Faculty Profiles - MATSUZAKI Hidenobu

Papers - MATSUZAKI Hidenobu

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Thermoradiotherapy combined with p53 gene therapy of human salivary gland adenocarcinoma cell line Reviewed

Jun-Ichi Asaumi, Yuzuru Higuchi, Jun Murakami, Hidenobu Matsuzaki, Toru Wakasa, Tetsuyoshi Inoue, Hiroshi Shigehara, Hironobu Konouchi, Miki Hisatomi, Shoji Kawasaki, Masahiro Kuroda, Yoshio Hiraki, Kanji Kishi

Oncology Reports 10 ( 1 ) 71 - 74 2003.1

Assessment of carcinoma in the sublingual region based on magnetic resonance imaging Reviewed

Jun-Ichi Asaumi, Hiroshi Shigehara, Hironobu Konouchi, Yoshinobu Yanagi, Miki Hisatomi, Hidenobu Matsuzaki, Kanji Kishi

Oncology Reports 9 ( 6 ) 1283 - 1287 2002.11

Language：English Publishing type：Research paper (scientific journal) Publisher：Spandidos Publications

In the present study, we attempted to diagnose and detect the extent of tumors in the sublingual region using magnetic resonance imaging (MRI) and dynamic MRI. MRI with or without gadopentetate dimeglumine (Gd-DTPA)-enhancement in seven lesions of the sublingual regions was performed. The seven lesions included four cases of mucoepidermoid carcinoma (mucoepidermoid Ca), two cases of adenoid cystic carcinoma (ACC), and one case of squamous cell carcinoma (SCC). Whether the tumor was malignant or benign, as well as the differential diagnosis, could not be determined on the basis of the MR signals, even when enhancement was performed. Dynamic MRI was performed in five cases, two cases of ACC, two cases of mucoepidermoid Ca, and one case of SCC. The dynamic MRI showed a rapid enhancement at 30-45 sec in all five cases before the normal sublingual gland began to be enhanced. The early phases at 30-45 sec of the dynamic MRI in five cases showed marked enhancement before the normal sublingual glands were enhanced, and therefore could clearly show the extent of the lesions. In conclusion, the dynamic MRI may be useful in differentiating malignant from benign tumors, and in detecting the extent of the tumors in the sublingual carcinomas.

DOI： 10.3892/or.9.6.1283

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Thermoradiotherapy in human head and neck squamous cell carcinoma cell lines. International journal

Jun-Ichi Asaumi, Yuzuru Higuchi, Jun Murakami, Masahiro Kuroda, Koichi Shibuya, Hironobu Konouchi, Miki Hisatomi, Hidenobu Matsuzaki, Hiroshi Shigehara, Shoji Kawasaki, Kanji Kishi, Yoshio Hiraki

International journal of molecular medicine 10 ( 3 ) 287 - 91 2002.9

Language：English Publishing type：Research paper (scientific journal)

Thermoradiosensitivity of 8 cell lines of head and neck squamous cell carcinoma (HO-1-u-1, HSC2, HSC3, HSC4, SAS, KB, Hep2, and Ca9-22) was investigated. The differences of radiosensitivity between the cell line with the highest radiosensitivity and the cell line with the lowest radiosensitivity were 1.7-, 7.7-, and 41-fold at 2, 6 and 8 Gy, respectively. The differences between the cell line with the highest thermosensitivity and the cell line with the lowest thermosensitivity were 2.4-, 6.2- and 34.4-fold at 43 degrees C for 40, 60 and 100 min, and 2.6-, 4.9- and 127-fold at 44 degrees C for 20, 30 and 50 min, respectively. These findings indicated that there were large differences in both radiosensitivity and thermosensitivity among the 8 cell lines. There was a negative relationship between radiosensitivity and thermosensitivity (43 degrees C: r=-0.600, 44 degrees C: r=-0.848) in 7 of 8 cell lines, the exception being the HSC4 cell line, which was resistant to both therapies. Four of the 8 cell lines at 43 degrees C and 5 at 44 degrees C in the radiotherapy combined with thermotherapy showed actual survival rates smaller than the theoretical survival rates. Thus, thermoradiotherapy was deemed effective in the head and neck carcinoma cell lines, although 1 of 8 cell lines was resistant to both radiotherapy and thermotherapy.

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Application of dynamic MRI to differentiating odontogenic myxomas from ameloblastomas. International journal

Jun-ichi Asaumi, Hidenobu Matsuzaki, Miki Hisatomi, Hironobu Konouchi, Hiroshi Shigehara, Kanji Kishi

European journal of radiology 43 ( 1 ) 37 - 41 2002.7

Language：English Publishing type：Research paper (scientific journal)

It is often difficult to radiographically distinguish odontogenic myxomas from ameloblastomas. In the present study, we tried to differentiate odontogenic myxomas from ameloblastomas using dynamic magnetic resonance imaging (dynamic MRI). Two cases of ameloblastoma with cystic components and two cases of odontogenic myxoma were compared by dynamic MRI. The dynamic MRI features of solid areas of ameloblastomas showed a rapid enhancement, reaching maximum contrast at 45-60 s, and maintained these enhancement levels or showed a gradual wash-out to 600 s thereafter; in contrast, those of the cystic areas of ameloblastomas showed no enhancement. The dynamic MRI features of the whole area of odontogenic myxomas (we considered the whole area to be the tumor substance in the odontogenic myxomas, as based on histopathological examinations) showed a gradual increase in enhancement at 500-600 s. The central portions of the odontogenic myxomas, which did not appear to be enhanced on Gd-T1 weighted images also showed a gradual increase in enhancement at 500-600 s, though the increase was minimal. These results indicate that the dynamic MRI features of odontogenic myxomas are different from those of ameloblastomas. Therefore, dynamic MRI may be a useful tool for diagnosis of myxoma.

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Assessment of dynamic MRI of Warthin's tumors arising as multiple lesions in the parotid glands. International journal

Miki Hisatomi, Jun-ichi Asaumi, Hironobu Konouchi, Yoshinobu Yanagi, Hidenobu Matsuzaki, Kanji Kishi

Oral oncology 38 ( 4 ) 369 - 72 2002.6

Language：English Publishing type：Research paper (scientific journal)

We examined three patients with multiple synchronous Warthin's tumors in the bilateral parotid and described the value of using dynamic MRI. The time course of the contrast index (CI curves) was calculated from a dynamic series. Warthin's tumors showed intermediate signal intensity on T1WI, heterogeneous high and intermediate signal intensity on T2WI and a slight enhancement on Gd-T1WI. Warthin's tumors of CI curves showed specific findings. CI curves in each lesion showed the same pattern. It was difficult to diagnose masses as Warthin's tumors using only MR images on T1, T2 and Gd-T1WI. Dynamic MRI can distinguish Warthin's tumors from other possible tumors except for oncocytoma. Therefore, the use of dynamic MRI is recommended as a diagnostic method for Warthin's tumors in multiple synchronous lesions of the parotid gland.

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Thermochemotherapy of a human salivary adenocarcinoma cell line Reviewed

JI Asaumi, Y Higuchi, H Matsuzaki, J Murakami, S Kawasaki, M Kuroda, K Shibuya, H Konouchi, M Hisatomi, T Wakasa, K Kishi, Y Hiraki

ONCOLOGY REPORTS 9 ( 2 ) 365 - 369 2002.3

Language：English Publishing type：Research paper (scientific journal) Publisher：PROFESSOR D A SPANDIDOS

We report on thermochemotherapy in a human salivary gland adenocarcinoma cell line. Hyperthermia reduced the survival rate to 50 and 20% by heating at 43degreesC for 40 and 60 min, respectively, and is by itself useful in human salivary gland carcinoma treatment. Adriamycin, cisplatin, and mitomycin C can possible be used clinically, while bleomycin and 5-fluorouracil cannot, to treat this carcinoma. The optimal temperature was considered to be 41degreesC in adriamycin, 42degreesC in cisplatin, 37degreesC in mitomycin C, and 42degreesC in bleomycin in the thermochemotherapy. Thermochemotherapy is a useful tool in the treatment of human salivary gland carcinoma cells, but it is necessary to select the best anticancer drugs and the optimal temperature for optimal success using this treatment.

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Two cases of polyostotic eosinophilic granuloma Reviewed

Asaumi J, Konouchi H, Hisatomi M, Matsuzaki H, Kishi K

Dento Maxillo Facial Radiology 29 ( 6 ) 382 - 385 2000.12

Effects of quercetin on the cell growth and the intracellular accumulation and retention of adriamycin Reviewed

JI Asaumi, H Matsuzaki, S Kawasak, M Kuroda, Y Takeda, K Kishi, Y Hiraki

ANTICANCER RESEARCH 20 ( 4 ) 2477 - 2483 2000.7

Language：English Publishing type：Research paper (scientific journal) Publisher：INT INST ANTICANCER RESEARCH

In this study, we examined the inhibitory effects on cell growth and the effects of quercetin on intracellular accumulation of adriamycin (ADR) in wild type Ehrlich ascites tumor cells (wild EAT cells) and their ADR-resistant strain. Quercetin strongly inhibited growth in both strains. Cell growth reached a plateau at 3.5 days in the wild type EAT cells and at 7 days in the ADR-resistant strain. The inhibitory concentration in 50% of the ADR-resistant cells on day 7 (24 mu M) was twice that of the wild type EAT cells on day 4 (12 mu M) after continuous treatment with quercetin. Quercetin decreased the ADR accumulation in the wild type cells but did not affect it in the ADR-resistant cells. Further quercetin did not affect the retention of ADR in either strain. These results indicated that qeurcetin decreased ADR accumulation without extruding ADR in the wild type EAT cells. ADR accumulation in the ADR-resistant cells treated with quercetin for 7 days was increased with increasing concentrations of quercetin. Moreover ADR accumulation in the ADR-resistant cells treated with 50 mu M quercetin for 7 days, increased to 186.6% and to 181.9% of that in untreated cells after 60 minutes and 120 minutes incubation, respectively, whilst it ina-eased to 70% from 37.5% of that in the wild type EAT cells after 60 minutes incubation. These findings indicated that quercetin might reverse ADR-resistance.

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第三大臼歯の萠出に関するX線学的検討

樋口譲, 浅海淳一, 繁原宏, 此内浩信, 松崎秀信, 岸幹二

岡山歯学会雑誌 19 ( 1 ) 155 - 159 2000.6

Influence of bovine calf serum on the intracellular accumulation and retention of adriamycin Reviewed

JI Asaumi, H Matsuzaki, S Kawasaki, M Kuroda, Y Takeda, K Kishi, Y Hiraki

ANTICANCER RESEARCH 20 ( 2A ) 769 - 772 2000.3

Language：English Publishing type：Research paper (scientific journal) Publisher：INT INST ANTICANCER RESEARCH

In this study, we observed the influence of bovine calf serum (BCS) on the intracellular accumulation of adriamycin (ADR) in Ehrlich ascites tumor cells (wild type EAT cells) and their ADR-resistant strain. The ADR accumulation treated in the medium not containing BCS was S-fold of that containing 10% BCS. ADR incorporated into cells was not effluxed in the absence of the BCS, while it was rapidly effluxed for 30 minutes to about 20% of the amount incorporated into the cells in the presence of 20% BCS in both strains. This suggests that BCS remarkably decreases the ADR accumulation due to the promotion of ADR efflux. Further; the ADR accumulation dea eased with increasing concentrations of BCS in both strains. This indicates that BCS promotes the ADR efflux, dependeing on its concentrations. BCS was heated at 100 degrees C for 7 minutes and its protein contents were degenerated. Irs influence in the ADR accumulation of wild type and ADR-resistant strain was apparent. The ADR accumulation decreased with increasing concentrations of heated BCS in both strains, as well as in the untreated BCS. Thus, the protein content of the BCS did not affect ADR accumulation. Therefore, it is necessary to investigate which components of BCS affect the promotion of ADR efflux.

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単純性骨嚢胞の臨床X線学的検討

松崎秀信, 相賀秀樹, 浅海淳一, 若狭亨, 岸幹二

岡山歯学会雑誌 18 ( 2 ) 339 - 346 1999.12

Language：Japanese Publisher：岡山歯学会

1)本病変は全て下顎に発症し,平均年齢は22.0歳であった. 2)X線写真上の特徴は,弱い辺縁を持つX線透過像を示し,頬舌的な膨隆は1例のみで認められた. 3)上方部辺縁が歯根に接する12症例中10例では,いわゆる"帆立貝状"を呈しており,下方辺縁が下顎骨下縁に達する3例では皮質骨の菲薄化が認められた. 4)生検のみを施行した3例も外科処置を施行した10例と同様に治癒傾向を示し再発を認めなかった.したがって,単純性骨嚢胞の処置は生検により確定診断を得た後に経過観察を行うことが有用な方法であると考えられた

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腎性骨異栄養症のX線学的検討

相賀秀樹, 松崎秀信, 浅海淳一, 若狭亨, 岸幹二, 竹林俊明, 松村智弘

岡山歯学会雑誌 18 ( 2 ) 347 - 353 1999.12

Language：Japanese Publisher：岡山歯学会

自験例では全ての症例にCa,Pの代謝異常に起因する腎性骨異栄養症を反映した歯周組織及び顎骨の様々な特徴的なX線像上の変化を認めた.したがって,歯科臨床上,患者の病歴,他疾患併発の可能性に留意すると共に本症発現に伴うX線写真上の顎骨変化も十分認識しておく必要がある

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顎関節におけるSynovial Osteochondromatosisの画像所見について

若狭亨, 繁原宏, 松崎秀信, 相賀秀樹, 岸幹二

岡山歯学会雑誌 18 ( 1 ) 259 - 269 1999.6

Language：Japanese Publisher：岡山歯学会

Synovial osteochondromatosisが疑われた6例及び病理組織学的に確定した2例について全例でX線撮影,8例中4例でCT検査,8例中3例でMRI検査を行った.X線所見では全例で遊離体がみられ,関節腔の拡大は3例,運動制限は5例,関節表面の不整や骨硬化像は各5例に認められた.CT所見では4例中2例でerosionと骨硬化像,1例でerosionのみ,1例で骨硬化像のみが認められ,全4例で翼突筋の圧迫偏位像を認めた.MRI所見では3例中2例においてT2強調像で翼突筋の信号が高くなり,1例では筋の信号の亢進はなかった.又,遊離体は3例共T1強調像で低信号を示したが,T2強調像では2例が高信号,1例が低信号であった

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