Faculty Profiles - KAWAKAMI Yoshio

Papers - KAWAKAMI Yoshio

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血管炎を伴う結節性紅斑様皮疹の後に,局面型サルコイドーシスを生じた1例

赤松由規, 横山恵美, 川上佳夫, 森実真

日本皮膚科学会雑誌 133 ( 8 ) 1898 - 1898 2023.7

口器除去後に残存したセメント物質により炎症が遷延したマダニ咬傷の1例

佐藤志帆, 川上佳夫, 安富陽平, 横山恵美, 山崎修, 森実真, 吉岡敏子

日本皮膚科学会雑誌 133 ( 8 ) 1885 - 1886 2023.7

四肢と左臀部に皮下硬結を形成したExtensive Subcutaneous Sarcoidosisの1例

臼井真菜, 杉原悟, 立花宏太, 川上佳夫, 森実真, 中本健太, 大塚文男

日本皮膚科学会雑誌 133 ( 8 ) 1889 - 1889 2023.7

BNT162b2 mRNA COVID-19ワクチン接種後に発症したacute diffuse and total alopecia of the female scalpの1例

川本雅也, 川上佳夫, 松田吉弘, 平井陽至, 森実真, 多田讓治

日本皮膚科学会雑誌 133 ( 8 ) 1891 - 1891 2023.7

口腔・鼻粘膜びらんを初発症状とした水疱型エリテマトーデスの1例

浦上仁志, 三宅智子, 篠倉美里, 森田安理, 竹崎大輝, 岡野真理, 川上佳夫, 森実真, 古賀浩嗣, 石井文人

西日本皮膚科 85 ( 3 ) 234 - 235 2023.6

LIPH遺伝子変異を認めた先天性縮毛症/乏毛症の兄妹例

岡野真理, 川上佳夫, 森実真, 鬼束真美, 下村裕

西日本皮膚科 85 ( 3 ) 231 - 231 2023.6

高齢者のセザリー症候群に対してインターフェロンγが奏功した1例

澤井希望, 三宅智子, 徳田真優, 佐藤志帆, 立花宏太, 杉本佐江子, 川上佳夫, 森実真, 萩谷英大, 淺田騰

日本皮膚科学会雑誌 133 ( 5 ) 1411 - 1411 2023.5

高齢者のセザリー症候群に対してインターフェロンγが奏功した1例

澤井希望, 三宅智子, 徳田真優, 佐藤志帆, 立花宏太, 杉本佐江子, 川上佳夫, 森実真, 萩谷英大, 淺田騰

日本皮膚科学会雑誌 133 ( 5 ) 1411 - 1411 2023.5

ラズベリーによるアナフィラキシーの1例

赤松由規, 川上佳夫, 藤田周作, 川本友子, 三宅智子, 平井陽至, 森実真

日本臨床皮膚科医会雑誌 40 ( 3 ) 465 - 465 2023.5

【乾癬】ブロダルマブ自己中断後に膿疱化を生じた乾癬性関節炎の1例

廣瀬梓, 川上佳夫, 吉永泰彦, 三宅智子, 森実真

皮膚科の臨床 65 ( 5 ) 569 - 572 2023.5

当院における強皮症合併重症下肢虚血7例の臨床学的検討

松田吉弘, 三宅智子, 戸田洋伸, 立花宏太, 野村隼人, 平井陽至, 川上佳夫, 迫田直也, 廣田真規, 森実真

日本皮膚科学会雑誌 133 ( 5 ) 1361 - 1361 2023.5

桂枝茯苓丸を併用した酒さ様皮膚炎の3例

高須賀琴巳, 横溝紗佑里, 横山恵美, 川上佳夫, 安井陽子, 神崎寛子, 森実真

日本臨床皮膚科医会雑誌 40 ( 3 ) 480 - 480 2023.5

セクキヌマブが奏功した掌蹠膿疱症を背景とする膿疱性乾癬の1例

澤井希望, 川上佳夫, 徳田真優, 廣瀬梓, 別木祐介, 高須賀琴巳, 篠倉美里, 立花宏太, 横山恵美, 三宅智子, 平井陽至, 森実真, 多田譲治

日本皮膚科学会雑誌 133 ( 3 ) 524 - 524 2023.3

新規ALOX12B遺伝子病的バリアントを認めた先天性魚鱗癬様紅皮症の1例

前琴絵, 梶田藍, 川上佳夫, 森実真, 野田達宏, 武市拓也, 秋山真志

日本皮膚科学会雑誌 133 ( 2 ) 262 - 262 2023.2

Cutaneous Pseudolymphoma Caused by an Injury with a Metallic Piece of a Mowing Machine Containing Tungsten. International journal

Mayu Tokuda, Yoshio Kawakami, Yoji Hirai, Kota Tachibana, Yuki Nakagawa, Satoru Sugihara, Tomoko Miyake, Osamu Yamasaki, Keiko Manabe, Shin Morizane

Indian journal of dermatology 68 ( 4 ) 468 - 470 2023

"Input/output cytokines" in epidermal keratinocytes and the involvement in inflammatory skin diseases. International journal

Shin Morizane, Tomoyuki Mukai, Ko Sunagawa, Kota Tachibana, Yoshio Kawakami, Mamoru Ouchida

Frontiers in immunology 14 1239598 - 1239598 2023

Language：English Publishing type：Research paper (scientific journal)

Considering the role of epidermal keratinocytes, they occupy more than 90% of the epidermis, form a physical barrier, and also function as innate immune barrier. For example, epidermal keratinocytes are capable of recognizing various cytokines and pathogen-associated molecular pattern, and producing a wide variety of inflammatory cytokines, chemokines, and antimicrobial peptides. Previous basic studies have shown that the immune response of epidermal keratinocytes has a significant impact on inflammatory skin diseases. The purpose of this review is to provide foundation of knowledge on the cytokines which are recognized or produced by epidermal keratinocytes. Since a number of biologics for skin diseases have appeared, it is necessary to fully understand the relationship between epidermal keratinocytes and the cytokines. In this review, the cytokines recognized by epidermal keratinocytes are specifically introduced as "input cytokines", and the produced cytokines as "output cytokines". Furthermore, we also refer to the existence of biologics against those input and output cytokines, and the target skin diseases. These use results demonstrate how important targeted cytokines are in real skin diseases, and enhance our understanding of the cytokines.

DOI： 10.3389/fimmu.2023.1239598

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Co-occurrence of non-alcoholic steatohepatitis exacerbates psoriasis associated with decreased adiponectin expression in a murine model. International journal

Daiki Takezaki, Shin Morizane, Kenta Ikeda, Masanori Iseki, Yuma Sakamoto, Yoshio Kawakami, Taishi Hashiguchi, Yuka Shirakata, Sohji Nishina, Tomoyuki Mukai

Frontiers in immunology 14 1214623 - 1214623 2023

Language：English Publishing type：Research paper (scientific journal)

INTRODUCTION: Clinical studies have suggested a bidirectional association between non-alcoholic steatohepatitis (NASH) and psoriasis, affecting each other's development and severity. Here, we explored bidirectional causal linkages between NASH and psoriasis using a murine model. METHODS: NASH was induced in mice by streptozotocin injection at 2 days of age and by high-fat diet feeding (STAM™ model). Psoriasis was induced by topical application of imiquimod (IMQ) on the ear. The severities of liver damage and psoriatic skin changes were determined using histological analysis. Gene expression in the skin tissues was evaluated using quantitative PCR analysis. Serum cytokine levels were determined using enzyme-linked immunosorbent assay. To examine the innate immune responses of normal human epidermal keratinocytes (NHEKs), the cells were treated with interleukin (IL)-17A, tumor necrosis factor (TNF)-α, and AdipoRon, an adiponectin receptor agonist. RESULTS AND DISCUSSION: There were no differences in the degree of liver tissue damage (fat deposition, inflammation, and fibrosis) between NASH mice with and those without psoriasis. Conversely, the co-occurrence of NASH significantly augmented psoriatic skin changes, represented by epidermal hyperplasia, in psoriatic mice. Pro-inflammatory cytokines were expressed in the inflamed skin of psoriatic mice, and the expression of genes, especially Il23a, Il1b, Il36g, and Mip2, was significantly upregulated by the co-occurrence of NASH. The expression of keratinocyte activation marker genes Defb4b and Krt16 was also upregulated by the co-occurrence of NASH. The serum TNF-α and IL-17 levels were increased by the co-occurrence of NASH and psoriasis. The serum adiponectin levels decreased in NASH mice compared with that in non-NASH mice. In NHEK culture, TNF-α and IL-17A synergistically upregulated CXCL1, CXCL8, and IL1B expression. The upregulated pro-inflammatory gene expression was suppressed by AdipoRon treatment, reflecting the anti-inflammatory capacity of adiponectin. CONCLUSION: The co-occurrence of NASH exacerbated psoriatic skin changes associated with increased serum inflammatory cytokine levels and decreased serum adiponectin levels. Combined with in vitro findings, increased inflammatory cytokine levels and decreased adiponectin levels likely promote innate immune responses in epidermal keratinocytes in psoriatic skin lesions. Overall, therapeutic intervention for co-occurring NASH is essential to achieve a favorable prognosis of psoriasis in clinical practice.

DOI： 10.3389/fimmu.2023.1214623

PubMed

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A case of generalized allergic contact dermatitis due to sodium lauroyl methylaminopropionate in a shampoo. International journal

Azusa Hirose, Yoshio Kawakami, Tomoko Miyake, Yoji Hirai, Shin Morizane

Contact dermatitis 87 ( 6 ) 546 - 548 2022.12

Cutaneous toxicity with suprabasal blisters and dyskeratosis following administration of enfortumab vedotin. International journal

Ken-Ichi Hasui, Yoshio Kawakami, Tomoko Miyake, Yoji Hirai, Hayato Nomura, Kohei Edamura, Motoo Araki, Shin Morizane

The Journal of dermatology 2022.11

A case of neuro-Behcet's disease preceded by cellulitis-like cutaneous arteritis and multiple pharyngeal ulcers. International journal

Emi Yokoyama, Yoshio Kawakami, Takayuki Katsuyama, Hidenori Marunaka, Shin Morizane

International journal of dermatology 2022.10

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Papers - KAWAKAMI Yoshio