Faculty Profiles - KAWAKAMI Yoshio

Papers - KAWAKAMI Yoshio

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臀部皮下腫瘤を主訴に受診し痔瘻と診断した2例

蓮井謙一, 立花宏太, 杉原悟, 川上佳夫, 森実真

日本皮膚外科学会誌 26 ( 2 ) 44 - 44 2022.9

全長BP180 ELISA法にて診断し得た水疱性類天疱瘡の1例

石井芙美, 三宅智子, 杉本佐江子, 川上佳夫, 松田真由子, 森田安理, 山崎修, 石井文人, 泉健太郎, 西江渉, 橋本隆, 森実真

皮膚科の臨床 64 ( 10 ) 1675 - 1679 2022.9

Language：Japanese Publisher：金原出版(株)

＜文献概要＞80歳,男性。2001年より夏季に下腿に水疱が出現した。病理組織像では好酸球浸潤を混じる表皮下水疱を認め,水疱性類天疱瘡を疑ったが,抗BP180 NC16a部位抗体,蛍光抗体法と全長BP180 ELISAは陰性だった。経過中,蛍光抗体間接法のみ表皮側に陽性となった。2018年に四肢・体幹にびらんと緊満性水疱が生じ,蛍光抗体直接法で表皮基底膜部にIgGが線状に沈着し,全長BP180 ELISAは陽性,免疫ブロット法でBP180 C末端部リコンビナント蛋白と120kDa LAD-1に対する抗体陽性,ELISAでBP230に対する抗体も陽性となり,水疱性類天疱瘡と診断した。症状を繰り返すなかでepitope spreading現象がおきたと考えた。

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COVID-19ワクチンの接種後に全身性膿疱性乾癬を発症した2例

徳田真優, 立花宏太, 川上佳夫, 佐藤志帆, 三宅智子, 内田隆文, 福島智恵, 杉浦一充, 森実真

日本皮膚科学会雑誌 132 ( 5 ) 1309 - 1309 2022.5

金属異物によって生じた前頸部pseudolymphoma

徳田真優, 平井陽至, 川上佳夫, 立花宏太, 中川裕貴, 杉原悟, 三宅智子, 山崎修, 森実真, 眞部恵子, 浅越健治

日本皮膚科学会雑誌 132 ( 3 ) 506 - 506 2022.3

特異疹が緊満性水疱を呈したATLLの1例

妹尾春佳, 橋本倫子, 神野泰輔, 川上佳夫, 平井陽至, 山崎修, 森実真, 谷口恒平, 松岡賢市

日本皮膚科学会雑誌 132 ( 1 ) 99 - 99 2022.1

Persistent local inflammation surrounding cement substance of a tick Amblyomma testudinarium after sufficient removal of its mouthpart. International journal

Shiho Sato, Yoshio Kawakami, Yohei Yasutomi, Emi Yokoyama, Toshiko Yoshioka, Osamu Yamasaki, Shin Morizane

The Journal of dermatology 49 ( 1 ) e9-e10 2022.1

Updated allele frequencies of SERPINB7 founder mutations in Asian patients with Nagashima-type palmoplantar keratosis/keratoderma. International journal

Yasutoshi Ito, Takuya Takeichi, Kenta Ikeda, Kana Tanahashi, Takenori Yoshikawa, Yuya Murase, Yoshinao Muro, Yoshio Kawakami, Yasuo Nakamura, Kanako Matsuyama, Jun Muto, Naoki Oiso, Shin Morizane, Kazumitsu Sugiura, Yasushi Suga, Mariko Seishima, Akira Kawada, Tomoo Ogi, Masashi Akiyama

Journal of dermatological science 103 ( 2 ) 116 - 119 2021.8

Apalutamide-induced exanthematous drug eruption displaying spongiotic dermatitis successfully treated with dose reduction. Reviewed International journal

Yoshio Kawakami, Masao Mitsui, Hitoshi Takamoto, Yasuo Yamamoto

International journal of dermatology 60 ( 8 ) e315-e317 2021.8

Granular C3 dermatosis: Report of a case resembling dermatophytid in association with tinea pedis. International journal

Yoshio Kawakami, Yumi Aoyama, Kotaro Tada, Kazushi Anzawa, Akiko Nishibu, Takashi Mochizuki, Shin Morizane

The Journal of dermatology 48 ( 7 ) e320-e321 2021.7

Cutaneous adult T-cell leukemia/lymphoma with granulomatous reaction. International journal

Yuki Nakagawa, Yoshio Kawakami, Tomoko Kawamoto, Tomoko Miyake, Yoji Hirai, Osamu Yamasaki, Shin Morizane

The Journal of dermatology 48 ( 6 ) e273-e274 2021.6

Two cases of severe congenital hypotrichosis caused by compound heterozygous mutations in the LSS gene. International journal

Mami Murata, Ryota Hayashi, Yoshio Kawakami, Shin Morizane, Yutaka Shimomura

The Journal of dermatology 48 ( 3 ) 392 - 396 2021.3

Language：English Publishing type：Research paper (scientific journal)

It has recently been shown that bi-allelic mutations in the lanosterol synthase (LSS) gene, which was originally reported as a causative gene for congenital cataracts, underlie a non-syndromic form of hypotrichosis. Furthermore, it has also been revealed that mutations in the LSS gene can cause syndromic forms of hypotrichosis. To date, however, clear genotype-phenotype correlations have not completely been characterized. In this study, we identified two Japanese patients who had severe congenital hypotrichosis without any other associated findings. Their scalp hairs were extremely short and thin, and were able to be plucked easily. Observation of the plucked hairs showed aberrantly-miniaturized anagen hair follicles. Genetic analysis demonstrated that both patients carried bi-allelic mutations in the LSS gene in a compound heterozygote state. Our findings further underscore the crucial roles of the LSS gene in hair follicle development and hair growth in humans.

DOI： 10.1111/1346-8138.15679

PubMed

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A case of allergic contact dermatitis due to 3-glyceryl ascorbate in a skin-lightening lotion. International journal

Yoshio Kawakami, Takatsune Umayahara, Yoji Hirai, Shin Morizane

Contact dermatitis 2021.2

A case of bromoderma improved by reduction of potassium bromide

Yohei Yasutomi, Yoshio Kawakami, Minori Sasakura, Yoji Hirai, Osamu Yamasaki, Shin Morizane

Nishinihon Journal of Dermatology 83 ( 1 ) 18 - 21 2021

A case of mycobacterium marinum infection following injury by stingray inhabiting seto inland sea in Japan

Shogo Tanimoto, Yoshio Kawakami, Yohei Yasutomi, Osamu Yamasaki, Shin Morizane

Nishinihon Journal of Dermatology 82 ( 6 ) 460 - 463 2021

Solitary fibrous tumor of the inguinal region displaying heterogeneous echogenicity and its correlation with histopathologic findings

Ai Kajita, Yoshio Kawakami, Tomoko Miyake, Wakako Oda, Osamu Yamasaki, Shin Morizane

Our Dermatology Online 11 ( 4 ) 432 - 433 2020.11

Coexistence of Mycobacterium ulcerans ssp. shinshuense and Mycobacterium avium in a patient with Buruli ulcer-compatible lesions. International journal

Shusaku Fujita, Yoshio Kawakami, Haruka Yamasaki, Satoru Sugihara, Tomoko Miyake, Yuji Miyamoto, Yoshihiko Hoshino, Norihisa Ishii, Osamu Yamasaki, Shin Morizane

The Journal of dermatology 47 ( 11 ) e400-e401 2020.11

Dermal fillers do not induce upregulation of NLRP3 inflammasomes or expression of inflammatory cytokines in granulomas. International journal

Markus Reinholz, Benjamin M Clanner-Engelshofen, Markus V Heppt, Enklajd Marsela, Yoshio Kawakami, Luitgard G Wiest, Lars E French, Wilhelm Stolz, Gerd G Gauglitz

Journal of cosmetic dermatology 19 ( 11 ) 2838 - 2844 2020.11

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Filling materials have increasingly been used in aesthetics over the last decades. Understanding the pathophysiology of granuloma formation as a very relevant unwanted side effect of filler application may be essential to help avoid these adverse events. AIMS: Our aim was to investigate the role of the inflammasome in the formation of filler granuloma, as a central column of the innate immune response. METHODS: RPMI 1640 medium was used for growth of THP-1 cells and the induction of THP-1 macrophages. Sonication was applied in order to crush the acrylic particles of the filler. ELISA was the method of analysis for the specific cytokines. Biopsy specimens of filler granuloma were analyzed by various immunohistochemical methods. GraphPad Prism 5 software was used for the statistical data analysis. RESULTS: Neither was the sensor NALP3 overexpressed, nor could an elevated expression of cleaved IL-1β, IL-18, or IFN-γ be detected. Furthermore, no increased expression of IL-8 or IL-1β was detectable in vitro. CONCLUSION: No increased inflammasome activation could be observed; however, filler granulomas were infiltrated with granulocytes and macrophages. Therefore, we speculate that an unspecific immune response might be the key player in the formation of filler granuloma.

DOI： 10.1111/jocd.13341

PubMed

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Classical Vohwinkel syndrome with heterozygous p.Asp66His mutation in GJB2 gene: Second Asian case. International journal

Kenta Ikeda, Takuya Takeichi, Yasutoshi Ito, Yoshio Kawakami, Yuki Nakagawa, Seiko Naito, Osamu Yamasaki, Masashi Akiyama, Shin Morizane

The Journal of dermatology 47 ( 10 ) e352-e354 2020.10

Familial nasal dermoid sinus cysts skipping generations. International journal

Kimiko Nishigaki, Osamu Yamasaki, Yoshio Kawakami, Minori Sasakura, Tomoko Miyake, Aiji Ohtsuka, Junko Kousogabe, Shin Morizane

The Journal of dermatology 47 ( 10 ) e373-e375 2020.10

在宅医と連携した進行期悪性黒色腫

石井芙美, 山崎修, 加持達弥, 川上佳夫, 森実真, 片山英樹, 國末充央, 武藤純, 小森栄作

Skin Cancer 35 ( 1 ) 1 - 5 2020.6

Language：Japanese Publisher：(一社)日本皮膚悪性腫瘍学会

近年、免疫チェックポイント阻害剤やBRAF+MEK阻害剤などの進行期悪性黒色腫に対する新規治療が生存期間の延長に寄与している。さらに進行した場合でも緩和治療を行いながら、積極的な治療介入も可能である。しかし緩和ケア病棟など緩和ケアを専門に提供する病院では原病の新規治療が困難な場合がある。がん診療専門病院と在宅医が連携することにより悪性黒色腫の新規治療をしながら在宅療養することも1つの選択肢となる。当科で経験した新規治療中で、訪問診療専門クリニックと連携した4例について検討した。男性3名、女性1名、年齢は36～84歳、全例病期IV、在宅医紹介時の治療は、BRAF+MEK阻害剤1例、ニボルマブ2例、イピリブマブ1例、在宅診療期間は24～84日であった。1例は当院、3例は自宅での看取りとなった。在宅診療の介入パターンはさまざまであるが、患者の希望に沿う進行期の治療が提供できた。(著者抄録)

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2020&ichushi_jid=J02197&link_issn=&doc_id=20200714360001&doc_link_id=10.5227%2Fskincancer.35.1&url=https%3A%2F%2Fdoi.org%2F10.5227%2Fskincancer.35.1&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_2.gif

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