Faculty Profiles - MATSUZAKI Hidenobu

Papers - MATSUZAKI Hidenobu

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角化嚢胞性歯原性腫瘍の診断におけるMRIのT1強調像の有用性

此内浩信, 久富美紀, 柳文修, 松崎秀信, 竹信俊彦, 若狭亨, 村上純, 畦坪輝寿, 浅海淳一

岡山歯学会雑誌 30 ( 2 ) 69 - 74 2011.12

Language：Japanese Publisher：岡山歯学会

角化嚢胞性歯原性腫瘍(KCOT)の診断におけるMRIのT1強調像の有用性について検討した。顎骨の歯原性腫瘍あるいは歯原性嚢胞の画像診断で外科的手術を施行し、KCOTと病理診断し、生検前にMRI検査を受けていた22例に対して後ろ向き調査を行った。T1強調像における嚢胞内容物が正のコントラストを示した症例は18例、4例のみが負のコントラストを示した。単房性と多房性のコントラストの差は有意ではなかった。コントラストと近遠心径の間とコントラストと頬舌径の間に相関関係は認めなかった。

Primary extranodal lymphoma of the maxilla: a case report with imaging features and dynamic data analysis of magnetic resonance imaging International journal

Hidenobu Matsuzaki, Naoki Katase, Marina Hara, Jun-Ichi Asaumi, Yoshinobu Yanagi, Teruhisa Unetsubo, Miki Hisatomi, Hironobu Konouchi, Toshihiko Takenobu, Hitoshi Nagatsuka

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY 112 ( 3 ) E59 - E69 2011.9

Language：English Publishing type：Research paper (scientific journal) Publisher：MOSBY-ELSEVIER

Malignant lymphoma is the second-most common malignancy in the head and neck region. Waldeyer's ring is the most common site of extranodal Hodgkin's lymphoma (NHL) in that region, and a small percentage of primary extranodal NHL occurs in the oral cavity. The most common sites of extranodal NHL in the oral region are the palate and maxilla, and nearly half of extranodal NHL cases arise from bone. It is difficult to diagnose extranodal NHL because of the variety of its radiological features. We report a case of primary extranodal NHL of the maxilla in a 68-year-old female patient with atypical imaging findings, along with the results of analysis of dynamic magnetic resonance imaging (MRI). (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011; 112: e59-e69)

DOI： 10.1016/j.tripleo.2011.02.052

Ameloblastic carcinoma: a case report with radiological features of computed tomography and magnetic resonance imaging and positron emission tomography International journal

Hidenobu Matsuzaki, Naoki Katase, Marina Hara, Jun-Ichi Asaumi, Yoshinobu Yanagi, Teruhisa Unetsubo, Miki Hisatomi, Hironobu Konouchi, Hitoshi Nagatsuka

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY 112 ( 1 ) E40 - E47 2011.7

Language：English Publishing type：Research paper (scientific journal) Publisher：MOSBY-ELSEVIER

Ameloblastic carcinoma is a rare malignant odontogenic carcinoma that has metastatic potential, and because of its rare incidence, there are few reports focusing on its radiologic imaging. If it shows aggressive appearances, it can be diagnosed as malignant tumor. But in case of negative appearance, it is difficult to distinguish ameloblastic carcinoma from ameloblastoma. We report a case of ameloblastic carcinoma of the maxilla in a 76-year-old female patient with radiologic images and pathologic features. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011; 112: e40-e47)

DOI： 10.1016/j.tripleo.2011.01.023

インプラントを希望して岡山大学歯学部を受診した患者の初診時パノラマX線像の検討

久富美紀, 竹信俊彦, 若狭亨, 此内浩信, 柳文修, 松崎秀信, 村上純, 畦坪輝寿, 浅海淳一

岡山歯学会雑誌 30 ( 1 ) 11 - 16 2011.6

Language：Japanese Publisher：岡山歯学会

2008年1月〜2010年9月にインプラント治療を希望して受診しパノラマX線撮影が行われた患者500例を対象に、患者背景やX線所見について統計学的に検討した。性別は男性192例(38%)、女性308例(62%)であった。年齢は17〜87歳(平均57.4歳)で、50〜60歳代が多く69%を占めていた。インプラント希望歯数は、1本の患者が125例(25%)、2本が114例(23%)、3本が79例(16%)、4本が54例(11%)、5本以上が128例(26%)であった。インプラント希望部位を年齢別にみると、若年層で前歯部が多く、高齢者で臼歯部が多いという特徴が認められた。X線で歯欠損以外の異常所見を認めたものが325例(65%)あり、内訳は歯根膿瘍307例(61%)、歯根膿瘍と他の異常所見が重複しているもの24例(5%)、歯根膿瘍以外の所見18例(4%)であった。歯根膿瘍は1患者平均2.05本認め、インプラント希望部位の隣在歯に認めたものが79例(16%)あった。

Radiotherapy for oral cancer

Toshihiko Takenobu, Jun-ichi Asaumi, Hidenobu Matsuzaki, Marina Hara, Mistuhiro Takemoto, Kuniaki Katsui, Masahiro Kuroda, Susumu Kanazawa

Oral Cancer: Causes, Diagnosis and Treatment 51 - 84 2011.4

Language：English Publishing type：Part of collection (book) Publisher：Nova Science Publishers, Inc.

Oral cancers occur at a relatively high rate in elderly patients. However, elderly patients often cannot undergo general anesthetization or surgery due to their declining physical condition. In addition, elderly patients who do undergo surgery for oral cancer occasionally develop problems with eating and swallowing or infectious disease. At the same time, oral cancers have been on the rise among patients in their 20s and 30s. For these younger patients, the aesthetic appearance of the oral region, as well as the full preservation of the abilities to eat, swallow, and enunciate, are especially important. Thus, in both elderly and younger patients, the preservation of aesthetic features and oral functions is critical when treating oral cancers. Conservative oral cancer treatment approaches include radiotherapy, chemotherapy, thermotherapy, immunotherapy, and gene therapy. In oral cancer cases in which surgery is not appropriate and a more conservative treatment must be used, radiotherapy is the most frequently chosen approach. Brachytherapy is often applied in early stage (stage I and II) and chemoradiotherapy in advanced stage (stage III and IV) oral cancers.The first part of this chapter presents the general method of radiotherapy for oral cancer and its potential side effects. The second portion of the chapter addresses the subject of brachytherapy, including low-dose rate and high-dose rate brachytherapy and mold therapy, and chemoradiotherapy. © 2011 by Nova Science Publishers, Inc. All rights reserved.

Diagnostic value of dynamic contrast-enhanced MRI for unilocular cystic-type ameloblastomas with homogeneously bright high signal intensity on T2-weighted or STIR MR images International journal

Miki Hisatomi, Yoshinobu Yanagi, Hironobu Konouchi, Hidenobu Matsuzaki, Toshihiko Takenobu, Teruhisa Unetsubo, Jun-ichi Asaumi

ORAL ONCOLOGY 47 ( 2 ) 147 - 152 2011.2

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER SCIENCE BV

Typical MR images of ameloblastomas on T2-weighted image (WI) or short inversion time inversion-recovery (STIR) show multiple bright high-signal-intensity loci on a high-signal-intensity background. Unilocular cystic-type ameloblastomas show homogeneously bright high signal intensity on T2WI or STIR as a water-like signal intensity. Therefore, it is difficult to distinguish unilocular cystic-type ameloblastoma from other cystic lesions such as keratocystic odontogenic tumors, radicular cysts (residual cysts) and dentigerous cysts only on the basis of MRI signal intensity. In the present study, we evaluated whether contrast-enhanced (CE)-T1WI and dynamic CE-MRI (DCE-MRI) could provide additional information for differential diagnosis in unilocular cystic-type ameloblastoma. Images from 12 cases of suspected unilocular cystic-type ameloblastoma were evaluated in the present study. Of them, 5 had areas suspected of indicating a solid component on T1WI and T2WI (or STIR). Ten had undergone additional CE-T1WI and DCE-MRI. On 5 of 10 cases of CE-T1WI, a tiny enhancement area was detected. On 6 of 10 DCE-images, a time-course enhanced area which was suspected to be a solid component was detected. CE-T1WI was helpful in the diagnosis of ameloblastoma because the tiny enhanced areas were taken to indicate possible solid components. Moreover, the rim-enhancement area on CE-T1WI could be divided into small regions of interest, and some of these showed slightly increased enhancement on DCE-MRI, which was taken to indicate a solid component and/or intramural nodule with focal invasion of ameloblastoma tissue. DCE-MRIs of the four remaining cases, which provided no clues to the diagnosis of ameloblastoma in the manner of the above descriptions, showed thicker rim enhancement than odontogenic cysts. Thus, CE-T1WI and DCE-MRI were helpful in the differential diagnosis of unilocular cystic-type ameloblastomas with homogeneously bright high signal intensity on T2WI or STIR. (C) 2010 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.oraloncology.2010.11.009

The utility of three-dimensional dynamic contrast-enhanced magnetic resonance imaging in delineating vessel-rich regions: a case report of an aneurysmal bone cyst of the mandible

Yoshinobu Yanagi, Mariko Fujita, Miki Hisatomi, Hidenobu Matsuzaki, Hironobu Konouchi, Naoki Katase, Hitoshi Nagatsuka, Jun-ichi Asaumi

ORAL RADIOLOGY 26 ( 2 ) 110 - 115 2010.12

Language：English Publishing type：Research paper (scientific journal) Publisher：SPRINGER

Aneurysmal bone cysts (ABCs) are classified as bone-related lesions based on the 2005 World Health Organization histological classification of odontogenic tumors. Most ABCs are diagnosed using a combination of conventional radiography, computed tomography, magnetic resonance imaging (MRI), and digital subtraction angiography. ABCs should be differentiated from true cysts or other pseudocysts because their treatment is different. Additionally, unlike other cysts, ABCs pose a hemorrhagic risk in surgery; thus, preoperative evaluation of intralesional blood flow is required. Here we report a case of a mandibular ABC in a 39-year-old woman and focus on its dynamic contrast-enhanced MRI (DCE-MRI) features. On DCE-MRI, the lesion was divided into two areas according to the enhancement pattern: the blood-pooling and blood-flow areas. The series of DCE-MR images of the blood-pooling area showed marked enhancement of the margin, but no enhancement in the inner part of the cavity. Additionally, the time-signal intensity curve (TIC) demonstrated no change in the signal intensity (SI) until approximately 15 min after gadolinium-diethylenetriamine penta-acetic acid (Gd-DTPA) administration. In contrast, the series of DCE-MR images of the blood-flow area exhibited marked enhancement in the cyst cavity in the early phase. The TIC showed a rapid increase in SI in the early phase, followed by a rapid decrease until 150 s, and finally a gradual decrease until approximately 15 min after Gd-DTPA administration. Thus, in the current patient, preoperative DCE-MRI clearly delineated the vessel-rich area within the lesion.

DOI： 10.1007/s11282-010-0048-3

Usefulness of MRI and dynamic contrast-enhanced MRI for differential diagnosis of simple bone cysts from true cysts in the jaw International journal

Yoshinobu Yanagi, Jun-ichi Asaumi, Teruhisa Unetsubo, Masakazu Ashida, Toshihiko Takenobu, Miki Hisatomi, Hidenobu Matsuzaki, Hironobu Konouchi, Naoki Katase, Hitoshi Nagatsuka

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY 110 ( 3 ) 364 - 369 2010.9

Language：English Publishing type：Research paper (scientific journal) Publisher：MOSBY-ELSEVIER

Introduction. It can be difficult to differentiate simple bone cysts (SBCs) from true cysts in the jaw when these lesions appear unilocular. The present study reports the MR imaging of subjects with SBCs and describes the diagnostic value of the MRI findings.Materials and methods. Ten subjects with SBCs in the jaw were examined using MRI. T1- and T2-weighted images (T1WI, T2WI) were obtained, and contrast-enhanced images and dynamic contrast-enhanced MRI (DCE-MRI) were acquired.Results. In all cases, the contrast-enhanced T1WI acquired approximately 6 minutes after the administration of GdDTPA showed marked enhancement of the margin and slight enhancement of the inner part of the cyst cavity. In all cases, the time-signal intensity (SI) curves show a gradual increase in the SI until approximately 15 minutes after the administration of Gd-DTPA. These findings might not be observed on the DCE-MRIs of the other true cysts with epithelial lining that show no enhancement in a cavity.Conclusion. MRI, especially DCE-MRI, can provide useful information for distinguishing SBCs from other cysts. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010;110:364-369)

DOI： 10.1016/j.tripleo.2010.05.001

下顎第一大臼歯萠出遅延症例に対する病理学的・X線学的検討

芦田昌和, 片瀬直樹, 松崎秀信, 畦坪輝寿, 柳文修, 村上純, 繁原宏, 若狭亨, 長塚仁, 浅海淳一

岡山歯学会雑誌 29 ( 1 ) 67 - 68 2010.6

A new phantom using polyethylene glycol as an apparent diffusion coefficient standard for MR imaging International journal

Ryohei Matsuya, Masahiro Kuroda, Yoshitsugu Matsumoto, Hirokazu Kato, Hidenobu Matsuzaki, Junichi Asaumi, Jun Murakami, Kazunori Katashima, Masakazu Ashida, Takanori Sasaki, Tetsuro Sei, Kengo Himei, Kuniaki Katsui, Norihisa Katayama, Mitsuhiro Takemoto, Susumu Kanazawa, Seiichi Mimura, Seiichiro Oono, Takuichi Kitayama, Seiji Tahara, Keiji Inamura

INTERNATIONAL JOURNAL OF ONCOLOGY 35 ( 4 ) 893 - 900 2009.10

Language：English Publishing type：Research paper (scientific journal) Publisher：SPANDIDOS PUBL LTD

In recent years, magnetic resonance imaging (MRI) with diffusion-weighted imaging (DWI) has seen wide clinical use, such as for early detection of cerebrovascular diseases and whole body screening for tumors. The apparent diffusion coefficient (ADC) standard phantom, which mimics the ADC values of several lesions in the body, is indispensable for the development of new pulse sequences for DWI, such as diffusion-weighted whole-body imaging with background body-signal suppression (DWIBS). However, information on the ADC values of the previously reported ADC standard phantoms is limited, because these phantoms were made using only a few different materials at a limited range of concentrations, and the ADC values were measured only at certain temperatures. It has been considered difficult, if not impossible, to create a phantom that provides arbitrary ADC values, because it is difficult to calculate the concentrations of the materials and the temperature at ADC measurement. In this study, we used polyethylene glycol (PEG) as a phantom material, and developed an empirical formula to calculate the PEG concentration at any measurement temperature to obtain arbitrary ADC values of the phantom. DWI images of phantoms made using seven different PEG concentrations were taken under heating from 17 to 46 degrees C at 1 degrees C intervals. Using ADC values calculated from these DWI images, we developed two empirical formulas: i) an empirical formula to calculate the ADC values of phantoms made using any PEG concentration at any measurement temperature; and ii) an empirical formula to calculate PEG concentrations to obtain arbitrary ADC values at any measurement temperature. We inspected the accuracy of these empirical formulas by newly made PEG phantoms. A comparison between the ADC values calculated with the empirical formulas and the measured ADC values confirmed the high accuracy of these formulas. PEG phantoms are safe, inexpensive and easy to make, compared with the previously reported ADC standard phantoms. Our empirical formulas enable us to calculate PEG concentrations that provide arbitrary ADC values at any measurement temperature. The empirical formulas could be used within a range of ADC values from 0.37x10(-3) to 3.67x10(-3) mm(2)/s, PEG concentrations from 0 to 120 mM, and measurement temperatures from IS to 45 degrees C. Using these formulas, it would be possible to make standard phantoms that mimic the ADC values of any clinical lesions. The PEG phantom might thus be an excellent new ADC standard phantom for MRI with DWI.

DOI： 10.3892/ijo_00000404

In vitro experimental study of the relationship between the apparent diffusion coefficient and changes in cellularity and cell morphology International journal

Yoshitsugu Matsumoto, Masahiro Kuroda, Ryohei Matsuya, Hirokazu Kato, Koichi Shibuya, Masataka Oita, Atsushi Kawabe, Hidenobu Matsuzaki, Junichi Asaumi, Jun Murakami, Kazunori Katashima, Masakazu Ashida, Takanor Sasaki, Tetsuro Sei, Susumu Kanazawa, Seiichi Mimura, Seiichiro Oono, Takuichi Kitayama, Seiji Tahara, Keiji Inamura

ONCOLOGY REPORTS 22 ( 3 ) 641 - 648 2009.9

Language：English Publishing type：Research paper (scientific journal) Publisher：SPANDIDOS PUBL LTD

Diffusion-weighted magnetic resonance imaging (MRI) is frequently used clinically, and is available for the whole-body screening for tumors. The exact mechanism by which the apparent diffusion coefficient (ADC) value decreases in tumorous tissue remains unclear, although various theories have been proposed, including intracellular and extracellular factor theories. It is impossible to distinguish each factor in the intracellular and extracellular spaces as the source of MR signal generation by means of conventional comparison between MR images and pathological specimens. Other factors which have been reported to affect ADC include cellularity and cellular edema of human tissues, and temperature of phantoms at the time of measurement. We employed a new technique that enables cellular MR imaging using a newly developed bio-phantom containing a living culture tumor cell line, Jurkat-N1. We investigated possible reasons for observed decreases in ADC values for tumors, and we considered the contribution of both the intracellular and extracellular space to such a decrease. The ADC values of the bio-phantom increased with increasing heat exposure from 27 to 45 degrees C. ADC values also increased after the destruction by sonication of tumor cell membranes. ADC values decreased as cellularity increased in the bio-phantorn. ADC values decreased due to cellular edema caused by a low salt concentration in the bio-phantom. Changes in pressure in the bio-phantom had no effect on the observed ADC values. We calculated both the intracellular ADC and extracellular ADC values using the ADC values, cellularity, and cellular volume of Jurkat-N1 cells in the bio-phantom. The extracellular ADC values in the bio-phantom were estimated to be lower than the ADC value of distilled water. These results indicate that not only intracellular ADC values, but also extracellular ADC values contribute to the determination of the ADC values of bio-phantoms. This is the first report to have examined the contribution of intracellular and extracellular space on the ADC values of bio-phantoms containing cultured tumor cells.

DOI： 10.3892/or_00000484

Dynamic contrast-enhanced magnetic resonance imaging for estimating tumor proliferation and microvessel density of oral squamous cell carcinomas International journal

Teruhisa Unetsubo, Hironobu Konouchi, Yoshinobu Yanagi, Jun Murakami, Masae Fujii, Hidenobu Matsuzaki, Miki Hisatomi, Hitoshi Nagatsuka, Jun-ichi Asaumi

ORAL ONCOLOGY 45 ( 7 ) 621 - 626 2009.7

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER SCIENCE BV

We evaluated the relationship between histopathological prognostic factors, tumor proliferation microvessel density (MVD), and enhancement parameters in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in oral squamous cell carcinoma (SCC). Twenty-eight T2 and T3 patients with primary oral SCC underwent DCE-MRI using three-dimensional fast imaging with a steady-state precession sequence. Tumor cell proliferation and MVD of all surgical specimens were evaluated using immunohistochemical staining with CD34 and the antibody for proliferating cell nuclear antigen (PCNA). Regression analysis was used to statistically analyze the relationship between the PCNA labeling index or MVD and each of three DCE-MRI parameters: maximum CI (CI-max), maximum CI gain (CI-gain) and the CI-gain / CI-max ratio. The PCNA labeling index and MVD showed significant correlations with the CI-gain/CI-max ratio (P = 0.0012, r = 0.581 and P = 0.00141, r = 0.574, respectively). The assessment of DCE-MRI parameters may prove to be a valuable non-invasive method for assessing tumor cell proliferation and MVD of patients with oral cancer. (C) 2008 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.oraloncology.2008.09.003

下顎側切歯部に認められた過剰歯の1例

片嶋和典, 芦田昌和, 村上純, 久富美紀, 柳文修, 松崎秀信, 此内浩信, 畦坪輝寿, 若狭亨, 繁原宏, 浅海淳一

岡山歯学会雑誌 28 ( 1 ) 61 - 63 2009.6

Language：Japanese Publisher：岡山歯学会

9歳女児。左側下顎乳臼歯のう蝕を主訴に近医を受診した。その際のX線検査によって、左側下顎側切歯遠心部における過剰歯の萠出、ならびに左側下顎第二小臼歯の先天的欠如の可能性を指摘された。左側下顎犬歯および第一小臼歯は未萠出で、将来同歯が正常に萠出するか不安を抱いたため、紹介受診した。左側切歯部に、切歯状を呈する歯が3本存在し、その3本のうち、過剰歯が1本存在していると考えられた。しかし、同歯を含む左側下顎切歯3本について、歯冠形態および萠出状態に差異はなく、また、若干黄ばんだ色調からも永久歯と思われ、いずれの歯が過剰歯か判然としなかった。パノラマX線写真による画像所見として、左側下顎前歯部の3本の切歯全てにおいて、エナメル質、象牙質、歯髄腔の区別ができ、歯冠形態および歯根の形成に差異はなく、また、根尖も同様に閉鎖、完成していることから、いずれの歯が過剰歯かは判然としなかった。

Analysis of magnetic resonance images of disk positions and deformities in 1,265 patients with temporomandibular disorder. International journal

Yong-Suk Choi, Jun-Ichi Asaumi, Miki Hisatomi, Teruhisa Unetsubo, Yoshinobu Yanagi, Hidenobu Matsuzaki, Hironobu Konouchi, Eui-Hwan Hwang, Sang-Rae Lee

The open dentistry journal 3 1 - 20 2009.3

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVES: To compare MRI manifestations according to gender and age and to identify correlations between clinical manifestations and MRI findings in patients with temporomandibular disorder (TMD) as based on a large series. MATERIALS AND METHODS: Fat suppressed oblique sagittal images of the open and closed mouth were acquired, and MRI scanning parameters were applied. RESULTS: The patients consisted of 946 females (average, 36.6 years old), and 319 males (average, 34.3 years old). In all TMD patients, 945 had symptoms in the unilateral temporomandibular joint (TMJ) and 320 in the bilateral TMJ. There were significant differences in the distribution of disk positions based on age, regardless of gender, in the unilaterally and bilaterally symptomatic groups; however, the results were not significant in the asymptomatic group. There were significant differences with respect to the distribution of disk positions between males and females in asymptomatic group and in the unilaterally symptomatic group, although the bilaterally symptomatic group did not show significant differences in this regard. As regards the disk positions in the joints of the three groups (asymptomatic group, unilaterally and bilaterally symptomatic groups), there were significant interactive effects of disk positions, regardless of gender. There were statistically significant age-related differences in disk deformities in all symptom groups, regardless of gender, except for in the group of males lacking symptoms in either joint. As regards disk deformities among the three groups studies here, there were significant interactive effects for disk positions, regardless of gender.

DOI： 10.2174/1874210600903010001

MRIを用いた顎骨内病変の鑑別

此内浩信, 柳文修, 久富美紀, 松崎秀信, 芦田昌和, 片嶋和典, 浅海淳一

日本口腔診断学会雑誌 22 ( 1 ) 143 - 144 2009.3

岡山大学歯学部の口腔領域悪性腫瘍患者におけるFDG-PET検査の有用性に関する検討

久富美紀, 此内浩信, 柳文修, 松崎秀信, 畦坪輝寿, 繁原宏, 加地充昌, 金澤右, 浅海淳一

岡山歯学会雑誌 27 ( 2 ) 99 - 103 2008.12

Language：Japanese Publisher：岡山歯学会

2006年4月〜2008年9月にPET撮影を行った頭頸部悪性腫瘍患者121名173例(男68名、女53名、年齢29〜89歳)を対象に検討した。半年毎の患者数は22例、32例、42例、38例、39例と推移し、術後の割合が36.4%、46.9%、57.1%、60.5%、64.1%と増加傾向を示した。原発巣は術前78例中73例(93.6%)にFDGの異常集積を認め、偽陰性5例は4例が上皮内癌からT1の表在性の悪性腫瘍で、1例が高血糖であった。術後94例中16例(17.0%)に異常集積を認め、表在性の悪性腫瘍1例は偽陰性であった。リンパ節は術前初発症例78例中24例(30.8%)、術後では94例中19例(20.2%)に異常集積を認め、偽陰性3例(1.7%)は高血糖1例、内部壊死を起こした2例であった。遠隔転移は7例で、2例は胸部CTで既に疑われており、5例はPET検査で認識でき、重複癌である多臓器原発の悪性腫瘍2例、原発性肺癌2例を認めた。以上より原発巣、所属リンパ節転移、遠位転移、重複癌の検出にPETの有用性が示されたが偽陰性も少なからずあることから、他のモダリティとの組み合わせにより診断能を向上させることが必要と考えた。

Evaluation of panoramic radiographs taken at the initial visit at a department of paediatric dentistry. International journal

J-I Asaumi, M Hisatomi, Y Yanagi, T Unetsubo, Y Maki, H Matsuzaki, Y Honda, H Konouchi

Dento maxillo facial radiology 37 ( 6 ) 340 - 3 2008.9

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVES: To examine oral and maxillofacial lesions other than those related to the chief complaint in panoramic radiographs taken at the department of paediatric dentistry at our hospital. METHODS: We retrospectively reviewed all 1092 patients who had visited the department of paediatric dentistry at our hospital and had a panoramic radiograph taken between August 1999 and October 2004. The following information was obtained from the patients' files and panoramic radiographs: gender, age, chief complaints and the presence or absence of lesions. RESULTS: Lesions were observed in 140 of the 1092 panoramic radiographs (12.8%). Among the 140 patients discovered to have lesions in the panoramic radiographs, 66 (47.1%, or 6.05% of the entire group of 1092 patients) had different lesions from those underlying the chief complaint. These 66 patients ages ranged from 3 years to 14 years and the lesions involved 39 (59.1%) missing teeth, 20 (30.3%) mesiodentes, 4 supernumerary teeth, 1 odontoma, 1 radicular cyst and 1 impacted tooth. The missing teeth were observed in the central and lateral incisor, canine, and first and second premolar positions of both jaws, especially in the lower lateral incisor and upper central incisor positions. CONCLUSIONS: We were able to detect incidental lesions at a rate of 6.05% (66 of 1092 patients) and at a relatively early age (mean 6.8 years) in the present study. Early treatment of these lesions could avoid maxillofacial deformity and other complications.

DOI： 10.1259/dmfr/31214423

放射線治療後の口腔乾燥に対し、塩酸ピロカルピン(サラジェン)を投与しフッ素塗布を用いた口腔ケアを行った2症例

水川展吉, 山中玲子, 山本龍生, 松崎秀信, 浅海淳一, 山近英樹, 植野高章, 高木慎, 菅原利夫

岡山歯学会雑誌 27 ( 1 ) 71 - 71 2008.6

放射線治療後の口腔乾燥症に対し、塩酸ピロカルピン(サラジェン)を投与しフッ素塗布を用いた口腔ケアを行った2症例

水川展吉, 山中玲子, 山本龍生, 松崎秀信, 浅海淳一, 山近英樹, 植野高章, 高木慎, 菅原利夫

岡山歯学会雑誌 26 ( 2 ) 129 - 133 2007.12

Language：Japanese Publisher：岡山歯学会

症例1:52歳男性。舌癌で放射線治療適応となり、組織内照射約70Gyを行った後、口腔乾燥を訴えるようになった。ガムテストでは6.2cc/10min.であった。放射線治療後の口腔乾燥症として塩酸ピロカルピン15mg/day投与と、齲蝕予防のために1〜2ヵ月に1回のフッ素塗布、連日のフッ素洗口を開始した。さらに家庭においてフッ化物配合歯磨剤を用いたブラッシングを勧めた。症例2:63歳男性。舌癌で放射線治療を希望し、外照射20Gyの後、組織内照射約70Gyを行った後、口腔乾燥を訴えるようになった。ガムテストでは5cc/10min.であった。放射線治療後の口腔乾燥症として塩酸ピロカルピン15mg/day投与と、齲蝕予防のために3週間に1回のフッ素塗布を開始した。さらに家庭においてフッ化物配合歯磨剤を用いたブラッシングを勧めた。症例1では自覚的にも他覚的にも口腔乾燥を脱し、副作用発現なく投与10週後に中止した。症例2では副作用の頻尿感などで投与10日後に中止となったが、2週間後には自覚的にも他覚的にも口腔乾燥感の改善がみられた。ともに齲蝕のコントロールは良好である。

Diagnostic value of dynamic contrast-enhanced MRI in the salivary gland tumors International journal

Miki Hisatomi, Jun-Ichi Asaumi, Yoshinobu Yanagi, Teruhisa Unetsubo, Yuu Maki, Jun Murakami, Hidenobu Matsuzaki, Yasutoshi Honda, Hironobu Konouchi

ORAL ONCOLOGY 43 ( 9 ) 940 - 947 2007.10

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER SCIENCE BV

To evaluate the diagnostic value of dynamic contrast-enhanced MRI (DCE-MRI) in salivary gland tumors, thirty-five patients (47 lesions) who underwent MR examinations and were histopathologically diagnosed with salivary gland tumors in Okayama University Hospital, between April 1998 and March 2005, were entered in the present study. The parameters included CImax300 or CImax6003 which was the contrast index (CI) at maximal contrast enhancement upon 300 s or 600 s, and T-max, which was the time that corresponded to the CImax300. Washout ratio (WR300 or WR600) was defined as follows: CImax300 - CI300s/CImax300 or CImax600 - CI600s/CImax600 X 100 (%), where CI300 or CI600 was the CI at 300 s or 600 s after contrast medium administration. We obtained the following results from the analysis of DCE-MRI parameters; (a) The salivary gland tumors were categorized into three Cl curve types according to Tmax and WR300; Pleomorphic adenoma; Tmax > 210 s and WR300 < 10%, Warthin tumor; Tmax < 60 s and WR300 > 40%, and malignant tumor; 60 s < Tmax < 210 s and 10% < WR300 < 30%; (b) On the basis of the relationship between Tmax and CImax or WR, all pleomorphic adenomas were successfully differentiated from Warthin tumor lesions. Of the 20 pleomorphic adenomas, 18 (90.0%) were successfully differentiated from malignant tumors. All Warthin tumor lesions were successfully differentiated from pleomorphic adenomas and malignant tumors. Of 12 the malignant tumors, 11 (91.7%) were successfully differentiated from pleomorphic adenomas. All malignant tumors were successfully differentiated from Warthin tumors. Thus, DCE-MRI parameters are useful in diagnosing salivary gland tumors on the basis of the combined assessment of Tmax and CImax or WR. (c) 2006 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.oraloncology.2006.11.009

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