研究者詳細 - 萩谷　英大

論文 - 萩谷　英大

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Successful Treatment of Persistent MRSA Bacteremia using High-dose Daptomycin Combined with Rifampicin 査読

Hideharu Hagiya, Tomohiro Terasaka, Kosuke Kimura, Asuka Satou, Kikuko Asano, Koichi Waseda, Yoshihisa Hanayama, Fumio Otsuka

INTERNAL MEDICINE 53 ( 18 ) 2159 - 2163 2014年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：JAPAN SOC INTERNAL MEDICINE

We herein report a case of persistent methicillin-resistant Staphylococcus aureus (MRSA) bacteremia that was successfully treated with combination therapy consisting of high-dose daptomycin (DAP, 10 mg/kg) and rifampicin. The patient's condition was complicated with multiple infectious foci, including an iliopsoas abscess and epidural abscess, as well as discitis and spondylitis at the cervical, thoracic and lumbar levels. Monotherapy treatments with vancomycin, linezolid and usual-dose DAP were all ineffective. It has been shown that usual-dose DAP administration may result in the emergence of a resistant strain and treatment failure. We would like to emphasize the importance of high-dose DAP therapy for MRSA bacteremia, a condition with a potentially high mortality rate.

DOI： 10.2169/internalmedicine.53.2711

Ceftriaxone-induced Biliary Sludge in a Patient with Uncontrolled Diabetes 査読

Hideharu Hagiya, Kou Hasegawa, Kikuko Asano, Fumio Otsuka

INTERNAL MEDICINE 53 ( 21 ) 2549 - 2550 2014年

Lower Limb Infection in an Infant with Haemophilus influenzae Serotype b

Hideharu Hagiya, Fumio Otsuka

General Medicine 15 ( 1 ) 56 - 58 2014年

[Aortic valve-sparing operation for chronic dissecting aneurysm of the sinus of valsalva associated with redissection in a young woman who experienced out-of-hospital cardiac arrest]. 査読

Matsumoto M, Kubo Y, Kemmochi R, Yamasawa T, Oka T, Iwasaki J, Morimoto N, Hagioka S, Sugiyama J, Hagiya H

Kyobu geka. The Japanese journal of thoracic surgery 66 ( 9 ) 799 - 802 2013年8月

記述言語：日本語出版者・発行元：(株)南江堂

38歳女。胸痛で受診した。妊娠4ヵ月であり、胸部X線検査のみ行った。胸痛は1ヵ月間続き、鎮痛薬でコントロールした。妊娠は継続し出産した。突然心肺停止となり、心肺蘇生を開始した。救急隊到着後、2回の除細動で心室細動(20分間)から心拍再開し、搬送された。入院時心電図所見では、左室肥大とV3～V6のST低下を認めた。3D-CT所見では、上行大動脈解離と右Valsalva洞部に動脈瘤を認めた。挙児の希望があり、Bentall手術となった場合は生体弁使用を念頭に、緊急手術を行った。2年前の胸痛の原因が大動脈解離であった可能性が示唆された。慢性解離性大動脈瘤によるsino-tubular junction拡大が大動脈弁逆流の原因であり、自己弁温存手術の方針とした。術後37日目に退院し、術後2ヵ月目に高次機能も問題なく職場復帰をはたした。

その他リンク： https://search.jamas.or.jp/default/link?pub_year=2013&ichushi_jid=J00349&link_issn=&doc_id=20130726020008&doc_link_id=1390001288081728128&url=https%3A%2F%2Fcir.nii.ac.jp%2Fcrid%2F1390001288081728128&type=CiNii&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00003_2.gif

[Surgical treatment of traumatic aortic rupture]. 査読

Yamasawa T, Matsumoto M, Kubo Y, Kemmochi R, Morimoto N, Hagioka S, Sugiyama J, Hagiya H, Nakai M

Kyobu geka. The Japanese journal of thoracic surgery 66 ( 7 ) 537 - 540 2013年7月

Systemic varicella-zoster virus infection in two critically ill patients in an intensive care unit 査読国際誌

Hideharu Hagiya, Maya Kimura, Toru Miyamoto, Fumio Otsuka

VIROLOGY JOURNAL 10 225 - 225 2013年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：BIOMED CENTRAL LTD

Varicella-zoster virus (VZV) usually causes localized zoster in adults. However, in immunocompromised patients, it can cause systemic infection accompanied by complications such as pneumonia, encephalitis, and hepatitis. Although most of critically ill patients in intensive care unit (ICU) are immunologically compromised, they are usually not considered to be at risk for systemic VZV infection.
We report two cases of systemic VZV infection occurring in critically ill patients in an ICU. One patient was a 69-year-old man with Streptococcus pneumoniae-induced purpurafulminans, and the other was a 75-year-old woman with severe acute pancreatitis. During the clinical course in the ICU, characteristic vesicles with umbilical fossa appeared diffusely and bilaterally on their face, trunk, and extremities. VZV-specific IgG levels were confirmed to be elevated compared to that of the pre-onset, and a diagnosis of recurrent VZV infection was made in both patients. The patients were treated at the same ICU but did not coincide with each other; therefore a cross-infection was unlikely. They were treated with intravenous acyclovir, but the latter patient eventually died of respiratory failure.
VZV infection can cause a number of serious complications, and can lead to death in some patients. Early detection and proper treatment are needed to prevent the infection from spreading out and save the patients. It might be necessary to consider antiviral prophylaxis against VZV infection for a part of critically ill patients in ICU, although the effectiveness of this approach is yet to be established.

DOI： 10.1186/1743-422X-10-225

Clinical Characteristics of Ochrobactrum anthropi Bacteremia 査読国際誌

Hideharu Hagiya, Kouhei Ohnishi, Miyako Maki, Naoto Watanabe, Tomoko Murase

JOURNAL OF CLINICAL MICROBIOLOGY 51 ( 4 ) 1330 - 1333 2013年4月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：AMER SOC MICROBIOLOGY

The clinical picture of Ochrobactrum anthropi infection is not well described because the infection is rare in humans and identification of the pathogen is difficult. We present a case of O. anthropi bacteremia that was initially misidentified as Ralstonia paucula and later identified by 16S rRNA sequencing and recA analysis.

DOI： 10.1128/JCM.03238-12

Co-infection with invasive pulmonary aspergillosis and Pneumocystis jirovecii pneumonia after corticosteroid therapy 査読国際誌

Hideharu Hagiya, Takayoshi Miyake, Yusuke Kokumai, Tomoko Murase, Yasutoshi Kuroe, Hiroyoshi Nojima, Junichi Sugiyama, Hiromichi Naito, Shingo Hagioka, Naoki Morimoto

JOURNAL OF INFECTION AND CHEMOTHERAPY 19 ( 2 ) 342 - 347 2013年4月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SPRINGER JAPAN KK

A 95-year-old man with chronic obstructive pulmonary disease and chronic hepatitis C virus infection was treated for acute lung injury caused by Chlamydophila pneumoniae with antibiotics and high-dose corticosteroids. In total, 7,500 mg methylprednisolone and 680 mg prednisolone were administered over 21 days. However, respiratory failure progressed, and chest computed tomography (CT) scan showed bilateral ground-glass opacity and cavity-forming consolidation in the right upper lobe. Despite intensive therapy, the patient died of multiple organ failure on day 7. CT-guided necropsy was performed, and pathological examination revealed invasive pulmonary aspergillosis and Pneumocystis jirovecii pneumonia. Invasive pulmonary aspergillosis and P. jirovecii pneumonia are both life-threatening opportunistic fungal infections. Co-infection of these organisms is rare but possible if the patient is in an extremely immunocompromised state. Short-term but high-dose systemic corticosteroid therapy was considered to be the risk factor in this case. We should pay more attention to immunocompromised hosts who might be suffering from co-infection of opportunistic infections. Moreover, we need to consider preventive measures in such high-risk cases.

DOI： 10.1007/s10156-012-0473-9

Delftia acidovorans bacteremia caused by bacterial translocation after organophosphorus poisoning in an immunocompetent adult patient 査読国際誌

Hideharu Hagiya, Tomoko Murase, Junichi Sugiyama, Yasutoshi Kuroe, Hiroyoshi Nojima, Hiromichi Naito, Shingo Hagioka, Naoki Morimoto

JOURNAL OF INFECTION AND CHEMOTHERAPY 19 ( 2 ) 338 - 341 2013年4月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SPRINGER JAPAN KK

A 46-year-old woman was transferred to our emergency unit because of impaired consciousness and respiratory failure with the history of excessive pesticide intake. The patient was hypersalivative and had bilateral pupillary miosis. Laboratory results showed markedly decreased cholinesterase. She was intubated and treated in the intensive care unit with the diagnosis of organophosphorus poisoning. The patient had persisted diarrhea, with a high fever and stomach tenderness on day 10. Whole-body contrast enhanced computed tomography revealed a swollen, enhanced small intestinal wall, and blood culture identified Delftia acidovorans. She was diagnosed as D. acidovorans bacteremia, probably caused by bacterial translocation based on the clinical presentation and the exclusion of other sources, and treated well with a total of 8 days of antibiotic therapy. So far as we know, this is the first case of D. acidovorans bacteremia that was presumably caused by bacterial translocation after organophosphorus poisoning in an immunocompetent adult patient.

DOI： 10.1007/s10156-012-0472-x

Disseminated Gonococcal Infection in An Elderly Japanese Man 査読

Hideharu Hagiya, Nobuhiko Onishi, Hirotaka Ebara, Yoshihisa Hanayama, Susumu Kokeguchi, Motoko Nose, Nobuchika Kusano, Fumio Otsuka

INTERNAL MEDICINE 52 ( 23 ) 2669 - 2673 2013年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：JAPAN SOC INTERNAL MEDICINE

We herein present the case of a 69-year-old Japanese man who had unprotected sexual contact with a local commercial sex worker in an East Asian country and was diagnosed as having disseminated gonococcal infection (DGI). The organism was confirmed to be Neisseria gonorrhoeae based on 16S rRNA sequencing and positive results for the cppB gene. This case indicates that a diagnosis of DGI should also be considered in elderly individuals. DGI potentially causes many complications, and the pathogen has recently been reported to be resistant to various antibiotics. Physicians must therefore pay more attention to the possible occurrence of DGI in various clinical settings.

DOI： 10.2169/internalmedicine.52.1033

Group A streptococcal meningitis in a patient with palmoplantar pustulosis 査読

Hideharu Hagiya, Fumio Otsuka

Internal Medicine 52 ( 23 ) 2675 - 2678 2013年

記述言語：英語掲載種別：研究論文（学術雑誌）

A 64-year-old man with a 10-year history of palmoplantar pustulosis, a recent history of cranial surgery and a persistent upper airway infection presented with a high fever and deep coma. The patient was diagnosed with Group A Streptococcal meningitis and promptly treated with antibiotics. Although his general condition recovered well, sensorineural hearing loss and facial palsy remained. Group A Streptococcal meningitis is a rare condition, and its typical clinical picture and epidemiological features remain poorly understood. Physicians need to be more aware of this infection, which is extremely rare but frequently causes various complications and yields a high mortality. © 2013 The Japanese Society of Internal Medicine.

DOI： 10.2169/internalmedicine.52.0499

A Fatal Case of Streptococcal Toxic Shock Syndrome due to Streptococcus dysgalactiae subsp equisimilis Possibly Caused by an Intramuscular Injection 査読

Hideharu Hagiya, Shunji Okita, Yasutoshi Kuroe, Hiroyoshi Nojima, Shinkichi Otani, Junichi Sugiyama, Hiromichi Naito, Susumu Kawanishi, Shingo Hagioka, Naoki Morimoto

INTERNAL MEDICINE 52 ( 3 ) 397 - 402 2013年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：JAPAN SOC INTERNAL MEDICINE

An 88-year-old man died of streptococcal toxic shock syndrome due to a group G streptococcus infection that was possibly caused by an intramuscular injection given 30 hours earlier in his right deltoid muscle. The causative pathogen was later identified to be Streptococcus dysgalactiae subsp. equisimilis (stG485). Although providing intramuscular injections is an essential skill of health care workers that is performed daily worldwide, it may constitute a port of entry for pathogens via skin breaches that can cause life-threatening infections. All invasive procedures should be carefully performed, especially when immunologically compromised patients are involved.

DOI： 10.2169/internalmedicine.52.8846

Pyometra Perforation Caused by Actinomyces without Intrauterine Device Involvement. 査読国際誌

Hagiya H

Case reports in obstetrics and gynecology 2013 658902 - 658902 2013年

Successful Treatment of Recurrent Candidemia due to Candidal Thrombophlebitis Associated with a Central Venous Catheter Using a Combination of Fosfluconazole and Micafungin 査読

Hideharu Hagiya, Hiroki Kajioka

INTERNAL MEDICINE 52 ( 18 ) 2139 - 2143 2013年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：JAPAN SOC INTERNAL MEDICINE

We herein report the case of an 85-year-old woman presenting with right internal jugular vein candidal thrombophlebitis associated with central venous catheters (CTCVC). The infecting agent was Candida albicans, which caused recurrent candidemia five times in total. Micafungin (MCFG) alone was ineffective; however, the combination of MCFG with fosfluconazole (F-FLCZ) successfully treated the patient without a need for any anticoagulant or surgical therapies. To the extent of our knowledge, this is the first report of CTCVC being successfully treated with a combination of F-FLCZ and MCFG. These new antifungal agents have better efficacy, tolerability and bioavailability; therefore, they can be useful alternatives to classical combination therapies such as amphotericin-B and 5-fluorocytosine.

DOI： 10.2169/internalmedicine.52.0584

Ineffectiveness of Daptomycin in the Treatment of Septic Pulmonary Emboli and Persistent Bacteremia Caused by Methicillin-resistant Staphylococcus aureus 査読

Hideharu Hagiya, Shingo Hagioka, Fumio Otsuka

INTERNAL MEDICINE 52 ( 22 ) 2577 - 2582 2013年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：JAPAN SOC INTERNAL MEDICINE

A 73-year-old man with long-term food deprivation and total parenteral nutrition was diagnosed with septic pulmonary emboli (SPE) and a persistent bacteremia caused by central line-associated blood stream methicillin-resistant Staphylococcus aureus (MRSA) infection. Although daptomycin (DAP) failed to treat the persistent bacteremia, linezolid successfully controlled it. DAP is inactivated by lung surfactant, and therefore, it should not be administered for lower respiratory infections. However, SPE caused by MRSA has been reported to be treatable with DAP since it is an infection of the lung parenchyma. We herein report the lack of effect of daptomycin in SPE treatment.

DOI： 10.2169/internalmedicine.52.0023

Emphysematous liver abscesses complicated by septic pulmonary emboli in patients with diabetes: Two cases 査読

Hideharu Hagiya, Yasutoshi Kuroe, Hiroyoshi Nojima, Shinkichi Otani, Junichi Sugiyama, Hiromichi Naito, Susumu Kawanishi, Shingo Hagioka, Naoki Morimoto

Internal Medicine 52 ( 1 ) 141 - 145 2013年

記述言語：英語掲載種別：研究論文（学術雑誌）

An emphysematous liver abscess is a fatal condition that often occurs in patients with uncontrolled diabetes mellitus. I herein describe two cases of Klebsiella pneumoniae-induced emphysematous liver abscesses complicated by septic pulmonary emboli in patients with poorly controlled diabetes mellitus. Both patients showed hemoglobin A1c levels of more than 10% and did not present with any abdominal symptoms on admission. However, they were diagnosed and successfully treated with percutaneous transhepatic abscess drainage and antibiotics. This fatal disease should be taken into consideration in patients with uncontrolled diabetes mellitus who suffer from prolonged fevers and uncharacteristic general malaise. © 2013 The Japanese Society of Internal Medicine.

DOI： 10.2169/internalmedicine.52.8737

Is wet swab superior to dry swab as an intranasal screening test? 査読国際誌

Hideharu Hagiya, Mitsunobu Mio, Tomoko Murase, Keiko Egawa, Yumi Kokumai, Taeko Uchida, Naoki Morimoto, Fumio Otsuka, Sumiko Shiota

Journal of Intensive Care 1 ( 1 ) 10 - 10 2013年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：BioMed Central Ltd.

Methicillin-resistant Staphylococcus aureus is still a great concern, and recognition of the carrier is essential for appropriate infection control in intensive care units. The utility of wet swab compared to dry swab as an intranasal screening test has not been well assessed yet. A comparative study of the wet and dry swab in its ability to detect the organism was performed against critically ill patients, and it was found that there were no statistically significant differences between the two different methods. The wet swab did not show increased sensitivity compared to dry one.

DOI： 10.1186/2052-0492-1-10

Severe Soft Tissue Infection of the Lower Extremity Caused by Haemophilus influenzae (serotype f, biotype II) in an Adult Patient 査読

Hideharu Hagiya, Tomoko Murase, Hiromichi Naito, Shingo Hagioka, Naoki Morimoto

INTERNAL MEDICINE 51 ( 13 ) 1783 - 1787 2012年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：JAPAN SOC INTERNAL MEDICINE

The infection caused by non-b-type Haemophilus influenzae has been increasing in this Hib (H. influenzae serotype b) vaccination era. H. influenzae serotype f (Hif) is considered as one of those emerging pathogens. In general, H. influenzae is a common pathogen of such as pneumonia, otitis media, and meningitis, but is rare in soft tissue infection, especially at the extremity. We report a rare case of severe soft tissue infection caused by Hif which occurred at the lower extremity of immunocompetent adult patient.

DOI： 10.2169/internalmedicine.51.7209

Necrotizing Duodenitis Caused by Clostridium perfringens Type A in a Japanese Young Man 査読

Hideharu Hagiya, Hiromichi Naito, Junichi Sugiyama, Hiroyoshi Nojima, Shingo Hagioka, Naoki Morimoto

INTERNAL MEDICINE 51 ( 20 ) 2973 - 2976 2012年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：JAPAN SOC INTERNAL MEDICINE

A 21-year-old Japanese man with a history of marked body weight loss over a short period of time died of necrotizing duodenitis caused by Clostridium perfringens (C. perfringens) type A. C. perfringens type A is considered to usually cause self-limiting gastroenteritis. Necrotizing enteritis sometimes occurs due to C. perfringens in developing countries; however, it is primarily caused by the type C strain and its site of onset is typically the jejunum or ileum. This is a rare case of necrotizing duodenitis caused by C. perfringens type A in a Japanese young man. Physicians need to be more aware of this emerging fatal disease in developed countries.

DOI： 10.2169/internalmedicine.51.8407

短時間で完遂した流行性ウイルス疾患に対する全職員対象の予防ワクチン接種活動査読

萩谷英大, 國米由美

日本環境感染学会誌 27 ( 6 ) 405 - 411 2012年

記述言語：英語出版者・発行元：(一社)日本環境感染学会

院内感染対策活動において職業感染防止策の徹底は、医療従事者を感染症から守るという意味において非常に重要である。医療従事者は日常的に感染症に曝露する可能性が高く、ワクチン予防可能疾患に対しては積極的にワクチン接種を行い、予防することが推奨されている。集中治療室における汎発性帯状疱疹患者の発生、手術室における流行性耳下腺炎患者の緊急手術事例をきっかけに、当院関連施設の全職員を対象としたワクチン接種活動を行うこととなった。対象疾患は麻疹、風疹、流行性耳下腺炎、水痘帯状疱疹の4疾患、対象人数は984人であった。発案・計画から抗体価測定、抗体陰性者に対する2回のワクチン接種の完了まで約7ヵ月という短期間で終了し、抗体価低値者全体におけるワクチン接種率は麻疹81.9%、風疹76.9%、流行性耳下腺炎76.2%、水痘帯状疱疹60%であった。院内でワクチン予防可能疾患の発症事例が続いたこと、Infection Control Teamだけでなく業務改善など他の事業と関連付けて他部署と協力して活動したこと、抗体価検査の全額とワクチン接種費用の半額を病院負担としたこと、ワクチンの同時接種を院内コンセンサスとして認めたこと、などが短期間で多数の職員に対して高い接種率でワクチン接種を完遂できた要因と考えられた。(著者抄録)

DOI： 10.4058/jsei.27.405

その他リンク： https://search.jamas.or.jp/default/link?pub_year=2012&ichushi_jid=J05141&link_issn=&doc_id=20121129370005&doc_link_id=10.4058%2Fjsei.26.210&url=https%3A%2F%2Fdoi.org%2F10.4058%2Fjsei.26.210&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

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