Faculty Profiles - KAWAKAMI Yoshio

Papers - KAWAKAMI Yoshio

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Monokine induced by gamma interferon levels in plasma might be a diagnostic marker of Hydroa vaccniforme lymphoproliferative disorder systemic form. International journal

Tomoko Miyake, Takenobu Yamamoto, Yoji Hirai, Takahide Takahashi, Takuya Furuhashi, Hisashi Nomura, Yoshio Kawakami, Shin Morizane

Journal of the American Academy of Dermatology 2024.11

A case of anaphylaxis to kumquat (Citrus japonica). International journal

Shogo Ikezawa, Emi Yokoyama, Hitoshi Urakami, Mikiko Takigawa, Tomoko Miyake, Yoji Hirai, Yoshio Kawakami, Shin Morizane

European journal of dermatology : EJD 34 ( 5 ) 539 - 541 2024.10

特集膠原病脱毛から診断に至った高齢期発症の全身性エリテマトーデスの1例

松本真理, 横山恵美, 川上佳夫, 勝山恵理, 山口春佳, 森実真

皮膚科の臨床 66 ( 9 ) 1207 - 1210 2024.8

The treatment effect of endovascular therapy for chronic limb-threatening ischemia with systemic sclerosis. International journal

Yoshihiro Matsuda, Tomoko Miyake, Hironobu Toda, Kota Tachibana, Hayato Nomura, Yoji Hirai, Yoshio Kawakami, Naoya Sakoda, Shin Morizane

The Journal of dermatology 51 ( 8 ) 1108 - 1112 2024.8

Language：English Publishing type：Research paper (scientific journal)

Systemic sclerosis (SSc) is a collagen disease with immune abnormalities, vasculopathy, and fibrosis. Ca blockers and prostaglandins are used to treat peripheral circulatory disturbances. Chronic limb-threatening ischemia (CLTI) is a disease characterized by extremity ulcers, necrosis, and pain due to limb ischemia. Since only a few patients present with coexistence of CLTI and SSc, the treatment outcomes of revascularization in these cases are unknown. In this study, we evaluated the clinical characteristics and treatment outcomes of seven patients with CLTI and SSc, and 35 patients with uncomplicated CLTI who were hospitalized from 2012 to 2022. A higher proportion of patients with uncomplicated CLTI had diabetes and male. There were no significant differences in the age at which ischemic ulceration occurred, other comorbidities, or in treatments, including antimicrobial agents, revascularization and amputation, improvement of pain, and the survival time from ulcer onset between the two subgroups. EVT or amputation was performed in six or two of the seven patients with CLTI and SSc, respectively. Among those who underwent EVT, 33% (2/6) achieved epithelialization and 67% (4/6) experienced pain relief. These results suggest that the revascularization in cases with CLTI and SSc should consider factors such as infection and general condition, since revascularization improve the pain of these patients.

DOI： 10.1111/1346-8138.17334

PubMed

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Acquired generalized anhidrosis following durvalumab treatment in a patient with advanced non-small cell lung cancer. International journal

Yuko Fujimoto, Yoshio Kawakami, Tomoko Miyake, Yoji Hirai, Masahiro Tabata, Shin Morizane

The Journal of dermatology 2024.7

A Gardner-Diamond Syndrome Accompanied by Complex Regional Pain Syndrome

Emi Yokoyama, Yoshio Kawakami, Ayumi Okada, Masato Yashiro, Tomoko Tetsunaga, Shin Morizane

Indian Journal of Dermatology 69 ( 4 ) 350 - 352 2024.7

Phase I/II clinical trial of brentuximab vedotin for pretreated Japanese patients with CD30-positive cutaneous T-cell lymphoma. International journal

Yoji Hirai, Jun Sakurai, Shiho Yoshida, Takashi Kikuchi, Toshiharu Mitsuhashi, Tomoko Miyake, Taku Fujimura, Riichiro Abe, Hiroki Fujikawa, Hikari Boki, Hiraku Suga, Sayaka Shibata, Tomomitsu Miyagaki, Takatoshi Shimauchi, Eiji Kiyohara, Yoshio Kawakami, Shin Morizane

The Journal of dermatology 2024.6

Language：English Publishing type：Research paper (scientific journal)

Brentuximab vedotin (BV), a conjugate of anti-CD30 antibody and monomethyl auristatin E, has emerged as a promising treatment option for refractory CD30+ mycosis fungoides (MF) and primary cutaneous anaplastic large-cell lymphoma (pcALCL). BV has been shown to be safe and effective in treating Hodgkin's lymphoma and peripheral T-cell lymphoma. This multicenter, prospective, single-arm phase I/II study evaluated the efficacy of BV in Japanese patients with CD30+ cutaneous lymphomas, namely CD30+ cutaneous T-cell lymphoma. Participants were divided into two groups: those with CD30+ MF or pcALCL (cohort 1, n = 13) and those with CD30+ lymphoproliferative disorders other than those in cohort 1 (cohort 2, n = 3). The studied population included the full analysis set (FAS), modified FAS (mFAS), and safety analysis set (SAF). These sets were identified in cohorts 1 and 1 + 2 and labeled FAS1 and FAS2, mFAS1 and mFAS2, and SAF1 and SAF2, respectively. Each treatment cycle lasted 3 weeks, and BV was continued for up to 16 cycles after the third cycle based on treatment response. The primary endpoint was the 4-month objective response rate (ORR4) determined by the Independent Review Forum (IRF). ORR4 was 69.2% for FAS1 and 62.5% for FAS2 (P < 0.0001). Secondary endpoints of ORR, assessed using the global response score (53.8% in FAS1) and modified severity-weighted assessment tool (62.5% in FAS1), using the IRF, provided results comparable to the primary findings. The incidence of ≥grade 3 adverse events (≥15%) in SAF1 was peripheral neuropathy in three patients (23%) and fever and eosinophilia in two patients (15%). In conclusion, BV showed favorable efficacy, tolerability, and safety profile in Japanese patients with relapsed or refractory CD30+ primary cutaneous T-cell lymphoma. The trial was registered with University Hospital Medical Information Network Clinical Trials Registry, Japan (protocol ID: UMIN000034205).

DOI： 10.1111/1346-8138.17324

PubMed

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Disseminated Lomentospora prolificans infection presenting with multiple cutaneous lesions in an immunocompromised host: A case report and literature review. International journal

Masaya Kawamoto, Yoshio Kawakami, Yoji Hirai, Saya Kubota, Hideaki Fujiwara, Yayoi Ueda, Kazushi Anzawa, Yoshinobu Maeda, Shin Morizane

The Journal of dermatology 2024.6

前頭部皮下腫瘤として術後再発した髄膜腫の1例

砂川滉, 神野泰輔, 三宅智子, 川上佳夫, 森実真, 藤井謙太郎

日本皮膚科学会雑誌 134 ( 7 ) 1920 - 1920 2024.6

Enfortumab vedotin投与後に四肢に水疱性病変を呈した2例

村田愛美, 蓮井謙一, 松田吉弘, 横溝紗佑里, 岡野真理, 三宅智子, 平井陽至, 川上佳夫, 森実真

西日本皮膚科 86 ( 3 ) 314 - 314 2024.6

オトガイ部の生検から診断に至った全身性ALアミロイドーシスの1例

坂田伽奈子, 川上佳夫, 横山恵美, 森実真, 長谷川功, 中野靖浩, 大塚文男, 白藤宜紀

日本皮膚科学会雑誌 134 ( 6 ) 1711 - 1711 2024.5

難治性下腿潰瘍の精査により診断したKlinefelter症候群の1例

川本雅也, 三宅智子, 神野泰輔, 高須賀琴巳, 別木祐介, 松本真理, 澤井希望, 川上佳夫, 森実真, 淺田騰, 戸田洋伸

日本皮膚科学会雑誌 134 ( 6 ) 1711 - 1711 2024.5

抗PD-L1抗体投与後にirAEとして無汗症を発症した1例

藤本裕子, 川上佳夫, 三宅智子, 平井陽至, 森実真, 田端雅弘

日本皮膚科学会雑誌 134 ( 5 ) 1557 - 1557 2024.5

外陰部病変を伴ったクローン病の1例

梶田藍, 川上佳夫, 平岡佐規子, 平賀順子, 森実真

西日本皮膚科 86 ( 2 ) 192 - 192 2024.4

NVX-CoV2373ワクチン投与後に血管浮腫様の眼瞼浮腫を生じた1例

松本真理, 川上佳夫, 三宅智子, 平井陽至, 森実真, 片岡仁美, 大塚文男

西日本皮膚科 86 ( 2 ) 198 - 198 2024.4

Elevated expression of interleukin‐6 (<scp>IL</scp>‐6) and serum amyloid A (<scp>SAA</scp>) in the skin and the serum of recessive dystrophic epidermolysis bullosa: Skin as a possible source of <scp>IL</scp>‐6 through Toll‐like receptor ligands and <scp>SAA</scp> Reviewed

Yoshio Kawakami, Ai Kajita, Ken‐Ichi Hasui, Yoshihiro Matsuda, Keiji Iwatsuki, Shin Morizane

Experimental Dermatology 33 ( 3 ) 2024.3

Authorship：Lead author Publishing type：Research paper (scientific journal) Publisher：Wiley

Abstract

The effect of persistent skin inflammation on extracutaneous organs and blood is not well studied. Patients with recessive dystrophic epidermolysis bullosa (RDEB), a severe form of the inherited blistering skin disorder, have widespread and persistent skin ulcers, and they develop various complications including anaemia, hyperglobulinaemia, hypoalbuminaemia and secondary amyloidosis. These complications are associated with the bioactivities of IL‐6, and the development of secondary amyloidosis requires the persistent elevation of serum amyloid A (SAA) level. We found that patients with RDEB had significantly higher serum levels of IL‐6 and SAA compared to healthy volunteers and patients with psoriasis or atopic dermatitis. Both IL‐6 and SAA were highly expressed in epidermal keratinocytes and dermal fibroblasts of the skin ulcer lesions. Keratinocytes and fibroblasts surrounding the ulcer lesions are continuously exposed to Toll‐like receptor (TLR) ligands, pathogen‐associated and damage‐associated molecular pattern molecules. In vitro, TLR ligands induced IL‐6 expression via NF‐κB in normal human epidermal keratinocytes (NHEKs) and dermal fibroblasts (NHDFs). SAA further induced the expression of IL‐6 via TLR1/2 and NF‐κB in NHEKs and NHDFs. The limitation of this study is that NHEKs and NHDFs were not derived from RDEB patients. These observations suggest that TLR‐mediated persistent skin inflammation might increase the risk of IL‐6‐related systemic complications, including RDEB.

File： Kawakami-2024-Elevated-expression-of-interleukin-.pdf

DOI： 10.1111/exd.15040

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ヒアルロン酸注入により下顎部に異物肉芽腫を生じた1例

坂田伽奈子, 神野泰輔, 川上佳夫, 森実真, 柳井広之

日本皮膚科学会雑誌 134 ( 2 ) 351 - 352 2024.2

メトトレキサート内服と圧迫療法が奏功した下腿の潰瘍型皮膚サルコイドーシス

前琴絵, 川上佳夫, 三宅智子, 平井陽至, 森実真, 品岡玲, 廣瀬梓

西日本皮膚科 86 ( 1 ) 89 - 89 2024.2

メトトレキサート内服と圧迫療法が奏効した下腿潰瘍を伴ったサルコイドーシスの1例

65 ( 13 ) 2044 - 2047 2023.12

キンカンによるアナフィラキシーの1例

池澤勝吾, 横山恵美, 浦上仁志, 瀧川充希子, 三宅智子, 平井陽至, 川上佳夫, 森実真

日本皮膚免疫アレルギー学会総会学術大会プログラム・抄録集 53回 201 - 201 2023.12

抗TIF1-γ抗体陽性の皮膚筋炎3例

川本雅也, 川上佳夫, 三宅智子, 平井陽至, 蓮井謙一, 松田吉弘, 森実真

日本皮膚免疫アレルギー学会総会学術大会プログラム・抄録集 53回 216 - 216 2023.12

メトトレキサート内服と圧迫療法が奏効した下腿潰瘍を伴ったサルコイドーシスの1例

前琴絵, 川上佳夫, 三宅智子, 平井陽至, 奥山倫弘, 品岡玲, 廣瀬梓, 森実真

皮膚科の臨床 65 ( 13 ) 2044 - 2047 2023.12

Language：Japanese Publisher：金原出版(株)

＜文献概要＞65歳,女性。初診4年前に右大腿の褐色萎縮性局面と右下肢腫脹を自覚し,1年前に皮膚生検で非乾酪性類上皮細胞肉芽腫,CTで縦隔リンパ節腫脹,肺野にsarcoid galaxy signを認め,サルコイドーシスと診断した。無治療で経過観察していたが,1年後に右下腿外側に2ヶ所の潰瘍形成を認め,潰瘍辺縁の生検組織はリポイド類壊死症に類似した肉芽腫の像を呈していた。下肢静脈超音波では,右大伏在静脈大腿静脈接合部の逆流を認めた。メトトレキサート開始後も1ヶ所の潰瘍が残存したため,圧迫療法の併用を開始したところ,潰瘍はすべて上皮化した。潰瘍形成には,サルコイドーシスと静脈うっ滞の2つの機序が関与していると考えた。

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2023&ichushi_jid=J01266&link_issn=&doc_id=20231222090027&doc_link_id=10.18888%2Fhi.0000004316&url=https%3A%2F%2Fdoi.org%2F10.18888%2Fhi.0000004316&type=%E5%8C%BB%E6%9B%B8.jp_%E3%82%AA%E3%83%BC%E3%83%AB%E3%82%A2%E3%82%AF%E3%82%BB%E3%82%B9&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

Pruritic folliculitis of pregnancy with granular deposition of immunoglobulin G along the basement membrane zone. International journal

Mana Usui-Taniguchi, Yoshio Kawakami, Yoichiro Toi, Tatsuya Kaji, Yoshiko Matsuura, Emi Yokoyama, Tomoko Miyake, Yoji Hirai, Shin Morizane

The Journal of dermatology 2023.11

廣瀬梓, 川上佳夫, 長尾聡子, 三宅智子, 森実真

皮膚科の臨床 65 ( 11 ) 1645 - 1647 2023.10

Language：Japanese Publisher：金原出版(株)

＜文献概要＞32歳,女性。発熱,両下腿の発赤・腫脹を主訴に受診した。肥満があり,両側下腿にnon-pitting edemaとびらん形成があり,右下腿には疣状・乳頭状増殖が認められ,黄白色の浸軟した痂皮が付着していた。うっ滞性皮膚炎によるelephantiasis nostrasから発症した右下腿蜂窩織炎と診断した。入院のうえ,セファゾリン点滴,ゲンタマイシン軟膏外用,弾性包帯による圧迫療法を開始したところ,感染徴候は軽快した。入院中の問診で,中学卒業以降引きこもり状態にあり,日中は立位で家事に従事し,夜間は部屋が狭いために座位で睡眠をとっていたことが発覚した。下肢挙上の重要性を説明し,臥位による睡眠と運動などの生活指導を行った結果,elephantiasis nostrasやうっ滞性皮膚炎の症状も軽快した。Elephantiasis nostrasの発症には生活習慣など社会的背景が関与していることが多い。生活環境の是正も含めて経過をみる必要がある。

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非特異的皮疹・口腔内アフタ・非特異的腸炎・血球減少を呈する成人発症の自己炎症性疾患を疑う1例

徳増一樹, 本多寛之, 奥延太希, 長岡寛和, 高瀬了輔, 八代将登, 高原政宏, 平岡佐規子, 川上佳夫, 長谷川功, 萩谷英大, 花山宜久, 大塚文男

日本免疫不全・自己炎症学会雑誌 2 ( 2 ) 61 - 61 2023.10

Cutaneous toxicity with subepidermal blisters and dyskeratosis following administration of pemetrexed in a patient with nivolumab-induced psoriasis and linear IgA bullous dermatosis. International journal

Sayuri Yokomizo, Tomoko Miyake, Yoshio Kawakami, Kadoaki Ohashi, Hiroshi Koga, Norito Ishii, Shin Morizane

The Journal of dermatology 2023.9

Vulvar Crohn's disease presenting with multiple exophytic nodules and labial swelling: A case report. International journal

Ai Kajita, Yoshio Kawakami, Sakiko Hiraoka, Junko Haraga, Shin Morizane

The Journal of dermatology 2023.8

Successful treatment with secukinumab in a patient with generalized pustular psoriasis preceded by palmoplantar lesions. International journal

Nozomi Sawai, Yoshio Kawakami, Kota Tachibana, Hayato Nomura, Tomoko Miyake, Emi Yokoyama, Yoji Hirai, Shin Morizane

The Journal of dermatology 2023.8

Angioedema‐like eyelid edema following the second NVX‐CoV2373 <scp>COVID</scp>‐19 vaccination

Mari Matsumoto, Yoshio Kawakami, Tomoko Miyake, Yoji Hirai, Hitomi Kataoka, Fumio Otsuka, Shin Morizane

Journal of Cutaneous Immunology and Allergy 6 ( 5 ) 194 - 195 2023.7

Coexpression of natural killer cell antigens by T-cell large granular lymphocytes in hydroa vacciniforme lymphoproliferative disorder and the involvement of Vδ1 + epithelial-type γδT cells.

Yoji Hirai, Keiji Iwatsuki, Takahide Takahashi, Tomoko Miyake, Yuki Nakagawa, Shogo Tanimoto, Yoshio Kawakami, Shin Morizane

International journal of hematology 118 ( 1 ) 54 - 64 2023.7

Language：English Publishing type：Research paper (scientific journal)

Hydroa vacciniforme lymphoproliferative disorder (HV-LPD) is a cutaneous variant of chronic active Epstein-Barr virus disease. We examined the coexpression of T- and natural killer (NK)-cell antigens in five patients with classic HV (cHV) and five with systemic HV (sHV). T-cell receptor (TCR) repertoire analysis was performed with high‑throughput sequencing. All five cHV patients had increased γδT cells (> 5%), whereas five sHV patients showed γδT- and αβT-cell dominance in two patients each, and a mixture of abnormal γδT and αβT cells in one. Circulating CD3 + T cells expressed CD16/CD56 at 7.8-42.3% and 1.1-9.7% in sHV and cHV, respectively. The percentage of CD16/CD56 + T cells was higher in the large granular lymphocyte or atypical T-cell fractions in sHV, but no TCR Vα24 invariant chain characteristic of NKT cells was detected. Considerable numbers of CD3 + cells expressing CD56 were observed in sHV skin infiltrates. Of the circulating γδT cells tested, TCR Vδ1 + cells characteristic of the epithelial type of γδT cells were dominant in two sHV cases. Thus, atypical αβT and γδT cells in HV-LPD can express NK-cell antigens, such as CD16 and CD56, and Vδ1 + epithelial-type γδT cells are a major cell type in some HV-LPD cases.

DOI： 10.1007/s12185-023-03599-7

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ダブラフェニブ・トラメチニブ内服中にサルコイド様皮疹を呈した悪性黒色腫の1例

別木祐介, 神野泰輔, 立花宏太, 三宅智子, 平井陽至, 川上佳夫, 森実真

日本皮膚科学会雑誌 133 ( 8 ) 1894 - 1894 2023.7

ブロダルマブの自己中断後に尋常性乾癬の膿疱化を生じた乾癬性関節炎の1例

廣瀬梓, 吉永泰彦, 三宅智子, 川上佳夫, 森実真

日本皮膚科学会雑誌 133 ( 8 ) 1888 - 1888 2023.7

ニボルマブ投与後に尋常性乾癬と線状IgA水疱症(LABD)を発症した1例

横溝紗佑里, 三宅智子, 川上佳夫, 森実真, 大橋圭明, 古賀浩嗣, 石井文人

日本皮膚科学会雑誌 133 ( 8 ) 1893 - 1893 2023.7

左前胸部に再発した皮膚原発粘液癌

澤井希望, 立花宏太, 川上佳夫, 森実真, 杉原悟

日本皮膚科学会雑誌 133 ( 8 ) 1899 - 1899 2023.7

家族性黒色表皮腫に合併したと考えた菌状息肉症の1例

立花宏太, 長尾僚祐, 川上佳夫, 森実真

日本皮膚科学会雑誌 133 ( 8 ) 1899 - 1899 2023.7

脱毛から診断に至った高齢期発症の全身性エリテマトーデスの1例

岡野真理, 横山恵美, 川上佳夫, 森実真, 勝山恵理, 山口春佳

日本皮膚科学会雑誌 133 ( 8 ) 1892 - 1892 2023.7

透析患者に生じた後天性穿孔性皮膚症の2例

岡野真理, 立花宏太, 川上佳夫, 森実真

日本皮膚科学会雑誌 133 ( 8 ) 1895 - 1895 2023.7

無症候性アミラーゼ血症に合併した皮下結節性脂肪壊死の1例

松本真理, 立花宏太, 野村隼人, 川上佳夫, 森実真, 岡田梨乃, 石井貴大, 山岡主知, 浅川知彦, 内田治仁

日本皮膚科学会雑誌 133 ( 8 ) 1898 - 1898 2023.7

血管炎を伴う結節性紅斑様皮疹の後に,局面型サルコイドーシスを生じた1例

赤松由規, 横山恵美, 川上佳夫, 森実真

日本皮膚科学会雑誌 133 ( 8 ) 1898 - 1898 2023.7

口器除去後に残存したセメント物質により炎症が遷延したマダニ咬傷の1例

佐藤志帆, 川上佳夫, 安富陽平, 横山恵美, 山崎修, 森実真, 吉岡敏子

日本皮膚科学会雑誌 133 ( 8 ) 1885 - 1886 2023.7

四肢と左臀部に皮下硬結を形成したExtensive Subcutaneous Sarcoidosisの1例

臼井真菜, 杉原悟, 立花宏太, 川上佳夫, 森実真, 中本健太, 大塚文男

日本皮膚科学会雑誌 133 ( 8 ) 1889 - 1889 2023.7

BNT162b2 mRNA COVID-19ワクチン接種後に発症したacute diffuse and total alopecia of the female scalpの1例

川本雅也, 川上佳夫, 松田吉弘, 平井陽至, 森実真, 多田讓治

日本皮膚科学会雑誌 133 ( 8 ) 1891 - 1891 2023.7

口腔・鼻粘膜びらんを初発症状とした水疱型エリテマトーデスの1例

浦上仁志, 三宅智子, 篠倉美里, 森田安理, 竹崎大輝, 岡野真理, 川上佳夫, 森実真, 古賀浩嗣, 石井文人

西日本皮膚科 85 ( 3 ) 234 - 235 2023.6

LIPH遺伝子変異を認めた先天性縮毛症/乏毛症の兄妹例

岡野真理, 川上佳夫, 森実真, 鬼束真美, 下村裕

西日本皮膚科 85 ( 3 ) 231 - 231 2023.6

高齢者のセザリー症候群に対してインターフェロンγが奏功した1例

澤井希望, 三宅智子, 徳田真優, 佐藤志帆, 立花宏太, 杉本佐江子, 川上佳夫, 森実真, 萩谷英大, 淺田騰

日本皮膚科学会雑誌 133 ( 5 ) 1411 - 1411 2023.5

高齢者のセザリー症候群に対してインターフェロンγが奏功した1例

澤井希望, 三宅智子, 徳田真優, 佐藤志帆, 立花宏太, 杉本佐江子, 川上佳夫, 森実真, 萩谷英大, 淺田騰

日本皮膚科学会雑誌 133 ( 5 ) 1411 - 1411 2023.5

ラズベリーによるアナフィラキシーの1例

赤松由規, 川上佳夫, 藤田周作, 川本友子, 三宅智子, 平井陽至, 森実真

日本臨床皮膚科医会雑誌 40 ( 3 ) 465 - 465 2023.5

【乾癬】ブロダルマブ自己中断後に膿疱化を生じた乾癬性関節炎の1例

廣瀬梓, 川上佳夫, 吉永泰彦, 三宅智子, 森実真

皮膚科の臨床 65 ( 5 ) 569 - 572 2023.5

Language：Japanese Publisher：金原出版(株)

＜文献概要＞71歳,男性。乾癬性関節炎に対してアダリムマブで加療するも二次無効となり,紅皮症化したためブロダルマブを開始した。その後皮膚症状,関節症状ともに速やかに改善したが,2ヵ月間の自己中断後に発熱,関節痛,皮疹の膿疱化を認めた。ブロダルマブを再開し,速やかに皮疹は改善した。今後も治療を自己中断する懸念があり,ブロダルマブをグセルクマブに変更した。しかし,関節症状が再燃したため,さらにセルトリズマブペゴルに変更し,皮膚,関節症状ともに改善した。抗IL-17受容体A抗体であるブロダルマブは,中止後にリバウンド現象として膿疱化が出現することがあるため,治療を自己中断しないよう厳格に指導する必要がある。

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当院における強皮症合併重症下肢虚血7例の臨床学的検討

松田吉弘, 三宅智子, 戸田洋伸, 立花宏太, 野村隼人, 平井陽至, 川上佳夫, 迫田直也, 廣田真規, 森実真

日本皮膚科学会雑誌 133 ( 5 ) 1361 - 1361 2023.5

桂枝茯苓丸を併用した酒さ様皮膚炎の3例

高須賀琴巳, 横溝紗佑里, 横山恵美, 川上佳夫, 安井陽子, 神崎寛子, 森実真

日本臨床皮膚科医会雑誌 40 ( 3 ) 480 - 480 2023.5

セクキヌマブが奏功した掌蹠膿疱症を背景とする膿疱性乾癬の1例

澤井希望, 川上佳夫, 徳田真優, 廣瀬梓, 別木祐介, 高須賀琴巳, 篠倉美里, 立花宏太, 横山恵美, 三宅智子, 平井陽至, 森実真, 多田譲治

日本皮膚科学会雑誌 133 ( 3 ) 524 - 524 2023.3

新規ALOX12B遺伝子病的バリアントを認めた先天性魚鱗癬様紅皮症の1例

前琴絵, 梶田藍, 川上佳夫, 森実真, 野田達宏, 武市拓也, 秋山真志

日本皮膚科学会雑誌 133 ( 2 ) 262 - 262 2023.2

Cutaneous Pseudolymphoma Caused by an Injury with a Metallic Piece of a Mowing Machine Containing Tungsten. International journal

Mayu Tokuda, Yoshio Kawakami, Yoji Hirai, Kota Tachibana, Yuki Nakagawa, Satoru Sugihara, Tomoko Miyake, Osamu Yamasaki, Keiko Manabe, Shin Morizane

Indian journal of dermatology 68 ( 4 ) 468 - 470 2023

"Input/output cytokines" in epidermal keratinocytes and the involvement in inflammatory skin diseases. International journal

Shin Morizane, Tomoyuki Mukai, Ko Sunagawa, Kota Tachibana, Yoshio Kawakami, Mamoru Ouchida

Frontiers in immunology 14 1239598 - 1239598 2023

Language：English Publishing type：Research paper (scientific journal)

Considering the role of epidermal keratinocytes, they occupy more than 90% of the epidermis, form a physical barrier, and also function as innate immune barrier. For example, epidermal keratinocytes are capable of recognizing various cytokines and pathogen-associated molecular pattern, and producing a wide variety of inflammatory cytokines, chemokines, and antimicrobial peptides. Previous basic studies have shown that the immune response of epidermal keratinocytes has a significant impact on inflammatory skin diseases. The purpose of this review is to provide foundation of knowledge on the cytokines which are recognized or produced by epidermal keratinocytes. Since a number of biologics for skin diseases have appeared, it is necessary to fully understand the relationship between epidermal keratinocytes and the cytokines. In this review, the cytokines recognized by epidermal keratinocytes are specifically introduced as "input cytokines", and the produced cytokines as "output cytokines". Furthermore, we also refer to the existence of biologics against those input and output cytokines, and the target skin diseases. These use results demonstrate how important targeted cytokines are in real skin diseases, and enhance our understanding of the cytokines.

DOI： 10.3389/fimmu.2023.1239598

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Co-occurrence of non-alcoholic steatohepatitis exacerbates psoriasis associated with decreased adiponectin expression in a murine model. International journal

Daiki Takezaki, Shin Morizane, Kenta Ikeda, Masanori Iseki, Yuma Sakamoto, Yoshio Kawakami, Taishi Hashiguchi, Yuka Shirakata, Sohji Nishina, Tomoyuki Mukai

Frontiers in immunology 14 1214623 - 1214623 2023

Language：English Publishing type：Research paper (scientific journal)

INTRODUCTION: Clinical studies have suggested a bidirectional association between non-alcoholic steatohepatitis (NASH) and psoriasis, affecting each other's development and severity. Here, we explored bidirectional causal linkages between NASH and psoriasis using a murine model. METHODS: NASH was induced in mice by streptozotocin injection at 2 days of age and by high-fat diet feeding (STAM™ model). Psoriasis was induced by topical application of imiquimod (IMQ) on the ear. The severities of liver damage and psoriatic skin changes were determined using histological analysis. Gene expression in the skin tissues was evaluated using quantitative PCR analysis. Serum cytokine levels were determined using enzyme-linked immunosorbent assay. To examine the innate immune responses of normal human epidermal keratinocytes (NHEKs), the cells were treated with interleukin (IL)-17A, tumor necrosis factor (TNF)-α, and AdipoRon, an adiponectin receptor agonist. RESULTS AND DISCUSSION: There were no differences in the degree of liver tissue damage (fat deposition, inflammation, and fibrosis) between NASH mice with and those without psoriasis. Conversely, the co-occurrence of NASH significantly augmented psoriatic skin changes, represented by epidermal hyperplasia, in psoriatic mice. Pro-inflammatory cytokines were expressed in the inflamed skin of psoriatic mice, and the expression of genes, especially Il23a, Il1b, Il36g, and Mip2, was significantly upregulated by the co-occurrence of NASH. The expression of keratinocyte activation marker genes Defb4b and Krt16 was also upregulated by the co-occurrence of NASH. The serum TNF-α and IL-17 levels were increased by the co-occurrence of NASH and psoriasis. The serum adiponectin levels decreased in NASH mice compared with that in non-NASH mice. In NHEK culture, TNF-α and IL-17A synergistically upregulated CXCL1, CXCL8, and IL1B expression. The upregulated pro-inflammatory gene expression was suppressed by AdipoRon treatment, reflecting the anti-inflammatory capacity of adiponectin. CONCLUSION: The co-occurrence of NASH exacerbated psoriatic skin changes associated with increased serum inflammatory cytokine levels and decreased serum adiponectin levels. Combined with in vitro findings, increased inflammatory cytokine levels and decreased adiponectin levels likely promote innate immune responses in epidermal keratinocytes in psoriatic skin lesions. Overall, therapeutic intervention for co-occurring NASH is essential to achieve a favorable prognosis of psoriasis in clinical practice.

DOI： 10.3389/fimmu.2023.1214623

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A case of generalized allergic contact dermatitis due to sodium lauroyl methylaminopropionate in a shampoo. International journal

Azusa Hirose, Yoshio Kawakami, Tomoko Miyake, Yoji Hirai, Shin Morizane

Contact dermatitis 87 ( 6 ) 546 - 548 2022.12

Cutaneous toxicity with suprabasal blisters and dyskeratosis following administration of enfortumab vedotin. International journal

Ken-Ichi Hasui, Yoshio Kawakami, Tomoko Miyake, Yoji Hirai, Hayato Nomura, Kohei Edamura, Motoo Araki, Shin Morizane

The Journal of dermatology 2022.11

A case of neuro-Behcet's disease preceded by cellulitis-like cutaneous arteritis and multiple pharyngeal ulcers. International journal

Emi Yokoyama, Yoshio Kawakami, Takayuki Katsuyama, Hidenori Marunaka, Shin Morizane

International journal of dermatology 2022.10

Novel homozygous missense mutation c.1654G>T in the ALOX12B gene causing congenital ichthyosiform erythroderma. International journal

Kotoe Mae, Yoshio Kawakami, Ai Kajita, Takuya Takeichi, Tatsuhiro Noda, Yoji Hirai, Masashi Akiyama, Shin Morizane

The Journal of dermatology 50 ( 1 ) e37-e38 2022.10

Flare-up of generalized pustular psoriasis following Pfizer-BioNTech BNT162b2 mRNA COVID-19 vaccine: Two cases without mutations of IL36RN and CARD14 genes. International journal

Kota Tachibana, Yoshio Kawakami, Mayu Tokuda, Shiho Sato, Satoru Sugihara, Tomoko Miyake, Kazumitsu Sugiura, Shin Morizane

The Journal of dermatology 49 ( 10 ) e393-e394 2022.10

臀部皮下腫瘤を主訴に受診し痔瘻と診断した2例

蓮井謙一, 立花宏太, 杉原悟, 川上佳夫, 森実真

日本皮膚外科学会誌 26 ( 2 ) 44 - 44 2022.9

全長BP180 ELISA法にて診断し得た水疱性類天疱瘡の1例

石井芙美, 三宅智子, 杉本佐江子, 川上佳夫, 松田真由子, 森田安理, 山崎修, 石井文人, 泉健太郎, 西江渉, 橋本隆, 森実真

皮膚科の臨床 64 ( 10 ) 1675 - 1679 2022.9

Language：Japanese Publisher：金原出版(株)

＜文献概要＞80歳,男性。2001年より夏季に下腿に水疱が出現した。病理組織像では好酸球浸潤を混じる表皮下水疱を認め,水疱性類天疱瘡を疑ったが,抗BP180 NC16a部位抗体,蛍光抗体法と全長BP180 ELISAは陰性だった。経過中,蛍光抗体間接法のみ表皮側に陽性となった。2018年に四肢・体幹にびらんと緊満性水疱が生じ,蛍光抗体直接法で表皮基底膜部にIgGが線状に沈着し,全長BP180 ELISAは陽性,免疫ブロット法でBP180 C末端部リコンビナント蛋白と120kDa LAD-1に対する抗体陽性,ELISAでBP230に対する抗体も陽性となり,水疱性類天疱瘡と診断した。症状を繰り返すなかでepitope spreading現象がおきたと考えた。

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COVID-19ワクチンの接種後に全身性膿疱性乾癬を発症した2例

徳田真優, 立花宏太, 川上佳夫, 佐藤志帆, 三宅智子, 内田隆文, 福島智恵, 杉浦一充, 森実真

日本皮膚科学会雑誌 132 ( 5 ) 1309 - 1309 2022.5

金属異物によって生じた前頸部pseudolymphoma

徳田真優, 平井陽至, 川上佳夫, 立花宏太, 中川裕貴, 杉原悟, 三宅智子, 山崎修, 森実真, 眞部恵子, 浅越健治

日本皮膚科学会雑誌 132 ( 3 ) 506 - 506 2022.3

特異疹が緊満性水疱を呈したATLLの1例

妹尾春佳, 橋本倫子, 神野泰輔, 川上佳夫, 平井陽至, 山崎修, 森実真, 谷口恒平, 松岡賢市

日本皮膚科学会雑誌 132 ( 1 ) 99 - 99 2022.1

Persistent local inflammation surrounding cement substance of a tick Amblyomma testudinarium after sufficient removal of its mouthpart. International journal

Shiho Sato, Yoshio Kawakami, Yohei Yasutomi, Emi Yokoyama, Toshiko Yoshioka, Osamu Yamasaki, Shin Morizane

The Journal of dermatology 49 ( 1 ) e9-e10 2022.1

Updated allele frequencies of SERPINB7 founder mutations in Asian patients with Nagashima-type palmoplantar keratosis/keratoderma. International journal

Yasutoshi Ito, Takuya Takeichi, Kenta Ikeda, Kana Tanahashi, Takenori Yoshikawa, Yuya Murase, Yoshinao Muro, Yoshio Kawakami, Yasuo Nakamura, Kanako Matsuyama, Jun Muto, Naoki Oiso, Shin Morizane, Kazumitsu Sugiura, Yasushi Suga, Mariko Seishima, Akira Kawada, Tomoo Ogi, Masashi Akiyama

Journal of dermatological science 103 ( 2 ) 116 - 119 2021.8

Apalutamide-induced exanthematous drug eruption displaying spongiotic dermatitis successfully treated with dose reduction. Reviewed International journal

Yoshio Kawakami, Masao Mitsui, Hitoshi Takamoto, Yasuo Yamamoto

International journal of dermatology 60 ( 8 ) e315-e317 2021.8

Granular C3 dermatosis: Report of a case resembling dermatophytid in association with tinea pedis. International journal

Yoshio Kawakami, Yumi Aoyama, Kotaro Tada, Kazushi Anzawa, Akiko Nishibu, Takashi Mochizuki, Shin Morizane

The Journal of dermatology 48 ( 7 ) e320-e321 2021.7

Cutaneous adult T-cell leukemia/lymphoma with granulomatous reaction. International journal

Yuki Nakagawa, Yoshio Kawakami, Tomoko Kawamoto, Tomoko Miyake, Yoji Hirai, Osamu Yamasaki, Shin Morizane

The Journal of dermatology 48 ( 6 ) e273-e274 2021.6

Two cases of severe congenital hypotrichosis caused by compound heterozygous mutations in the LSS gene. International journal

Mami Murata, Ryota Hayashi, Yoshio Kawakami, Shin Morizane, Yutaka Shimomura

The Journal of dermatology 48 ( 3 ) 392 - 396 2021.3

Language：English Publishing type：Research paper (scientific journal)

It has recently been shown that bi-allelic mutations in the lanosterol synthase (LSS) gene, which was originally reported as a causative gene for congenital cataracts, underlie a non-syndromic form of hypotrichosis. Furthermore, it has also been revealed that mutations in the LSS gene can cause syndromic forms of hypotrichosis. To date, however, clear genotype-phenotype correlations have not completely been characterized. In this study, we identified two Japanese patients who had severe congenital hypotrichosis without any other associated findings. Their scalp hairs were extremely short and thin, and were able to be plucked easily. Observation of the plucked hairs showed aberrantly-miniaturized anagen hair follicles. Genetic analysis demonstrated that both patients carried bi-allelic mutations in the LSS gene in a compound heterozygote state. Our findings further underscore the crucial roles of the LSS gene in hair follicle development and hair growth in humans.

DOI： 10.1111/1346-8138.15679

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A case of allergic contact dermatitis due to 3-glyceryl ascorbate in a skin-lightening lotion. International journal

Yoshio Kawakami, Takatsune Umayahara, Yoji Hirai, Shin Morizane

Contact dermatitis 2021.2

A case of bromoderma improved by reduction of potassium bromide

Yohei Yasutomi, Yoshio Kawakami, Minori Sasakura, Yoji Hirai, Osamu Yamasaki, Shin Morizane

Nishinihon Journal of Dermatology 83 ( 1 ) 18 - 21 2021

A case of mycobacterium marinum infection following injury by stingray inhabiting seto inland sea in Japan

Shogo Tanimoto, Yoshio Kawakami, Yohei Yasutomi, Osamu Yamasaki, Shin Morizane

Nishinihon Journal of Dermatology 82 ( 6 ) 460 - 463 2021

Solitary fibrous tumor of the inguinal region displaying heterogeneous echogenicity and its correlation with histopathologic findings

Ai Kajita, Yoshio Kawakami, Tomoko Miyake, Wakako Oda, Osamu Yamasaki, Shin Morizane

Our Dermatology Online 11 ( 4 ) 432 - 433 2020.11

Coexistence of Mycobacterium ulcerans ssp. shinshuense and Mycobacterium avium in a patient with Buruli ulcer-compatible lesions. International journal

Shusaku Fujita, Yoshio Kawakami, Haruka Yamasaki, Satoru Sugihara, Tomoko Miyake, Yuji Miyamoto, Yoshihiko Hoshino, Norihisa Ishii, Osamu Yamasaki, Shin Morizane

The Journal of dermatology 47 ( 11 ) e400-e401 2020.11

Dermal fillers do not induce upregulation of NLRP3 inflammasomes or expression of inflammatory cytokines in granulomas. International journal

Markus Reinholz, Benjamin M Clanner-Engelshofen, Markus V Heppt, Enklajd Marsela, Yoshio Kawakami, Luitgard G Wiest, Lars E French, Wilhelm Stolz, Gerd G Gauglitz

Journal of cosmetic dermatology 19 ( 11 ) 2838 - 2844 2020.11

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Filling materials have increasingly been used in aesthetics over the last decades. Understanding the pathophysiology of granuloma formation as a very relevant unwanted side effect of filler application may be essential to help avoid these adverse events. AIMS: Our aim was to investigate the role of the inflammasome in the formation of filler granuloma, as a central column of the innate immune response. METHODS: RPMI 1640 medium was used for growth of THP-1 cells and the induction of THP-1 macrophages. Sonication was applied in order to crush the acrylic particles of the filler. ELISA was the method of analysis for the specific cytokines. Biopsy specimens of filler granuloma were analyzed by various immunohistochemical methods. GraphPad Prism 5 software was used for the statistical data analysis. RESULTS: Neither was the sensor NALP3 overexpressed, nor could an elevated expression of cleaved IL-1β, IL-18, or IFN-γ be detected. Furthermore, no increased expression of IL-8 or IL-1β was detectable in vitro. CONCLUSION: No increased inflammasome activation could be observed; however, filler granulomas were infiltrated with granulocytes and macrophages. Therefore, we speculate that an unspecific immune response might be the key player in the formation of filler granuloma.

DOI： 10.1111/jocd.13341

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Classical Vohwinkel syndrome with heterozygous p.Asp66His mutation in GJB2 gene: Second Asian case. International journal

Kenta Ikeda, Takuya Takeichi, Yasutoshi Ito, Yoshio Kawakami, Yuki Nakagawa, Seiko Naito, Osamu Yamasaki, Masashi Akiyama, Shin Morizane

The Journal of dermatology 47 ( 10 ) e352-e354 2020.10

Familial nasal dermoid sinus cysts skipping generations. International journal

Kimiko Nishigaki, Osamu Yamasaki, Yoshio Kawakami, Minori Sasakura, Tomoko Miyake, Aiji Ohtsuka, Junko Kousogabe, Shin Morizane

The Journal of dermatology 47 ( 10 ) e373-e375 2020.10

在宅医と連携した進行期悪性黒色腫

石井芙美, 山崎修, 加持達弥, 川上佳夫, 森実真, 片山英樹, 國末充央, 武藤純, 小森栄作

Skin Cancer 35 ( 1 ) 1 - 5 2020.6

Language：Japanese Publisher：(一社)日本皮膚悪性腫瘍学会

近年、免疫チェックポイント阻害剤やBRAF+MEK阻害剤などの進行期悪性黒色腫に対する新規治療が生存期間の延長に寄与している。さらに進行した場合でも緩和治療を行いながら、積極的な治療介入も可能である。しかし緩和ケア病棟など緩和ケアを専門に提供する病院では原病の新規治療が困難な場合がある。がん診療専門病院と在宅医が連携することにより悪性黒色腫の新規治療をしながら在宅療養することも1つの選択肢となる。当科で経験した新規治療中で、訪問診療専門クリニックと連携した4例について検討した。男性3名、女性1名、年齢は36～84歳、全例病期IV、在宅医紹介時の治療は、BRAF+MEK阻害剤1例、ニボルマブ2例、イピリブマブ1例、在宅診療期間は24～84日であった。1例は当院、3例は自宅での看取りとなった。在宅診療の介入パターンはさまざまであるが、患者の希望に沿う進行期の治療が提供できた。(著者抄録)

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Atezolizumab-induced lichen planus pemphigoides in a patient with metastatic non-small-cell lung cancer. International journal

Haruka Senoo, Yoshio Kawakami, Emi Yokoyama, Osamu Yamasaki, Shin Morizane

The Journal of dermatology 47 ( 4 ) e121-e122 2020.4

A case of leukocytoclastic vasculitis occurred during combination chemotherapy of cetuximab and paclitaxel

Yohei Yasutomi, Yoshio Kawakami, Minori Sasakura, Taisuke Kanno, Yuko Fujimoto, Tomoko Miyake, Osamu Yamasaki, Shin Morizane

Nishinihon Journal of Dermatology 82 ( 4 ) 271 - 275 2020

Pediatric-onset annular pustular psoriasis in a patient with Down syndrome. International journal

Anri Morita, Yoshio Kawakami, Tatsuya Kaji, Yoji Hirai, Tomoko Miyake, Masayuki Takahashi, Osamu Yamasaki, Kazumitsu Sugiura, Shin Morizane

The Journal of dermatology 46 ( 10 ) e367-e368 2019.10

訪問診療専門クリニックと連携した進行期悪性黒色腫

石井芙美, 山崎修, 加持達弥, 川上佳夫, 片山英樹, 國末充央, 武藤純, 小森栄作

日本皮膚悪性腫瘍学会学術大会プログラム・抄録集 35回 114 - 114 2019.4

直接作用型抗ウイルス薬によるC型肝炎治療後も症状が持続していた形質細胞性口唇炎の1例

永瀬喬之, 梶田藍, 小田和歌子, 原裕一, 川上佳夫

皮膚科の臨床 61 ( 3 ) 419 - 422 2019.3

Language：Japanese Publisher：金原出版(株)

＜文献概要＞70歳,女性。3年前より下口唇にびらんが出現した。1年半前にC型慢性肝炎に対して,レジパスビル/ソホスブビル内服による直接作用型抗ウイルス薬治療を行いHCV RNAは陰性化したが,下口唇の症状は残存していた。初診時,下口唇にびらんを認め,病理検査では真皮内に多数の形質細胞浸潤がみられた。下口唇のびらんは0.1%タクロリムス軟膏を外用して治癒した。形質細胞性口唇炎と肝疾患との関連について述べた報告があるが,自験例ではHCVのウイルス量と口唇炎の病勢との間に直接的な関連は認められなかった。今後は症例の蓄積により,HCVとの関連が示唆される皮膚疾患に対する,直接作用型抗ウイルス薬の効果の有無が明らかにされることを期待したい。

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Local desensitization and progression of multiple fixed drug eruption. International journal

Seiko Mitsui, Chieko Katayama, Yumi Aoyama, Yoshiko Mizukawa, Michiyo Kuyama, Yoshio Kawakami

European journal of dermatology : EJD 28 ( 3 ) 378 - 380 2018.6

Unopposed IL-36 Activity Promotes Clonal CD4+ T-Cell Responses with IL-17A Production in Generalized Pustular Psoriasis. International journal

Akiko Arakawa, Sigrid Vollmer, Petra Besgen, Adrian Galinski, Burkhard Summer, Yoshio Kawakami, Andreas Wollenberg, Klaus Dornmair, Michael Spannagl, Thomas Ruzicka, Peter Thomas, Jörg C Prinz

The Journal of investigative dermatology 138 ( 6 ) 1338 - 1347 2018.6

Language：English Publishing type：Research paper (scientific journal)

Generalized pustular psoriasis (GPP) is the most severe psoriasis variant. Mutations in the IL-36 antagonist IL36RN, in CARD14 or AP1S3 provide genetic evidence for autoinflammatory etiology but cannot explain its pathogenesis completely. Here we demonstrate that unopposed IL-36 signaling promotes antigen-driven and likely pathogenic T-helper type 17 (Th17) responses in GPP. We observed that CD4+ T cells in blood and skin lesions of GPP patients were characterized by intense hyperproliferation, production of the GPP key mediator, IL-17A, and highly restricted TCR repertoires with identical T-cell clones in blood and skin lesions, indicating antigen-driven T-cell expansions. The clonally expanded CD4+ T cells were major producers of IL-17A. IL-36 signaling substantially enhanced TCR-mediated proliferation of CD4+ T cells. Moreover, GPP patients showed preferences for HLA-DRB1∗14, HLA-DQB1∗05, and HLA-DQB1∗03. We conclude that in GPP unopposed IL-36 signaling and certain HLA-class II alleles may cooperate in promoting antigen-driven Th17 responses, which in the obvious absence of exogenous triggers may reflect autoimmune reactions. This study reveals a pathogenic pathway where innate immune dysregulation promotes T-cell-mediated inflammation in GPP.

DOI： 10.1016/j.jid.2017.12.024

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Anaphylaxis due to ingestion of jellyfish with possible evidence of epicutaneous sensitization. International journal

Yoshio Kawakami, Shu Taga

The Journal of dermatology 45 ( 1 ) e23-e24 2018.1

Case of inflammatory tinea corporis affecting the dorsal surface of the thumb in a nail salon technician. International journal

Yoshio Kawakami, Shuichiro Hirano, Seiko Mitsui, Michiyo Kuyama, Akiko Nishibu, Kazushi Anzawa, Takashi Mochizuki

The Journal of dermatology 44 ( 11 ) e294-e295 2017.11

Successful use of etoposide for pyoderma gangrenosum associated with myelodysplastic syndrome and trisomy 8: cytokine profiles during treatment. International journal

Dan Fujiwara, Toshihisa Hamada, Osamu Yamasaki, Yasuhisa Sando, Kyosuke Saeki, Nobuharu Fujii, Yoshio Kawakami, Keiji Iwatsuki

European journal of dermatology : EJD 27 ( 5 ) 525 - 527 2017.10

A case of porokeratosis ptychotropica: successful treatment with topical 5% imiquimod cream

Y. Kawakami, S. Mitsui

Clinical and Experimental Dermatology 42 ( 7 ) 839 - 841 2017.10

An unusual clinical presentation of lupus erythematosus tumidus localized on the thigh

T. Hashimoto, Y. Kawakami, H. Wakabayashi, W. Oda, T. Hamada, H. Doi, Y. Aoyama, K. Iwatsuki

Clinical and Experimental Dermatology 42 ( 6 ) 638 - 641 2017.8

Candida albicans-induced pustular lesions in mice. International journal

Yoshio Kawakami, Toshiyuki Yamamoto

The Journal of dermatology 44 ( 5 ) 596 - 597 2017.5

Persistent elevation of serum interleukin-6 and serum amyloid A levels in patients with recessive dystrophic epidermolysis bullosa. International journal

Shin Morizane, Kazuko Mizuno, Tetsuya Takiguchi, Satoko Ogita, Yoshinobu Nishida, Yoshio Kawakami, Keiji Iwatsuki

European journal of dermatology : EJD 27 ( 1 ) 80 - 81 2017.2

A case of disseminated superficial porokeratosis with inflammatory stage

Yoshio Kawakami, Seiko Mitsui, Kenji Imajo

Nishinihon Journal of Dermatology 79 ( 6 ) 558 - 561 2017

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Western Division of Japanese Dermatological Association

A 79-year-old female who had suffered from asymptomatic, annular, hyperkeratotic, brownish macules on the extremities and trunk for 7 years spontaneously developed pruritic erythematous changes of the pre-existing lesions as well as newly formed erythematous papules. A histopathological examination showed typical cornoid lamella and a perivascular infiltration of lymphocytes and eosinophils in the upper dermis. Laboratory investigations revealed eosinophilia. After an inflammatory period lasting for 16 months, the pruritic erythematous changes and the eosinophilia gradually improved, leaving annular, brownish, mildly hyperkeratotic macules. Our case was unusual for its transient inflammatory condition of disseminated superficial porokeratosis (DSP), which was consistent with the previously reported "Inflammatory stage of DSP".

DOI： 10.2336/nishinihonhifu.79.558

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A Case of Streptobacillus moniliformis Infection with Cutaneous Leukocytoclastic Vasculitis.

Yoshio Kawakami, Takashi Katayama, Masayuki Kishida, Wakako Oda, Yasuro Inoue

Acta medica Okayama 70 ( 5 ) 377 - 381 2016.10

Language：English

A 71-year-old man presented with a high fever, polyarthralgia, petechiae and palpable purpura accompanied by livedoid change on his legs and feet. Histopathological findings of the purpura revealed perivascular infiltration of neutrophils, mononuclear cells, and nuclear debris, and extravasation of red cells mainly in the upper dermis: all signs consistent with leukocytoclastic vasculitis. Small vessel thrombi, which are characteristic features of septic vasculopathy, were also observed. Direct immunofluorescence showed negative results. Blood culture revealed the growth of gram-negative bacilli. Subsequently, 16S rRNA sequencing of DNA confirmed the organism as Streptobacillus moniliformis, which is the causative pathogen of rat-bite fever. He had frequently encountered wild rats in his house although there was no evidence of rat bite on his body. Empiric therapy with intravenous administration of ceftriaxone in combination with azithromycin hydrate led to a prompt resolution of the symptoms. Precise history-taking related to contact with rats and detection of skin eruptions suggestive of leukocytoclastic vasculitis on the extremities, especially on the feet, can be clues to Streptobacillus moniliformis infection. Familiarity with its cutaneous features is important for early diagnosis; the evidence herein may also help in understanding its underlying pathogenesis.

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A case of methotrexate-induced stomatitis and skin erosions accompanied by pancytopenia

Seiko Mitsui, Yoshio Kawakami, Takashi Katayama, Masayuki Kishida, Masaaki Usui, Tomoko Hashimoto

Nishinihon Journal of Dermatology 78 ( 4 ) 391 - 394 2016

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Western Division of Japanese Dermatological Association

A 77-year-old female with a 19-year history of rheumatoid arthritis was admitted to our hospital because of the simultaneous appearance of oral mucositis and erosions on her back accompanied by appetite loss.She had been treated with increasing doses of oral methotrexate (MTX), which had started 3 years and 9 months previously, up to 8 mg/week combined with oral prednisolone 5 mg/day.Laboratory investigation revealed leukocytopenia and thrombocytopenia, followed by anemia 3 days later.MTX was stopped and the patient was successfully treated with folic acid 24 mg/day and granulocytecolony stimulating factor 75 μg/day for 3 days.Although oral mucositis is a well-known side effect of MTX, the initial diagnosis of our case was difficult because of the unusual symptom of erosions on her back, which were reminiscent of pemphigus.It is important to recognize that oral mucositis is a predictive sign of bone marrow suppression and to be aware of the appearance of skin erosions and/or ulcerations as side effects of MTX therapy.

DOI： 10.2336/nishinihonhifu.78.391

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Injection site reactions of adalimumab spreading on the trunk in a psoriatic arthritis patient. International journal

Yasunobu Kato, Yoshio Kawakami, Toshiyuki Yamamoto

The Journal of dermatology 40 ( 11 ) 931 - 2 2013.11

HPV16 activates the AIM2 inflammasome in keratinocytes Reviewed

M. Reinholz, Y. Kawakami, S. Salzer, A. Kreuter, Y. Dombrowski, S. Koglin, S. Kresse, T. Ruzicka, J. Schauber

Archives of Dermatological Research 305 ( 8 ) 723 - 732 2013.10

Case of rippled-pattern sebaceoma with clinically yellowish surface and histopathological paucity of lipid-containing neoplastic cells. International journal

Yoshio Kawakami, Shin-ichi Ansai, Taeko Nakamura-Wakatsuki, Toshiyuki Yamamoto

The Journal of dermatology 39 ( 7 ) 644 - 6 2012.7

Hemophagocytic syndrome occurred in a patient with subcutaneous panniculitis-like T-cell lymphoma without overt skin lesion: successful treatment with steroid pulse therapy. International journal

Takako Miura, Yoshio Kawakami, Masataka Sato, Mikio Ohtsuka, Toshiyuki Yamamoto

The Journal of dermatology 38 ( 11 ) 1113 - 1115 2011.11

Letter: Necrobiotic xanthogranuloma of extremities in an elderly patient successfully treated with low-dose prednisolone. International journal

Yoshio Kawakami, Toshiyuki Yamamoto

Dermatology online journal 17 ( 6 ) 13 - 13 2011.6

Language：English

We describe a 93-year-old Japanese woman who developed a painful yellowish plaque with reddish border on her left lower leg. Histological evaluation demonstrated hyaline necrobiosis and granulomatous lesions composed of histiocytes (some with foamy cytoplasm), multinucleated giant cells, and numerous cholesterol crystals. Serum electrophoresis displayed the presence of an M-peak with IgG λ paraproteinemia. There was progressive ulcer formation in the location of the biopsy on the left leg. Multiple tender red dermal and subcutaneous skin nodules developed on her extremities. Oral administration of prednisolone 20 mg daily (0.5 mg/kg) was started. After 4 weeks, she obtained resolution of the skin lesions.

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Childhood tinea incognito caused by Trichophyton mentagrophytes var. interdigitale mimicking pustular psoriasis. International journal

Yoshio Kawakami, Noritaka Oyama, Erika Sakai, Kyoko Nishiyama, Tatsuo Suzutani, Toshiyuki Yamamoto

Pediatric dermatology 28 ( 6 ) 738 - 739 2011

Language：English Publishing type：Research paper (scientific journal)

Tinea incognito refers to fungal infection whose clinical appearance is modified or aggravated by administration of systemic or topical corticosteroids. We report a case of pustular psoriasis-like tinea incognito caused by Trichophyton mentagrophytes var. interdigitale under topical corticosteroid therapy. Sequence analysis of the internal transcribed spacer 2 region, in addition to the D1D2 domain of the 26S ribosomal RNA gene, was helpful in identifying the fungal species.

DOI： 10.1111/j.1525-1470.2010.01380.x

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Seborrheic dermatitis-like eruption following interleukin-2 administration. International journal

Yoshio Kawakami, Taeko Nakamura-Wakatsuki, Toshiyuki Yamamoto

Dermatology online journal 16 ( 9 ) 12 - 12 2010.9

Language：English

We describe a 72-year-old man suffering from renal cell carcinoma with lung metastases who developed scaly erythema on his face after the administration of recombinant interleukin-2 (rIL-2). A skin biopsy revealed intraepidermal and superficial perivascular infiltrate of mononuclear cells that were mainly composed of CD3 positive T-cells. There have been two cases of seborrheic dermatitis-like eruption induced by rIL-2. However, neither of them had histopathological evaluation. To our knowledge, this is the first case of seborrheic dermatitis-like eruption following rIL-2 administration whose histopathological investigations were performed.

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A rare co-occurrence of primary localized cutaneous amyloidosis and chronic C type hepatitis. International journal

Mariko Abe, Yoshio Kawakami, Noritaka Oyama, Taeko Nakamura-Wakatsuki, Toshiyuki Yamamoto

International journal of dermatology 49 ( 8 ) 960 - 2 2010.8

A case of sebaceous naevus of the leg with secondarily developed trichoblastoma. International journal

Yoshio Kawakami, Christian Hafner, Noritaka Oyama, Toshiyuki Yamamoto

Acta dermato-venereologica 90 ( 2 ) 194 - 5 2010.3

Pyoderma gangrenosum following surgical procedures. International journal

Nobuyuki Kikuchi, Yuka Hanami, Takako Miura, Yoshio Kawakami, Masataka Satoh, Mikio Ohtsuka, Toshiyuki Yamamoto

International journal of dermatology 49 ( 3 ) 346 - 8 2010.3

Basal cell carcinoma on the toe. International journal

Yuko Suzuki, Taeko Nakamura-Wakatsuki, Masataka Satoh, Akiko Nishibu, Yoshio Kawakami, Noritaka Oyama, Toshiyuki Yamamoto

Dermatology online journal 16 ( 2 ) 15 - 15 2010.2

A case of pemphigus herpetiformis with absence of antibodies to desmogleins 1 and 3 Reviewed

T Miura, Y Kawakami, N Oyama, M Ohtsuka, Y Suzuki, B Ohyama, T Hashimoto, Y Motoki, T Yamamoto

Journal of the European Academy of Dermatology and Venereology 24 ( 1 ) 101 - 103 2010.1

Cutaneous cryptococcosis in a patient with cirrhosis and hepatitis C virus infection. International journal

Takako Miura, Yoshio Kawakami, Mikio Otsuka, Masahiro Hachiya, Takahiro Yamanoi, Kazutaka Ohashi, Tatsuo Suzutani, Toshiyuki Yamamoto

Acta dermato-venereologica 90 ( 1 ) 106 - 7 2010

A case of lichen sclerosus of the scalp associated with autoantibodies to extracellular matrix protein 1. International journal

Yoshio Kawakami, Noritaka Oyama, Yuka Hanami, Tetsunori Kimura, Kazuhiro Kishimoto, Toshiyuki Yamamoto

Archives of dermatology 145 ( 12 ) 1458 - 60 2009.12

Multiple morphea-like lesions associated with chronic graft-versus-host disease after cord blood transplantation. International journal

Yoshio Kawakami, Mikio Ohtsuka, Atsushi Kikuta, Toshiyuki Yamamoto

Acta dermato-venereologica 89 ( 1 ) 86 - 7 2009

A case of localized dermatitis herpetiformis of the face. International journal

Yoshio Kawakami, Noritaka Oyama, Koichiro Nakamura, Fumio Kaneko

Journal of the American Academy of Dermatology 58 ( 2 Suppl ) S59-60 2008.2

Regression of cutaneous squamous cell carcinoma in a patient with chronic myeloid leukaemia on imatinib mesylate treatment. International journal

Yoshio Kawakami, Koichiro Nakamura, Akiko Nishibu, Hirokatsu Yanagihori, Hideo Kimura, Toshiyuki Yamamoto

Acta dermato-venereologica 88 ( 2 ) 185 - 6 2008

Systemic sclerosis complicated by ovarian cancer. International journal

Yoshio Kawakami, Koichiro Nakamura, Taeko Nakamura-Wakatsuki, Mikio Ohtsuka, Noritaka Oyama, Fumio Kaneko

The Journal of dermatology 34 ( 10 ) 720 - 3 2007.10

Psoriasiform eruption associated with graft-versus-host disease. International journal

Yoshio Kawakami, Noritaka Oyama, Koichiro Nakamura, Fumio Kaneko, Atsushi Kikuta, Hitoshi Suzuki

Acta dermato-venereologica 87 ( 5 ) 436 - 8 2007

A case of 'giant' aneurysmal benign fibrous histiocytoma Reviewed

Y. Kawakami, N. Oyama, A. Nishibu, K. Nakamura, F. Kaneko

Clinical and Experimental Dermatology 31 ( 3 ) 456 - 457 2006.5

A case of sclerodermatous graft-versus-host disease following autologous peripheral blood stem cell transplantation. International journal

Koichiro Nakamura, Yoshio Kawakami, Noritaka Oyama, Fumio Kaneko, Hiroyuki Abe, Hiroya Sagara, Hitoshi Ohto

The Journal of dermatology 33 ( 2 ) 135 - 8 2006.2

Language：English Publishing type：Research paper (scientific journal)

We report a 65-year-old woman with chronic graft-versus-host disease (GVHD) who developed severely sclerotic skin on the fingers, hand and trunk following autologous peripheral blood stem cell transplantation (APBSCT). The patient had suffered from breast cancer and been treated with surgery and chemotherapy. She showed pancytopenia and was treated with APBCST. Four years after APBSCT, she developed the severe sclerotic changes on the fingers, hands, extremities and trunk. The skin biopsy showed a flattened epidermis and a proliferation of collagen bundles in the dermis. No anti-nucleolar DNA titers were detected in the serum. She was diagnosed with chronic GVHD. Despite treatment with oral prednisolone, the skin sclerotic change developed and the breast cancer recurred. She died due to pericarditis. This is a rare case of sclerodermatous GVHD following APBSCT. The serum interleukin (IL)-12 levels were examined during the treatment.

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Increased serum levels of interleukin-6, immunoglobulin and acute phase protein in patients with the severe clinical form of inherited epidermolysis bullosa. International journal

Yoshio Kawakami, Noritaka Oyama, Mikio Ohtsuka, Koichiro Nakamura, Fumio Kaneko

The Journal of dermatology 32 ( 6 ) 503 - 5 2005.6

Mannose-binding lectin polymorphisms in patients with Behçet's disease. International journal

Hongwei Wang, Koichiro Nakamura, Tomoko Inoue, Hirokatsu Yanagihori, Yoshio Kawakami, Shinichi Hashimoto, Noritaka Oyama, Fumio Kaneko, Teizo Fujita, Tomomi Nishida, Nobuhisa Mizuki

Journal of dermatological science 36 ( 2 ) 115 - 7 2004.11

Development of antigen-specific ELISA for circulating autoantibodies to extracellular matrix protein 1 in lichen sclerosus. International journal

Noritaka Oyama, Ien Chan, Sallie M Neill, Andrew P South, Fenella Wojnarowska, Yoshio Kawakami, David D'Cruz, Kirti Mepani, Graham J Hughes, Balbir S Bhogal, Fumio Kaneko, Martin M Black, John A McGrath

The Journal of clinical investigation 113 ( 11 ) 1550 - 9 2004.6

Language：English Publishing type：Research paper (scientific journal)

Lichen sclerosus is a common, acquired chronic inflammatory skin disease of unknown etiology, although circulating autoantibodies to the glycoprotein extracellular matrix protein 1 (ECM1) have been detected in most patients' sera. We have examined the nature of ECM1 epitopes in lichen sclerosus sera, developed an ELISA system for serologic diagnosis, and assessed clinicopathological correlation between ELISA titer and disease. Epitope-mapping studies revealed that lichen sclerosus sera most frequently recognized the distal second tandem repeat domain and carboxyl-terminus of ECM1. We analyzed serum autoantibody reactivity against this immunodominant epitope in 413 individuals (95 subjects with lichen sclerosus, 161 normal control subjects, and 157 subjects with other autoimmune basement membrane or sclerosing diseases). The ELISA assay was highly sensitive; 76 of 95 lichen sclerosus patients (80.0%) exhibited IgG reactivity. It was also highly specific (93.7%) in discriminating between lichen sclerosus and other disease/control sera. Higher anti-ECM1 titers also correlated with more longstanding and refractory disease and cases complicated by squamous cell carcinoma. Furthermore, passive transfer of affinity-purified patient IgG reproduced some histologic and immunopathologic features of lichen sclerosus skin. This new ELISA is valuable for the accurate detection and quantification of anti-ECM1 autoantibodies. Moreover, the values may have clinical significance in patients with lichen sclerosus.

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A case of generalized pustular psoriasis associated with Turner syndrome. International journal

Yoshio Kawakami, Noritaka Oyama, Kazuhiro Kishimoto, Keiji Yamazaki, Akiko Nishibu, Koichiro Nakamura, Satoshi Hoshi, Fumio Kaneko

The Journal of dermatology 31 ( 1 ) 16 - 20 2004.1

Language：English Publishing type：Research paper (scientific journal)

UNLABELLED: We report a 27-year-old Japanese woman with Turner syndrome who had generalized pustular psoriasis of the von Zumbusch type. She developed a febrile diffuse erythema and pustular eruption without any history of preceding psoriasis vulgaris or drug ingestion. Oral treatment with 3.2 mg/kg cyclosporin per day successfully resulted in rapid improvement, followed by a complete remission. To our knowledge, this is the first report describing the unusual coexistence of these two systemic disorders. We discuss a hormone imbalance that might have contributed to the predisposition to pustular psoriasis and difficulties in the management of the patent's treatment. ABBREVIATIONS: TS: Turner syndrome, GPP: generalized pustular psoriasis

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A case of intravascular large B-cell lymphoma with multiple organ involvement. International journal

Hirokatsu Yanagihori, Noritaka Oyama, Yoshio Kawakami, Yohko Sakuma-Oyama, Koichiro Nakamura, Keiji Iwatsuki, Fumio Kaneko

The Journal of dermatology 30 ( 12 ) 910 - 4 2003.12

Language：English Publishing type：Research paper (scientific journal)

Intravascular large B-cell lymphoma (IVL) is a rare systemic disease characterized by clonal proliferation of neoplastic lymphoid cells within the capillary lumina of small blood vessels. The most common sites of involvement are cerebrovascular or sinusoid areas, resulting in a wide variety of neurologic deficits. Herein we describe a case of IVL that presented with multiple internal and external organ involvements, including the skin, bilateral kidneys, and lung, and with an aggressive clinical course. The confirmative diagnosis was based on the microscopic findings of the skin lesion with a B-cell immunophenotype. The patient suffered from repeated severe dyspnea, hypoxemia, and high-grade fever with a simultaneous increase in serum lactate dehydrogenase and soluble IL-2 receptor levels. These manifestations responded dramatically to intravenous injection of corticosteroid (500 mg/day for 3 days). Despite various clinical presentations, no neurological abnormality was observed until the patient died 12 months after the initial combination chemotherapy.

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Multicentric Castleman's disease associated with inherited epidermolysis bullosa. International journal

Yoshio Kawakami, Akiko Nishibu, Satoshi Kikuchi, Mikio Ohtsuka, Koichiro Nakamura, Yoshihiro Nozawa, Masafumi Abe, Keiji Iwatsuki, Fumio Kaneko

The Journal of dermatology 30 ( 9 ) 689 - 93 2003.9

Language：English Publishing type：Research paper (scientific journal)

Multicentric Castleman's disease (MCD) is a rare disorder characterized by fever, polyclonal hypergammaglobulinemia, and generalized lymphadenopathy. It has three histological characteristics: a recognizable architecture, germinal center abnormalities, and plasmacytosis. Inherited epidermolysis bullosa (EB) is also a rare disorder caused by a genetic defect. We report a 43-year-old patient with dystrophic EB, non-Hallopeau-Siemens recessive type or dominant type, displaying clinicopathologic features of MCD. In addition, his serum interleukin-6, which is thought to be responsible for the clinical symptoms in MCD, was elevated.

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