研究者詳細 - 萩谷　英大

Silent Native-valve Endocarditis Caused by Propionibacterium acnes. 査読

Yamamoto R, Miyagawa S, Hagiya H, Kimura K, Nishi I, Yamamoto N, Yoshida H, Akeda Y, Tomono K, Toda K, Sawa Y

Internal medicine (Tokyo, Japan) 57 ( 16 ) 2417 - 2420 2018年3月

ミャンマー連邦共和国の臨床及び環境由来町内細菌科細菌におけるNDM搭載プラスミドの伝播

菅原庸, 明田幸宏, 萩谷英大, 坂本典子, 竹内壇, 山本倫久, 岡田和久, 朝野和典, 浜田茂幸

2018年3月

Desulfovibrio desulfuricans bacteremia: A case report and literature review 査読国際誌

Hideharu Hagiya, Keigo Kimura, Isao Nishi, Norihisa Yamamoto, Hisao Yoshida, Yukihiro Akeda, Kazunori Tomono

Anaerobe 49 112 - 115 2018年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Academic Press

Desulfovibrio spp. are sulfate-reducing, anaerobic bacteria that are ubiquitously found in the environment. These organisms infrequently cause human infections, and the clinical characteristics of infection with Desulfovibrio spp. remain unclear. Here, we describe a case of Desulfovibrio desulfuricans bacteremia in an 88-year-old Japanese man with a past medical history of thoracic endovascular aortic repair (TEVAR). His chief complaint was hemoptysis for 2 weeks. A chest contrast-enhanced computed tomography demonstrated an enlarged thoracic aortic aneurysm surrounded by a ring-enhanced lesion, recognized as mediastinal abscess. Gram-negative spiral bacilli were detected in anaerobic blood culture. These bacteria could not be identified using conventional methods, but by analyzing a full base sequence of 16S rDNA, they were identified as D. desulfuricans subsp. desulfuricans. The patient underwent an emergent re-TEVAR, and the infection subsided after being treated with tazobactam/piperacillin and clindamycin, followed by metronidazole. A literature review of previous cases of D. desulfuricans bacteremia suggested that the pathogen was derived from bacterial translocation from the intestine in most cases. Desulfovibrio infection is presumably underestimated due to its infrequency, indolent growth, and difficulty in identification. Desulfovibrio spp. should be suspected when spiral rods are observed in anaerobic culture, and molecular analysis is required for accurate species-level differentiation of the pathogens. To better understand the pathogenicity of these fastidious organisms, further cases based on the exact bacterial identification should be investigated.

DOI： 10.1016/j.anaerobe.2017.12.013

Emergence of Carbapenem Non-susceptible Campylobacter coli after Long-term Treatment against Recurrent Bacteremia in a Patient with X-linked Agammaglobulinemia. 査読

Hagiya H, Kimura K, Nishi I, Yoshida H, Yamamoto N, Akeda Y, Tomono K

Internal medicine (Tokyo, Japan) 57 ( 14 ) 2077 - 2080 2018年2月

Emergence of Carbapenem Non-susceptible Campylobacter coli after Long-term Treatment against Recurrent Bacteremia in a Patient with X-linked Agammaglobulinemia. 査読

Hagiya H, Kimura K, Nishi I, Yoshida H, Yamamoto N, Akeda Y, Tomono K

Internal Medicine 2018年2月

Available, Bed-sided, Comprehensive (ABC) score to a diagnosis of Methicillin-resistant Staphylococcus aureus infection: A derivation and validation study 査読国際誌

Nori Yoshioka, Matsuo Deguchi, Hideharu Hagiya, Hisao Yoshida, Norihisa Yamamoto, Shoji Hashimoto, Yukihiro Akeda, Kazunori Tomono

BMC Infectious Diseases 18 ( 1 ) 19 - 19 2018年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：BioMed Central Ltd.

Background: Methicillin-resistant Staphylococcus aureus (MRSA) infections continue to be a leading problem in health care facilities worldwide. Methods: This single-center retrospective cohort study consisted of a derivation phase and a validation phase. The derivation phase included all patients admitted to Osaka University Hospital between May 2010 and April 2011. We proposed a provisional available, bed-sided, comprehensive (ABC) score, and evaluated its accuracy using the clinical diagnosis as a reference. We subsequently revised ABC scores based on k coefficient scores of each variable this revision was validated by applying it to another patient population. Results: A total of 172 patients and 154 cases were enrolled in the derivation and validation studies, respectively. The revised ABC score consisted of four simple variables: type of clinical specimen (1 to 3 points), Gram-staining result (1 point), presence of local inflammation (2 points), and a systemic inflammatory response (2 points). A revised score of ≥5 points was sensitive (93.8%) and specific (90.6%), and the area under the receiver-operating curve was 0.969 (95% CI
0.957-1). Conclusions: We developed a simple and comprehensive scoring system for diagnosis of nosocomial MRSA infections
this system is applicable in a wide variety of situations.

添付ファイル：研究業績書　萩谷 (20180413).docx

DOI： 10.1186/s12879-017-2919-2

Available, Bed-sided, Comprehensive (ABC) score to a diagnosis of Methicillin-resistant Staphylococcus aureus infection: A derivation and validation study 査読

Nori Yoshioka, Matsuo Deguchi, Hideharu Hagiya, Hisao Yoshida, Norihisa Yamamoto, Shoji Hashimoto, Yukihiro Akeda, Kazunori Tomono

BMC Infectious Diseases 18 ( 1 ) 19 2018年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：BioMed Central Ltd.

DOI： 10.1186/s12879-017-2919-2

Clinical characteristics and outcome of critically ill patients with bacteremia caused by extended-spectrum β-lactamase-producing and non-producing Escherichia coli. 査読国際誌

Haruki Y, Hagiya H, Haruki M, Sugiyama T

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 24 ( 11 ) 944 - 947 2018年

Far east scarlet-like fever masquerading as adult-onset Kawasaki disease 査読

Kazuki Ocho, Masaya Iwamuro, Kou Hasegawa, Hideharu Hagiya, Kammei Rai, Tetsuya Yumoto, Fumio Otsuka

Internal Medicine 57 ( 3 ) 437 - 440 2018年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Japanese Society of Internal Medicine

A previously healthy 31-year-old man was referred to us with refractory septic shock accompanied by bilateral conjunctival congestion and erythema of his right lower limb. Nine days after admission, he had bilateral desquamation of the fingertips, and his presentation satisfied the criteria for Kawasaki disease. A serological examination was positive for Yersinia pseudotuberculosis, and he was diagnosed with Far East scarlet-like fever (FESLF). Interestingly, his 11-month-old baby boy had similar symptoms around the same time, indicating the intrafamilial transmission of the pathogen. We should consider FESLF when we encounter a familial occurrence of systemic manifestations of Kawasaki disease.

DOI： 10.2169/internalmedicine.9250-17

Risk factors for fecal carriage of IMP-6-producing Enterobacteriaceae at a long-term care hospital in Japan: A follow-up report from the northern Osaka multicentre study group 査読国際誌

Hideharu Hagiya, Norihisa Yamamoto, Ryuji Kawahara, Yukihiro Akeda, Rathina Kumar Shanmugakani, Akiko Ueda, Isao Nishi, Rumiko Asada, Hisao Yoshida, Kazunori Tomono

Journal of Infection and Chemotherapy 24 ( 9 ) 769 - 772 2018年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Elsevier B.V.

The prevalence of carbapenem-resistant Enterobacteriaceae (CRE) has been increasing at medical institutions in Japan without even noticing. Recently, we performed a point prevalence survey for CRE carriage at a medical facility in northern Osaka that demonstrated an unexpectedly high prevalence of blaIMP-6-positive CRE, particularly at long-term care hospitals (LTCH). To identify the risk factors for CRE carriage, we collected clinical data of patients at a representative LTCH. Of 140 patients who were included in this study, 27 (19.3%) were colonized with metallo-beta-lactamase (IMP-6) producers. Pulsed-field gel electrophoresis of the IMP-6 producing Enterobacteriaceae suggested a non-clonal transmission of Escherichia coli, while a clonal spread was shown for Klebsiella pneumoniae. Risk factors for CRE colonization were a longer stay at the hospital stay and a lower independence state, as measured by Norton scales. We propose that a paradigm shift in infection control, inciting a coordinated regional effort to involve LTCHs, should be discussed in the aging society of Japan.

DOI： 10.1016/j.jiac.2018.03.009

Comparison of the temperature influence on the activity of currently available Procalcitonin reagents 査読国際誌

Nori Yoshioka, Matsuo Deguchi, Hideharu Hagiya, Masanori Kagita, Satomi Yukawa, Yoh Hidaka, Kazunori Tomono

Clinical Laboratory 64 ( 1-2 ) 201 - 204 2018年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Verlag Klinisches Labor GmbH

Background: Procalcitonin (PCT) is a stable biomarker for bacterial infections
however, limited data is available on new trivalent reagents. We evaluated temperature influence on the activity of PCT reagents. Methods: Using both conventional and trivalent reagents, we measured PCT levels of 30 clinical samples, stored residuum at refrigerator (4°C) and room temperature (24°C), and reexamined it after 24 hours. We defined a reduction rate as a percentage of PCT level at 24 hours compared to that after defrost and evaluated a ratio of reduction rate in 4°C to that in 24°C. Results: The reduction rate at room temperature decreased significantly compared to that in the refrigerated condition for all the reagents examined (p &lt
0.001). In addition, the ratio of reduction rate between the conventional and trivalent reagents showed a significant difference (p &lt
0.001) Conclusions: The serum PCT levels significantly decrease at room temperature, particularly when using newer trivalent reagents.

DOI： 10.7754/Clin.Lab.2017.170510