論文 - 松尾　俊彦

Detailed Ophthalmic and Pathological Features of Choroidal Metastasis From Breast Cancer: A Case Series of Five Patients. 査読

Toshihiko Matsuo, Takehiro Tanaka, Tadahiko Shien, Atsushi Muraoka, Hiroyoshi Doihara

Cureus   17 ( 5 )   e83484   2025年5月

　詳細を見る

掲載種別：研究論文（学術雑誌）  

添付ファイル： Comments Cureus Breast cancer20250503.docx

researchmap

Bilateral Scleritis and Neutrophilic Dermatosis With Cytogenetic Chromosomal Aberrancy Related to Pyoderma Gangrenosum: A Case Report of a 20-Year Follow-Up 査読

Toshihiko Matsuo, Takehiro Tanaka, Noboru Asada, Mikako Obika, Ryotaro Omichi, Keiji Iwatsuki

Cureus   17 ( 4 )   e82348   2025年4月

　詳細を見る

担当区分：筆頭著者   掲載種別：研究論文（学術雑誌）  

添付ファイル： Cureus2025 pyoderma scleritis.pdf

researchmap

Presumed Autoimmune Keratitis in Both Eyes Without Systemic Manifestations: A 40-Year Course of a Patient With Corneal Infiltrates and Melt 査読

Toshihiko Matsuo, Takehiro Tanaka

Cureus   17 ( 2 )   e79852   2025年3月

　詳細を見る

担当区分：筆頭著者   掲載種別：研究論文（学術雑誌）  

添付ファイル： Cureus2025-autoimmune-keratitis.pdf

researchmap

A Natural Course From Primary Intraocular Lymphoma to Brain Lymphoma in Four Years According to Patient's Choice 査読

Toshihiko Matsuo, Takehiro Tanaka, Joji Ishida, Shotaro Kondo, Ken-ichi Matsuoka

Cureus   17 ( 3 )   e81476   2025年3月

　詳細を見る

担当区分：筆頭著者   掲載種別：研究論文（学術雑誌）  

添付ファイル： Cureus Intraocular lymphoma Matsuo.pdf

researchmap

Eyelid Spindle Cell Lipoma: Case Report and Review of Three Patients in Literature 査読

Toshihiko Matsuo, Kiyoshi Yamada, Yasumasa Monobe, Takehiro Tanaka

Clinical Case Reports   13 ( e70097 )   1 - 4   2025年1月

　詳細を見る

担当区分：筆頭著者   掲載種別：研究論文（学術雑誌）  

添付ファイル： Clin Case Rep Eyelid Spindle Cell Lipoma.pdf

researchmap

Local Control of Conjunctival Malignant Melanoma by Proton Beam Therapy in a Patient With No Metastasis in Six Years From in Situ to Nodular Lesions. 査読

Toshihiko Matsuo, Takeshi Ogata, Takahiro Waki, Takehiro Tanaka, Kota Tachibana, Tomokazu Fuji, Takuya Adachi, Osamu Yamasaki

Journal of Medical Cases   16 ( 1 )   28 - 36   2025年1月

　詳細を見る

担当区分：筆頭著者   掲載種別：研究論文（学術雑誌）  

添付ファイル： jmc4351 melanoma protom beam.pdf

researchmap

Perspectives of traditional herbal medicines in treating retinitis pigmentosa 査読

Shihui Liu, Toshihiko Matsuo, Chie Matsuo, Takumi Abe, Jinghua Chen, Chi Sun, Qing Zhao

Frontiers in Medicine   11 ( 1468230 )   2024年12月

　詳細を見る

担当区分：責任著者   掲載種別：研究論文（学術雑誌）  

添付ファイル： front Med Kampo Liu2024.pdf

DOI： 10.3389/fmed.2024.1468230

researchmap

Axillary Reactive Lymphoid Hyperplasia, Likely Due to Unicentric Castleman Disease, and the Concurrent Presence of Orbital Mucosa- Associated Lymphoid Tissue (MALT) Lymphoma: A Six-Year Follow-Up Study. 査読

Toshihiko Matsuo, Takehiro Tanaka, Tomokazu Fuji, Daisuke Ennishi

Cureus   16 ( 11 )   e73775   2024年11月

　詳細を見る

担当区分：筆頭著者  

添付ファイル： Cureus 309150 Castleman disease & MALT.pdf

researchmap

Infective Endocarditis With Origin in Orbital Vascular Malformation and Maxillary Sinusitis: A Case Report and Review of Four Patients in the Literature 査読

Toshihiko Matsuo, Yoshitaka Iwamoto, Hironori Okamoto, Daisuke Iguchi

Cureus   16 ( 11 )   e74873   2024年11月

　詳細を見る

担当区分：筆頭著者   掲載種別：研究論文（学術雑誌）  

添付ファイル： Cureus infective endocarditis 2024.pdf

researchmap

Presumed Choroidopathy of IgG4-Related Disease Discovered During 16-Year Follow-Up of a Patient With Polycystic Kidney Disease. 査読

Toshihiko Matsuo, Takehiro Tanaka, Kenji Tsuji

Cureus   16(10) ( e70865 )   1 - 5   2024年10月

　詳細を見る

担当区分：筆頭著者  

添付ファイル： Cureus choroidopathy-of-IgG4.pdf

researchmap

Intravitreal Fluconazole Injection for Fungal Endophthalmitis as Treatment Option in a Patient With End-Stage Liver and Kidney Diseases. 査読

Toshihiko Matsuo, Yasuyuki Kobayashi, Shingo Nishimura, Naoko Yoshioka, Yasushi Takahashi, Yasutaka Iguchi

Journal of Medical Cases   15 ( 11 )   359 - 366   2024年10月

　詳細を見る

担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

添付ファイル： Fungal endophthalmitis JMedCases.pdf

researchmap

Pathological findings in enucleated eyes of patients with neurofibromatosis type 1: report of a case with 15-year follow-up and review of 14 patients in the literature. 査読

Toshihiko Matsuo, Kenji Nishida, Takehiro Tanaka, Takaya Seno, Kiyoshi Yamada, Shigeki Ono

BMC Ophthalmology   24 ( 341 )   1 - 13   2024年8月

　詳細を見る

担当区分：筆頭著者   掲載種別：研究論文（学術雑誌）  

添付ファイル： BMC Ophthalmol neurofibromatosis -1.pdf

researchmap

Anterior Uveitis After Discontinuation of Janus Kinase Inhibitor, Ruxolitinib 査読

Toshihiko Matsuo, Naoto Ikeda, Yasumasa Monobe, Takehiro Tanaka

Journal of Medical cases   15 ( 8 )   208 - 214   2024年8月

　詳細を見る

担当区分：筆頭著者   掲載種別：研究論文（学術雑誌）  

添付ファイル： J Med Cases myelofibrosis.pdf

researchmap

Genome-Wide Association Study with Three Control Cohorts of Japanese Patients with Esotropia and Exotropia of Comitant Strabismus and Idiopathic Superior Oblique Muscle Palsy. 査読

Toshihiko Matsuo, Ichiro Hamasaki, Yoichiro Kamatani, Takahisa Kawaguchi, Izumi Yamaguchi, Fumihiko Matsuda, Akira Saito, Kazuyuki Nakazono, Shigeo Kamitsuji

International Journal of Molecular Sciences   25 ( 6986 )   1 - 25   2024年6月

　詳細を見る

担当区分：筆頭著者   掲載種別：研究論文（学術雑誌）  

添付ファイル： ijms-25-06986 strabismus GWAS.pdf

DOI： 10.3390/ijms25136986

researchmap

Decades of stability of conjunctival vascular malformations in two patients. 査読

Toshihiko Matsuo, Takehiro Tanaka, Yoshihiro Kimata

Clinical Case Reports   12 ( e8933 )   1 - 7   2024年5月

　詳細を見る

担当区分：筆頭著者   掲載種別：研究論文（学術雑誌）  

添付ファイル： ClinCaseRep conjunctival vascular malformations.pdf

researchmap

Spontaneous regression and rare relapse after excisional biopsy in long-term observation of 31 patients with primary conjunctival lymphoma. 査読

Toshihiko Matsuo, Takehiro Tanaka

Journal of Clinical and Experimental Hematopathology   64 ( 2 )   86 - 96   2024年5月

　詳細を見る

担当区分：筆頭著者   掲載種別：研究論文（学術雑誌）  

添付ファイル： JCEH conj lymphoma2024.pdf

DOI： 10.3960/jslrt.24002

researchmap

Pericardial Effusion in Association With Periodontitis: Case Report and Review of 8 Patients in Literature. 査読

Toshihiko Matsuo, Chie Nakago Matsuo, Nobuhiko Matsuo, Ayano Mori, Masaaki Murakami, Hiroshi Ito

Journal of Investigative Medicine High Impact Case Reports   12 ( 23247096241239559 )   1 - 8   2024年3月

　詳細を見る

担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

添付ファイル： JIM2024 pericarditis and periodontitis.pdf

researchmap

Vogt-Koyanagi- Harada disease in pregnancy: Case report and review of 32 patients in the literature. 査読

Toshihiko Matsuo, Kasumi Takahashi, Tsunemasa Kondo

Clinical Case Reports   12 ( e8643 )   1 - 12   2024年3月

　詳細を見る

担当区分：筆頭著者   掲載種別：研究論文（学術雑誌）  

添付ファイル： Clinical Case Reports Harada in pregnancy.pdf

researchmap

sarcoidosis-lymphoma 症候群 招待

松尾俊彦

「別冊日本臨床 血液症候群（第3版）IV その他の血液疾患を含めて   29   413 - 417   2024年2月

　詳細を見る

担当区分：筆頭著者   掲載種別：論文集(書籍)内論文  

添付ファイル： 日本臨牀(別冊)血液症候群(第3版)松尾sarcoidosis-lymphoma IVB2402085.pdf

researchmap

Rare Combination of Abducens Nerve Palsy and Optic Neuritis on the Same Side: Case Report and Review of 8 Patients in Literature. 査読

Toshihiko Matsuo, Daisuke Iguchi

Journal of Investigative Medicine High Impact Case Reports   12 ( 23247096231225873 )   1 - 7   2024年1月

　詳細を見る

担当区分：筆頭著者  

添付ファイル： optic neuritis & abducens palsy.pdf

researchmap

Morphometric Analysis of the Eye by Magnetic Resonance Imaging in MGST2-Gene-Deficient Mice. 査読

Chaomulige, Toshihiko Matsuo, Kohei Sugimoto, Mary Miyaji, Osamu Hosoya, Masashi Ueda, Ryosuke Kobayashi, Takuro Horii, Izuho Hatada

Biomedicines   12 ( 370 )   1 - 14   2024年1月

　詳細を見る

担当区分：責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

添付ファイル： biomedicines-12-00370.pdf

researchmap

[Relapsed primary central nervous system lymphoma treated with CD19 chimeric antigen receptor T-cell therapy and allogeneic hematopoietic stem cell transplantation]. 査読

Fuminari Fujii, Toshiki Terao, Hisakazu Nishimori, Kentaro Fujii, Toshihiko Matsuo, Tadashi Yoshino, Hiroko Ueda, Tadashi Oyama, Akifumi Matsumura, Kaho Kondo, Chisato Matsubara, Kanako Fujiwara, Keisuke Seike, Hideaki Fujiwara, Noboru Asada, Daisuke Ennishi, Keiko Fujii, Nobuharu Fujii, Ken-Ichi Matsuoka, Yoshinobu Maeda

[Rinsho ketsueki] The Japanese journal of clinical hematology   65 ( 7 )   622 - 627   2024年

　詳細を見る

記述言語：日本語   掲載種別：研究論文（学術雑誌）  

Relapsed and/or refractory (R/R) primary central nervous system lymphoma (PCNSL) has a poor prognosis. A 57-year-old man diagnosed with PCNSL achieved a complete response by high-dose methotrexate-based chemotherapy followed by autologous hematopoietic stem cell transplantation (ASCT). The disease was not cured, so he was treated with the anti-CD19 chimeric antigen receptor (CAR) T-cell therapy tisagenlecleucel after the third relapse. However, the disease relapsed again 28 days after CAR T-cell therapy. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) was attempted as curative therapy after bridging with second ASCT and tirabrutinib monotherapy. Although a temporary response was achieved, the disease relapsed 98 days after allo-HSCT. While receiving tirabrutinib for relapse after allo-HSCT, the patient developed acute respiratory failure due to transplant-related toxicity and post-transplant thrombotic microangiopathy. He died 175 days after allo-HSCT. Although various treatments for PCNSL have been investigated in recent years, the treatment strategy for R/R PCNSL has not been established. Further studies are warranted to improve the outcomes of patients with R/R PCNSL.

DOI： 10.11406/rinketsu.65.622

PubMed

researchmap

特集 指定難病 Up to Date 網膜色素変性症 招待 査読

松尾俊彦

岡山医学会雑誌   135 ( 3 )   147 - 151   2023年12月

　詳細を見る

担当区分：筆頭著者  

添付ファイル： 09　特集 (難病)　松尾俊彦.pdf

researchmap

Nontuberculous mycobacterial abscess of lacrimal sac and eyelid debridement: Case report 査読

Toshihiko Matsuo, Takehiro Tanaka, Kiyoshi Yamada, Motoko Nose, Yasushi Tanimoto

Clinical Case Reports   11 ( e8364 )   1 - 6   2023年12月

　詳細を見る

担当区分：筆頭著者  

添付ファイル： Clinical Case Reports 2023NTM.pdf

researchmap

A simple method for culturing Acanthamoeba from soft contact lens at a clinical laboratory of a hospital: Case report of Acanthamoeba keratitis. 査読

Toshihiko Matsuo, Motoko Nose

Clinical Case Reports   11 ( e8248 )   1 - 5   2023年11月

　詳細を見る

担当区分：筆頭著者  

添付ファイル： Clinical Case Reports 2023Acanthamoeba.pdf

researchmap

Resection of Orbital Myxoma With Magnetic Resonance Imaging Evidence of Ethmoid Sinus Origin: Case Report and Review of 20 Patients in the Literature. 査読

Toshihiko Matsuo, Takehiro Tanaka

Journal of Investigative Medicine High Impact Case Reports   11 ( 10.1177/23247096231201013 )   1 - 6   2023年9月

　詳細を見る

担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

添付ファイル： matsuo-tanaka-2023 orbital myxoma.pdf

researchmap

Bilateral lacrimal gland mantle cell lymphoma in 11-year follow-up: case report and review of 48 cases with ocular adnexal presentation in the literature. 査読

Toshihiko Matsuo, Takehiro Tanaka, Kazuya Okada, Kenji Notohara, Keiko Fujii, Nobuharu Fujii

Journal of Investigative Medicine High Impact Case Reports   11 ( 23247096231185483 )   2023年7月

　詳細を見る

担当区分：筆頭著者   掲載種別：研究論文（学術雑誌）  

添付ファイル： matsuo-et-al-2023-lacrimal-gland-mantle-cell-lymphoma.pdf

researchmap

Bilateral Optic Neuritis and Hypophysitis With Diabetes Insipidus 1 Month After COVID-19 mRNA Vaccine: Case Report and Literature Review 査読

Toshihiko Matsuo, Kohei Okubo, Hirofumi Mifune, Takeshi Imao

Journal of Investigative Medicine High Impact Case Reports   11 ( 23247096231186046 )   1 - 10   2023年7月

　詳細を見る

担当区分：筆頭著者   掲載種別：研究論文（学術雑誌）  

添付ファイル： matsuo-et-al-2023-bilateral-optic-neuritis-and-hypophysitis.pdf

researchmap

ANCA-associated vasculitis with scleritis, corneal melt, and perforation rescued by rituximab: Case report and literature review 査読

Toshihiko Matsuo, Sumie Hiramatsu-Asano, Hiroshi Sawachika, Hirotake Nishimura

Clinical Case Reports   11 ( e7595 )   1 - 8   2023年6月

　詳細を見る

担当区分：筆頭著者   掲載種別：研究論文（学術雑誌）  

添付ファイル： Clinical Case Reports 2023 Matsuo ANCA.pdf

researchmap

両側涙腺原発マントル細胞リンパ腫に対する末梢血幹細胞移植後10年診た1例

松尾 俊彦, 田中 健大, 岡田 和也, 能登原 憲司, 藤井 敬子, 藤井 伸治

日本リンパ網内系学会会誌   63   126 - 126   2023年6月

　詳細を見る

記述言語：日本語   出版者・発行元：(一社)日本リンパ網内系学会  

researchmap

Revisitng cyptocyanine dye, NK-4, as an old and new drug: review and future perspectives. 査読

Shuihui Liu, Toshihiko Matsuo, Takumi Abe

Internnational Journal of Molecular Sciences   24 ( 4411 )   1 - 14   2023年2月

　詳細を見る

担当区分：責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

添付ファイル： ijms-24-04411-v2 NK-4 review.pdf

researchmap

Revisiting Cryptocyanine Dye, NK-4, as an Old and New Drug: Review and Future Perspectives

Shihui Liu, Toshihiko Matsuo, Takumi Abe

International Journal of Molecular Sciences   2023年2月

　詳細を見る

掲載種別：研究論文（学術雑誌）  

DOI： 10.3390/ijms24054411

researchmap

Are Prophylactic Systemic Antibiotics Required in Patients with Cataract Surgery at Local Anesthesia? 査読

Toshihiko Matsuo, Masahiro Iguchi, Noriyasu Morisato, Tatsuya Murasako, Hideharu Hagiya

International Journal of Environmental Research and Public Health   19 ( 15796 )   1 - 8   2022年11月

　詳細を見る

担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

添付ファイル： cataract surgery ijerph-19-15796.pdf

DOI： 10.3390/ijerph192315796

researchmap

Temporal association of vitreous hemorrhage and hypertension after COVID- 19 mRNA vaccines. 査読

Toshihiko Matsuo, Hiroshi Noda

Clinical Case Reports   10 ( e06657 )   1 - 3   2022年11月

　詳細を見る

担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

添付ファイル： Clinical Case Reports - 2022 - Matsuo - Temporal association of vitreous hemorrhage and hypertension after COVID‐19 mRNA.pdf

researchmap

Traditional Chinese Medicines and Prescriptions Brought from China to Japan by a Monk (Jianzhen, Japanese: Ganjin): A Historical Review. 査読

Shihui Liu, Toshihiko Matsuo, Chie Matsuo, Takumi Abe

Compounds   2 ( 4 )   267 - 284   2022年10月

　詳細を見る

担当区分：責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

添付ファイル： compounds-02-00022.pdf

DOI： 10.3390/compounds2040022

researchmap

Diffuse large B-cell lymphoma in the course of systemic sarcoidosis: A case report and review of 30 Japanese patients with sarcoidosis-lymphoma syndrome. 査読

Toshihiko Matsuo, Takehiro Tanaka, Rika Omote, Toshiaki Okada, Kenji Notohara, Kazuya Okada

Journal of Clinical and Experimental Hematopathology   62 ( 4 )   22 - 237   2022年9月

　詳細を見る

担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

添付ファイル： JCEH sarcoidosis and lymphoma2022.pdf

researchmap

Candidate Genes in Testing Strategies for Linkage Analysis and Bioinformatic Sorting of Whole Genome Sequencing Data in Three Small Japanese Families with Idiopathic Superior Oblique Muscle Palsy. 査読

Toshihiko Matsuo, Chaomulige, Mary Miyaji, Osamu Hosoya, Akira Saito, Kazuyuki Nakazono

International Journal of Molecular Sciences   23 ( 8626 )   1 - 16   2022年8月

　詳細を見る

担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

添付ファイル： SO palsy WGS final ijms-23-08626.pdf

DOI： 10.3390/ijms23158626

researchmap

CD19 immunostaining of a stored paraffin-embedded vitrectomy cell block of intraocular lymphoma contributing to chimera antigen receptor T-cell therapy. 査読

Matsuo T, Tanaka T, Fujii N, Fujii K, Kondo E

Journal of Clinical and Experimental Hematopathology   62 ( 3 )   187 - 189   2022年8月

　詳細を見る

担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

添付ファイル： JCEH2022 CAR-T.pdf

DOI： 10.3960/jslrt.22007.

researchmap

Photorefraction with Spot Vision Screener Versus Visual Acuity Testing as Community-Based Preschool Vision Screening at the Age of 3.5 Years in Japan

Toshihiko Matsuo, Chie Matsuo, Masami Kayano, Aya Mitsufuji, Chiyori Satou, Hiroaki Matsuoka

International Journal of Environmental Research and Public Health   19 ( 8655 )   1 - 15   2022年7月

　詳細を見る

担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

添付ファイル： ijerph-19-08655.pdf

DOI： 10.3390/ijerph19148655

researchmap

人工臓器の最前線vol.3「光電変換色素薄膜型の人工網膜OUReP（オーレップ） 招待

松尾俊彦, 内田哲也, 石金浩史

医学のあゆみ   282 ( 4 )   304 - 312   2022年7月

　詳細を見る

担当区分：筆頭著者   記述言語：日本語   掲載種別：研究論文（学術雑誌）  

添付ファイル： 医学のあゆみ 3光電変換色素薄膜型の人工網膜OUReP(オーレップ)松尾俊彦.pdf

researchmap

モンゴル伝統医学とその現代的意義

梶井一暁, 包雪峰, 朝木力格, 松尾俊彦, 白烏日罕

岡山大学大学院教育学研究科研究集録   180 ( 1 )   1 - 8   2022年6月

　詳細を見る

記述言語：日本語  

添付ファイル： モンゴル伝統医学とその現代的意義2022.pdf

researchmap

サルコイドーシス経過中にびまん性大細胞B細胞リンパ腫を発症した1例

松尾 俊彦, 田中 健大, 表 梨華, 岡田 俊明, 能登原 憲司, 岡田 和也

日本リンパ網内系学会会誌   62   93 - 93   2022年6月

　詳細を見る

記述言語：日本語   出版者・発行元：(一社)日本リンパ網内系学会  

researchmap

Whole exome-sequencing of pooled genomic DNA samples to detect quantitative trait loci in esotropia and exotropia of stra-bismus in Japanese. 査読

Zhang J, Matsuo T, Hamasaki I, Sato K

Life   12 ( 41 )   1 - 12   2022年1月

　詳細を見る

担当区分：責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

添付ファイル： life-12-00041.pdf

researchmap

Proton Beam Therapy Followed by Pembrolizumab for Giant Ocular Surface Conjunctival Malignant Melanoma: Case Report. 査読

Matsuo T, Yamasaki O, Tanaka T, Katsui K, Waki T

Molecular and Clinical Oncology   16 ( 12 )   1 - 5   2022年1月

　詳細を見る

担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

添付ファイル： Mol Clin Oncol2021 proton beam.pdf

researchmap

COVID-19 mRNA Vaccine–Associated Uveitis Leading to Diagnosis of Sarcoidosis: Case Report and Review of Literature 査読 国際誌

Toshihiko Matsuo, Hiroyuki Honda, Takehiro Tanaka, Kensuke Uraguchi, Masaaki Kawahara, Hideharu Hagiya

Journal of Investigative Medicine High Impact Case Reports   10   232470962210864 - 232470962210864   2022年1月

　詳細を見る

担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：SAGE Publications  

A 34-year-old Japanese person with male gender identity who had been taking intramuscular injection of methyltestosterone depot for 11 years after bilateral mastectomy noticed blurred vision 5 days after the second vaccination for COVID-19 (Tozinameran; Pfizer-BioNTech) in the interval of 3 weeks following the first vaccination. The patient was diagnosed as granulomatous iritis with mutton-fat keratic precipitates and small iris nodules at the pupillary margin in the right eye and began to have 0.1% betamethasone eye drops with good response. The patient, however, continued to have fever and malaise and showed a high level of serum soluble interleukin-2 receptor (sIL-2R) even 4 weeks after the second vaccination. Computed tomographic scan disclosed mediastinal and bilateral hilar small lymphadenopathy together with limited granular lesion in the right lung. Gallium-67 scintigraphy demonstrated high uptake not only in mediastinal and hilar lymph nodes but also in bilateral parotid glands. Right parotid gland biopsy revealed noncaseating granulomas and proved pathological diagnosis of sarcoidosis. The systemic symptoms were relieved by oral prednisolone 20 mg daily. Even though the causal relationship remains undetermined, this case is unique at the point that vaccine-associated uveitis led to the detection of pulmonary lesions and lymphadenopathy, resulting in clinical and pathological diagnosis of sarcoidosis. In literature review, 3 patients showed sarcoidosis-like diseases after COVID-19 vaccination: 2 patients were diagnosed clinically as Lofgren syndrome with acute onset of erythema nodosum and ankle swelling, with or without mediastinal and hilar lymphadenopathy, whereas 1 patient with mediastinal lymphadenopathy but no uveitis was diagnosed pathologically by biopsy as sarcoidosis.

添付ファイル： JIM High Inpact CaseRep Coronavirus vacciation.pdf

DOI： 10.1177/23247096221086450

PubMed

researchmap

その他リンク： http://journals.sagepub.com/doi/full-xml/10.1177/23247096221086450

Effect of NK-5962 on gene expression profiling of retina in a rat model of retinitis pigmentosa. 査読

Shihui Liu, Mary Miyaji, Osamu Hosoya, Toshihiko Matsuo

International Journal of Molecular Sciences   22 ( 13276 )   1 - 16   2021年12月

　詳細を見る

担当区分：最終著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

添付ファイル： ijms-22-13276NK-5962.pdf

DOI： 10.3390/ijms222413276

researchmap

Diffuse large B-cell lymphoma 18 years after bilateral lacrimal gland IgG4-related disease: case report and literature review. 査読

Matsuo T, Tanaka T, Notohara K, Okada K

Journal of Investigative Medicine High Impact Case Reports   10 ( DOI:10.1177/23247096211067894 )   1 - 10   2021年12月

　詳細を見る

担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

添付ファイル： IgG4 DLBCL.pdf

researchmap

Bilateral Optic Disc Swelling as a Plausible Common Ocular Sign of Autoinflammatory Diseases: Report of Three Patients with Blau Syndrome or Cryopyrin-Associated Periodic Syndrome. 査読 国際誌

Matsuo T, Yashiro M, Yamasaki O, Tanaka T, Manki A

Life   11 ( 1433 )   2021年12月

　詳細を見る

担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

添付ファイル： life-11-01433.pdf

DOI： 10.3390/life11121433

PubMed

researchmap

Whole Exome-Sequencing of Pooled Genomic DNA Samples to Detect Quantitative Trait Loci in Esotropia and Exotropia of Strabismus in Japanese

Jingjing Zhang, Toshihiko Matsuo, Ichiro Hamasaki, Kazuhiro Sato

Life   2021年12月

　詳細を見る

掲載種別：研究論文（学術雑誌）  

DOI： 10.3390/life12010041

researchmap

Clarification of degradation mechanism on retinal prosthesis using photoelectric dyes coupled to polyethylene film by mass spectrometry. 査読

Koichiro Yamashita, Mayu Mitui, Toshihiko Matsuo, Tetsuya Uchida

Materials Letters   307(2022) ( 130978 )   1 - 4   2021年10月

　詳細を見る

記述言語：英語   掲載種別：研究論文（学術雑誌）  

添付ファイル： materials Letters2021Yamashita.pdf

researchmap

Accuracy of deep learning algorithms for the diagnosis of retinopathy of prematurity by fundus images: systematic review and meta-analysis. 査読

Jingjing Zhang, Yangyang Liu, Toshiharu Mitsuhashi, Toshihiko Matsuo

Journal of Ophthalmology   2021 ( 8883946 )   1 - 11   2021年8月

　詳細を見る

担当区分：最終著者   記述言語：英語  

添付ファイル： ZhangJingjing ROP2021 J Ophthalmol.pdf

researchmap

Alcohol Consumption and Age related Macular Degeneration: A Systematic Review and Dose response Meta analysis. 査読

Jingjing Zhang, Toshiharu Mitsuhashi, Toshihiko Matsuo, Takashi Yorifuji, Jun Hamada, Yangyang Liu

Current Eye Research   2021年7月

　詳細を見る

添付ファイル： Alcohol Consumption and AMD.pdf

researchmap

The effect of cyanine dye NK-4 on photoreceptor degeneration in a rat model of early-stage retinitis pigmentosa. 査読

Shihui Liu, Toshihiko Matsuo, Mary Miyaji, Osamu Hosoya

Pharmaceuticals   14 ( 694 )   1 - 14   2021年7月

　詳細を見る

担当区分：責任著者   記述言語：英語   掲載種別：研究論文（国際会議プロシーディングス）  

添付ファイル： pharmaceuticals-14-00694-v3.pdf

DOI： 10.3390/ph14070694

researchmap

Photoelectric dye, NK-5962, as a potential drug for preventing retinal neurons from apoptosis: pharmacokinetic studies based on review of the evidence 査読 国際誌

Matsuo T, Liu S, Uchida T, Onoue S, Nakagawa S, Ishii M, Kanamitsu K

life   11 ( 591 )   1 - 19   2021年6月

　詳細を見る

担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

添付ファイル： life-11-00591.pdf

DOI： 10.3390/life11060591

PubMed

researchmap

Prostate cancer detected by choroidal tumor and complete response to hormonal therapy: Case report and literature review of 24 patients with choroidal metastasis from prostate cancer. 査読

Matsuo T, Tanaka T, Nakamura A, Wada K

Journal of Investigative Medicine High Impact Case Reports   9 ( 23247096211026471 )   1 - 8   2021年6月

　詳細を見る

担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

添付ファイル： Prostate Ca2021.pdf

researchmap

両側涙腺IgG4関連疾患の18年後に発症した全身のびまん性大細胞B細胞リンパ腫

松尾 俊彦, 田中 健大, 岡田 和也, 能登原 憲司

日本リンパ網内系学会会誌   61   91 - 91   2021年5月

　詳細を見る

記述言語：日本語   出版者・発行元：(一社)日本リンパ網内系学会  

researchmap

Development and chemical properties of retinal prostheses using photoelectric dyes coupled to polyethylene films with various anions to achieve high durability. 査読

Yamashita K, Tanaka T, Matsuo T, Uchida T

Polymer Journal   53   719 - 729   2021年4月

　詳細を見る

記述言語：英語   掲載種別：研究論文（学術雑誌）  

添付ファイル： PJ2021OUReP.pdf

researchmap

Modelling the visual response to an OUReP retinal prosthesis with photoelectric dye coupled to polyethylene film. 査読

Koichiro Yamashita, Prathima Sundaram, Tetsuya Uchida, Toshihiko Matsuo, Willy Wong

Journal of Neural Engineering   18 ( 045006 )   1 - 14   2021年4月

　詳細を見る

記述言語：英語   掲載種別：研究論文（学術雑誌）  

添付ファイル： J Neural Eng2021.pdf

researchmap

Development of highly durable retinal prosthesis using photolectric dyes coupled to polyethylene film and quantitative in vitro evaluation of its durability. 査読

Yamashita K, Tanaka T, Matsuo T, Uchida T

Biomedical Materials   16 ( 4 )   045001   2021年4月

　詳細を見る

記述言語：英語   掲載種別：研究論文（学術雑誌）  

添付ファイル： bmm_16_4_045001.pdf

researchmap

Television-watching in the early years of life and the association with parents’ concerns about decreased visual acuity in their elementary school-aged child: results of a nationwide population-based longitudinal survey of Japan. 査読

Matsuo T, Yorifuji T

Japanese Journal of Ophthalmology   65   561 - 568   2021年3月

　詳細を見る

担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

添付ファイル： JJO 21st century final202106.pdf

researchmap

Follow-up with serum IgG4-monitoring in 8 patients with IgG4-related disease diagnosed by a lacrimal gland mass. 査読

Matsuo T, Tanaka T, Sato Y, Kataoka H, Uka M, Ennishi D, Yano T

Journal of Clinical and Experimental Hematopathology   61 ( 1 )   10 - 21   2021年3月

　詳細を見る

担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

添付ファイル： JCEH IgG42021.pdf

DOI： 10.3960/jslrt.20048

PubMed

researchmap

「2-12. 人工網膜」テクノロジー・ロードマップ2021-2030 医療・健康・食農編 招待

松尾俊彦, 内田哲也

テクノロジー・ロードマップ2021-2030 医療・健康・食農編 日経BP   226 - 229   2021年2月

　詳細を見る

担当区分：筆頭著者   記述言語：日本語  

添付ファイル： 人工網膜TechnologyRoadMap2021-30.pdf

researchmap

Photoelectric dye-based retinal prosthesis (OUReP) as a novel type of artificial retina 招待 査読

Toshihiko Matsuo, Tetsuya Unchida

Internal Medicine Review   7 ( 1(916) )   1 - 17   2021年1月

　詳細を見る

担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

添付ファイル： 916-Photoelectric dye-based retinal prosthesis (1).pdf

researchmap

Pathologically-proven intraocular infiltration with adult T-cell leukemia/lymphoma: two new cases with either vitreous opacity or aqueous hypopyon and literature review of 16 cases. 査読

Matsuo T, Shimizu T, Tanaka T, Yamamoto A, Takasuka H

Journal of Investigative Medicine High Inpact Case Reports   8   1 - 8   2020年10月

　詳細を見る

担当区分：筆頭著者   掲載種別：研究論文（研究会，シンポジウム資料等）  

添付ファイル： ATL eye J Invest Med HIgh Inpact Case Rep2020.pdf

researchmap

Curved-Tip Disposable Injector (OUReP Injector) to Insert Photoelectric Dye-Coupled Polyethylene Film (OUReP) as Retinal Prosthesis into Subretinal Space of Rabbit Eyes. 査読

Toshihiko Matsuo, Chie Matsuo, Tetsuya Uchida, Koichiro Yamashita, Tenu Tanaka, Yusuke Kawakami, Toshiya Hitomi, Kanji Taga, Tatsuya Sanada, Yusuke Yamashita

Journal of Surgical Techniques and Procedures   4 ( 1040 )   1 - 6   2020年9月

　詳細を見る

担当区分：筆頭著者   掲載種別：研究論文（学術雑誌）  

添付ファイル： jstp-v4-id1040 final20201003.pdf

researchmap

Long-term control of macular edema with adalimumab after cataract surgery in a Japanese child with juvenile idiopathic arthritis: case report and review of 26 Japanese patients. 査読

Toshihiko Matsuo, Masato Yashiro

Journal of Investigative Medicine High Inpact Case Reports   8   1 - 10   2020年8月

　詳細を見る

担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（国際会議プロシーディングス）  

添付ファイル： JIA case J InvestMed High Impact Case Rep2020.pdf

researchmap

Step-by-Step Procedure to Test Photoelectric Dye-Coupled Polyethylene Film as Retinal Prosthesis to Induce Light-Evoked Spikes in Isolated Retinal Dystrophic Tissue of rd1 Mice. 査読

Matsuo T, Terada K, Sakurai M, Liu S, Yamashita K, Uchida T

Clinics in Surgery   5 ( 2903 )   1 - 9   2020年8月

　詳細を見る

担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

添付ファイル： cis-v5-id2903final20200905.pdf

researchmap

Interview オール岡山の技術が光を取り戻す！－いよいよ最終段階に来た人工網膜とは 招待

松尾俊彦, 内田哲也

Optronics   463   124 - 129   2020年7月

　詳細を見る

担当区分：筆頭著者  

添付ファイル： optronics202007人工網膜.pdf

researchmap

涙腺腫脹でIgG4関連疾患と診断された6例の血清IgG4値による長期経過観察

松尾 俊彦, 田中 健大, 佐藤 康晴, 片岡 仁美, 宇賀 麻由, 遠西 大輔, 矢野 朋文

日本リンパ網内系学会会誌   60   92 - 92   2020年7月

　詳細を見る

記述言語：日本語   出版者・発行元：(一社)日本リンパ網内系学会  

researchmap

The timing for diagnosis of anisometropia in Japanese children with congenital eyelid ptosis. 査読

Toshihiko Matsuo

Clinics in Surgery   5 ( 2842 )   1 - 3   2020年6月

　詳細を見る

担当区分：筆頭著者   掲載種別：研究論文（学術雑誌）  

添付ファイル： cis-v5-id2842 final20200630.pdf

researchmap

Superior conjunctiva-sparing intraocular lens-suturing technique with straight long suture needles advanced from the opposite side. 査読

Toshihiko Matsuo

Clinics in Surgery   5 ( 2847 )   1 - 5   2020年6月

　詳細を見る

担当区分：筆頭著者  

添付ファイル： cis-v5-id2847final20200905.pdf

researchmap

特集：人工視覚の現状と展望 「色素結合薄膜型の人工網膜OUReP（オーレップ）」 招待

松尾俊彦, 内田哲也

光アライアンス   31 ( 7 )   13 - 18   2020年

　詳細を見る

担当区分：筆頭著者  

添付ファイル： 光アライアンス2020;31(7)人工網膜.pdf

researchmap

Are there primary intraocular lymphomas that do not develop into central nervous system lymphomas? 査読

Matsuo T, Tanaka T

Journal of Clinical and Experimental hematopathology   59 ( 4 )   168 - 174   2019年12月

　詳細を見る

担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

添付ファイル： JCEH2019final intraocular lymphma.pdf

DOI： 10.3960/jslrt.19019

PubMed

researchmap

Lacrimal Sac Malignant Melanoma in 15 Japanese Patients: Case Report and Literature Review. 査読

Matsuo T, Tanaka T, Yamasaki O

Journal of investigative medicine high impact case reports   7   2324709619888052   2019年1月

　詳細を見る

添付ファイル： lacrimal sac melanoma.pdf

DOI： 10.1177/2324709619888052

PubMed

researchmap

Vision evaluation by functional observational battery, operant behavior test, and light/dark box test in retinal dystrophic RCS rats versus normal rats. 査読

Matsuo T, Uchida T, Yamashita K, Takei S, Ido D, Fujiwara A, Iino M, Oguchi M

Heliyon   5 ( e01936 )   2019年

　詳細を見る

担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

添付ファイル： Heliyon2019 RCSrat.pdf

DOI： 10.1016/j.heliyon.2019.e01936

Web of Science

researchmap

Photoelectric dye-coupled polyethylene film: photoresponsive properties evaluated by Kelvin probe and in vitro biological response detected in dystrophic retinal tissue of rats. 査読

Matsuo T, Sakurai M, Terada K, Uchida T, Yamashita K, Tanaka T, Takarabe K

Advanced Biomedical Engineering   8   137 - 144   2019年

　詳細を見る

担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

添付ファイル： ABE2019 OUReP.pdf

DOI： 10.14326/abe.8.137

Web of Science

researchmap

Long-term outcome in 7 patients with idiopathic orbital myositis. 査読

Matsuo T

Japanese Clinical Medicine   10   1 - 5   2019年

　詳細を見る

添付ファイル： JpnClinMed2019OrbitalMyositis.pdf

researchmap

Intraocular lymphoma as relapse after chemotherapy for primary breast diffuse large B-cell lymphoma.

Toshihiko Matsuo, Takehiro Tanaka, Tomofumi Yano

Journal of clinical and experimental hematopathology : JCEH   58 ( 4 )   180 - 183   2018年12月

　詳細を見る

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.3960/jslrt.18026

PubMed

researchmap

Visual Evoked Potential Recovery by Subretinal Implantation of Photoelectric Dye-Coupled Thin Film Retinal Prosthesis in Monkey Eyes With Macular Degeneration. 査読

Matsuo T, Uchida T, Sakurai J, Yamashita K, Matsuo C, Araki T, Yamashita Y, Kamikawa K

Artificial organs   42 ( 8 )   E186 - E203   2018年8月

　詳細を見る

記述言語：英語   掲載種別：研究論文（学術雑誌）  

添付ファイル： final version Matsuo_et_al-2018-Artificial_Organs.pdf

DOI： 10.1111/aor.13120

Web of Science

PubMed

researchmap

Visual evoked potential in rabbits’ eyes with subretinal implantation by vitrectomy of Okayama university-type retinal prosthesis (OURePTM) 査読

Toshihiko Matsuo, Tetsuya Uchida, Koichiro Yamashita, Shigiko Takei, Daisuke Ido, Mamoru Tanaka, Masao Oguchi, Toshinori Furukawa

Journal of Veterinary Medical Science   80 ( 2 )   247 - 259   2018年2月

　詳細を見る

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Japanese Society of Veterinary Science  

Okayama University-type retinal prosthesis (OURePTM) is a photoelectric dye-coupled polyethylene film which generates electric potential in response to light and stimulates nearby neurons. This study aims to test surgical feasibility for subretinal film implantation and to examine functional durability of films in subretinal space. Dye-coupled films were implanted subretinally by vitrectomy in the right eye of normal white rabbits: 8 rabbits for 1 month and 8 rabbits for 6 months. The implanted films were removed by vitrectomy in 4 of these 8 rabbits in 1-month or 6-month implantation group. The films were also implanted in 4 rhodopsin-transgenic retinal dystrophic rabbits. Visual evoked potential was measured before film implantation as well as 1 or 6 months after film implantation, or 1 month after film removal. The films were successfully implanted in subretinal space of retinal detachment induced by subretinal fluid injection with a 38G polyimide tip. The retina was reattached by fluid-air exchange in vitreous cavity, retinal laser coagulation, and silicone oil injection. The ratios of P2 amplitudes of visual evoked potential in the implanted right eye over control left eye did not show significant changes between pre-implantation and post-implantation or post-removal (paired t-test). In Kelvin probe measurements, 4 pieces each of removed films which were implanted for 1 or 6 months showed proportional increase of surface electric potential in response to increasing light intensity. The film implantation was safe and implanted films were capable of responding to light.

添付ファイル： JVMS2018 rabbit OUReP.pdf

DOI： 10.1292/jvms.17-0422

Scopus

PubMed

researchmap

MGST2 and WNT2 are candidate genes for comitant strabismus susceptibility in Japanese patients 査読

Jingjing Zhang, Toshihiko Matsuo

PEERJ   5 ( e3935 )   e3935   2017年10月

　詳細を見る

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：PEERJ INC  

Background/Aim, Strabismus is a common condition with misalignment between two eyes that may lead to decrease of visual acuity, lack of binocularity, and diplopia, It is caused by heterogeneous environmental and genetic risk factors. Our previous research has identified new chromosomal susceptibility loci in 4q28.3 and 7831,2 regions for comitant strabismus in Japanese families, We conducted a verification study by linkage analysis to narrow the chromosomal loci down to a single gene,
Methods. From Japanese and U.S,databases, 24 rsSNPs and 233 rsSNPs were chosen from the 4828,3 and 7831.2 region, respectively, and were typed in 108 affected subjects and 96 unaffected subjects of 58 families with primary and non-syndromic comitant strabismus. Three major analytical methods were used: transmission disequilibrium test (TDT), TDT allowing for errors (TDTae), and linkage analysis under dominant and recessive inheritance.
Results. The SNPs with significant P values in TDT and TDTae were located solely at the gene, microsomal glutathione S-transferase 2 (MGST2), on chromosome 4q28.3 locus. In contrast, significant SNPs were dispersed in a few genes, containing wingless-type MMTV integration site family member 2 ( WNT2), on chromosome 7q31.2 locus. The distribution of significant SNPs on the 7q31.2 locus showed that only the ST7 to WNT2 region in the same big haplotype block contained significant SNPs for all three methods of linkage analysis.
Conclusions. This study suggests that MG ST2 and WNT2 are potential candidates for comitant strabismus in Japanese population.

添付ファイル： Strabismus SNP PeerJ.pdf

DOI： 10.7717/peerj.3935

Web of Science

PubMed

researchmap

Visual evoked potential in RCS rats with Okayama University-type retinal prosthesis (OUReP™) implantation. 査読

Alamusi, Matsuo T, Hosoya O, Uchida T

Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs   20 ( 2 )   158 - 165   2017年6月

　詳細を見る

記述言語：英語   掲載種別：研究論文（学術雑誌）  

添付ファイル： Alamusi RCSrat VEP 2017-JAO.pdf

DOI： 10.1007/s10047-016-0943-4

Web of Science

PubMed

researchmap

Vogt-Koyanagi-Harada disease-like posterior uveitis in the course of nivolumab (anti-PD-1 antibody), interposed by vemurafenib (BRAF inhibitor), for metastatic cutaneous malignant melanoma. 査読

Matsuo T, Yamasaki O

Clinical case reports   5 ( 5 )   694 - 700   2017年5月

　詳細を見る

添付ファイル： Harada nivolumab.pdf

DOI： 10.1002/ccr3.911

PubMed

researchmap

眼窩涙腺部腫瘍生検で木村病と確定した後にネフローゼ症候群を発症した1例

松尾 俊彦, 田中 健大, 木野村 賢

日本リンパ網内系学会会誌   57   109 - 109   2017年5月

　詳細を見る

記述言語：日本語   出版者・発行元：(一社)日本リンパ網内系学会  

researchmap

Photoelectric Dye Used for Okayama University-Type Retinal Prosthesis Reduces the Apoptosis of Photoreceptor Cells 査読

Shihui Liu, Toshihiko Matsuo, Osamu Hosoya, Tetsuya Uchida

JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS   33 ( 3 )   149 - 160   2017年4月

　詳細を見る

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：MARY ANN LIEBERT, INC  

Purpose: Our previous study demonstrated that photoelectric dye-coupled polyethylene film (Okayama University-type retinal prosthesis), which was implanted in subretinal space of the eyes of Royal College of Surgeons (RCS) rats, prevented retinal neurons from apoptotic death. In this study, we aimed to examine whether photoelectric dye itself would protect retinal neurons from apoptosis in RCS rats.
Methods: RCS rats received intravitreous injection of different concentrations of the dye in the left eye and housed under a 12-h light-dark cycle. Saline injection in the right eye served as control. In addition, RCS rats with dye injection were kept in 24-h daily dark condition. Sections were processed for terminal deoxynucleotidyl transferase-mediated fluorescein-conjugated-dUTP nick-end-labeling (TUNEL) assay and immunohistochemical staining of glial fibrillary acidic protein (GFAP) and protein kinase C alpha (PKC alpha).
Results: The number of TUNEL-positive cells significantly decreased in the retina of dye-injected eyes compared with those in saline-injected eyes (P = 0.0001, 2-factor analysis of variance [ANOVA]), under 12-h light-dark cycle. Significant decrease of TUNEL-positive cells was noted in the retina of rats with dye injection compared with those with saline injection, kept under 24-h dark condition (P = 0.0001, 2-factor ANOVA). Immunoreactive area for GFAP decreased significantly in the retina of dye-injected eyes compared with that in controls (P = 0.0001, 2-factor ANOVA), whereas immunoreactive area for PKCa increased significantly in the retina of dye-injected eyes compared with that in controls (P = 0.01, 2-factor ANOVA).
Conclusions: Photoelectric dye inhibits apoptotic death of photoreceptor cells in RCS rats and downregulates GFAP expression in retinal Muller cells. Photoelectric dye may be a candidate agent for neuroprotection in retinitis pigmentosa and other retinal diseases.

添付ファイル： Liu NK5962 final jop.2016.0093.pdf

DOI： 10.1089/jop.016.0093

Web of Science

PubMed

researchmap

Positive bacterial culture in conjunctival sac before cataract surgery with night stay is related to diabetes mellitus 査読

Tetsuhiro Kawata, Toshihiko Matsuo

BMC OPHTHALMOLOGY   17 ( 1 )   14   2017年2月

　詳細を見る

担当区分：責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：BIOMED CENTRAL LTD  

Background: The aim of this study is to elucidate background clinical factors in patients with positive bacterial culture for the conjunctival sac before cataract surgery in Japan.
Methods: Retrospective review was made on medical records of 576 consecutive patients who underwent conjunctival sac culture before cataract surgery with night stay at a hospital in 2 years from January 2013 to December 2014. In the patients with sequential bilateral surgeries, the data were chosen for bacterial culture in the eye which had earlier surgery. The age at surgery ranged from 33 to 100 years (mean, 76.7 years). Clinical factors, analyzed in relation with positive or negative bacterial culture, included the sex, the age, the presence of hypertension or diabetes mellitus, history of cancer, and history of hospital-based surgery at other specialties.
Results: Bacterial culture of the conjunctival sac was positive in 168 patients while negative in 408 patients. In multiple regression analysis, the positive bacterial culture was related with the older age (P = 0.01), the presence of diabetes mellitus (P = 0.004), and the history of hospital-based surgery at other specialties (P = 0.001).
Conclusions: Elderly patients with diabetes mellitus or previous hospital-based surgeries at other specialties have a higher rate of positive bacterial culture in the conjunctival sac before cataract surgery. This study would provide a hint for identifying patients at risk for carrying bacterial flora in the conjunctival sac.

添付ファイル： Conj Sac Culture BMC Ophthalmol2017.pdf

DOI： 10.1186/s12886-017-0413-7

Web of Science

PubMed

researchmap

Nephrotic syndrome during the tapering of oral steroids after pathological diagnosis of Kimura disease from a lacrimal gland mass: case report and review of 10 Japanese patients. 査読

Matsuo T, Tanaka T, Kinomura M

Journal of clinical and experimental hematopathology : JCEH   57 ( 3 )   147 - 152   2017年

　詳細を見る

記述言語：英語   掲載種別：研究論文（学術雑誌）  

添付ファイル： Kimura disease Matsuo.pdf

DOI： 10.3960/jslrt.17028

PubMed

researchmap

Subretinal implantation of Okayama university-type retinal prosthesis (OURepTM) in canine eyes by vitrectomy 査読

Toshihiko Matsuo, Tetsuya Uchida, Makoto Nitta, Koichiro Yamashita, Shigiko Takei, Daisuke Ido, Mamoru Tanaka, Masao Oguchi, Toshinori Furukawa

Journal of Veterinary Medical Science   79 ( 12 )   1939 - 1946   2017年

　詳細を見る

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Japanese Society of Veterinary Science  

Okayama University-type retinal prosthesis (OUReP™) is a photoelectric dye-coupled polyethylene film which generates electric potential in response to light and stimulates nearby neurons. This study aims to test surgical feasibility of subretinal implantation and functional durability of dye-coupled films in the subretinal space. The dye-coupled films were implanted subretinally by 25-gauge vitrectomy in the right eye of 11 normal beagle dogs: 2 dogs served for film removal after 5-month film implantation, 3 dogs for film removal after 3-month film implantation, 3 dogs for 3-month film implantation and pathological examination, and 3 dogs for sham surgery. The surface electric potential of the removed dye-coupled films in response to light was measured by the Kelvin Probe system. At surgery, rolled-up dye-coupled films in 5 × 5 mm square size could be inserted into subretinal space of retinal detachment induced by fluid injection with a 38-gauge polyimide tip. Retinal attachment was maintained by silicone oil injection in vitreous cavity. At autopsy, the retina in all dogs maintained the ganglion cell layer, inner and outer nuclear layers while it lost the outer segments in some part. All 5 sheets of removed dye-coupled films maintained the dye color. One sheet of the 5-month implanted film showed proportional increase of surface potential in response to increasing light intensity. Subretinal implantation of OUReP™ by vitrectomy was technically feasible in canine eyes, and OUReP™ maintained the function of generating light-evoked surface potential after 5 months in subretinal implantation.

添付ファイル： dog surgeryOUReP2017JVMS.pdf

DOI： 10.1292/jvms.17-0450

Scopus

PubMed

researchmap

Orbital MALT Lymphoma after Autologous Stem Cell Transplantation for Follicular Lymphoma as Relapse of Diffuse Large B-Cell Lymphoma. 査読

Matsuo T, Tanaka T, Fujii N

Journal of clinical and experimental hematopathology : JCEH   56 ( 3 )   170 - 175   2017年

　詳細を見る

DOI： 10.3960/jslrt.56.170

PubMed

researchmap

Clinical decision upon resection or observation of ocular surface dermoid lesions with the visual axis unaffected in pediatric patients 査読

Toshihiko Matsuo

SPRINGERPLUS   4 ( 1 )   534   2015年9月

　詳細を見る

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：SPRINGER INTERNATIONAL PUBLISHING AG  

Ocular surface or epibulbar dermoid lesions may present as limbal dermoids at the corneal limbus or dermolipomas in the conjunctival fornix. The purpose of this study is to review clinical features of ocular surface dermoids (grade I), with the visual axis unaffected, in pediatric patients, in order to find key features for making clinical decision, either resection or observation. The study involved 13 consecutive patients with limbal dermoids or fornix dermolipomas which did not affect the visual axis, seen in 11 years at a referral-based institution. Eight patients underwent surgical resection at the age, ranging from 1 to 18 (median, 4) years, with concurrent preauricular appendage resection in 3 patients. Limbal dermoids in 6 patients presented dome-shaped elevation from the ocular surface, and extended in inferotemporal quadrant for 1-2 clock hours. The remaining 2 patients showed dermolipomas in the temporal conjunctival fornix. Postoperative astigmatism at the final visit ranged from 0 to 7 (median, 2.9) diopters in 6 patients with limbal dermoids while ranged from 0 to 1 diopters in 2 patients with fornix dermolipomas. All patients with meaningful astigmatism wore glasses before and after the surgery, resulting in no apparent ametropic or anisometropic amblyopia. Observation was chosen in 5 patients with the age at initial visit, ranging from 0 to 2 (median, 1) years, and the age at the final visit, ranging from 2 to 6 (median, 3) years. Flat limbal dermoids, extending for 1-2 clock hours, were noted in 3 patients, a dome-shaped limbal dermoid for 1 clock hour in one, and a fornix dermolipoma in one. Three patients had preauricular appendages. No patient, except for one with a dome-shaped limbal dermoid, showed astigmatism, greater than one diopter. In conclusions, dome-shaped limbal dermoids were excised while flat limbal dermoids observed. The age at surgery varied largely in pediatric patients with limbal dermoids (grade I) or fornix dermolipomas which did not affect the visual axis. The surgical timing was influenced by surgical scheduling for preauricular appendage resection, determined by a plastic surgeon. Surgical decision was made for cosmetic purposes, but not for medical needs to avoid amblyopia.

添付ファイル： Dermoid Springerplus.pdf

DOI： 10.1186/s40064-015-1326-7

Web of Science

Scopus

PubMed

researchmap

Vision maintenance and retinal apoptosis reduction in RCS rats with Okayama University-type retinal prosthesis (OUReP™) implantation. 査読

Alamusi, Matsuo T, Hosoya O, Tsutsui KM, Uchida T

Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs   18 ( 3 )   264 - 271   2015年9月

　詳細を見る

記述言語：英語   掲載種別：研究論文（学術雑誌）  

添付ファイル： alamusi J Artif Org2015.pdf

DOI： 10.1007/s10047-015-0825-1

Web of Science

PubMed

researchmap

How far is observation allowed in patients with ectopia lentis? 査読

Toshihiko Matsuo

SpringerPlus   4   461   2015年8月

　詳細を見る

記述言語：英語  

添付ファイル： ectopia lentis Springerplus.pdf

DOI： 10.1186/s40064-015-1239-5

Web of Science

PubMed

researchmap

Clinical factors underlying a single surgery or repetitive surgeries to treat superior oblique muscle palsy 査読

Kana Aoba, Toshihiko Matsuo, Ichiro Hamasaki, Kayoko Hasebe

SPRINGERPLUS   4 ( 166 )   166   2015年4月

　詳細を見る

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：SPRINGER INTERNATIONAL PUBLISHING AG  

The purpose of this study is to know clinical factors underlying either a single surgery or repetitive surgeries, required to treat superior oblique muscle palsy. Retrospective review was made on 246 consecutive patients with idiopathic (n = 212) or acquired (n = 34) superior oblique muscle palsy who underwent surgeries in 8 years at one institution. Idiopathic palsy included congenital and decompensated palsies while acquired palsy included traumatic and ischemic palsies. Clinical factors, compared between groups with a single surgery (n = 203) and two or more surgeries (n = 43), were surgical methods, sex, age at surgery, horizontal, vertical, and cyclotorsional deviations, and stereopsis at near fixation. Inferior oblique muscle recession on paretic side was chosen in about 60% of the single-surgery and repetitive-surgery group as an initial surgery, followed by inferior rectus muscle recession on non-paretic side. The age at surgery was significantly older, vertical and cyclotorsional deviations were significantly larger in the repetitive-surgery group, compared with the single-surgery group (P = 0.01, P < 0.001, P = 0.02, Mann-Whitney U-test, respectively). The 95% confidence interval of vertical deviations was 15-17 prism diopters in the single-surgery group and 23-28 prism diopters in the repetitive surgery group. Significant differences in vertical deviations were replicated also in subgroups of patients with either idiopathic or acquired palsy. In conclusions, the 95% confidence interval of vertical deviations, determined by alternate prism and cover test, would be used as a common benchmark for predicting either a single surgery or repetitive surgeries, required to treat idiopathic and acquired superior oblique muscle palsy, in the process of obtaining the informed consent.

添付ファイル： Aoba2015_Article_ClinicalFactorsUnderlyingASing.pdf

DOI： 10.1186/s40064-015-0945-3

Web of Science

PubMed

researchmap

Intraocular Relapse with Hypopyon and Retinal Infiltrates after Chemotherapy and Peripheral Blood Stem Cell Transplantation for Extranodal NK/T-Cell Lymphoma. 査読

Matsuo T, Tanaka T, Ichimura K, Meguri Y

Journal of clinical and experimental hematopathology : JCEH   55 ( 3 )   157 - 161   2015年

　詳細を見る

DOI： 10.3960/jslrt.55.157

PubMed

researchmap

Oral infection control to assist infliximab therapy in a Behçet's disease patient with severe eye inflammation in response to dental treatment: a case report. 査読 国際誌

Kudo C, Wakabayashi H, Shimoe M, Kobayashi H, Ito T, Ohkawa T, Isoshima-Nakamura A, Mineshiba J, Yoshioka N, Nawachi K, Maeda H, Matsuo T, Makino H, Takashiba S

Clinical case reports   2 ( 6 )   274 - 280   2014年12月

　詳細を見る

記述言語：英語  

DOI： 10.1002/ccr3.112

PubMed

researchmap

Infective Endocarditis With Origin in Orbital Vascular Malformation and Maxillary Sinusitis: A Case Report and Review of Four Patients in the Literature 査読

Toshihiko Matsuo, Yoshitaka Iwamoto, Hironori Okamoto, Daisuke Iguchi

Cureus   16 ( 11 )   e74873   2014年12月

　詳細を見る

担当区分：筆頭著者   掲載種別：研究論文（学術雑誌）  

添付ファイル： Cureus infective endocarditis 2024.pdf

researchmap

Mantle cell lymphoma diagnosed by conjunctival salmon-pink lesion biopsy. 査読

Matsuo T, Ichimura K, Kubonishi S

Journal of clinical and experimental hematopathology : JCEH   54 ( 2 )   143 - 147   2014年

　詳細を見る

DOI： 10.3960/jslrt.54.143

PubMed

researchmap

眼底綿花様白斑を合併した全身性エリテマトーデスの1例 眼合併症と疾患活動性との関連性に関する検討

杉生 真帆, 青山 裕美, 梶田 藍, 竹島 千夏, 濱田 利久, 松尾 俊彦, 赤塚 俊文, 岩月 啓氏

臨床皮膚科   66 ( 12 )   960 - 964   2012年11月

　詳細を見る

記述言語：日本語   出版者・発行元：(株)医学書院  

24歳,女性.両頬の蝶形紅斑と抗核抗体陽性により精査加療目的で当院を受診した.他臓器病変は認めなかった.全身性エリテマトーデス(systemic lupns erythematosus:SLE)と診断しステロイド治療を開始した.順調にテーパリングを行っていたが,治療開始から4ヵ月後に突然眼のかすみと視力低下を自覚し,眼底に綿花様白斑を認めSLE網膜症と診断された.このとき,皮膚症状は改善し血液データの変動もなかった.SLEのさまざまな眼合併症は,通常はSLEの病勢と一致して出現するが,過去9年間の当院のSLE患者の眼合併症の検討では,必ずしも皮膚症状や血液検査データにおけるSLEの病勢とは一致していなかった.SLEの眼合併症を皮疹や臨床検査値などから予測することは困難だが,放置していれば重篤な視力障害につながる危険が高く,注意すべき合併症である.(著者抄録)

researchmap

その他リンク： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2012&ichushi_jid=J01559&link_issn=&doc_id=20121112150005&doc_link_id=10.11477%2Fmf.1412103457&url=https%3A%2F%2Fdoi.org%2F10.11477%2Fmf.1412103457&type=%88%E3%8F%91.jp_%83I%81%5B%83%8B%83A%83N%83Z%83X&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

MDSをともない、経過中に涙丘と骨髄浸潤をきたした芽球性形質細胞様樹状細胞腫瘍の1例

濱田 利久, 鈴木 大介, 竹島 千夏, 三宅 智子, 杉生 真帆, 岩月 啓氏, 松尾 俊彦

Skin Cancer   26 ( 3 )   387 - 387   2012年2月

　詳細を見る

記述言語：日本語   出版者・発行元：(一社)日本皮膚悪性腫瘍学会  

researchmap

SLEに発症した網膜症(綿花様白斑)と疾患活動性との比較検討

杉生 真帆, 梶田 藍, 竹島 千夏, 濱田 利久, 青山 裕美, 岩月 啓氏, 松尾 俊彦, 赤塚 俊文

日本皮膚科学会雑誌   121 ( 11 )   2278 - 2278   2011年10月

　詳細を見る

記述言語：日本語   出版者・発行元：(公社)日本皮膚科学会  

researchmap

MDSをともない、経過中に涙丘と骨髄浸潤をきたした芽球性形質細胞様樹状細胞腫瘍の1例

濱田 利久, 鈴木 大介, 竹島 千夏, 三宅 智子, 杉生 真帆, 松尾 俊彦, 岩月 啓氏

日本皮膚悪性腫瘍学会学術大会プログラム・抄録集   27回   121 - 121   2011年6月

　詳細を見る

記述言語：日本語   出版者・発行元：(一社)日本皮膚悪性腫瘍学会  

researchmap

Optical coherence tomographic parameters as objective signs for visual acuity in patients with retinitis pigmentosa, future candidates for retinal prostheses 査読

Miho Tamaki, Toshihiko Matsuo

Journal of Artificial Organs   14 ( 2 )   140 - 150   2011年

　詳細を見る

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Springer Tokyo  

To find optical coherence tomographic parameters related with visual acuity, and, thus, which might be used as objective signs to predict visual acuity after future treatment, for example retinal prosthesis implantation, 86 eyes of 45 consecutive patients with retinitis pigmentosa, who showed no macular diseases, underwent optical coherence tomography to measure macular retinal thickness and peripapillary retinal nerve fiber layer (RNFL) thickness, and to obtain horizontal cross-sectional images at the fovea for observation of the inner segment/outer segment (IS/OS) junction line. Best-corrected visual acuity was significantly better either in the right eyes or in the left eyes with greater retinal thickness of all four quadrants of the macular area in the inner ring, encompassing 1-3 mm from the foveal center (P\\0.05, Spearman rank correlation test), and also with the presence of the IS/OS line at the fovea (P\\0.0001, Wilcoxon-Kruskal-Wallis rank sum test). Retinal average thickness in the posterior pole covering the 6 9 6 mm square area was positively correlated with peripapillary RNFLaverage thickness either in the right eyes or in the left eyes (P\\0.05). The average thickness of the peripapillary RNFLbecame significantly less with age (P\\0.05), but was not related with visual acuity. Macular retinal thickness and the presence of the IS/OS line, but not peripapillary RNFLthickness, could serve as objective signs for better visual acuity in retinitis pigmentosa. The macular retinal thickness might be used as an objective predictor to choose patients with retinitis pigmentosa who would be expected to gain vision after retinal prosthesis implantation. © The Japanese Society for Artificial Organs 2011.

DOI： 10.1007/s10047-011-0557-9

Scopus

PubMed

researchmap

Erratum: Optical coherence tomographic parameters as objective signs for visual acuity in patients with retinitis pigmentosa, future candidates for retinal prostheses (Journal of Artificial Organs (2011) 14, (140-150) DOI: 10.1007/s10047-011-0557-9) 査読

Miho Tamaki, Toshihiko Matsuo

Journal of Artificial Organs   14 ( 4 )   385   2011年

　詳細を見る

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Springer Tokyo  

DOI： 10.1007/s10047-011-0597-1

Scopus

researchmap

脈絡膜黒色腫の病期、再発診断におけるFDG-PET/CTの初期経験

荻野 裕香, 奥村 能啓, 佐藤 修平, 新家 崇義, 原田 聡介, 檜垣 文代, 宗田 由子, 山本 岳玄, 加藤 勝也, 郷原 英夫, 平木 隆夫, 三村 秀文, 加地 充昌, 松尾 俊彦, 金澤 右

日本医学放射線学会秋季臨床大会抄録集   46回   S530 - S530   2010年8月

　詳細を見る

記述言語：日本語   出版者・発行元：(公社)日本医学放射線学会  

researchmap

Immunoglobulin G4 (IgG4)-positive or -negative ocular adnexal benign lymphoid lesions in relation to systemic involvement. 査読

Matsuo T, Ichimura K, Sato Y, Tanimoto Y, Kiura K, Kanazawa S, Okada T, Yoshino T

Journal of clinical and experimental hematopathology : JCEH   50 ( 2 )   129 - 142   2010年

　詳細を見る

記述言語：英語   出版者・発行元：The Japanese Society for Lymphoreticular Tissue Research  

The purpose of this study is to determine the relationship of ocular adnexal benign or reactive lymphoid hyperplasia, including orbital pseudotumor, with immunoglobulin G4 (IgG4)-related diseases. Medical charts of 9 consecutive patients with ocular adnexal benign lymphoid lesions, seen in the Department of Ophthalmology, Okayama University Hospital, were reviewed, and pathological sections were restained immunohistochemically for IgG4-, IgG-, and CD138-positive plasma cells. The diagnosis of IgG4-positive lesions was based on 10 or more IgG4-positive plasma cells in a high-power field and greater than 40% ratios of IgG4-positive plasma cells/CD138-positive plasma cells and IgG4-positive plasma cells/IgG-positive plasma cells. IgG4-positive lesions were determined as absent in 5 patients (4 with bilateral lacrimal/orbital lesions and one with a unilateral conjunctival lesion), none of whom showed systemic manifestations. In contrast, IgG4-positive lesions were present in 4 patients (3 with bilateral lacrimal/orbital lesions and one with a unilateral lacrimal/orbital lesion), who showed systemic manifestations : one with Hashimoto thyroiditis, one with IgG4-positive bilateral interstitial lung disease and hepatic inflammatory pseudotumor, one with bilateral interstitial lung disease, and one with systemic lymphadenopathy and antiphospholipid syndrome. In conclusion, IgG4-positive ocular adnexal benign lymphoid lesions might be used as a benchmark for the probable presence of other systemic lymphoid lesions.

DOI： 10.3960/jslrt.50.129

PubMed

CiNii Article

CiNii Books

researchmap

その他リンク： http://search.jamas.or.jp/link/ui/2011254628

A case of aplasia of inferior rectus muscle

Tomoko Watanabe, Toshihiko Matsuo, Takashi Furuse, Satoshi Hasebe, Toshihiro Yanagawa, Toshinari Shimizu, Hiroshi Ohtsuki

Japanese Journal of Clinical Ophthalmology   62 ( 8 )   1309 - 1314   2008年8月

　詳細を見る

記述言語：日本語   掲載種別：研究論文（国際会議プロシーディングス）  

Purpose : To report a case of aplasia of inferior rectus muscle detected at an advanced age. Case : A 73-year-old female had superior displacement of her right eye since birth that exacerbated recently. Findings : Her corrected visual acuity was 0.1 right and 0.8 left. The right eye was displaced superior-temporally at the primary position. Ocular motility was restricted in 5 directions except superiorly, presented with exacerbation of superior displacement of her right eye. Magnetic resonance imaging (MRI) showed absence of inferior rectus muscle in the right eye, atrophy of superior rectus and levator muscle, and constriction in the posterior portion of medical rectus muscle. There was no polymorphism of ARIX and PHOX2B genes. Transposition of horizontal muscles in the right eye resulted in alignment in the primary position and improved right visual acuity to 0.7. Reported Cases : There are 16 cases of aplasia of inferior rectus muscle reported in Japan. The series comprised 4 males, 8 females, and unknown in 4 cases. Associated lesion included microcornea, nanophthalmos, displaced pupil, and choroidal coloboma. Conclusion : Aplasia of inferior rectus muscle is a possibility when limitation in downward gaze is present. Forced duction test and MRI are useful adjunct diagnostic modalities.

Scopus

researchmap

Different histopathological types of orbital lymphoma 16 years after systemic follicular lymphoma: immunohistochemical and immunogenetic analyses of two cases. 査読

Matsuo T, Ichimura K, Shinagawa K, Yoshino T

Journal of clinical and experimental hematopathology : JCEH   48 ( 1 )   17 - 24   2008年4月

　詳細を見る

記述言語：英語   出版者・発行元：The Japanese Society for Lymphoreticular Tissue Research  

The purpose of this study is to show that the histopathological type of an orbital lymphoma can differ from the systemic follicular lymphoma that precedes it. A 44-year-old man (Patient #1) and a 50-year-old man (Patient #2) presented with generalized lymphadenopathy due to grade 1 follicular lymphoma proven on lymph node biopsy. Patient #1 was followed without treatment for 16 years when he developed a right orbital mass. Patient #2 underwent several courses of combination chemotherapy as well as radiation but relapsed. The second biopsy of the lymph node nine years later showed the same histopathological type of follicular lymphoma. He developed an orbital mass on the right side 16 years after the initial presentation. In Patient #1, excisional biopsy of the orbital masses showed extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). In Patient #2, biopsy revealed the orbital mass to be T-cell/histiocyte-rich diffuse large B-cell lymphoma. In Patient #1, when comparing the original lymph node biopsy to the orbital biopsy obtained years later, no evidence for clonality was noted by polymerase chain reaction. In Patient #2, the amplification by polymerase chain reaction of the immunoglobulin heavy chain gene rearrangement in the lymph node lesion and the orbital lesion gave rise to a single discrete band with the same DNA sequence except for five nucleotide changes, indicating the same clonality in the presence of genomic changes. In conclusion, orbital lymphomas can occur as a second lymphoma with a different histopathological type in the long-term follow-up of systemic lymphomas. The original and subsequent lymphomatous lesions may or may not share neoplastic cell clonality and all genomics. [J Clin Exp Hematopathol 48(1) : 17-24, 2008]

DOI： 10.3960/jslrt.48.17

PubMed

CiNii Article

CiNii Books

researchmap

その他リンク： http://search.jamas.or.jp/link/ui/2008264833

Clinical features, ARIX and PHOX2B nucleotide changes in three families with congenital superior oblique muscle palsy 査読

Sayuri Imai, Toshihiko Matsuo, Emi Itoshima, Hiroshi Ohtsuki

ACTA MEDICA OKAYAMA   62 ( 1 )   45 - 53   2008年2月

　詳細を見る

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：OKAYAMA UNIV MED SCHOOL  

We analyzed nucleotide changes in 3 genes, ARIX, PHOX2B, and KIF21A, in 6 patients of 3 families with congenital superior oblique muscle palsy. Three exons of ARIX, 3 exons of PHOX2B, and exons 8, 20, and 21 of KIF21A were amplified by polymerase chain reaction from genomic DNA isolated from the peripheral blood. The DNA fragments were directly sequenced in both directions. In 2 different families, a heterozygous nucleotide change, ARIX 153G > A, in the 5'-untranslated region was found in common between a father and daughter with muscle palsy and between a mother and daughter with muscle palsy (Family No. I and No. 3). In the other family (Family No. 2), a heterozygous 15-nucleotide deletion, PHOX2B 1124del15, resulting in loss of 5 alanine residues in the alanine repeat of the protein, was found in the daughter with muscle palsy and her father with normal traits, but was not found in the mother with muscle palsy. No KIF21A nucleotide change was found in any patients. The ARIX 153G > A polymorphism might be a genetic risk factor for the development of congenital superior oblique muscle palsy.

DOI： 10.18926/AMO/30985

Web of Science

PubMed

researchmap

[Vision engineering--photoelectric dye-based retinal prostheses: Okayama University model]. 査読

Matsuo T

Brain and nerve = Shinkei kenkyu no shinpo   59 ( 4 )   331 - 338   2007年4月

　詳細を見る

記述言語：日本語   出版者・発行元：医学書院  

PubMed

CiNii Article

CiNii Books

researchmap

その他リンク： http://search.jamas.or.jp/link/ui/2007235727

Vision engineering - Photoelectric dye-based retinal prostheses: Okayama university model 査読

Toshihiko Matsuo

Brain and Nerve   59 ( 4 )   331 - 338   2007年4月

　詳細を見る

記述言語：日本語   掲載種別：研究論文（学術雑誌）  

Patients with retinitis pigmentosa lose photoreceptor cells by genetic abnormalities and hence become blind. Neurons such as bipolar cells and ganglion cells still remain alive even in the retina of these patients, and ganglion cells send axons to the brain as the optic nerve. The replacement of dead photoreceptor cells with something artificial is the basic concept of retinal prostheses. The remaining retinal neurons can be stimulated by either electric current or electric potential. Photodiode array and electrode array are two main ways to stimulate retinal neurons as retinal prostheses. These retinal prostheses have problems such as low sensitivity and requiring outer electric sources (batteries). To overcome the problems, we are developing photoelectric dye-based retinal prostheses which absorb light and convert photon energy to electric potentials. The prototype, photoelectric dye-coupled polyethylene film, could generate intracellular calcium elevation in photoreceptor-lacking retinal tissues and also in cultured retinal neurons. The photoelectric dye-based retinal prostheses are thin and soft, and therefore, a sheet of the film in a large size, corresponding to wide visual field, can be inserted into the vitreous and then to the subretinal space through a small opening by rolling up the film. After the production control and the quality control have been established, clinical trials of the photoelectric dye-based retinal prostheses would be planned in concordance with the Drugs and Medical Devices Law to prove the safety and the efficacy.

Scopus

PubMed

researchmap

A low-vision-care viewpoint of cataract surgery for patients with retinitis pigmentosa

Noriko Morimoto, Toshihiko Matsuo, Hiroshi Ohtsuki

Folia Ophthalmologica Japonica   58 ( 3 )   153 - 157   2007年3月

　詳細を見る

記述言語：日本語   掲載種別：研究論文（学術雑誌）  

Purpose : To evaluate the outcomes and patient satisfaction with cataract surgery in patients with retinitis pigmentosa (RP). Methods : A retrospective review was conducted of the medical records of 12 patients (21 eyes) with RP who underwent cataract surgery at Okayama University Hospital between June 2004 and March 2006, and the patients were interviewed regarding their satisfaction with the surgery. Results : Best-corrected visual acuity improved in 17 eyes. Regarding complications, aftercataract, anterior capsular contraction, and temporary elevation of intraocular pressure occurred in 7, 1, and 1 patients, respectively. Subjective improvement in visual acuity, visual field, photophobia, ability to read and write, mobility, activities of daily life, and social life were noted in 10, 2, 4, 7, 6, 10, and 1 patients, respectively. All patients regarded the decision to undergo surgery as a good one. Conclusions : In this study, patients with RP were satisfied with their visual acuities and abilities to perform activities of daily living after cataract surgery, and we considered complications of this surgery to be minor. These results show that when patients are well informed before giving consent to the surgery, satisfaction with the results of surgery will be high. Cataract surgery should be performed before the patient's quality of life declines.

Scopus

researchmap

Detection of strabismus and amblyopia in 1.5-and 3-year-old children by a preschool vision-screening program in Japan 査読

Toshihiko Matsuo, Chie Matsuo, Hiroaki Matsuoka, Keiko Kio

ACTA MEDICA OKAYAMA   61 ( 1 )   9 - 16   2007年2月

　詳細を見る

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：OKAYAMA UNIV MED SCHOOL  

All children at the age of 1.5 and 3 years in Japan undergo physical, mental, and developmental checkups including dental, eye, and hearing examinations. The vision-screening program consists of 3 steps: questionnaires and home visual acuity testing as the first step (only for 3-year-old children), visual acuity testing by nurses and inspection by medical officers at regional Health Centers as the second step, and detailed examinations by ophthalmologists as the third step. This study aims to reveal the prevalence of strabismus and amblyopia as obtained from data in the vision-screening program. The final diagnoses made by ophthalmologists and sent back to the Health Centers in Okayama City were reviewed to elucidate the prevalence of strabismus, amblyopia, refractive errors, and other diseases in 1.5- and 3-year-old children in Okayama City in 5 years from 2000 to 2004. Of approximately 6,500-6,900 total children, 83.7-86.8% at 1.5 years old and 77.8-81.9% at 3 years old were brought to the Health Centers. The rates of strabismus were 0.01-0.12% at 1.5 years old and 0.20-0.34% at 3 years old, while the rates of amblyopia were 0% at 1.5 years old and 0.13-0.18 % at 3 years old. The higher rates of strabismus at 3 years old were attributed mainly to the increase of exotropia and intermittent exotropia. In conclusions, the prevalence of strabismus was different between 1.5- and 3-year-old children. The vision-screening program in Japan functions to detect strabismus and amblyopia.

DOI： 10.18926/AMO/32910

Web of Science

PubMed

researchmap

Prostaglandins F-2 alpha and E-2 in aqueous humor of patients with cataract surgery 査読

T Matsuo

JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS   20 ( 2 )   101 - 106   2004年4月

　詳細を見る

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：MARY ANN LIEBERT INC PUBL  

To understand the role of prostaglandins F-2alpha, and E-2 in aqueous humor under the normal condition, their concentrations were measured by enzyme immunoassay in aqueous fluid obtained from either eye of 60 patients during cataract surgery and correlated with clinical factors as the age and intraocular pressure. The concentrations of prostaglandin F-2alpha in the aqueous of all patients were below the level of detection. The concentrations of prostaglandin E-2 in the aqueous were below the level of detection in 37 patients while ranged from 9 to 48 pg/mL (median, 31) in 23 patients. The levels of prostaglandin E-2 did not have correlation with the age of the patients or the intraocular pressure of the eyes. In conclusions, the concentrations of prostaglandin E-2 were apparently higher than the concentrations of prostaglandin F-2alpha in the aqueous. This study could not prove the relationship between prostaglandin levels and the intraocular pressure or the age.

DOI： 10.1089/108076804773710768

Web of Science

PubMed

researchmap

ARIX gene polymorphisms in patients with congenital superior oblique muscle palsy 査読

Y Jiang, T Matsuo, H Fujiwara, S Hasebe, H Ohtsuki, T Yasuda

BRITISH JOURNAL OF OPHTHALMOLOGY   88 ( 2 )   263 - 267   2004年2月

　詳細を見る

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：B M J PUBLISHING GROUP  

Aim: To identify ARIX gene polymorphisms in patients with congenital superior oblique muscle palsy and to find the relation between the ARIX gene and congenital superior oblique muscle palsy.
Methods: The three exons of the ARIX gene were sequenced by genomic DNA amplification with polymerase chain reaction (PCR) and direct sequencing in 15 patients with superior oblique muscle palsy (13 with congenital and two with acquired palsy) and 54 normal individuals. PCR products cloned into plasmids were also sequenced. A family with father and a daughter each having congenital superior oblique muscle palsy was also involved in this study.
Results: Four patients with congenital superior oblique muscle palsy carried heterozygous nucleotide changes in the ARIX gene. One patient with the absence of the superior oblique muscle had T7C in the 5'-UTR of the exon 1 and C-44A in the promoter region, both of which were located on the same strand. Another unrelated patient with congenital superior oblique muscle palsy had C76G in the 5'-UTR of the exon 1 and C-9A in the promoter region on the same strand. G153A in the 5'-UTR of exon 1 was found in common in two affected members of a family with congenital superior oblique muscle palsy. This G153A in the 5'-UTR of exon 1 was also present in four unrelated normal individuals. No other heterozygous nucleotide changes were found in normal individuals.
Conclusions: The nucleotide change (G153A) in the 5'-UTR of exon 1 co-segregated with congenital superior oblique muscle palsy in one family. Four other nucleotide changes in the exon 1 or the promoter region were found only in patients with congenital superior oblique muscle palsy. These nucleotide polymorphisms may be one of the risk factors for the development of congenital superior oblique muscle palsy.

DOI： 10.1136/bjo2003.021527

Web of Science

researchmap

A Simple Method for Screening Photoelectric Dyes towards Their Use for Retinal Prostheses 査読

Toshihiko Matsuo

Acta Medica Okayama   57 ( 5 )   257 - 260   2003年10月

　詳細を見る

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Photoelectric dyes absorb light and convert photon energy to electric potentials. To test whether these dyes could be used for retinal prostheses, a simple in vitro screening system was developed. Retinal neurons were cultured from the eyes of chick embryos at the 10-day embryonic stage, at which time no retinal photoreceptor cells have yet developed. Intracellular calcium elevation was observed with Fluo-4 in cultured retinal neurons before and after photoelectric dye was applied at varying concentrations to the culture medium. Five of 7 photoelectric dyes tested in this in vitro system induced intracellular calcium elevation in cultured chick retinal neurons. The intracellular calcium elevation generated by the 5 photoelectric dyes was blocked by extracellular calcium depletion in the case of all 5 dyes, and, except for one dye, by the presence of voltage-gated calcium channel blockers. The photoelectric dyes absorbed light under an inverted microscope and stimulated retinal neurons. This simple in vitro system allows the screening of photoelectric dyes which can be used for retinal prostheses.

Scopus

PubMed

researchmap

Clinical correlations of aggrecan in the resected medial rectus muscle of patients with intermittent exotropia 査読

T Yamane, T Matsuo, S Hasebe, H Ohtsuki

ACTA MEDICA OKAYAMA   57 ( 4 )   199 - 204   2003年8月

　詳細を見る

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：OKAYAMA UNIV MED SCHOOL  

The purpose of this study was to elucidate the role of extracellular matrix components such as aggrecan, fibronectin, and laminin in the extraocular muscle of patients with strabismus. Resected tissues of the medial rectus muscle of 47 patients with intermittent exotropia obtained during recession-resection surgery were frozen under liquid nitrogen and pulverized by a Freezer/Mill to solubilize the tissue for enzyme immunoassay. The total amounts of aggrecan, fibronectin, and laminin in the resected tissue were correlated with clinical data of patients such as age, exodeviation, and refractive error. The amount of aggrecan decreased significantly with the advance of age (P < 0.0001, Spearman rank correlation test), while the amount of laminin or fibronectin had no correlation with age. Patients with basic type intermittent exotropia showed larger, although not significantly, amounts of aggrecan than those with convergence insufficiency type (P = 0.0538, Mann-Whitney U-test). The amount of aggrecan may be related to motor aspects of intermittent exotropia.

DOI： 10.18926/AMO/32803

Web of Science

PubMed

researchmap

Genome-wide search for strabismus susceptibility loci 査読

H Fujiwara, T Matsuo, M Sato, T Yamane, M Kitada, S Hasebe, H Ohtsuki

ACTA MEDICA OKAYAMA   57 ( 3 )   109 - 116   2003年6月

　詳細を見る

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：OKAYAMA UNIV MED SCHOOL  

The purpose of this study was to search for chromosomal susceptibility loci for comitant strabismus. Genomic DNA was isolated from 10 mL blood taken from each member of 30 nuclear families in which 2 or more siblings are affected by either esotropia or exotropia. A genome-wide search was performed with amplification by polymerase chain reaction of 400 markers in microsatellite regions with similar to10 cM resolution. For each locus, non-parametric affected sib-pair analysis and nonparametric linkage analysis for multiple pedigrees (Genehunter software, http://linkage. rockefeller.edu/soft/) were used to calculate multipoint lod scores and non-parametric linkage (NPL) scores, respectively. In sib-pair analysis, lod scores showed basically flat lines with several peaks of 0.25 on all chromosomes. In non-parametric linkage analysis for multiple pedigrees, NPL scores showed one peak as high as 1.34 on chromosomes 1, 2, 4, 7, 10, 15, and 16, while 2 such peaks were found on chromosomes 3, 9, 11, 12, 18, and 20. Non-parametric linkage analysis for multiple pedigrees of 30 families with comitant strabismus suggested a number of chromosomal susceptibility loci. Our ongoing study involving a larger number of families will refine the accuracy of statistical analysis to pinpoint susceptibility loci for comitant strabismus.

Web of Science

researchmap

Multiple sclerosis-like disease secondary to alpha interferon 査読

T Matsuo, R Takabatake

OCULAR IMMUNOLOGY AND INFLAMMATION   10 ( 4 )   299 - 304   2002年12月

　詳細を見る

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：SWETS ZEITLINGER PUBLISHERS  

Purpose: To describe bilateral optic neuritis that occurred as an adverse effect of recombinant and natural interferon a administration. Methods: Report of two cases. Case 1, a 62-year-old woman, developed bilateral optic neuritis with decreased sensation of vibration and increased deep tendon reflex in the lower extremities after a seven-month use of recombinant interferon alpha-2a for chronic active hepatitis C. Case 2, a 29-year-old woman, developed bilateral optic neuritis combined with numbness of the lower extremities as well as bowel and bladder dysfunction after a 22-month use of recombinant interferon alpha-2b for chronic myelogenous leukemia. After a two-month interruption of interferon administration, natural interferon a was given but followed by another episode of the same neurological manifestations. Results: In both cases, magnetic resonance imaging demonstrated multiple small high-intensity areas in the cerebral white matter and spinal cord, while cerebrospinal fluid examination disclosed mononuclear cell increase and protein elevation including myelin basic protein, all of which simulated the features of multiple sclerosis. The two patients underwent several courses of pulse corticosteroid therapy, each course consisting of three days of methylprednisolone 1000 mg daily, resulting in visual recovery to some extent. Conclusions: Optic neuritis in combination with other neurological signs, simulating multiple sclerosis, should be included in the list of adverse effects of recombinant and natural interferon a administration.

DOI： 10.1076/ocii.10.4.299.15588

Web of Science

PubMed

researchmap

Seropositivity of human herpesvirus-8 in patients with uveitis 査読

T Matsuo, M Itami

OCULAR IMMUNOLOGY AND INFLAMMATION   10 ( 3 )   197 - 199   2002年9月

　詳細を見る

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：SWETS ZEITLINGER PUBLISHERS  

Purpose: To explore the role of human herpesvirus-8 (HHV-8) in the pathogenesis of uveitis and other forms of ocular inflammation. Methods: Serum antibody titers to HHV-8 were measured in 76 patients with uveitis from various causes and other types of ocular inflammation in either the acute phase, the convalescent phase, or both. Results: Only one 21-year-old male patient in the convalescent phase of unilateral pars planitis showed a positive titer for HHV-8. His serum was negative for human immunodeficiency virus-I. Conclusions: Although the seropositive rate in the patient population was higher than that in the general population, the increased incidence was not statistically significant. The role of HHV-8 in the pathogenesis of intraocular inflammation appears to be limited.

DOI： 10.1076/ocii.10.3.197.15602

Web of Science

PubMed

researchmap

Submacular exudates with serous retinal detachment caused by cat scratch disease 査読

T Matsuo, M Kato

OCULAR IMMUNOLOGY AND INFLAMMATION   10 ( 2 )   147 - 150   2002年6月

　詳細を見る

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：SWETS ZEITLINGER PUBLISHERS  

Purpose: To present submacular exudates as a manifestation of cat scratch disease. Methods: Report of two cases. Results: The first patient, a 34-year-old man, developed submacular exudates with serous retinal detachment ten days after having axillary lymphadenopathy and fever. The second patient, a 30-year-old woman, developed submacular exudates with serous retinal detachment mimicking central serous chorioretinopathy. Fluorescein angiography revealed late staining of the subretinal lesions in both cases. The lesion resolved spontaneously in the first patient, while sulfamethoxazole and trimethoprim was required for the second patient. Both patients had a positive IgG titer for Bartonella henselae. Conclusions: Submacular exudates with serous retinal detachment can occur in cat scratch disease. Cat scratch disease should be included in the differential diagnosis of submacular exudates with central serous chorioretinopathy.

DOI： 10.1076/ocii.10.2.147.13979

Web of Science

PubMed

researchmap

The incidence and pathology of conjunctival ulceration in Behçet's syndrome. 査読

Matsuo T, Itami M, Nakagawa H, Nagayama M

The British journal of ophthalmology   86 ( 2 )   140 - 143   2002年2月

　詳細を見る

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Web of Science

PubMed

researchmap

Two cases of ocular injury due to air-bag activation

F. Nonaka, M. Nagayama, T. Matsuo, F. Shiraga, H. Ohtsuki

Japanese Journal of Clinical Ophthalmology   55 ( 2 )   158 - 162   2001年

　詳細を見る

記述言語：日本語   掲載種別：研究論文（学術雑誌）  

We observed two cases of ocular injury due to air-bag activation. Both the cases were wearing a seat-belt at the time of injury. One was a 62-year-old male who was seated at the passenger seat in the front row. His left eye showed corneal endothelial damage, iridodialysis, lens luxation and vitreous hemorrhage. Traumatic macular hole was found after the second surgery two weeks after the injury. The final visual acuity of 0.05. The corneal endothelial cell population per mm3 was 1,547 right and 2,012 left. The other was a 62-year-old male driver. His left eye showed corneal erosion, corneal endothelial damage, commotio retinae and macular edema. The visual acuity improved to 0.9 one month after injury. The corneal endothelial cell population was 2,915 right and 1,447 left. These two cases showed that the left eye was more severely affected than the right and that corneal endothelial damage was an outstanding feature.

Scopus

researchmap

A novel gene (retinovin) expressed selectively in the early stage of chick retinal development 査読

M Itami, T Matsuo, H Ohtsuki

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   276 ( 1 )   12 - 15   2000年9月

　詳細を見る

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：ACADEMIC PRESS INC  

To understand molecular mechanisms of retinal development, genes expressed selectively only in the early stage of retinal development were isolated by subtractive hybridization based on suppression polymerase chain reaction. The retina has no layered structure in 7-day chick embryos, in contrast with the fully developed multilayered structure of neurons in 15-day embryos. The subtraction between cDNA derived from retinal tissues at these different stages, followed by repeat rounds of 5'-RACE (rapid amplification of cDNA ends) and 3'-RACE, led to isolation of a novel gene with an open reading frame encoding a putative protein with 753 amino acids. Its specific expression in the 7-day embryonic retina was confirmed by Northern blot analysis. The gene, named "retinovin," would be used as a marker for identifying retinal stem cells present at the early stage of retinal development. (C) 2000 Academic Press.

Web of Science

researchmap

Identification of ingrowth site of idiopathic subfoveal choroidal neovascularization by indocyanine green angiography 査読

Fumio Shiraga, Chieko Shiragami, Toshihiko Matsuo, Shiho Yokoe, Ippei Takasu, Hiroshi Ohtsuki

Ophthalmology   107 ( 3 )   600 - 607   2000年3月

　詳細を見る

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Purpose: This study aimed to determine whether indocyanine green (ICG) angiography is useful to identify the ingrowth site of idiopathic choroidal neovascularization (CNV), which can predict visual outcomes after surgical removal of idiopathic CNV. Design: Consecutive, observational case series. Participants: Twenty-six patients with idiopathic subfoveal CNV, of whom six underwent submacular surgery. Intervention: Indocyanine green videoangiography with a scanning laser ophthalmoscope. Main Outcome Measures: We studied ICG videoangiographic images of choroidal neovascular membranes from the early phase to the late phase with special attention to abnormal findings, which can indicate the ingrowth site of CNV. Results: Early ICG angiography demonstrated distinct neovascular vessels in 24 of the 26 patients (92%). Hypofluorescent rims continuously or intermittently surrounded neovascular membranes on late ICG angiograms in 21 of the 26 patients (81%). In 22 of the 26 patients (85%), ICG angiography demonstrated hypofluorescent areas within the CNV. These hypofluorescent areas frequently became ring shaped in the middle to late phase of the ICG angiography. In 14 of 16 patients (88%) with CNV larger than half a disc area, the filling of neovascular vessels appeared from the inside of the hypofluorescent areas and branched out toward the surrounding hyperfluorescent membrane in the early phase. In all six patients who underwent surgical removal of CNV, ICG videoangiography showed these hypofluorescent areas from which neovascular vessels emanated. Three of the four surgical patients, in whom hypofluorescent areas or central fluorescent areas surrounded by ring-shaped hypofluorescence were extrafoveal or juxtafoveal, had a best postoperative visual acuity of 20/60 or better. In contrast, both surgical patients with subfoveal hypofluorescent areas had a best postoperative visual acuity of 20/70 or worse. Conclusions: Although further observations are needed, ICG angiography may be a useful adjunct in the identification of the ingrowth site of idiopathic CNV, which can predict visual outcomes after surgery. (C) 2000 by the American Academy of Ophthalmology.

DOI： 10.1016/S0161-6420(99)00126-8

Scopus

PubMed

researchmap

Risk for ocular attacks following phacoemulsification and intraocular lens implantation in patients of Behcet disease

M. Takahashi, T. Matsuo, A. Yamaoka, H. Kuwada, H. Ohtsuki, Y. Inoue, K. Egi

Japanese Journal of Clinical Ophthalmology   54 ( 8 )   1499 - 1502   2000年

　詳細を見る

記述言語：日本語   掲載種別：研究論文（学術雑誌）  

We reviewed 16 eyes of 12 patients with Behcet disease who underwent intraocular implantation for complicated cataract. The incidence of acute ocular attack during the first postoperative year was significantly higher in longstanding cases and in patients who received surgery within 6 months after the last attack. The incidence of acute ocular attack was independent on the extraocular manifestations or sysemic mediation Cataract surgery did not induce more frequent ocular attacks. Postoperative visual acuity improved in all the eyes. Severe intra- or postoperative complications were absent throughout. The findings show that cataract surgery in patients of Behcet disease is relatively safe when performed 6 months or more after the last ocular attack.

Scopus

researchmap

Surgical treatment of submacular hemorrhage associated with idiopathic polypoidal choroidal vasculopathy 査読

Fumio Shiraga, Toshihiko Matsuo, Shiho Yokoe, Ippei Takasu, Toshio Okanouchi, Hiroshi Ohtsuki, Hans E. Grossniklaus

American Journal of Ophthalmology   128 ( 2 )   147 - 154   1999年8月

　詳細を見る

記述言語：英語   掲載種別：研究論文（学術雑誌）  

PURPOSE: To report the visual outcome of surgical treatment of submacular hemorrhage associated with idiopathic polypoidal choroidal vasculopathy. METHODS: Eight eyes of eight consecutive patients with thick submacular hemorrhages associated with idiopathic polypoidal choroidal vasculopathy were treated with pars plana vitrectomy and tissue plasminogen activator-assisted removal of subretinal blood (December 1995 to September 1997) or intravitreal 100% sulfur hexafluoride gas injection without tissue plasminogen activator (October 1997 to March 1998). RESULTS: Postoperatively, laser treatment was performed for active polypoidal lesions outside the foveal avascular zone in four eyes. A retinal pigment epithelial tear was seen outside the foveal avascular zone in three eyes, and one eye developed a retinal detachment. The best-corrected visual acuity improved (by 3 or more lines) or stabilized in seven of the eight eyes. Four eyes had a final best- corrected visual acuity of 20/40 or better, and three eyes had a final best- corrected visual acuity of 20/50 to 20/200. In one eye, the visual acuity decreased from 20/100 to 20/500 because of the development of a subfoveal neovascular membrane. The membrane was excised, and histologic examination showed fibrovascular tissue between the retina and retinal pigment epithelium (type 2 pattern). CONCLUSIONS: Surgical intervention may be of benefit in eyes with submacular hemorrhage associated with idiopathic polypoidal choroidal vasculopathy.

DOI： 10.1016/S0002-9394(99)00078-1

Scopus

PubMed

researchmap

A novel gene (oculomedin) induced by mechanical stretching in human trabecular cells of the eye 査読

Yukiko Sato, Toshihiko Matsuo, Hiroshi Ohtsuki

Biochemical and Biophysical Research Communications   259 ( 2 )   349 - 351   1999年6月

　詳細を見る

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Academic Press Inc.  

To understand molecular mechanisms underlying the response to pressure in human trabecular cells of the eye, genes induced by cyclic mechanical stretching were isolated by subtractive hybridization assisted by polymerase chain reaction. A novel gene containing an Alu repetitive element in the 5' untranslated region was identified, and its expression was confirmed by Northern blot analysis to be stretch-specific in trabecular cells. The gene was also expressed in the retina, but not in the other tissues, including the brain. The gene encoded a putative small protein with 44 amino acids, which showed homology with neuromedin K. The putative novel protein was named as 'oculomedin,' and would be used as a candidate gene for glaucoma.

DOI： 10.1006/bbrc.1999.0797

Scopus

PubMed

researchmap

Choroidal abnormalities in Behçet disease observed by simultaneous indocyanine green and fluorescein angiography with scanning laser ophthalmoscopy. 査読 国際誌

T Matsuo, Y Sato, F Shiraga, C Shiragami, Y Tsuchida

Ophthalmology   106 ( 2 )   295 - 300   1999年2月

　詳細を見る

記述言語：英語   掲載種別：研究論文（学術雑誌）  

OBJECTIVE: To examine choroidopathy in patients with Behçet disease. DESIGN: Prospective clinical study. PARTICIPANTS: Thirty-three patients (63 eyes) with Behçet disease. INTERVENTION: Patients underwent simultaneous indocyanine green (ICG) and fluorescein angiography with a double detector of scanning laser ophthalmoscopy. MAIN OUTCOME MEASURES: Angiographic findings recorded on videotapes were evaluated. The relation of angiographic findings with systemic activity and aqueous inflammation was also analyzed. RESULTS: Fluorescein angiography showed leakage in varying degrees from retinal vessels in 30 patients (53 eyes, 84%). The ICG angiographic findings were choroidal vascular wall staining in 16 eyes (25%), hyperfluorescent spots in 42 eyes (66%) and hypofluorescent plaques in 22 eyes (35%), both of which were not evident with fluorescein, leakage from choroidal vessels in 3 eyes (5%), and irregular filling of choriocapillaris in 11 eyes (17%). These findings did not have a statistically significant correlation with the presence or absence of aqueous inflammation or oral aphthous ulcerations. CONCLUSIONS: The patients with Behçet disease showed choroidal abnormalities, which could be revealed only by ICG angiography, but not with funduscopy or fluorescein angiography. Simultaneous ICG and fluorescein angiography would be useful for examining choroidal lesions in Behçet disease.

PubMed

researchmap

Choroidal lesions in sarcoidosis evaluated by indocyanine green angiography

M. Itami, T. Matsuo, C. Shiragami, F. Shiraga, Y. Sato, H. Ohtsuki

Japanese Journal of Clinical Ophthalmology   53 ( 4 )   641 - 644   1999年

　詳細を見る

記述言語：日本語   掲載種別：研究論文（国際会議プロシーディングス）  

We studied 21 eyes of 11 patients of systemic sarcoidosis by simultaneous fluorescein and indocyanine green (ICG) angiography using a scanning laser ophthalmoscope. We paid particular attention to choroidal abnormalities. ICG angiographic findings, which were not evident on fluorescein angiogram, included moth-eaten or patchy areas of hypofluorescence, hyperfluorescente dots, staining of choroidal vascular wall, and reduced number of choroidal vessels. The moth-eaten hypofluorescence was more frequent in eyes with extensive leakage of fluorescein from retinal vessels than in those with less leakage. These findings illustrate the value of simultaneous fluorescein and ICG angiography in assessing the choroidal lesions and in evaluating the activity of sarcoidosis in the choroid.

Scopus

researchmap

Transplanted and repopulated retinal pigment epithelial cells on damaged Bruch's membrane in rabbits. 国際誌

C Shiragami, T Matsuo, F Shiraga, N Matsuo

The British journal of ophthalmology   82 ( 9 )   1056 - 62   1998年9月

　詳細を見る

記述言語：英語   掲載種別：研究論文（学術雑誌）  

AIMS: The authors studied how artificially damaged Bruch's membrane influenced growth and differentiation of transplanted embryonic retinal pigment epithelial (RPE) cells and of host RPE cells in rabbits. METHODS: Embryonic RPE cells obtained from pigmented rabbits were transplanted into the subretinal space of adult albino rabbits. The host RPE was removed with a silicone cannula, and Bruch's membrane was damaged by scratching with a microhooked 27 gauge needle under the detached retina in closed vitrectomy. The transplantation sites were examined 3, 7, and 14 days after surgery by light and electron microscopy. RESULTS: Varying degrees of damage in Bruch's membrane were observed. Pigmented and hypopigmented RPE cells showed a normal polarity and tight junctions were seen at the sites of mild to moderate damage 3-7 days after the surgery. In contrast, fibroblast-like cells with no such features of RPE cells formed multiple layers at the sites of severe damage involving the full thickness of Bruch's membrane and the choriocapillaris even 14 days after the surgery. Without transplantation, host RPE cells repopulated the damaged areas in the same way as transplanted RPE cells. CONCLUSIONS: Transplanted embryonic RPE cells as well as host RPE cells grew and differentiated on the moderately damaged Bruch's membrane, while the severely damaged Bruch's membrane did not allow differentiation of RPE cells although these cells could grow and cover the damaged areas.

PubMed

researchmap

Bovine trabecular cells produce TIMP-1 and MMP-2 in response to mechanical stretching 査読

Y Okada, T Matsuo, H Ohtsuki

JAPANESE JOURNAL OF OPHTHALMOLOGY   42 ( 2 )   90 - 94   1998年3月

　詳細を見る

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：ELSEVIER SCIENCE INC  

Bovine trabecular cells in growth phase were exposed to cyclic mechanical stretching of the bottom of a culture dish at a cycle of 30 seconds for 72 hours, The stretched cells produced significantly larger amounts of metalloproteinase-2 (MMP-2) and tissue inhibitor of metalloproteinase-1 (TIMP-1) after 72 hours, compared with cells in nonstretched control. In contrast, TIMP-2 and MMP-9 levels were not influenced by mechanical stretching. Trabecular cells would modify extracellular matrix in response to such mechanical stimuli as bending of trabecular meshwork or aqueous flow by the production of TIMP-1 and MMP-2. (C) 1998 Japanese Ophthalmological Society.

Web of Science

researchmap

Aqueous vascular endothelial growth factor increases in anterior segment ischemia in rabbits 査読

T Tanaka, T Matsuo, H Ohtsuki

JAPANESE JOURNAL OF OPHTHALMOLOGY   42 ( 2 )   85 - 89   1998年3月

　詳細を見る

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：ELSEVIER SCIENCE INC  

Both long posterior ciliary arteries were occluded or the three extraocular muscles were tenotomized to produce anterior segment ischemia in rabbits, and the aqueous levels of vascular endothelial growth factor (VEGF) were measured. The occlusion of both long posterior ciliary arteries led to clinical and histological anterior segment ischemia in varying degrees. The aqueous VEGF levels increased significantly compared with controls on all days examined (Mann-Whitney U test: day 1, P = 0.0039; day 4, P = 0.0065; day 7, P = 0.0039; day 14, P = 0.0104), while the levels at days 7 and 14 decreased significantly compared with those at day 4 (Wilcoxon signed-rank test; day 4 to day 7 and day 4 to day 14, P = 0.0464). In contrast, tenotomy of the three extraocular muscles resulted in no histological changes. The VEGF levels increased significantly compared with controls at day 1 and day 4 after surgery (Mann-Whitney U test: day 1 and day 4, P = 0.0104), while the levels at day 14 decreased significantly compared with those at day 1 (Wilcoxon signed-rank test, P = 0.0499). Aqueous VEGF levels represent the severity of anterior segment ischemia and could be used as an indicator for the extent of ischemia. (C) 1998 Japanese Ophthalmological Society.

Web of Science

researchmap

Geographic choroiditis and retinal vasculitis in rheumatoid arthritis 査読

Toshihiko Matsuo, Ikuya Masuda, Nobuhiko Matsuo

Japanese Journal of Ophthalmology   42 ( 1 )   51 - 55   1998年1月

　詳細を見る

記述言語：英語   掲載種別：研究論文（学術雑誌）  

A 37-year-old man developed geographic choroiditis and retinal vasculitis in the left eye while taking 3.5 mg/day oral prednisolone for rheumatoid arthritis. The choroidal lesions stopped growing when the dose of prednisolone was increased to 60 mg/day, while its tapering resulted in the recurrence and enlargement of the choroidal lesions to the macula. The patient experienced further recurrence twice in the following year. Indocyanine green angiography demonstrated the obstruction of choroidal arteries in addition to the complete obstruction of the choriocapillaris in a fresh lesion. This case was the first to have geographic choroiditis on the background of a systemic inflammatory disease.

DOI： 10.1016/S0021-5155(97)00102-0

Scopus

PubMed

researchmap

Metastasis to the iris in squamous cell lung cancer 査読

Akio Hiraki, Hiroshi Ueoka, Toshihiko Matsuo, Tomio Nakagawa, Tadashi Yoshino, Katsuyuki Kiura, Masahiro Tabata, Katsuyoshi Sakae, Yuji Ohtsuki, Yoshio Hiraki, Mine Harada

International Journal of Clinical Oncology   3 ( 3 )   186 - 190   1998年

　詳細を見る

記述言語：英語   掲載種別：研究論文（学術雑誌）  

A 72-year-old Japanese woman, suffering from squamous cell lung cancer with brain metastasis, underwent 2 courses of combination chemotherapy, consisting of cisplatin and vindesine. Although both the primary tumor and the brain metastasis regressed markedly, she developed left ocular pain with blurred vision. An abnormal mass was found in the left iris, and cytologic examination of the aqueous aspirate revealed a few malignant cells, which, when examined by electron microscopy, were considered to be derived from squamous cell carcinoma of the lung.

DOI： 10.1007/BF02489914

Scopus

researchmap

A case of atypical Treacher-Collins syndrome

Hirotake Fujiwara, Michio Sugihara, Toshihiko Matsuo, Miki Nouso, Satoshi Hasebe, Hiroshi Ohtsuki

Folia Ophthalmologica Japonica   48 ( 9 )   1154 - 1157   1997年9月

　詳細を見る

記述言語：日本語   掲載種別：研究論文（学術雑誌）  

We report a 15 month-old male with atypical Treacher-Collins syndrome, who presented with strabismus due to hyperexotropia of the right eye. The diagnosis was based on findings of micrognathia, lowness and hypoplasia of bilateral external ears, conductive deafness, ventricular extrasystole, nursing difficulty, abnormal arrangement of the teeth and mental retardation. Magnetic resonance imaging showed hyperplasia of the cartilage involving the left trochlea and osteo-hyperplasia of the right internal ear
moreover, increased fatty tissue was found between the inner wall and medial rectus muscle of the left orbit. These findings suggest mild dysplasia of the orbital bone. The mechanism of strabismus remains unknown, but this orbital deformity could cause malposition of the eye.

Scopus

researchmap

Bilateral iridocyclitis with retinal capillaritis in juveniles 査読

T. Matsuo, N. Matsuo

Ophthalmology   104 ( 6 )   939 - 944   1997年

　詳細を見る

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Elsevier Inc.  

Purpose: The authors present clinical features of 18 juvenile patients with a new type of uveitis termed bilateral iridocyclitis with retinal capillaritis (BIRC). Methods: The authors reviewed medical records of 18 consecutive patients who showed bilateral iridocyclitis with retinal capillary leakage but no systemic manifestations during an 11-year period from January 1985 to December 1995. Results: Twelve of the 18 patients were female and the age at onset ranged from 9 to 17 years old. All patients had many cells in the anterior chamber and anterior vitreous, together with mutton fat keratic precipitates. Fluorescein angiography showed leakage from the optic disc and retinal capillaries, mainly in the midperiphery, which corresponded to retinal cloudiness. Macular edema was minimal, and all patients maintained good vision. The inflammation responded well to topical, oral, and intravenous administration of corticosteroids, the choice of which was based on the extent of retinal inflammation. Human leukocyte antigen (HLA)-DR6 and HLA-Cw7 were associated significantly with the presence of BIRC (chi square test, P &lt
0.0001). Conclusions: Bilateral retinal capillaritis affecting capillaries in various areas of the retina and overlying retinal cloudiness with no distinct lesions are unique to these patients. Fluorescein angiography is essential for diagnosis of BIRC.

DOI： 10.1016/S0161-6420(97)30203-6

Scopus

PubMed

researchmap

Abducens nerve palsy in a case under treatment with systemic interferon

M. Hosogi, S. Hasebe, T. Matsuo, H. Ohtsuki

Japanese Journal of Clinical Ophthalmology   51 ( 7 )   1357 - 1360   1997年

　詳細を見る

記述言語：日本語   掲載種別：研究論文（学術雑誌）  

A 42-year-old male developed right abducens nerve palsy. He had been under treatment with systemic interferon- α for chronic hepatitis C since 17 days before. The abducens palsy rapidly improved after discontinuation of interferon. Diplopia disappeared one month after discontinuation. Neurological examinations including magnetic resonance imaging failed to identify the cause of abducens palsy. This case illustrates that oculomotor narve palsy is a liability in patients under treatment with systemic interferon.

Scopus

researchmap

Insufficiency of accommodation and convergence in whiplash injuries

Y. Tsutsui, T. Matsuo, K. Hasebe, H. Ohtsuki, N. Matsuo

Japanese Journal of Clinical Ophthalmology   49 ( 4 )   775 - 778   1995年

　詳細を見る

記述言語：日本語   掲載種別：研究論文（学術雑誌）  

We reviewed 7 patients with insufficiency of convergence and accommodation secondary to blunt trauma to the head and neck, or whiplash injury, during the past 10-year period. Accommodation was reduced in all the 7 patients, convergence was normal in 3, weakened in 3 and absent in 2. Subjective symptoms improved in all cases by wearing convex lenses for near and/or base in prisms. The state of insufficiency of convergence and acommodation persisted throughout. Convergence and accommodation insufficiency has to be suspected when patients present with ophthalmological complaints after whiplash injuries.

Scopus

researchmap

ANOMALOUS POSTERIOR INSERTION OF MEDIAL RECTUS MUSCLE SIMULATING CONGENITAL OCULOMOTOR PALSY 査読

M OKANO, T MATSUO, H KONISHI, S HASEBE, Y TADOKORO, H OHTSUKI

JAPANESE JOURNAL OF OPHTHALMOLOGY   34 ( 3 )   275 - 279   1990年

　詳細を見る

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：JAPAN J OPHTHALMOL  

Web of Science

researchmap

Familial hypo-retinol-binding proteinemia found in a child with keratomalacia 査読

T. Matsuo, N. Matsuo, F. Shiraga, N. Koide

Journal of Japanese Ophthalmological Society   92 ( 4 )   694 - 698   1988年

　詳細を見る

記述言語：日本語   掲載種別：研究論文（学術雑誌）  

Retinol-binding protein (RBP) is a plasma protein with a molecular weight of 21,000 synthesized in the hepatocytes, binds with retinol (vitamin A), and transports it to peripheral tissues. Keratomalacia is caused by deficiency of vitamin A itself and/or protein-calorie malnutrition in the latter of which production of RBP is inhibited. We found for the first time familial hypo-retinol-binding proteinemia in a child at an age of 19 months who developed keratomalacia during measles infection in spite of good nourishment. The patient, her sister and mother showed persistent low levels, about half the normal levels of retinol and RBP which were unresponsive to oral vitamin A and protein diet. But they had normal liver function tests, normal levels of the other serum proteins, lipids, and fat-soluble vitamins. This hypo-retinol binding proteinemia was thought to predispose the child to develop keratomalacia during measles. The family members involved would be heterozygous for the normal gene and the defective gene of RBP.

Scopus

PubMed

researchmap

Mild type acute retinal necrosis syndrome involving both eyes at three-year interval 査読

T. Matsuo, T. Nakayama, T. Koyama, N. Matsuo

Japanese Journal of Ophthalmology   31 ( 3 )   455 - 460   1987年

　詳細を見る

記述言語：英語   掲載種別：研究論文（学術雑誌）  

A 44-year-old man was seen as having acute retinal necrosis syndrome involving both eyes at an interval of 3 years. The cement-like exudates typical to this disease were observed in the fundus of both eyes
they were self-limiting, finally resulting in retinochoroidal degeneration without retinal detachment before becoming confluent. The patient showed an elevation of the convalescent antibody titer to varicella-zoster virus in the aqueous humor during the second eye involvement. We suggest that there exists a self-limiting mild type of acute retinal necrosis syndrome of which the present case is an example.

Scopus

PubMed

researchmap