Faculty Profiles - MATSUZAKI Hidenobu

Papers - MATSUZAKI Hidenobu

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Fibrous dysplasia of the maxilla: a case report together with its conventional imaging and dynamic magnetic resonance imaging findings

Marina Hara, Hidenobu Matsuzaki, Naoki Katase, Teruhisa Unetsubo, Yoshinobu Yanagi, Hitoshi Nagatsuka, Jun-ichi Asaumi

ORAL RADIOLOGY 30 ( 1 ) 105 - 110 2014.1

Language：English Publishing type：Research paper (scientific journal) Publisher：SPRINGER

We previously reported that dynamic contrast-enhanced MRI parameters and time-signal intensity curves (TICs; also known as contrast index curves) are useful for the differential diagnosis of jawbone lesions. In particular, odontogenic fibroma and ossifying fibroma, which possess similar histopathological features (i.e., a mixture of hard and soft tissue components), display unique TIC patterns, and we consider that the TIC patterns of these lesions reflect their hard and soft tissue components. Therefore, fibrous dysplasia, which contains fibrous tissue and immature isolated trabeculae composed of woven bone, is expected to display an interesting TIC. The purpose of this study was to assess the utility of TICs for differentiating between the abovementioned lesions, which have similar histopathological components.

DOI： 10.1007/s11282-013-0137-1

Diagnostic value of MR imaging for dentigerous cysts

Hironobu Konouchi, Jun-ichi Asaumi, Yoshinobu Yanagi, Miki Hisatomi, Emiko Saito Arita, Plauto Christopher Aranha Watanabe, Jun Murakami, Teruhisa Unetsubo, Mariko Fujita, Shunsuke Okada, Hidenobu Matsuzaki, Toshihiko Takenobu, Toru Wakasa

ORAL RADIOLOGY 30 ( 1 ) 13 - 19 2014.1

Language：English Publishing type：Research paper (scientific journal) Publisher：SPRINGER

It is known that the magnetic resonance (MR) imaging features of dentigerous cysts (DCs) are the same as those of other cysts. The cavities of DCs generally show low signal intensity (SI) on T1-weighted imaging (T1WI). However, in our experience, DCs often show high SI on T1WI, rendering them difficult to distinguish from keratocystic odontogenic tumors (KCOTs). In this study, we evaluated seven cases of DC and 23 cases of KCOT to assess whether MR imaging can provide additional information for the differential diagnosis of DC and KCOT.Two trials were evaluated. The first trial was an analysis of the cystic cavity SI on T1WI. To compare the SI between patients, we performed T1WI with contrast (T1c). The second trial analyzed the SI uniformity (U (I )) pound on T1WI, T2-weighted imaging (T2WI), and short inversion time inversion recovery (STIR) images of the cystic cavity, because it has been reported that an MR imaging feature of KCOT is heterogeneous SI. Statistical analyses were performed using the Mann-Whitney U test and a receiver operating characteristic (ROC) curve.The T1c values of DCs were significantly higher than those for KCOTs. The U (I ) pound values on T1WI and STIR images were significantly higher for DCs than for KCOTs. The T1c cutoff values (0.66 and 0.84) and U (I ) pound cutoff values for T1WI (82.1 %) and STIR images (79.8 %) were determined from the ROC analyses.T1c and U (I ) pound values provide useful additional information for the differential diagnosis of DC and KCOT.

DOI： 10.1007/s11282-013-0128-2

In Vitro Assessment of Factors Affecting the Apparent Diffusion Coefficient of Jurkat Cells Using Bio-phantoms

Kazunori Katashima, Masahiro Kuroda, Masakazu Ashida, Takanori Sasaki, Takehito Taguchi, Hidenobu Matsuzaki, Jun Murakami, Yoshinobu Yanagi, Miki Hisatomi, Marina Hara, Hirokazu Kato, Yuichi Ohmura, Tomoki Kobayashi, Susumu Kanazawa, Sosuke Harada, Mitsuhiro Takemoto, Seiichiro Ohno, Seiichi Mimura, Junichi Asaumi

ACTA MEDICA OKAYAMA 67 ( 6 ) 359 - 367 2013.12

Language：English Publishing type：Research paper (scientific journal) Publisher：OKAYAMA UNIV MED SCHOOL

It is well known that many tumor tissues show lower apparent diffusion coefficient (ADC) values, and that several factors are involved in the reduction of ADC values. The aim of this study was to clarify how much each factor contributes to decreases in ADC values. We investigate the roles of cell density, extracellular space, intracellular factors, apoptosis and necrosis in ADC values using bio-phantoms. The ADC values of bio-phantoms, in which Jurkat cells were encapsulated by gellan gum, were measured by a 1.5-Tesla magnetic resonance imaging device with constant diffusion time of 30 sec. Heating at 42 degrees C was used to induce apoptosis while heating at 48 degrees C was used to induce necrosis. Cell death after heating was evaluated by flow cytometric analysis and electron microscopy. The ADC values of bio-phantoms including non-heated cells decreased linearly with increases in cell density, and showed a steep decline when the distance between cells became less than 3 mu m. The analysis of ADC values of cells after destruction of cellular structures by sonication suggested that approximately two-thirds of the ADC values of cells originate from their cellular structures. The ADC values of bio-phantoms including necrotic cells increased while those including apoptotic cells decreased. This study quantitatively clarified the role of the cellular factors and the extracellular space in determining the ADC values produced by tumor cells. The intermediate diffusion time of 30 msec might be optimal to distinguish between apoptosis and necrosis.

Swelling of the floor of the mouth in an infant International journal

Hidenobu Matsuzaki, Naoki Katase, Norifumi Moritani, Marina Hara, Yoshinobu Yanagi, Jun-Ichi Asaumi

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY 116 ( 4 ) 392 - 397 2013.10

Diagnostic value of MRI for odontogenic tumours

M. Fujita, H. Matsuzaki, Y. Yanagi, M. Hara, N. Katase, M. Hisatomi, T. Unetsubo, H. Konouchi, H. Nagatsuka, J. I. Asaumi

Dentomaxillofacial Radiology 42 ( 5 ) 2013.5

Publishing type：Research paper (scientific journal)

Objectives: To evaluate the diagnostic value of MRI for odontogenic tumours. Materials and methods: 51 patients with odontogenic tumours were subjected to preoperative MRI examinations. For tumours with liquid components, i.e. ameloblastomas and keratocystic odontogenic tumours (KCOTs), the signal intensity (SI) uniformity of their cystic components (US) was calculated and then their US values were compared. For tumours with solid components that had been examined using dynamic contrast-enhanced MRI (DCEMRI), their CI max (maximum contrast index), Tmax (the time when CImax occurred), CIpeak (CImax×0.90), Tpeak (the time when CIpeak occurred) and CI300 (i.e. the CI observed at 300 s after contrast medium injection) values were determined from CI curves. We then classified the odontogenic tumours according to their DCE-MRI parameters. Results: Significant differences between the US values of the ameloblastomas and KCOT were observed on T1 weighted images, T2 weighted images and short TI inversion recovery images. Depending on their DCE-MRI parameters, we classified the odontogenic tumours into the following five types: Type A, CIpeak > 2.0 and Tpeak < 200 s; Type B, CIpeak < 2.0 and Tpeak < 200 s; Type C, CI 300 > 2.0 and Tmax < 600 s; Type D, CI300 > 2.0 and Tmax > 600 s; Type E, CI300 < 2.0 and Tmax > 600 s. Conclusion: Cystic component SI uniformity was found to be useful for differentiating between ameloblastomas and KCOT. However, the DCE-MRI parameters of odontogenic tumours, except for odontogenic fibromas and odontogenic myxomas, contributed little to their differential diagnosis. © 2013 The British Institute of Radiology.

DOI： 10.1259/dmfr.20120265

Clinical application of coneone-beam computed tomography by oral surgeons

Hidenobu Matsuzaki, Marina Hara, Takanobu Haruki, Jun-Ichi Asaumi

Computed Tomography: New Research 112 - 122 2013.3

Language：English Publishing type：Part of collection (book) Publisher：Nova Science Publishers, Inc.

The development of cone-beam computed tomography (CBCT) has improved the diagnosis and treatment in the oral and maxillofacial region. CBCT is reliable for evaluating hard tissues and anatomical structures in the case of jawbone fractures. CBCT can detect clearly hard tissue lesions such as mesiodens and odontoma. CBCT images allow oral surgeons to understand the three-dimensional (3D) anatomy of the lesion, including the surrounding structures, in detail. In this chapter, we will describe the clinical use of CBCT for the imaging of traumatic injuries, mesiodens, odontomas, osteomyelitis and cystic lesions in the jaw by oral surgeons. © 2013 Nova Science Publishers, Inc. All rights reserved.

Conditions Inhibiting Eruption of Permanent First Molars

Hidenobu Matsuzaki, Yoshinobu Yanagi, Naoki Katase, Hitoshi Nagatsuka, Marina Hara, Masakazu Ashida, Teruhisa Unetsubo, Akiko Sato, Mariko Fujita, Toshihiko Takenobu, Jun-ichi Asaumi

PEDIATRIC DENTISTRY 35 ( 1 ) 67 - 70 2013.1

Language：English Publishing type：Research paper (scientific journal) Publisher：AMER ACAD PEDIATRIC DENTISTRY

Purpose: The purpose of this study was to evaluate the radiological and histopathological findings of 11 patients with unerupted first molars to verify the factors obstructing spontaneous eruption. Methods: The patients' clinical, radiological, and histopathological data were evaluated retrospectively to determine histopathological diagnosis, radiographic findings, methods of surgical management, and postoperative course. Results: This study involved 4 male and 7 female patients (mean age=9.5 years old). Nine cases involved the mandible. The patients' histopathological diagnoses included 3 odontogenic tumors, 2 odontogenic cysts, and 6 hyperplastic dental follicles. Radiographically, 10 cases showed characterless enlargement of the follicular space, while only 1 displayed radiopaque bodies. One patient with a tumor underwent enucleation, and 1 with a cyst underwent cystectomy and tooth extraction. The others underwent wide excision or partial excision of the surrounding tissue at the top of the impacted tooth. Tumor relapse was observed in 3 cases. Conclusion: Surgeons should perform aggressive treatment for patients with unerupted teeth because spontaneous eruption is rare in cases involving non-neoplastic lesions such as hyperplastic dental follicles.

「歯科放射線学分野」の講義試験におけるe-learning(WebClassシステム)の活用

此内浩信, 畔坪輝寿, 久富美紀, 柳文修, 松崎秀信, 竹信俊彦, 若狭亨, 村上純, 岡田俊輔, 浅海淳一

岡山歯学会雑誌 31 ( 2 ) 73 - 79 2012.12

Language：Japanese Publisher：岡山歯学会

「歯科放射線学分野」の講義試験としてe-learning(WebClassシステム)によるPCを用いた試験を試み、受験生56名に試験後アンケート調査を行ってその有用性について検討した。肯定的回答(大変そう思う・そう思う)の割合は、PC使用試験については「共用試験CBTの予行として役立つ」100%、「試験解説がすぐに受けられる」93%、「試験結果がすぐに公表される」78%で、低かったのは「試験に集中しやすい」46%、「システムの使用が難しい」49%であった。試験会場については「席による不公平がない」91%、「講義室からの移動が面倒」71%であった。視覚素材については、「あると問題が理解しやすい」96%、「問題が難しくなる」52%であった。試験内容(選択問題)については、「国家試験、CBTの予行になる」「採点結果が明確」100%、「理解度をアピールしにくい」72%、「楽だ」35%、「語彙力、理解力低下につながる」47%であった。共用試験CBT後のアンケートではPC使用試験が「予行として役立った」98%であった。

Solid-type primary intraosseous squamous cell carcinoma of the mandible: a case report with histopathological and imaging features International journal

Hidenobu Matsuzaki, Naoki Katase, Tatsushi Matsumura, Marina Hara, Yoshinobu Yanagi, Hitoshi Nagatsuka, Seiji Iida, Jun-Ichi Asaumi

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY 114 ( 5 ) E71 - E77 2012.11

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER SCIENCE INC

Primary intraosseous squamous cell carcinoma (PIOSCC) is a rare malignant odontogenic tumor arising from odontogenic epithelial remnants within the jawbones. PIOSCC is histopathologically divided into 3 types: solid-type carcinoma, carcinoma derived from a keratocystic odontogenic tumor, and carcinoma derived from an odontogenic cyst. In this article, we report a case of solid-type PIOSCC involving reactive bone formation in the mandible in a 60-year-old female patient together with its histopathological and imaging findings. (Oral Surg Oral Med Oral Pathol Oral Radiol 2012;114:e71-e77)

DOI： 10.1016/j.oooo.2012.05.019

Diagnostic value of dynamic contrast-enhanced MRI for submucosal palatal tumors International journal

Hidenobu Matsuzaki, Yoshinobu Yanagi, Marina Hara, Naoki Katase, Miki Hisatomi, Teruhisa Unetsubo, Hironobu Konouchi, Toshihiko Takenobu, Hitoshi Nagatsuka, Jun-ichi Asaumi

EUROPEAN JOURNAL OF RADIOLOGY 81 ( 11 ) 3306 - 3312 2012.11

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER IRELAND LTD

Objectives: To evaluate the diagnostic value of dynamic contrast-enhanced MRI (DCE-MRI) for differentiating between benign and malignant tumors in the palate.Materials and methods: 26 patients with submucosal palatal tumors were preoperatively examined using DCE-MRI. Their maximum contrast index (CImax), time of CImax (Tmax), and washout ratios (WR300 and WR600) were determined from contrast index curves. The submucosal palatal tumors were divided into two groups according to their Tmax values: the early enhancement group (Tmax < 300 s) consisted of 9 malignant tumors and 6 benign tumors, while the late enhancement group (Tmax >= 300 s) included one malignant tumor and 10 benign tumors. We compared the following DCE-MRI parameters between the benign and malignant tumors: CImax and Tmax in all cases and CImax, Tmax, and the washout ratios in the early enhancement group. In addition, we performed a regression analysis of the relationships between tumor size and DCE-MRI parameters; i. e., CImax, Tmax, and washout ratios, among the malignant salivary gland tumors and pleomorphic adenomas.Results: In all cases and the early enhancement group, significant differences in Tmax were detected between the benign and malignant tumors (P < 0.001 and P < 0.05, respectively), and the optimal Tmax cutoff value for differentiating between them was found to be 165 s. None of the other parameters displayed significant differences between the benign and malignant tumors. Only the WR600 of the pleomorphic adenomas was significantly correlated with tumor size (R-2 = 0.92, P < 0.001).Conclusions: Tmax is a useful parameter for distinguishing between benign and malignant submucosal palatal tumors. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

DOI： 10.1016/j.ejrad.2012.04.009

Minor salivary gland tumors in the oral cavity: Diagnostic value of dynamic contrast-enhanced MRI International journal

Hidenobu Matsuzaki, Yoshinobu Yanagi, Marina Hara, Naoki Katase, Jun-ichi Asaumi, Miki Hisatomi, Teruhisa Unetsubo, Hironobu Konouchi, Toshihiko Takenobu, Hitoshi Nagatsuka

EUROPEAN JOURNAL OF RADIOLOGY 81 ( 10 ) 2684 - 2691 2012.10

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER IRELAND LTD

Objective: To evaluate the diagnostic value of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for minor salivary gland tumors in the oral cavity.Materials and methods: Thirty-two patients with minor salivary gland tumors were examined preoperatively using DCE-MRI. Their maximum contrast index (CImax), time of CImax (Tmax), Tpeak; i.e., the time that corresponded to the CImax x 0.90, and washout ratios (WR300 and WR600) were determined from contrast index (CI) curves. We compared these parameters between benign and malignant tumors and among the different histopathological types of minor salivary gland tumors. Then, we categorized the patients' CI curves into four patterns (gradual increase, rapid increase with high washout ratio, rapid increase with low washout, and flat).Results: Statistically significant differences in Tmax (P = 0.004) and Tpeak (P = 0.002) were observed between the benign and malignant tumors. Regarding each histopathological tumor type, significant differences in Tmax (P < 0.001), Tpeak (P < 0.001), and WR600 (P = 0.026) were observed between the pleomorphic adenomas and mucoepidermoid carcinomas. It was difficult to distinguish between benign and malignant tumors using our CI curve classification because that two-thirds of the cases were classified into the same type (gradual increase).Conclusion: The DCE-MRI parameters of minor salivary gland tumors contributed little to their differential diagnosis compared with those for major salivary gland tumors. During the diagnosis of minor salivary gland tumors, Tmax is useful for distinguishing between benign and malignant tumors. (c) 2011 Elsevier Ireland Ltd. All rights reserved.

DOI： 10.1016/j.ejrad.2011.11.005

Ossifying fibroma of the maxilla: a case report including its imaging features and dynamic magnetic resonance imaging findings International journal

Marina Hara, Hidenobu Matsuzaki, Naoki Katase, Yoshinobu Yanagi, Teruhisa Unetsubo, Jun-ichi Asaumi, Hitoshi Nagatsuka

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY 114 ( 4 ) E139 - E146 2012.10

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER SCIENCE INC

Ossifying fibroma (OF), a rare nonodontogenic tumor, is defined as a bone-related jawbone lesion. The main histopathological feature of OF is the replacement of bone by benign connective tissue. Ossifying fibroma usually occurs in the second to fourth decades of life and shows a predilection for females. Ossifying fibroma most commonly occurs in the mandible, and OF arising from the anterior part of the maxilla is rare. Ossifying fibromas display various radiographic findings, including varying degrees of radiolucency and radiopacity, depending on the proportions of their soft and hard tissue components. Depending on their components, it can be difficult to distinguish OF from other fibroosseous lesions and some odontogenic tumors by using conventional radiographs, computed tomography, and magnetic resonance imaging (MRI). We report a case of OF in the anterior maxilla in a 56-year-old man, together with its histopathological and imaging findings including the dynamic MRI findings. (Oral Surg Oral Med Oral Pathol Oral Radiol 2012;114:e139-e146)

DOI： 10.1016/j.oooo.2012.04.015

Unusual MRI appearance of a lymphoepithelial cyst in the parotid gland

Hidenobu Matsuzaki, Naoki Katase, Yoshinobu Yanagi, Marina Hara, Mariko Fujita, Teruhisa Unetsubo, Hitoshi Nagatsuka, Jun-ichi Asaumi

ORAL RADIOLOGY 28 ( 2 ) 133 - 139 2012.9

Language：English Publishing type：Research paper (scientific journal) Publisher：SPRINGER

Lymphoepithelial cysts, which are also known as branchial cleft cysts, commonly occur in the lateral cervical region. Lymphoepithelial cysts arising in the parotid gland are rare and must be distinguished from parotid gland tumors. Magnetic resonance imaging (MRI) is useful for diagnosing parotid gland lesions, and MR images of lymphoepithelial cysts typically display a cystic mass that appears homogeneously hypointense on T1-weighted images and homogeneously hyperintense on T2-weighted images. However, some parotid gland tumors that retain fluid in their inner sections show similar MRI findings to lymphoepithelial cysts. Furthermore, lymphoepithelial cysts are sometimes modified by inflammation, and these cases are hard to diagnose. We report the case of a 59-year-old female with a lymphoepithelial cyst that arose in the parotid gland. The cyst had been affected by inflammation and displayed atypical imaging findings, i.e., heterogeneous signal intensity of the liquid component and the presence of a well-enhanced capsule-like structure surrounding the liquid component. In addition, we compare the MRI findings of this case with those of two other cervical lymphoepithelial cysts.

DOI： 10.1007/s11282-012-0086-0

Imaging features of adenoid cystic carcinoma of the tongue with dedifferentiated components: a case report

Yoshinobu Yanagi, Hidenobu Matsuzaki, Naoki Katase, Tomoo Onoda, Marina Hara, Teruhisa Unetsubo, Hitoshi Nagatsuka, Jun-ichi Asaumi

ORAL RADIOLOGY 28 ( 2 ) 157 - 165 2012.9

Language：English Publishing type：Research paper (scientific journal) Publisher：SPRINGER

Adenoid cystic carcinoma (ACC) of the head and neck region is an uncommon epithelial tumor of the major and minor salivary glands. In the oral region, although ACC arising from the minor salivary glands is the second most commonly found tumor in the tongue base, its occurrence in the anterior part of the tongue is rare. Histopathologically, ACC is categorized into three growth patterns (tubular, cribriform, and solid types) and three histologic grades (I-III) that are based on the proportions of these patterns. According to this classification, tubular- and cribriform-type ACCs are considered to be lower grade lesions, while solid-type ACCs are considered to be higher grade lesions. A fourth histopathological type has recently been reported by some authors, namely, dedifferentiation or high-grade transformation of ACC. However, very few studies have focused on the imaging features of these ACCs. We report here the case of a 63-year-old female patient with ACC of the tongue with dedifferentiated components, together with the radiological images and pathological features of this ACC.

DOI： 10.1007/s11282-012-0097-x

In Vitro Assessment of Factors Affecting the Apparent Diffusion Coefficient of Ramos Cells Using Bio-phantoms

Takanori Sasaki, Masahiro Kuroda, Kazunori Katashima, Masakazu Ashida, Hidenobu Matsuzaki, Junichi Asaumi, Jun Murakami, Seiichiro Ohno, Hirokazu Kato, Susumu Kanazawa

ACTA MEDICA OKAYAMA 66 ( 3 ) 263 - 270 2012.6

Language：English Publishing type：Research paper (scientific journal) Publisher：OKAYAMA UNIV MED SCHOOL

The roles of cell density, extracellular space, intracellular factors, and apoptosis induced by the molecularly targeted drug rituximab on the apparent diffusion coefficient (ADC) values were investigated using bio-phantoms. In these bio-phantoms, Ramos cells (a human Burkitt's lymphoma cell line) were encapsulated in gellan gum. The ADC values decreased linearly with the increase in cell density, and declined steeply when the extracellular space became less than 4 gm. The analysis of ADC values after destruction of the cellular membrane by sonication indicated that approximately 65% of the ADC values of normal cells originate from the cell structures made of membranes and that the remaining 35% originate from intracellular components. Microparticles, defined as particles smaller than the normal cells, increased in number after rituximab treatments, migrated to the extracellular space and significantly decreased the ADC values of bio-phantoms during apoptosis. An in vitro study using bio-phantoms was conducted to quantitatively clarify the roles of cellular factors and of extracellular space in determining the ADC values yielded by tumor cells and the mechanism by which apoptosis changes those values.

Central odontogenic fibroma of the jawbone: 2 case reports describing its imaging features and an analysis of its DCE-MRI findings International journal

Marina Hara, Hidenobu Matsuzaki, Naoki Katase, Yoshinobu Yanagi, Teruhisa Unetsubo, Jun-Ichi Asaumi, Hitoshi Nagatsuka

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY 113 ( 6 ) E51 - E58 2012.6

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER SCIENCE INC

Odontogenic fibroma (OF) is a rare nonepithelial benign tumor arising from the odontogenic mesenchymal tissue in the jawbone. OFs are topographically categorized into 2 types, the central type and peripheral type, and are histopathologically divided into the epithelium-poor type and epithelium-rich type. The radiological findings of central OF commonly include a uni- or multilocular radiolucent area with a well-defined margin, which are similar to those of cysts and other benign tumors of the jawbone. Therefore, it is difficult to distinguish OF from these jawbone lesions on radiographs because of their noncharacteristic radiological findings. In this article, we report the cases of 2 patients with central OF who underwent magnetic resonance (MR) examinations and describe the usefulness of dynamic contrast-enhanced MR imaging for diagnosing OF. (Oral Surg Oral Med Oral Pathol Oral Radiol 2012;113:e51-e58)

DOI： 10.1016/j.oooo.2011.12.013

Recent advances in the diagnostic imaging of cysts and pseudocysts in the oral and maxillofacial region

Jun ichi Asaumi, Hironobu Konouchi, Yoshinobu Yanagi, Miki Hisatomi, Hidenobu Matsuzaki, Jun Murakami, Teruhisa Unetsubo, Mariko Fujita, Marina Hara

Cysts: Causes, Diagnosis and Treatment Options 1 - 53 2012.3

Publishing type：Part of collection (book)

It is sometimes difficult to differentiate cysts and pseudocysts from tumors in the jawbone on the basis of conventional radiographs. Moreover, cysts and pseudocysts that arise in soft tissue can not be detected on radiographic images without the use of contrast agents. Therefore, additional information is sometimes required to diagnose these lesions. Computed tomography and magnetic resonance imaging (CT; MRI) have been demonstrated to be very useful for depicting normal structures and pathological processes in the oral and maxillofacial region. Whereas CT is best for depicting bone structures, MRI is superior to CT at evaluating soft tissue. The contents of bone lesions might also be better visualized on MRI. In this chapter, among the variety of lesions that occur in the oral and maxillofacial region, we would like to focus on those arising in the jaw or adjacent soft tissue. We present their representative CT and MRI findings and discuss the imaging characteristics that most contribute to their differential diagnosis. © 2012 by Nova Science Publishers, Inc. All rights reserved.

Magnetic resonance imaging (MRI) and dynamic MRI evaluation of extranodal non-Hodgkin lymphoma in oral and maxillofacial regions International journal

Hidenobu Matsuzaki, Marina Hara, Yoshinobu Yanagi, Jun-ichi Asaumi, Naoki Katase, Teruhisa Unetsubo, Miki Hisatomi, Hironobu Konouchi, Toshihiko Takenobu, Hitoshi Nagatsuka

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY 113 ( 1 ) 126 - 133 2012.1

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER SCIENCE INC

Objective. The purpose of this study was to evaluate the diagnostic value of magnetic resonance imaging (MRI), especially dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), in extranodal non-Hodgkin lymphoma (NHL) of oral and maxillofacial regions.Study design. Thirteen cases with extranodal NHL were examined using MRI. T1-weighted images (T1WI) and T2-weighted images (T2WI) or short TI inversion recovery (STIR) images were obtained in all cases. Contrast-enhanced images and DCEM-RI were acquired in 10 and 7 cases, respectively. On DCE-MRIs, we analyzed the parameters as follows: contrast index at maximal contrast enhancement (CImax), maximum contrast index (CI) gain/CImax ratio, and washout ratios (WR300, WR600, and WR900) at 300, 600, and 900 seconds after contrast medium injection.Results. The signal intensity of all lesions was hypointense to isointense on T1WIs and showed variable contrast enhancement patterns. On T2WIs and STIR images, the signal intensity was isointense to hyperintense in almost all cases. Analysis of DCE-MRI parameters in extranodal NHLs resulted in the identification of 4 types of CI curves according to CImax and WR: (1) CImax greater than 2.0 and WR900 greater than 40%, (2) CImax greater than 2.0 and WR900 less than 40%, (3) CImax less than 1.5 and WR900 greater than 40%, and (4) CImax less than 1.5 and WR900 greater than 40%.Conclusions. The signal intensities on MRI were not specific to extranodal NHL and resembled those of other tumor types. When CImax was less than 1.5 or WR900 was less than 40%, these parameters contributed to diagnosis in extranodal NHLs. (Oral Surg Oral Med Oral Pathol Oral Radiol 2012; 113: 126-133)

DOI： 10.1016/j.tripleo.2011.07.038

Two-piece customized mold technique for high-dose-rate brachytherapy on cancers of the buccal mucosa and lip International journal

Hidenobu Matsuzaki, Mitsuhiro Takemoto, Marina Hara, Teruhisa Unetsubo, Yoshinobu Yanagi, Kuniaki Katsui, Norihisa Katayama, Kotaro Yoshio, Toshihiko Takenobu, Masahiro Kuroda, Susumu Kanazawa, Jun-Ichi Asaumi

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY 113 ( 1 ) 118 - 125 2012.1

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER SCIENCE INC

Objective. High-dose-rate (HDR) brachytherapy using a customized mold is a minimally invasive treatment for oral cancer; however, it is difficult to use this technique for buccal and lip cancers involving the commissura labiorum, owing to its anatomic form. The purpose of this study was to introduce an improved customized mold consisting of 2 pieces to allow the fixation of molds to these sites.Study design. Five patients with buccal carcinoma and 1 patient with lip carcinoma were treated with this technique after external beam radiotherapy. One patient with neck metastasis underwent both neck dissection and partial tumor resection before HDR brachytherapy.Results. At the end of the follow-up period, 5 patients had no tumor recurrence, and 1 patient had suffered local recurrence.Conclusions. Our technique is a viable therapeutic option for patients with buccal and lip carcinomas for whom the therapeutic modalities are limited by age, performance status, and other factors. (Oral Surg Oral Med Oral Pathol Oral Radiol 2012;113:118-125)

DOI： 10.1016/j.tripleo.2011.06.038

歯科用コーンビームCTの適正使用について被曝量と放射線防護の観点から

柳文修, 林邦夫, 竹信俊彦, 松崎秀信, 村上純, 片嶋和典, 藤田麻里子, 浅海淳一

岡山歯学会雑誌 30 ( 2 ) 88 - 89 2011.12

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