研究者詳細 - 松尾　俊彦

眼窩涙腺部腫瘍生検で木村病と確定した後にネフローゼ症候群を発症した1例

Visual evoked potential in RCS rats with Okayama University-type retinal prosthesis (OUReP™) implantation. 査読

Alamusi, Matsuo T, Hosoya O, Uchida T

Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs 20 ( 2 ) 158 - 165 2017年6月

Vogt-Koyanagi-Harada disease-like posterior uveitis in the course of nivolumab (anti-PD-1 antibody), interposed by vemurafenib (BRAF inhibitor), for metastatic cutaneous malignant melanoma. 査読

Matsuo T, Yamasaki O

Clinical case reports 5 ( 5 ) 694 - 700 2017年5月

松尾俊彦, 田中健大, 木野村賢

日本リンパ網内系学会会誌 57 109 - 109 2017年5月

Photoelectric Dye Used for Okayama University-Type Retinal Prosthesis Reduces the Apoptosis of Photoreceptor Cells 査読

Shihui Liu, Toshihiko Matsuo, Osamu Hosoya, Tetsuya Uchida

JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS 33 ( 3 ) 149 - 160 2017年4月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：MARY ANN LIEBERT, INC

Purpose: Our previous study demonstrated that photoelectric dye-coupled polyethylene film (Okayama University-type retinal prosthesis), which was implanted in subretinal space of the eyes of Royal College of Surgeons (RCS) rats, prevented retinal neurons from apoptotic death. In this study, we aimed to examine whether photoelectric dye itself would protect retinal neurons from apoptosis in RCS rats.
Methods: RCS rats received intravitreous injection of different concentrations of the dye in the left eye and housed under a 12-h light-dark cycle. Saline injection in the right eye served as control. In addition, RCS rats with dye injection were kept in 24-h daily dark condition. Sections were processed for terminal deoxynucleotidyl transferase-mediated fluorescein-conjugated-dUTP nick-end-labeling (TUNEL) assay and immunohistochemical staining of glial fibrillary acidic protein (GFAP) and protein kinase C alpha (PKC alpha).
Results: The number of TUNEL-positive cells significantly decreased in the retina of dye-injected eyes compared with those in saline-injected eyes (P = 0.0001, 2-factor analysis of variance [ANOVA]), under 12-h light-dark cycle. Significant decrease of TUNEL-positive cells was noted in the retina of rats with dye injection compared with those with saline injection, kept under 24-h dark condition (P = 0.0001, 2-factor ANOVA). Immunoreactive area for GFAP decreased significantly in the retina of dye-injected eyes compared with that in controls (P = 0.0001, 2-factor ANOVA), whereas immunoreactive area for PKCa increased significantly in the retina of dye-injected eyes compared with that in controls (P = 0.01, 2-factor ANOVA).
Conclusions: Photoelectric dye inhibits apoptotic death of photoreceptor cells in RCS rats and downregulates GFAP expression in retinal Muller cells. Photoelectric dye may be a candidate agent for neuroprotection in retinitis pigmentosa and other retinal diseases.

添付ファイル： Liu NK5962 final jop.2016.0093.pdf

DOI： 10.1089/jop.016.0093

Positive bacterial culture in conjunctival sac before cataract surgery with night stay is related to diabetes mellitus 査読

Tetsuhiro Kawata, Toshihiko Matsuo

BMC OPHTHALMOLOGY 17 ( 1 ) 14 2017年2月

担当区分：責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：BIOMED CENTRAL LTD

Background: The aim of this study is to elucidate background clinical factors in patients with positive bacterial culture for the conjunctival sac before cataract surgery in Japan.
Methods: Retrospective review was made on medical records of 576 consecutive patients who underwent conjunctival sac culture before cataract surgery with night stay at a hospital in 2 years from January 2013 to December 2014. In the patients with sequential bilateral surgeries, the data were chosen for bacterial culture in the eye which had earlier surgery. The age at surgery ranged from 33 to 100 years (mean, 76.7 years). Clinical factors, analyzed in relation with positive or negative bacterial culture, included the sex, the age, the presence of hypertension or diabetes mellitus, history of cancer, and history of hospital-based surgery at other specialties.
Results: Bacterial culture of the conjunctival sac was positive in 168 patients while negative in 408 patients. In multiple regression analysis, the positive bacterial culture was related with the older age (P = 0.01), the presence of diabetes mellitus (P = 0.004), and the history of hospital-based surgery at other specialties (P = 0.001).
Conclusions: Elderly patients with diabetes mellitus or previous hospital-based surgeries at other specialties have a higher rate of positive bacterial culture in the conjunctival sac before cataract surgery. This study would provide a hint for identifying patients at risk for carrying bacterial flora in the conjunctival sac.

添付ファイル： Conj Sac Culture BMC Ophthalmol2017.pdf

DOI： 10.1186/s12886-017-0413-7

Nephrotic syndrome during the tapering of oral steroids after pathological diagnosis of Kimura disease from a lacrimal gland mass: case report and review of 10 Japanese patients. 査読

Matsuo T, Tanaka T, Kinomura M

Journal of clinical and experimental hematopathology : JCEH 57 ( 3 ) 147 - 152 2017年

Subretinal implantation of Okayama university-type retinal prosthesis (OURepTM) in canine eyes by vitrectomy 査読

Toshihiko Matsuo, Tetsuya Uchida, Makoto Nitta, Koichiro Yamashita, Shigiko Takei, Daisuke Ido, Mamoru Tanaka, Masao Oguchi, Toshinori Furukawa

Journal of Veterinary Medical Science 79 ( 12 ) 1939 - 1946 2017年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Japanese Society of Veterinary Science

Okayama University-type retinal prosthesis (OUReP™) is a photoelectric dye-coupled polyethylene film which generates electric potential in response to light and stimulates nearby neurons. This study aims to test surgical feasibility of subretinal implantation and functional durability of dye-coupled films in the subretinal space. The dye-coupled films were implanted subretinally by 25-gauge vitrectomy in the right eye of 11 normal beagle dogs: 2 dogs served for film removal after 5-month film implantation, 3 dogs for film removal after 3-month film implantation, 3 dogs for 3-month film implantation and pathological examination, and 3 dogs for sham surgery. The surface electric potential of the removed dye-coupled films in response to light was measured by the Kelvin Probe system. At surgery, rolled-up dye-coupled films in 5 × 5 mm square size could be inserted into subretinal space of retinal detachment induced by fluid injection with a 38-gauge polyimide tip. Retinal attachment was maintained by silicone oil injection in vitreous cavity. At autopsy, the retina in all dogs maintained the ganglion cell layer, inner and outer nuclear layers while it lost the outer segments in some part. All 5 sheets of removed dye-coupled films maintained the dye color. One sheet of the 5-month implanted film showed proportional increase of surface potential in response to increasing light intensity. Subretinal implantation of OUReP™ by vitrectomy was technically feasible in canine eyes, and OUReP™ maintained the function of generating light-evoked surface potential after 5 months in subretinal implantation.

添付ファイル： dog surgeryOUReP2017JVMS.pdf

DOI： 10.1292/jvms.17-0450

Scopus

Orbital MALT Lymphoma after Autologous Stem Cell Transplantation for Follicular Lymphoma as Relapse of Diffuse Large B-Cell Lymphoma. 査読

Matsuo T, Tanaka T, Fujii N

Journal of clinical and experimental hematopathology : JCEH 56 ( 3 ) 170 - 175 2017年

Clinical decision upon resection or observation of ocular surface dermoid lesions with the visual axis unaffected in pediatric patients 査読

Toshihiko Matsuo

SPRINGERPLUS 4 ( 1 ) 534 2015年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SPRINGER INTERNATIONAL PUBLISHING AG

Ocular surface or epibulbar dermoid lesions may present as limbal dermoids at the corneal limbus or dermolipomas in the conjunctival fornix. The purpose of this study is to review clinical features of ocular surface dermoids (grade I), with the visual axis unaffected, in pediatric patients, in order to find key features for making clinical decision, either resection or observation. The study involved 13 consecutive patients with limbal dermoids or fornix dermolipomas which did not affect the visual axis, seen in 11 years at a referral-based institution. Eight patients underwent surgical resection at the age, ranging from 1 to 18 (median, 4) years, with concurrent preauricular appendage resection in 3 patients. Limbal dermoids in 6 patients presented dome-shaped elevation from the ocular surface, and extended in inferotemporal quadrant for 1-2 clock hours. The remaining 2 patients showed dermolipomas in the temporal conjunctival fornix. Postoperative astigmatism at the final visit ranged from 0 to 7 (median, 2.9) diopters in 6 patients with limbal dermoids while ranged from 0 to 1 diopters in 2 patients with fornix dermolipomas. All patients with meaningful astigmatism wore glasses before and after the surgery, resulting in no apparent ametropic or anisometropic amblyopia. Observation was chosen in 5 patients with the age at initial visit, ranging from 0 to 2 (median, 1) years, and the age at the final visit, ranging from 2 to 6 (median, 3) years. Flat limbal dermoids, extending for 1-2 clock hours, were noted in 3 patients, a dome-shaped limbal dermoid for 1 clock hour in one, and a fornix dermolipoma in one. Three patients had preauricular appendages. No patient, except for one with a dome-shaped limbal dermoid, showed astigmatism, greater than one diopter. In conclusions, dome-shaped limbal dermoids were excised while flat limbal dermoids observed. The age at surgery varied largely in pediatric patients with limbal dermoids (grade I) or fornix dermolipomas which did not affect the visual axis. The surgical timing was influenced by surgical scheduling for preauricular appendage resection, determined by a plastic surgeon. Surgical decision was made for cosmetic purposes, but not for medical needs to avoid amblyopia.

添付ファイル： Dermoid Springerplus.pdf

DOI： 10.1186/s40064-015-1326-7

Vision maintenance and retinal apoptosis reduction in RCS rats with Okayama University-type retinal prosthesis (OUReP™) implantation. 査読

Alamusi, Matsuo T, Hosoya O, Tsutsui KM, Uchida T

Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs 18 ( 3 ) 264 - 271 2015年9月

How far is observation allowed in patients with ectopia lentis? 査読

Toshihiko Matsuo

SpringerPlus 4 461 2015年8月

Clinical factors underlying a single surgery or repetitive surgeries to treat superior oblique muscle palsy 査読

Kana Aoba, Toshihiko Matsuo, Ichiro Hamasaki, Kayoko Hasebe

SPRINGERPLUS 4 ( 166 ) 166 2015年4月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SPRINGER INTERNATIONAL PUBLISHING AG

The purpose of this study is to know clinical factors underlying either a single surgery or repetitive surgeries, required to treat superior oblique muscle palsy. Retrospective review was made on 246 consecutive patients with idiopathic (n = 212) or acquired (n = 34) superior oblique muscle palsy who underwent surgeries in 8 years at one institution. Idiopathic palsy included congenital and decompensated palsies while acquired palsy included traumatic and ischemic palsies. Clinical factors, compared between groups with a single surgery (n = 203) and two or more surgeries (n = 43), were surgical methods, sex, age at surgery, horizontal, vertical, and cyclotorsional deviations, and stereopsis at near fixation. Inferior oblique muscle recession on paretic side was chosen in about 60% of the single-surgery and repetitive-surgery group as an initial surgery, followed by inferior rectus muscle recession on non-paretic side. The age at surgery was significantly older, vertical and cyclotorsional deviations were significantly larger in the repetitive-surgery group, compared with the single-surgery group (P = 0.01, P < 0.001, P = 0.02, Mann-Whitney U-test, respectively). The 95% confidence interval of vertical deviations was 15-17 prism diopters in the single-surgery group and 23-28 prism diopters in the repetitive surgery group. Significant differences in vertical deviations were replicated also in subgroups of patients with either idiopathic or acquired palsy. In conclusions, the 95% confidence interval of vertical deviations, determined by alternate prism and cover test, would be used as a common benchmark for predicting either a single surgery or repetitive surgeries, required to treat idiopathic and acquired superior oblique muscle palsy, in the process of obtaining the informed consent.

添付ファイル： Aoba2015_Article_ClinicalFactorsUnderlyingASing.pdf

DOI： 10.1186/s40064-015-0945-3

眼底綿花様白斑を合併した全身性エリテマトーデスの1例眼合併症と疾患活動性との関連性に関する検討

Intraocular Relapse with Hypopyon and Retinal Infiltrates after Chemotherapy and Peripheral Blood Stem Cell Transplantation for Extranodal NK/T-Cell Lymphoma. 査読

Matsuo T, Tanaka T, Ichimura K, Meguri Y

Journal of clinical and experimental hematopathology : JCEH 55 ( 3 ) 157 - 161 2015年

Oral infection control to assist infliximab therapy in a Behçet's disease patient with severe eye inflammation in response to dental treatment: a case report. 査読国際誌

Kudo C, Wakabayashi H, Shimoe M, Kobayashi H, Ito T, Ohkawa T, Isoshima-Nakamura A, Mineshiba J, Yoshioka N, Nawachi K, Maeda H, Matsuo T, Makino H, Takashiba S

Clinical case reports 2 ( 6 ) 274 - 280 2014年12月

Infective Endocarditis With Origin in Orbital Vascular Malformation and Maxillary Sinusitis: A Case Report and Review of Four Patients in the Literature 査読

Toshihiko Matsuo, Yoshitaka Iwamoto, Hironori Okamoto, Daisuke Iguchi

Cureus 16 ( 11 ) e74873 2014年12月

Mantle cell lymphoma diagnosed by conjunctival salmon-pink lesion biopsy. 査読

Matsuo T, Ichimura K, Kubonishi S

Journal of clinical and experimental hematopathology : JCEH 54 ( 2 ) 143 - 147 2014年

杉生真帆, 青山裕美, 梶田藍, 竹島千夏, 濱田利久, 松尾俊彦, 赤塚俊文, 岩月啓氏

臨床皮膚科 66 ( 12 ) 960 - 964 2012年11月

記述言語：日本語出版者・発行元：(株)医学書院

24歳,女性.両頬の蝶形紅斑と抗核抗体陽性により精査加療目的で当院を受診した.他臓器病変は認めなかった.全身性エリテマトーデス(systemic lupns erythematosus:SLE)と診断しステロイド治療を開始した.順調にテーパリングを行っていたが,治療開始から4ヵ月後に突然眼のかすみと視力低下を自覚し,眼底に綿花様白斑を認めSLE網膜症と診断された.このとき,皮膚症状は改善し血液データの変動もなかった.SLEのさまざまな眼合併症は,通常はSLEの病勢と一致して出現するが,過去9年間の当院のSLE患者の眼合併症の検討では,必ずしも皮膚症状や血液検査データにおけるSLEの病勢とは一致していなかった.SLEの眼合併症を皮疹や臨床検査値などから予測することは困難だが,放置していれば重篤な視力障害につながる危険が高く,注意すべき合併症である.(著者抄録)