研究者詳細 - 萩谷　英大

Emergence of third-generation cephalosporin-resistant Enterobacteriacae in a Japanese critical care setting. 査読国際誌

Hagiya H, Murase T, Suzuki M, Otsuka F, Shibayama K

Acute medicine & surgery 1 ( 4 ) 256 - 258 2014年10月

Clinical utility of string test as a screening method for hypermucoviscosity-phenotype Klebsiella pneumoniae. 査読国際誌

Hagiya H, Watanabe N, Maki M, Murase T, Otsuka F

Acute medicine & surgery 1 ( 4 ) 245 - 246 2014年10月

Clinical characteristics of Raoultella ornithinolytica bacteremia: A case series and literature review 査読国際誌

Yuto Haruki, Hideharu Hagiya, Akiko Sakuma, Tomoko Murase, Tetsuhiro Sugiyama, Sachiyo Kondo

JOURNAL OF INFECTION AND CHEMOTHERAPY 20 ( 9-10 ) 589 - 591 2014年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SPRINGER JAPAN KK

Raoultella ornithinolytica is a rare pathogen in human infection and bacteremic cases had been scarcely reported. For further comprehension of the rare infection, we summarized clinical characteristics of 6 cases that were detected at our medical facility and 5 cases from previous literature. The most common infectious focus was biliary infection and elderly patients with a history of any biliary intervention or malignancy were considered to be at a great risk for the infection. The prognosis of the patients was quite satisfactory. Bacterial identification in this report was performed on the basis of biochemical tests alone, and further investigations by molecular analysis are required to confirm our findings. (C) 2014, Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.jiac.2014.05.005

A Case of Vascular Graft Infection Caused by Staphylococcus lugdunensis after Femoropopliteal Bypass Operation 査読

Hideharu Hagiya, Mitsuaki Matsumoto, Takahiko Yamasawa, Yuto Haruki, Fumio Otsuka

ACTA MEDICA OKAYAMA 68 ( 3 ) 171 - 175 2014年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：OKAYAMA UNIV MED SCHOOL

A 79-year-old man who had undergone a right femoropopliteal (FP) bypass operation 6 weeks previously was diagnosed with vascular graft infection caused by Staphylococcus lugdunensis. Another FP bypass operation was performed, with long-term administration of antibiotics, and the patient eventually recovered well without any recurrences for over 2 years. Although S. lugdunens is classified as coagulase-negative Staphylococcus, its pathogenicity has been reported to be equal to that of S. aureus. Based on the literature review, the organism characteristically colonizes the inguinal area of human skin; thus, operations such as FP bypass grafting may place patients at a relatively high risk for infection by S. lugdunensis, a potentially high-pathogenicity organism.

DOI： 10.18926/AMO/52658

難治性MRSA感染症に対して高用量ダプトマイシンとリファンピシンの併用療法が有効であった一例

萩谷英大, 寺坂友博, 木村耕介, 佐藤明香, 浅野喜久子, 早稲田公一, 花山宜久, 近藤英生, 大塚文男

日本病院総合診療医学会雑誌 6 ( 2 ) 105 - 105 2014年6月

Effects of Antibiotics Administration on the Incidence of Wound Infection in Percutaneous Dilatational Tracheostomy 査読

Hideharu Hagiya, Hiromichi Naito, Shingo Hagioka, Shuji Okahara, Naoki Morimoto, Nobuchika Kusano, Fumio Otsuka

ACTA MEDICA OKAYAMA 68 ( 2 ) 57 - 62 2014年4月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：OKAYAMA UNIV MED SCHOOL

The effect of antibiotics during the perioperative period of percutaneous dilatational tracheostomy (PDT) is still controversial. A total of 297 patients who underwent the PDT procedure were divided into 2 groups: those administered antibiotics perioperatively and those not administered antibiotics. Wound infections were noted in 7 cases (incidence rate, 2.36%) and no death was recorded. Of the 69 patients without antibiotics, 5 developed wound infections (incidence rate, 7.25%), while only 2 of the 228 patients with antibiotics developed wound infections (incidence rate, 0.88%) (p = 0.002; risk ratio, 8.82; 95% confidence interval, 1.67-46.6). Of the 7 cases of wound infection, 5 cases occurred during the early period after PDT (within 7 days). Collectively, the present results suggest that prophylactic administration of antibiotics may prevent the incidence of PDT-induced wound infection, especially in the early phase after the PDT procedures. The need for antibiotics in PDT should be reconsidered.

DOI： 10.18926/AMO/52402

Postpartum Breast Abscess Caused by Community-Acquired Methicillin-Resistant Staphylococcus aureus in Japan 査読

Hideharu Hagiya, Sumiko Shiota, Wakana Sugiyama, Fumio Otsuka

BREASTFEEDING MEDICINE 9 ( 1 ) 45 - 46 2014年1月

Chromobacterium violaceum nosocomial pneumonia in two Japanese patients at an intensive care unit 査読国際誌

Hideharu Hagiya, Tomoko Murase, Masato Suzuki, Keigo Shibayama, Yumi Kokumai, Naoto Watanabe, Miyako Maki, Fumio Otsuka

JOURNAL OF INFECTION AND CHEMOTHERAPY 20 ( 1-2 ) 139 - 142 2014年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SPRINGER JAPAN KK

Chromobacterium violaceum is sensitive to temperature and the infection is usually confined to tropical or subtropical regions. Since Japan has a warm climate, C. violaceum has been scarcely isolated from clinical specimens. With global warming, however, the geographical distribution of C violaceum infection is likely to change. We report two cases of C violaceum nosocomial pneumonia that occurred at an intensive care center in Japan. C violaceum was first detected from a patient in the same center as a pathogenic organism of pneumonia. Later, the organism was isolated from sputum and a ventilator circuit tube of another patient in the center. The two patients were admitted to the center in nearby beds for several days. All of the pathogens were confirmed to be C violaceum by the nucleic acid sequence of the 16S rRNA gene and were proven to be genetically identical organisms by pulsed field gel electrophoresis. Both patients were managed with well-humidified and heated oxygen using a venturi mask and ventilator to promote excretion of sputum. It was thought that the medical respiratory care devices that provide a humid and warm environment, an optimal condition for proliferation of C violaceum, can contribute to C violaceum infection in a hospital environment. (C) 2013, Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.jiac.2013.10.001

Recurrent Stenotrophomonas maltophilia Bacteremia after Iliac Crest Bone Graft Harvest 査読

Hideharu Hagiya, Hiroko Ogawa, Tomoharu Ishida, Tomohiro Terasaka, Kosuke Kimura, Koichi Waseda, Yoshihisa Hanayama, Masahiro Horita, Yasunori Shimamura, Eisei Kondo, Fumio Otsuka

INTERNAL MEDICINE 53 ( 15 ) 1693 - 1698 2014年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：JAPAN SOC INTERNAL MEDICINE

We describe a rare case of recurrent Stenotrophomonas maltophilia bacteremia in a previously healthy 45-year-old man. The infection was caused by osteomyelitis at the site of an iliac crest bone graft harvest. A genetic analysis using enterobacterial repetitive intergenic consensus polymerase chain reaction (ERIC-PCR) revealed that the blood isolates and pathogens obtained from the surgical wound were identical. Initial treatment with levofloxacin and cefozopran was ineffective, but the patient's infection was successfully treated by long-term administration of latamoxef and trimethoprim-sulfamethoxazole. The present case suggests that attention should be given to the possibility of S. maltophilia infection in any situations.

DOI： 10.2169/internalmedicine.53.1995

Epiglottic Aphthous Ulcers 査読

Hideharu Hagiya, Hiroyuki Hanakawa, Takayuki Katsuyama, Fumio Otsuka

INTERNAL MEDICINE 53 ( 15 ) 1731 - 1731 2014年

Filarial Chyluria as a Rare Cause of Urinary Retention 査読

Hideharu Hagiya, Tomohiro Terasaka, Kosuke Kimura, Asuka Satou, Kikuko Asano, Koichi Waseda, Yoshihisa Hanayama, Takahide Takahashi, Michinori Aoe, Koji Iio, Toshiyuki Watanabe, Eisei Kondo, Fumio Otsuka

INTERNAL MEDICINE 53 ( 17 ) 2001 - 2005 2014年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：JAPAN SOC INTERNAL MEDICINE

We herein describe a case of Wuchereria bancrofti infection in a previously healthy 37-year-old Nepalese man. The patient presented with a history of milky urine with subsequent acute urinary retention lasting for a few days. The presence of microfilariae was confirmed on both peripheral blood and urine smears obtained at midnight. He was conservatively treated with diethylcarbamazine combined with doxycycline. Filariasis was previously endemic in southern parts of Japan, although it has been eradicated. Clinicians should remember filariasis as a potential etiology of urinary retention, especially in cases that may be associated with imported infectious disease.

DOI： 10.2169/internalmedicine.53.2572

Calcium Oxalate Crystals in the Lungs 査読

Hideharu Hagiya, Soichiro Fushimi, Junya Itakura, Fumio Otsuka

INTERNAL MEDICINE 53 ( 17 ) 2025 - 2026 2014年

Actinomyces meyeri Meningitis: The Need for Anaerobic Cerebrospinal Fluid Cultures 査読

Hideharu Hagiya, Fumio Otsuka

INTERNAL MEDICINE 53 ( 1 ) 67 - 71 2014年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：JAPAN SOC INTERNAL MEDICINE

We herein present a rare case of Actinomyces meyeri-induced meningitis that occurred in a patient of advanced age with poor oral hygiene. Although Gram staining of the cerebrospinal fluid (CSF) revealed Grampositive rods and a blood culture was positive for the organism, a bacterial culture of the CSF was negative. Anaerobic cultures of CSF specimens are not routinely performed; however, anaerobes are sometimes involved in central nervous system infection. We therefore believe that anaerobic cultures should be considered in high-risk cases, such as those involving necrotizing bowel lesions or poor oral hygiene. A negative result on a CSF culture can result in misdiagnosis and inappropriate treatment.

DOI： 10.2169/internalmedicine.53.0403

Acute Generalized Exanthematous Pustulosis Caused by Daptomycin in a Critically Ill Burn Victim 査読

Hideharu Hagiya, Maya Kimura, Toru Miyamoto, Yuto Haruki, Fumio Otsuka

INTERNAL MEDICINE 53 ( 5 ) 511 - 514 2014年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：JAPAN SOC INTERNAL MEDICINE

Acute generalized exanthematous pustulosis (AGEP) is a self-limiting type of drug eruption that frequently occurs as a reaction to antibiotics, particularly penicillins or macrolides. Daptomycin (DAP) is a newly developed antibiotic that specifically targets methicillin-resistant Staphylococcus aureus infection. We herein present the case of a 77-year-old severe burn victim who was diagnosed with DAP-induced AGEP while receiving treatment in an intensive care unit. Although rare, physicians should be aware that the administration of DAP can cause AGEP, which may complicate the clinical course of patients with a high fever and inflammation.

DOI： 10.2169/internalmedicine.53.0679

Rhombencephalitis Caused by Listeria monocytogenes 査読

Hideharu Hagiya, Fumio Otsuka

INTERNAL MEDICINE 53 ( 6 ) 639 - 640 2014年

Comprehensive Analysis of Systemically Disseminated ST8/non-USA300 type Community-acquired Methicillin-resistant Staphylococcus aureus Infection 査読

Hideharu Hagiya, Junzo Hisatsune, Taro Kojima, Sumiko Shiota, Hiromichi Naito, Shingo Hagioka, Naoki Morimoto, Fumio Otsuka, Motoyuki Sugai

INTERNAL MEDICINE 53 ( 8 ) 907 - 912 2014年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：JAPAN SOC INTERNAL MEDICINE

Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) is genetically heterogeneous and various genotypes are spreading worldwide. We herein report a case of systematically disseminated Japan-intrinsic CA-MRSA infection that was successfully treated. A genetically identical single strain was isolated from a total of 11 different parts of the patient's body, and the pathogen was found to be multilocus sequence type 8, staphylococcal cassette chromosome mec IV, coagulase type III and negative for both Panton-Valentine leukocidin and arginine catabolic mobile element. The epidemiology and pathogenicity of the Japan-intrinsic CA-MRSA strain remain unknown, and further investigation of this life-threatening organism is warranted.

DOI： 10.2169/internalmedicine.53.1746