Faculty Profiles - MATSUZAKI Hidenobu

Papers - MATSUZAKI Hidenobu

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ANL Secondary Publication 上顎洞癌に対する動注化学放射線治療の病理学的評価

牧野琢丸, 橘智靖, 假谷伸, 松井裕輔, 松崎秀信, 藤本将平, 折田頼尚, 藤井邦明, 平木隆夫, 佐藤康晴, 金澤右, 西崎和則

日本耳鼻咽喉科頭頸部外科学会会報 125 ( 5 ) 913 - 915 2022.5

Pathological evaluation of radiotherapy and concomitant intraarterial cisplatin for maxillary sinus cancer International journal

Takuma Makino, Tomoyasu Tachibana, Shin Kariya, Yusuke Matsui, Hidenobu Matsuzaki, Shohei Fujimoto, Yorihisa Orita, Kuniaki Katsui, Takao Hiraki, Yasuharu Sato, Susumu Kanazawa, Kazunori Nishizaki

AURIS NASUS LARYNX 47 ( 5 ) 881 - 886 2020.10

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER SCI LTD

Objective: Since 2010, we have mainly performed surgical treatment following radiotherapy and concomitant intraarterial cisplatin (RADPLAT) for locally advanced maxillary sinus cancer (MSC). The present study investigated treatment results and pathological evaluations following RADPLAT for MSC.Methods: Pathological response to RADPLAT was evaluated using surgical specimens. Pathological response was graded in accordance with the classification method that Shimosato reported in 1964, as grade V (no tumor cells remain in any of section), grade IV, III, II, I, and 0. Five-year overall and disease-specific survival rates were estimated using Kaplan-Meier methods. Univariate analyses of correlations between recurrence of MSC and other clinicopathological parameters were evaluated using the chi-square or Fisher's exact tests.Result: 19 patients were enrolled in this study, 5 patients showed T3 disease and 14 had T4 disease. One patient demonstrated local recurrence and 3 patients experienced distant metastasis. The 5-year overall survival rate was 67.1% (T3, 50.0%; T4, 69.6%), and the 5-year disease-specific survival rate was 81.9% (T3, 100%; T4, 76.0%). Histological response was categorized as grade V in 9 cases. No significant risk factors for residual cancer were identified.Conclusion: Our study suggested that RADPLAT not only has a low risk of side effects, but also could represent an effective procedure for locally advanced MSC by pathological evaluation. Increasing the therapeutic intensity of RADPLAT might provide an effective modality to avoid highly invasive surgery. (C) 2020 Oto-Rhino-Laryngological Society of Japan Inc. Published by Elsevier B.V. All rights reserved.

DOI： 10.1016/j.anl.2020.04.004

Morphological characteristics of radicular cysts using computed tomography

Shintaro Sukegawa, Hidenobu Matsuzaki, Naoki Katase, Hotaka Kawai, Takahiro Kanno, Jun-ichi Asaumi, Yoshihiko Furuki

ODONTOLOGY 108 ( 1 ) 74 - 83 2020.1

Language：English Publishing type：Research paper (scientific journal) Publisher：SPRINGER

The purpose of this study was to evaluate computed tomography (CT) findings of radicular cysts with a focus on location, size, and condition of the surrounding bone. Subjects comprised 60 men and 86 women (mean age 47.2 years) with histopathologically confirmed radicular cysts who underwent CT examination between 2012 and 2014. Mesiodistal and buccolingual diameters were measured at the location where the lesion appeared to be largest on CT axial images. Of the 146 cases, 103 lesions were in the maxilla and 43 were in the mandible. Mesiodistal diameter of the maxillary lesions was significantly larger than that of the mandibular lesions. However, the ratio of mesiodistal diameter to buccolingual diameter in the mandible was significantly larger than that in the maxilla. Bone expansion was more significant in the maxilla than in the mandible. Mesiodistal and buccolingual diameters in only the maxilla and perilesional sclerotic radiolucency in images of both jaws were significantly associated with the severity of clinical symptoms. The findings suggest that radicular cysts in the maxilla are accompanied by bone expansion in the mesiodistal and buccolingual directions and those in the mandible progress in the mesiodistal direction without bone expansion. Clinical acute symptoms (pain and swelling) are correlated with lesion size in the maxilla; such a correlation is not clear for mandibular lesions, and discovery of mandibular lesions may, therefore, be delayed.

DOI： 10.1007/s10266-019-00443-5

Evaluation of weight loss during intensity-modulated radiation therapy for head and neck cancer patients

Matsuzaki Hidenobu, Yoshiyama Masahiro, Asaumi Jun-ichi, Kimata Yoshihiro, Katsui Kuniaki, Matsuzaki Kumiko, Nagamoto Yukiko, Takahara Yoko, Kubo Kazuko, Kajikiyo Tomomi, Mizukawa Nobuyoshi, Kariya Shin

Toukeibu Gan 46 ( 3 ) 264 - 269 2020

Language：Japanese Publisher：Japan Society for Head and Neck Cancer

The purpose of this study was to investigate the predictive factors of weight loss in head and neck cancer patients treated by intensity-modulated radiation therapy （IMRT）. We retrospectively reviewed 43 patients with head and neck cancers treated with radical RT at doses ≥ 60Gy from January 2016 to December 2018. All patients received chemo-IMRT. The median weight loss was 8.5％. The incidence of weight loss ≥ 5％ was 88％（38 patients） and ≥ 10％ was 35％（15 patients）. The factors significantly associated with ≥ 10％ weight loss in the univariate analysis were younger age （p＝0.009）, size of planning target volume for gross tumor volume （＜0.001）, size of total planning target volume including prophylactic nodal areas （p＝0.021）, presence of lymph node metastasis （p＝0.04）, higher maximum radiation dose in the oral cavity （p＝0.02）, and dental status （maxillary and/or mandibular edentulous, p＝0.008）. Sex, body mass index, tumor site, T stage, diabetes mellitus, percutaneous endoscopic gastrostomy, and mean dose of radiation in the oral cavity were not significantly associated with weight loss. In multivariate analysis of ≥ 10％ weight loss, younger age （p＝0.03） and dental status （dentulous patient, p＝0.013） were significantly associated with weight loss. From these results, younger age and dental status （dentulous patient） might be predictors of ≥ 10％ weight loss during IMRT for head and neck cancer.

DOI： 10.5981/jjhnc.46.264

Single institutional experience of radiation therapy for angiosarcoma of the scalp without cervical lymph node metastases: Impact of concurrent chemoradiation with maintenance chemotherapy using taxanes on patient prognosis International journal

Hiroki Ihara, Tatsuya Kaji, Kuniaki Katsui, Tomoko Miyake, Takahiro Waki, Norihisa Katayama, Hidenobu Matsuzaki, Osamu Yamasaki, Masahiro Kuroda, Shin Morizane, Susumu Kanazawa

MOLECULAR AND CLINICAL ONCOLOGY 11 ( 5 ) 498 - 504 2019.11

Language：English Publishing type：Research paper (scientific journal) Publisher：SPANDIDOS PUBL LTD

Cutaneous angiosarcoma is a rare aggressive malignant tumor. Concurrent chemoradiation (CCRT) with maintenance chemotherapy using taxanes is one of the primary treatments. The aim of the present study was to retrospectively analyze the efficacy of CCRT with maintenance chemotherapy using taxanes in localized angiosarcoma of the scalp without cervical lymph node metastases. A total of 19 patients treated with radiation therapy for localized angiosarcomas of the scalp without cervical lymph node metastases were enrolled. The overall survival (OS), progression-free survival (PFS), and local control (LC) rates were calculated using Kaplan-Meier analysis. Univariate analyses were performed for various potential prognostic factors for OS, PFS, and LC. The median radiation dose was 70 Gy (range, 60-70 Gy), and the fractional dose was 2 Gy. Radiation therapy alone, radiation therapy + interleukin-2, surgery + CCRT with maintenance chemotherapy, CCRT with maintenance chemotherapy, and CCRT without maintenance chemotherapy were administered to 2, 4, 2, 9 and 2 patients, respectively. The 1- and 3-year OS, PFS, and LC rates were 88 and 52%, 47 and 33%, and 74 and 56%, respectively. CCRT with maintenance chemotherapy and surgery were significant prognostic factors for PFS (P=0.036 and 0.025, respectively). Therefore, CCRT with maintenance chemotherapy using taxanes might be effective in treating localized angiosarcomas of the scalp without cervical lymph node metastases.

DOI： 10.3892/mco.2019.1918

Dose distribution of intensity-modulated proton therapy with and without a multi-leaf collimator for the treatment of maxillary sinus cancer: a comparative effectiveness study International journal

Soichi Sugiyama, Kuniaki Katsui, Yuki Tominaga, Takahiro Waki, Norihisa Katayama, Hidenobu Matsuzaki, Shin Kariya, Masahiro Kuroda, Kazunori Nishizaki, Susumu Kanazawa

RADIATION ONCOLOGY 14 ( 1 ) 209 - 209 2019.11

Language：English Publishing type：Research paper (scientific journal) Publisher：BMC

Background Severe complications, such as eye damage and dysfunciton of salivary glands, have been reported after radiotherapy among patients with head and neck cancer. Complications such as visual impairment have also been reported after proton therapy with pencil beam scanning (PBS). In the case of PBS, collimation can sharpen the penumbra towards surrounding normal tissue in the low energy region of the proton beam. In the current study, we examined how much the dose to the normal tissue was reduced by when intensity-modulated proton therapy (IMPT) was performed using a multi-leaf collimator (MLC) for patients with maxillary sinus cancer. Methods Computed tomography findings of 26 consecutive patients who received photon therapy at Okayama University Hospital were used in this study. We compared D2% of the region of interest (ROI; ROI-(D2%)) and the mean dose of ROI (ROI-(mean)) with and without the use of an MLC. The organs at risk (OARs) were the posterior retina, lacrimal gland, eyeball, and parotid gland. IMPT was performed for all patients. The spot size was approximately 5-6 mm at the isocenter. The collimator margin was calculated by enlarging the maximum outline of the target from the beam's eye view and setting the margin to 6 mm. All plans were optimized with the same parameters. Results The mean of ROI-(D2%) for the ipsilateral optic nerve was significantly reduced by 0.48 Gy, and the mean of ROI-(mean) for the ipsilateral optic nerve was significantly reduced by 1.04 Gy. The mean of ROI-(mean) to the optic chiasm was significantly reduced by 0.70 Gy. The dose to most OARs and the planning at risk volumes were also reduced. Conclusions Compared with the plan involving IMPT without an MLC, in the dose plan involving IMPT using an MLC for maxillary sinus cancer, the dose to the optic nerve and optic chiasm were significantly reduced, as measured by the ROI-(D2%) and the ROI-(mean). These findings demonstrate that the use of an MLC during IMPT for maxillary sinus cancer may be useful for preserving vision and preventing complications.

DOI： 10.1186/s13014-019-1405-y

Oropharyngeal adenoid cystic carcinoma invading the mandibular bone through the mandibular foramen

Yohei Takeshita, Shunsuke Okada, Miki Hisatomi, Hidenobu Matsuzaki, Hotaka Kawai, Yohei Noda, Jun Murakami, Mariko Fujita, Hitoshi Nagatsuka, Yoshinobu Yanagi, Junichi Asaumi

ORAL RADIOLOGY 35 ( 3 ) 335 - 340 2019.9

Language：English Publishing type：Research paper (scientific journal) Publisher：SPRINGER

Adenoid cystic carcinoma (ACC) is a rare epithelial tumor of the head and neck region, and one of the most common malignant tumors of the salivary glands. ACC is a slow-growing tumor characterized by perineural invasion and often has a high-recurrence rate. We describe a case of oropharyngeal ACC invading the mandibular bone through the mandibular foramen that showed a rare pattern of origin and invasion. A 70-year-old woman complained of noise and pain around the right temporomandibular joint. Osteomyelitis was suspected on the initial imaging examinations, although the findings were slightly atypical. However, a mass was observed in the right oropharyngeal wall on subsequent imaging examinations, and mandibular bone invasion, rather than osteomyelitis, was additionally suspected. The mass in the right oropharyngeal wall and right mandible was surgically excised. On postoperative histopathological examination, the mass was finally diagnosed as ACC. As tumor cells were also observed around the inferior alveolar nerve, mandibular bone invasion through the mandibular foramen was suspected. An oropharyngeal ACC invading the mandibular bone through the mandibular foramen is extremely rare. The present case suggests that bone invasion should be considered carefully with several imaging examinations when a malignant tumor such as ACC is observed around the jaw bone.

DOI： 10.1007/s11282-018-0359-3

Evaluation of Setup Errors at the Skin Surface Position for Whole Breast Radiotherapy of Breast Cancer Patients

Kanae Miyahara, Masahiro Kuroda, Yuuki Yoshimura, Hideki Aoyama, Masataka Oita, Irfan Sugianto, Hidenobu Matsuzaki, Hiroki Ihara, Norihisa Katayama, Kuniaki Katsui, Susumu Kanazawa, Junichi Asaumi

ACTA MEDICA OKAYAMA 72 ( 4 ) 331 - 336 2018.8

Language：English Publishing type：Research paper (scientific journal) Publisher：OKAYAMA UNIV MED SCHOOL

We used image-processing software to analyze the setup errors at the skin surface position of breast cancer patients (n=66) who underwent post-operative whole breast irradiation at our hospital in 2014-2015. The sixty-six digital reconstructed radiographs (DRR) were created at the treatment planning for each patient. The lineacgraphies (n=377) were taken after the patients' setup during radiotherapy. The lineacgraphies and DRR were superimposed at the skin surface position for each patient with the image-processing software. We measured the deviations of the isocenters for the nipple-lung (X) direction and craniocaudal (Y) direction and the deviation of the rotation angle of the XY axes between the lineacgraphy and DRR on the superimposed images. The systematic error (mu, Sigma) and random error (sigma) were calculated from the X and Y deviations and rotation angle deviation. The mu of X, Y, and rotation angle were 0.01 mm, -1.2 mm, and 0.05 degrees, respectively. The Sigma of X, Y, and rotation angle were 1.8 mm, 1.5 mm, and 0.9 degrees, respectively. The s of X, Y, and rotation angle were 2.0 mm, 1.5 mm, and 1.0 degrees, respectively. Our analyses thus revealed that evaluations using image-processing software at the skin surface position in routine breast radiotherapy result in sufficiently small setup errors.

DOI： 10.18926/AMO/56167

Clinical analysis of osteoradionecrosis of the mandible

Matsuzaki Hidenobu, Kimata Yoshihiro, Katsui Kuniaki, Matsuzaki Kumiko, Tsumura Munechika, Ikeda Atsushi, Ibaragi Soichiro, Mizukawa Nobuyoshi, Onoda Tomoo, Asaumi Jun-ichi

Toukeibu Gan 44 ( 1 ) 57 - 61 2018

Language：Japanese Publisher：Japan Society for Head and Neck Cancer

The purpose of this study was to analyze the risk factors for osteoradionecrosis （ORN） of the mandible after radiotherapy for treatment of oral or oropharyngeal cancers. Sixty patients with oral or oropharyngeal cancers who had undergone external radiotherapy from January 2011 to December 2016 were retrospectively reviewed. Seven patients （12%） had ORN, and the median time to the development of ORN was 15 months （range, 1-53 months）. In the analysis of the whole mandible, univariate analysis revealed that tooth extractions within one month before radiotherapy （p<0.001）, the mean dose of radiotherapy to the mandible （p=0.04）, and the volume of mandible receiving doses of 40Gy （p=0.02） and 50Gy （p=0.04） were significant risk factors for ORN. In the analyses of the right and left sides of the mandible, the mean dose of radiotherapy to the mandible and the volume of mandible receiving a dose of 40Gy were significant risk factors （p=0.04 for each）. In the multivariate analysis, tooth extractions in the analysis of the whole mandible was the only significant risk factor for ORN （p<0.01）. Incorporation of both mean dose constraints to the mandible in addition to maximal dose constraints might be needed to reduce the occurrence rate of ORN.

DOI： 10.5981/jjhnc.44.57

The role of dentistry other than oral care in patients undergoing radiotherapy for head and neck cancer International journal

Hidenobu Matsuzaki, Kumiko Tanaka-Matsuzaki, Fuminobu Miyazaki, Hideki Aoyama, Hiroki Ihara, Norihisa Katayama, Kuniaki Katsui, Kengo Himei, Tetsuo Takeuchi, Tomoo Onoda, Yoshihiro Kimata, Jun-Ichi Asaumi

JAPANESE DENTAL SCIENCE REVIEW 53 ( 2 ) 46 - 52 2017.5

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER SCI LTD

The usefulness of dental approaches, such as oral management, has gained recognition among patients treated for head and neck cancer. In particular, oral management plays a very important role before, during, and after treatment in patients undergoing radiotherapy, or a combination of both. However, specialized dentistry knowledge and techniques that are useful for patients undergoing radiotherapy for head and neck cancer have yet to be reported. Therefore, in this review article, our aim is to introduce dental approaches in radiotherapy for patients with head and neck cancer that have been developed and are currently being used at our institute. (C) 2016 The Author(s). Published by Elsevier Ltd on behalf of Japanese Association for DentalScience.

DOI： 10.1016/j.jdsr.2016.09.003

De novo myoepithelial carcinoma with multiple metastases arising from a submandibular salivary gland: A case report International journal

Karina Cecilia Panelli Santos, Hidenobu Matsuzaki, Teruhisa Unetsubo, Shimo Tsuyoshi, Hitoshi Nagatsuka, Jun-Ichi Asaumi

ONCOLOGY LETTERS 13 ( 4 ) 2679 - 2683 2017.4

Language：English Publishing type：Research paper (scientific journal) Publisher：SPANDIDOS PUBL LTD

Salivary gland carcinomas are rare tumors, representing similar to 0.5% of all malignancies. Myoepithelioma is also uncommon, representing similar to 1% of all salivary gland tumors. Myoepithelial carcinoma (MC) is even rarer, representing 0.2 to 0.6% of all salivary gland tumors. We herein report a case of MC with multiple metastases arising from a submandibular gland in a 71-year-old male patient and present the associated imaging findings. The patient was considered to have a de novo type of myoepithelial carcinoma, which is reportedly associated with higher malignancy than the transformation type of the disease (i.e., a malignant change from pleomorphic adenoma or myoepithelioma). This was reflected in the multiple lung and bone metastases sites and strong positivity for p53 and Ki-67.

DOI： 10.3892/ol.2017.5783

頭頸部がん治療における歯科技工士の役割

竹内哲男, 松崎秀信, 青山英樹, 宇野弘文, 松原理紗, 水川展吉, 小野田友男, 浅海淳一, 木股敬裕, 窪木拓男

日本口腔顎顔面技工研究会会誌 15 ( 1 ) 31 - 31 2016.12

当科における舌扁平上皮癌Stage I・II症例の頸部リンパ節後発転移に関する臨床的検討

吉田祥子, 岸本晃治, 村瀬友里香, 銅前昇平, 伊原木聰一郎, 柳文修, 松崎秀信, 志茂剛, 佐々木朗

岡山歯学会雑誌 35 ( 1 ) 13 - 18 2016.6

Language：Japanese Publisher：岡山歯学会

2000年4月〜2014年3月に一次治療を行った舌扁平上皮癌Stage I・II症例93例(Stage I 40例、Stage II 53例)を対象に、一次治療終了以降に転移が判明した症例(後発転移)の頻度とそれに影響を及ぼす臨床因子、後発転移発現までの期間、生存率について検討した。後発転移は全93例中23例(24.7%)に認められた。ステージ別ではStage I 40例中6例(15.0%)、Stage II 53例中17例(32.1%)、治療法別では手術群81例中17例(21.0%)、放射線療法群12例中6例(50.0%)にそれぞれ後発転移が発現した。後発転移の有無は、分化度、浸潤様式、原発巣の厚みと相関していたが、放射線療法を行った症例ではStage IIで原発巣の厚みが5mm以上であることが強く影響していた。後発転移への期間は、手術群で平均8.1ヵ月、中央値6ヵ月、放射線療法群で平均5ヵ月、中央値6ヵ月で、治療法による有意差は認められなかった。生存率と関連する臨床因子を検討したところ、有意な影響が認められた因子は後発転移のみであった。

A massive osteonecrosis with Le Fort I-type pathological fracture, caused by bisphosphonate-related osteonecrosis of the jaw (BRONJ): A rare case report

Shintaro Sukegawa, Takahiro Kanno, Naoki Katase, Hidenobu Matsuzaki, Akane Shibata, Yuka Takahashi, Yoshihiko Furuki

JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY 28 ( 3 ) 255 - 258 2016.5

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER SCIENCE INC

Bisphosphonates (BPs) are useful drugs for the management of osteoporosis and metastatic bone disease, and are used to prevent skeletal-related events. However, the side effects of BPs, bisphosphonate-related osteonecrosis of the jaw (BRONJ), sometimes severely impairs patient quality of life. Here we report a case of severe BRONJ in the maxilla, which caused Le Fort I-type fracture-like bone fracture due to formation of a large sequestrum in the maxilla. (C) 2015 Asian AOMS, ASOMP, JSOP, JSOMS, JSOM, and JAMI. Published by Elsevier Ltd. All rights reserved.*

DOI： 10.1016/j.ajoms.2015.10.001

下顎骨内へ広範に浸潤した中咽頭腺様嚢胞癌の一例

松崎秀信, 河合穂高, 野田洋平, 松本洋, 水川展吉, 柳井広之, 小野田友男, 浅海淳一, 木股敬裕

頭頸部癌 42 ( 2 ) 230 - 230 2016.5

頭頸部がんに対する放射線治療において歯科技工士の果たす役割

宮崎文伸, 松崎秀信, 青山英樹, 田中久美子, 宇野弘文, 水川展吉, 竹内哲男, 勝井邦彰, 小野田友男, 浅海淳一, 木股敬裕, 窪木拓男

岡山歯学会雑誌 34 ( 2 ) 77 - 78 2015.12

High-dose-rate brachytherapy using molds for lip and oral cavity tumors International journal

Teruhisa Unetsubo, Hidenobu Matsuzaki, Mitsuhiro Takemoto, Kuniaki Katsui, Marina Hara, Norihisa Katayama, Takahiro Waki, Susumu Kanazawa, Jun-ichi Asaumi

RADIATION ONCOLOGY 10 81 - 81 2015.4

Language：English Publishing type：Research paper (scientific journal) Publisher：BIOMED CENTRAL LTD

Background: High-dose-rate (HDR) brachytherapy using the mold technique is a less invasive treatment for early lip and oral cavity cancer. However, limited reports exist regarding the feasibility of this method. In this retrospective study, we evaluated the outcome of this therapy and investigated its feasibility for lip and oral cavity tumors.Methods: Between May 2002 and December 2010, 17 patients (median age, 80.0 years) with histologically confirmed squamous cell carcinoma of the lip or oral cavity were treated by means of HDR brachytherapy using the mold technique after external beam radiotherapy (EBRT). Tumor sites included the buccal mucosa in eight cases, the gingiva in three cases, the lips in two cases, the floor of the mouth in two cases, and the hard palate in two cases. For all patients, EBRT (30 Gy/15 fractions), was performed before HDR brachytherapy. Two 6-Gy fractions were delivered twice daily for 2 days a week with an interval of 6 hours between the fractions. The total HDR brachytherapy dose was 24 Gy. Prior to EBRT, two patients with neck metastasis underwent neck dissection, and one patient with an exophytic tumor underwent tumor resection.Results: The median follow-up period was 53.4 (range, 4.8-83.4) months. Of the 17 patients, 14 (82.4%) achieved a complete response, and three (17.6%) displayed a partial response. The overall 3-and 5-year survival rates were both 68.8%, the 3-and 5-year disease-specific survival rates were both 86.7%, and the 3-and 5-year local control rates were both 54.1%. Seven patients developed local recurrence at a median time of 3.4 (range, 1.7-29.1) months after treatment. Nodal and lung metastases occurred separately in two patients. By the end of the follow-up period, two patients had died of the primary disease and four patients had died of other causes.Conclusions: Although there is a need to improve the technical aspects of the treatment protocol, HDR brachytherapy using the mold technique might be a therapeutic option for superficial lip or oral cavity tumors, especially in older patients who have a poor performance status or are in poor physical condition.

DOI： 10.1186/s13014-015-0390-z

Primary intraosseous squamous cell carcinoma of the maxilla possibly arising from an infected residual cyst: A case report International journal

Shintaro Sukegawa, Hidenobu Matsuzaki, Naoki Katase, Takahiro Kanno, Toshiko Mandai, Yuka Takahashi, Jun-Ichi Asaumi, Yoshihiko Furuki

ONCOLOGY LETTERS 9 ( 1 ) 131 - 135 2015.1

Language：English Publishing type：Research paper (scientific journal) Publisher：SPANDIDOS PUBL LTD

Primary intraosseous squamous cell carcinoma (PIOSCC) is a rare type of odontogenic carcinoma arising from the jawbone. Odontogenic cysts are true cysts that arise from the dental epithelium, which is associated with tooth formation. The epithelial lining of odontogenic cysts has the potential to transform into various types of odontogenic tumor; however, this transformation from an odontogenic cyst to a malignant tumor is rare. The definitive diagnosis for PIOSCC generally requires the observation of either features of squamous cell carcinoma (SCC) within the jawbone that are distinct from direct invasion from the surface oral epithelium, or evidence of SCC arising from odontogenic epithelium and from tumors that have metastasized to the jawbone from distant sites. In the present study, a case of PIOSCC of the maxilla is presented, which, based on the results of computed tomography and the clinical course, was hypothesized to have originated from an infected residual cyst.

DOI： 10.3892/ol.2014.2644

下顎骨筋突起による介達骨折と考えられた上顎洞後壁、眼窩下壁骨折の1例

助川信太郎, 管野貴浩, 松崎秀信, 万代とし子, 高畑和路, 高橋由佳, 篠原丈裕, 浅海淳一, 古木良彦

口腔顎顔面外傷 13 ( 1 ) 22 - 27 2014.11

Language：Japanese Publisher：日本口腔顎顔面外傷学会

症例は53歳男性で、飲酒後に数人から殴打され、救命救急科へ搬送された。X線で左上顎洞後壁、蝶形骨翼状突起基部から眼窩底部に骨折を認め、下顎骨ではオトガイ部骨折および切痕から左顎関節突起基底部に骨折線がみられた。下顎骨骨折については咬合偏位が著明で、抗凝固療法中であることより早期の手術を計画した。眼窩下壁骨折は眼科で左眼窩底部骨片圧迫による下直筋障害を指摘され、手術適応と判断された。下直筋障害増悪を認めたため、第6病日に下顎骨骨折および眼窩骨折の整復術を施行した。眼窩下壁骨折は、上顎洞後壁が前方に偏位し外眼筋を圧迫していたため、経結膜切開による眼窩アプローチを選択し、眼窩前方から骨折部を明示して眼窩内に偏位していた骨片を整復した。良好な眼球運動機能改善が得られ、眼窩底部の再建は行わなかった。術後経過良好で、複視症状や咬合不全も改善した。

A new phantom and empirical formula for apparent diffusion coefficient measurement by a 3 Tesla magnetic resonance imaging scanner International journal

Marina Hara, Masahiro Kuroda, Yuichi Ohmura, Hidenobu Matsuzaki, Tomoki Kobayashi, Jun Murakami, Kazunori Katashima, Masakazu Ashida, Seiichiro Ohno, Jun-Ichi Asaumi

ONCOLOGY LETTERS 8 ( 2 ) 819 - 824 2014.8

Language：English Publishing type：Research paper (scientific journal) Publisher：SPANDIDOS PUBL LTD

The aim of this study was to create a new phantom for a 3 Tesla (3T) magnetic resonance imaging (MRI) device for the calculation of the apparent diffusion coefficient (ADC) using diffusion-weighted imaging (DWI), and to mimic the ADC values of normal and tumor tissues at various temperatures, including the physiological body temperature of 37 C. The phantom was produced using several concentrations of sucrose from 0 to 1.2 M, and the DWI was performed using various phantom temperatures. The accurate ADC values were calculated using the DWIs of the phantoms, and an empirical formula was developed to calculate the ADC values of the phantoms from an arbitrary sucrose concentration and arbitrary phantom temperature. The empirical formula was able to produce ADC values ranging between 0.33 and 3.02x10(-3) mm(2)/sec, which covered the range of ADC values of the human body that have been measured clinically by 3T MRI in previous studies. The phantom and empirical formula developed in this study may be available to mimic the ADC values of the clinical human lesion by 3T MRI.

DOI： 10.3892/ol.2014.2187

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