger number of families will refine the accuracy of statistical analysis to pinpoint susceptibility loci for comitant strabismus.

Multiple sclerosis-like disease secondary to alpha interferon 査読

T Matsuo, R Takabatake

OCULAR IMMUNOLOGY AND INFLAMMATION 10 ( 4 ) 299 - 304 2002年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SWETS ZEITLINGER PUBLISHERS

Purpose: To describe bilateral optic neuritis that occurred as an adverse effect of recombinant and natural interferon a administration. Methods: Report of two cases. Case 1, a 62-year-old woman, developed bilateral optic neuritis with decreased sensation of vibration and increased deep tendon reflex in the lower extremities after a seven-month use of recombinant interferon alpha-2a for chronic active hepatitis C. Case 2, a 29-year-old woman, developed bilateral optic neuritis combined with numbness of the lower extremities as well as bowel and bladder dysfunction after a 22-month use of recombinant interferon alpha-2b for chronic myelogenous leukemia. After a two-month interruption of interferon administration, natural interferon a was given but followed by another episode of the same neurological manifestations. Results: In both cases, magnetic resonance imaging demonstrated multiple small high-intensity areas in the cerebral white matter and spinal cord, while cerebrospinal fluid examination disclosed mononuclear cell increase and protein elevation including myelin basic protein, all of which simulated the features of multiple sclerosis. The two patients underwent several courses of pulse corticosteroid therapy, each course consisting of three days of methylprednisolone 1000 mg daily, resulting in visual recovery to some extent. Conclusions: Optic neuritis in combination with other neurological signs, simulating multiple sclerosis, should be included in the list of adverse effects of recombinant and natural interferon a administration.

DOI： 10.1076/ocii.10.4.299.15588

Seropositivity of human herpesvirus-8 in patients with uveitis 査読

T Matsuo, M Itami

OCULAR IMMUNOLOGY AND INFLAMMATION 10 ( 3 ) 197 - 199 2002年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SWETS ZEITLINGER PUBLISHERS

Purpose: To explore the role of human herpesvirus-8 (HHV-8) in the pathogenesis of uveitis and other forms of ocular inflammation. Methods: Serum antibody titers to HHV-8 were measured in 76 patients with uveitis from various causes and other types of ocular inflammation in either the acute phase, the convalescent phase, or both. Results: Only one 21-year-old male patient in the convalescent phase of unilateral pars planitis showed a positive titer for HHV-8. His serum was negative for human immunodeficiency virus-I. Conclusions: Although the seropositive rate in the patient population was higher than that in the general population, the increased incidence was not statistically significant. The role of HHV-8 in the pathogenesis of intraocular inflammation appears to be limited.

DOI： 10.1076/ocii.10.3.197.15602

Submacular exudates with serous retinal detachment caused by cat scratch disease 査読

T Matsuo, M Kato

OCULAR IMMUNOLOGY AND INFLAMMATION 10 ( 2 ) 147 - 150 2002年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SWETS ZEITLINGER PUBLISHERS

Purpose: To present submacular exudates as a manifestation of cat scratch disease. Methods: Report of two cases. Results: The first patient, a 34-year-old man, developed submacular exudates with serous retinal detachment ten days after having axillary lymphadenopathy and fever. The second patient, a 30-year-old woman, developed submacular exudates with serous retinal detachment mimicking central serous chorioretinopathy. Fluorescein angiography revealed late staining of the subretinal lesions in both cases. The lesion resolved spontaneously in the first patient, while sulfamethoxazole and trimethoprim was required for the second patient. Both patients had a positive IgG titer for Bartonella henselae. Conclusions: Submacular exudates with serous retinal detachment can occur in cat scratch disease. Cat scratch disease should be included in the differential diagnosis of submacular exudates with central serous chorioretinopathy.

DOI： 10.1076/ocii.10.2.147.13979

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