Faculty Profiles - HANAMOTO Katsumi

Papers - HANAMOTO Katsumi

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磁化を指標にしたMRIによる温度測定

花元克巳, 加藤博和, 黒田昌宏, 澁谷光一, 川崎祥二, 金澤右

日本ハイパーサーミア学会誌 21 ( Suppl. ) 60 - 60 2004.9

Development of a phantom compatible for MRI and hyperthermia using carrageenan gel - relationship between dielectric properties and NaCl concentration Reviewed

H Kato, K Yoshimura, M Kuroda, A Yoshida, K Hanamoto, S Kawasaki, K Shibuya, Y Yamamoto, M Tsunoda, M Takemoto, Y Hiraki

INTERNATIONAL JOURNAL OF HYPERTHERMIA 20 ( 5 ) 529 - 538 2004.8

Language：English Publishing type：Research paper (scientific journal) Publisher：TAYLOR & FRANCIS LTD

A phantom has previously been developed containing carrageenan, agarose and gadolmium chloride (called CAG phantom) for MRI with 1.5T. T-1 and T-2 relaxation times of this phantom are independently changeable by varying concentrations of relaxation-time modifiers to simulate relaxation times of the various types of human tissues. The CAG phantom has a T, value of 202-1904 ms and a T-2 value of 38-423 ins, when the GdCl3 concentration is varied from 0-140 mumol/kg and the agarose concentration is varied from 0-1.6%. A new phantom has now been developed (called CAGN phantom), made by adding an electric conductive agent, NaCl, to the CAG phantom for use in the areas of MRI and hyperthermia research. Dielectric properties of the CAGN phantom were measured and the results of experiments were expressed by the Cole-Cole equation in the frequency range of 5-130 MHz. The relationship between the conductivity of the CAGN phantom and the concentration of NaCl was expressed by a linear function in the frequency range of 1-130 MHz. The linear function involves a parameter of frequency and, when the frequency is 10 MHz, the conductivity of the CAGN phantom can be changed from 0.27-1.26 Sm-1 by increasing the NaCl concentration from 0-0.7%. The CAGN phantom developed can be employed in basic experiments for non-invasive temperature measurement using MRI and as a loading phantom for MRI with up to 3 T.

DOI： 10.1080/0265673042000199277

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MRIエコー信号のサンプリング時間測定と画像再構成

加藤博和, 花元克巳, 澁谷光一, 川崎祥二, 黒田昌宏, 吉村孝一, 吉田敦史, 津野田雅敏, 平木祥夫, 小山矩

日本医学放射線学会雑誌 64 ( 5 ) 339 - 339 2004.7

Biochemical comparison between radon effects and thermal effects on humans in radon hot spring therapy

K Yamaoka, F Mitsunobu, K Hanamoto, K Shibuya, S Mori, Y Tanizaki, K Sugita

JOURNAL OF RADIATION RESEARCH 45 ( 1 ) 83 - 88 2004.3

Language：English Publishing type：Research paper (scientific journal) Publisher：JAPAN RADIATION RESEARCH SOC

The radioactive and thermal effects of radon hot spring were biochemically compared under a sauna room or hot spring conditions with a similar chemical component, using the parameters that are closely involved in the clinic for radon therapy. The results showed that the radon and thermal therapy enhanced the antioxidation functions, such as the activities of superoxide dismutase (SOD) and catalase, which inhibit lipid peroxidation and total cholesterol produced in the body. Moreover the therapy enhanced concanavalin A (ConA)-induced mitogen response and increased the percentage of CD4 positive cells, which is the marker of helper T cells, and decreased the percentage of CD8 positive cells, which is the common marker of killer T cells and suppressor T cells, in the white blood cell differentiation antigen (CD8/CD4) assay. Furthermore, the therapy increased the levels of a atrial natriuretic polypeptide (alphaANP), beta endorphin, adrenocorticotropic hormone (ACTH), insulin and glucose-6-phosphate dehydrogenase (G-6-PDH), and it decreased the vasopression level. The results were on the whole larger in the radon group than in the thermal group. The findings suggest that radon therapy contributes more to the prevention of life-style-related diseases related to peroxidation reactions and immune suppression than to thermal therapy. Moreover, these indicate what may be a part of the mechanism for the alleviation of hypertension, osteoarthritis (pain), and diabetes mellitus brought about more by radon therapy than by thermal therapy.

DOI： 10.1269/jrr.45.83

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Inhibitory effects of prior low-dose X-ray irradiation on carbon tetrachloride-induced hepatopathy in acatalasemic mice

K Yamaoka, T Kataoka, T Nomura, T Taguchi, DH Wang, S Mori, K Hanamoto, S Kira

JOURNAL OF RADIATION RESEARCH 45 ( 1 ) 89 - 95 2004.3

Language：English Publishing type：Research paper (scientific journal) Publisher：JAPAN RADIATION RESEARCH SOC

The catalase activities in blood and organs of the acatalasemic (C3H/AnLCs(b)Cs(b)) mouse of C3H strain are lower than those of the normal (C3H/AnLCs(a)Cs(a)) mouse. We examined the effects of prior low-dose (0.5 Gy) X-ray irradiation, which reduced the oxidative damage under carbon tetrachloride-induced hepatopathy in the acatalasemic or normal mice. The acatalasemic mice showed a significantly lower catalase activity and a significantly higher glutathione peroxidase activity compared with those in the normal mice. Moreover, low-dose irradiation increased the catalase activity in the acatalasemic mouse liver to a level similar to that of the normal mouse liver. Pathological examinations and analyses of blood glutamic oxaloacetic and glutamic pyruvic transaminase activity and lipid peroxide levels showed that carbon tetrachloride induced hepatopathy was inhibited by low-dose irradiation. These findings may indicate that the free radical reaction induced by the lack of catalase and the administration of carbon tetrachloride is more properly neutralized by high glutathione peroxidase activity and low-dose irradiation in the acatalasemic mouse liver.

DOI： 10.1269/jrr.45.89

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MRIにおけるサンプリング時間の測定と画像の再構成

加藤博和, 花元克巳, 川崎祥二, 澁谷光一, 黒田昌宏, 小山矩

岡山大学医学部保健学科紀要 14 ( 2 ) 121 - 128 2004.3

Language：Japanese Publisher：岡山大学医学部保健学科

MRはX線のように形態画像を表示できる以外に,機能画像,代謝画像,術中画像を表示できることから,重要な撮像モダリティーであるが,成書にはその画像再構成法の具体的な記述はなされていない.そこで,ファントムを用いて具体的に画像を再構成することを試みた.まず矩形ファントムを用いてサンプリング時間の測定を行った.次にMRI MULTI-TEST PHANTOMをスキャンすることによりファントムのエコー信号を採取した.このエコー信号を矩形ファントムで求めたサンプリング時間ごとにサンプリングすることによりk-spaceを得た.このk-spaceから逆フーリエ変換を行うことにより画像の再構成を行った.得られた画像とMRI装置に表示された画像の比較を行い,画像が再現されていることを確認した

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Study on biologic effects of radon and thermal therapy on osteoarthritis

K Yamaoka, F Mitsunobu, K Hanamoto, S Mori, Y Tanizaki, K Sugita

JOURNAL OF PAIN 5 ( 1 ) 20 - 25 2004.2

Language：English Publishing type：Research paper (scientific journal) Publisher：CHURCHILL LIVINGSTONE

Radon therapy uses radon (Rn-222) gas, which mainly emits alpha-rays and induces a small amount of active oxygen in the body. We first examined the temporal changes in antioxidants, immune, vasoactive, and pain-associated substances in human blood by therapy to elucidate the mechanism of osteoarthritis in which radon therapy is used as a treatment. Results showed that radon inhalation enhanced the antioxidation and immune function, and the findings suggest that radon therapy contributes to the prevention of osteoarthritis related to peroxidation reactions and immune depression. Moreover, the changes in vasoactive and pain-associated substances indicated increases in tissue perfusion brought about by radon therapy, suggesting that radon inhalation plays a role in alleviating pain.
Perspective: The findings suggest that an appropriate amount of active oxygen is produced in the body after radon inhalation, and this contributes to the alleviation of the symptoms of active oxygen diseases such as osteoarthritis. (C) 2004 by the American Pain Society.

DOI： 10.1016/j.jpain.2003.09.005

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Using Physiological Indices to Consider the Effects of Negative Air Ions on the Human Body.

白井喜代子, 山岡聖典, 花元克巳, 山本尚武

Journal of International Society of Life Information Science 22 ( 1 ) 2004

誘電型加温電極を用いた組織内または腔内加温のSARシミュレーション(SAR Simulation of Interstitial or Intracavitary Hyperthermia with One or Two External Flat Electrodes for Current Field Heating)

花元克巳, 加藤博和, 黒田昌宏, 澁谷光一, 川崎祥二, 池田裕子, 金澤右

日本ハイパーサーミア学会誌 20 ( 4 ) 241 - 247 2004

Language：English Publisher：(一社)日本ハイパーサーミア学会

組織内加温や腔内加温は一般に内部電極と外部電極の2電極で行われる.しかしながら,一対の平面外部電極の間に内部電極を留置する方法も行なわれている.この2つの加温方法の発熱分布を比較するために,今回,内部電極に1個と外部に誘電型加温電極を2個使用し,合計3電極でSARシミュレーションを行った.その結果,3電極の場合と2電極の場合を比較すると,3電極法では加熱方向を制御でき,熱放散の少ない加温ができることが示唆された

DOI： 10.3191/thermalmedicine.20.241

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22 教育・研究用小型MRIの開発 : RFコイルの設計と作製(MR検査装置)(一般研究発表)(第32回秋季学術大会)

大胡文彦, 門久繁文, 坂井千尋, 青山良宏, 帆足正勝, 加藤博和, 花元克己

日本放射線技術学会雑誌 60 ( 9 ) 1196 - 1196 2004

23 教育・研究用小型MRI装置の開発 : 傾斜磁場コイルの設計と作製(MR検査装置)(一般研究発表)(第32回秋季学術大会)

青山良宏, 帆足正勝, 加藤博和, 溝渕真一, 田中雅大, 馬場園喬, 花元克巳

日本放射線技術学会雑誌 60 ( 9 ) 1196 - 1197 2004

24 教育・研究用小型MRI装置の開発 : シーケンシャルパルスの生成(MR検査装置)(一般研究発表)(第32回秋季学術大会)

帆足正勝, 青山良宏, 加藤博和, 西健二, 大胡文彦, 花元克巳

日本放射線技術学会雑誌 60 ( 9 ) 1197 - 1197 2004

Development of a tissue-equivalent MRI phantom using carrageenan gel

K Yoshimura, H Kato, M Kuroda, A Yoshida, K Hanamoto, A Tanaka, M Tsunoda, S Kanazawa, K Shibuya, S Kawasaki, Y Hiraki

MAGNETIC RESONANCE IN MEDICINE 50 ( 5 ) 1011 - 1017 2003.11

Language：English Publishing type：Research paper (scientific journal) Publisher：JOHN WILEY & SONS INC

A new tissue-equivalent MRI phantom based on carrageenan gel was developed. Carrageenan gel is an ideal solidifying agent for making large, strong phantoms in a wide variety of shapes. GdCl3 was added as a T-1 modifier and agarose as a T-2 modifier. The relaxation times of a very large number of samples were estimated using 1.5-T clinical MRI equipment. The developed phantom was found to have a T-1 value of 202-1904 ms and a T-2 value of 38-423 ms when the GdCl3 concentration was varied from 0-140 mumol/kg and the agarose concentration was varied from 0-1.6% in a carrageenan concentration that was fixed at 3%. The range of measured relaxation times covered those of all types of human tissue. Empirical formulas linking the relaxation time with the concentration of the modifier were established to enable the accurate and easy calculation of the modifier concentration needed to achieve the required relaxation times. This enables the creation of a phantom having an arbitrary combination of T-1 and T-2 values and which is capable of retaining its shape. Magn Reson Med 50:1011-1017, 2003. (C) 2003 Wiley-Liss, Inc.

DOI： 10.1002/mrm.10619

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誘電型加温電極を組み合わせた組織内加温のSAR分布シミュレーション

花元克巳, 加藤博和, 澁谷光一, 川崎祥二, 黒田昌宏, 平木祥夫

日本ハイパーサーミア学会誌 19 ( Suppl. ) 109 - 109 2003.9

MRI特性および電気的特性が人体と等価なファントムの開発成分濃度とMRIおよび電気的特性の関係

加藤博和, 黒田昌宏, 吉村孝一, 吉田敦史, 花元克巳, 川崎祥二, 澁谷光一, 津野田雅敏, 武本充広, 平木祥夫

日本ハイパーサーミア学会誌 19 ( Suppl. ) 149 - 149 2003.9

プロテインキナーゼ阻害剤,H89は温熱耐性発現を促進する

澁谷光一, 川崎祥二, 加藤博和, 花元克巳, 黒田昌宏, 浅海淳一, 平木祥夫

日本ハイパーサーミア学会誌 19 ( Suppl. ) 135 - 135 2003.9

カラギーナンゲルを用いた人体組織等価MRIファントムの開発 NaClの緩和時間に及ぼす効果の検討

吉田敦史, 加藤博和, 花元克巳, 黒田昌宏, 吉村孝一, 平木祥夫

日本ハイパーサーミア学会誌 19 ( Suppl. ) 148 - 148 2003.9

Elevation of antioxidant enzymes in the clinical effects of radon and thermal therapy for bronchial asthma

F Mitsunobu, K Yamaoka, K Hanamoto, S Kojima, Y Hosaki, K Ashida, K Sugita, Y Tanizaki

JOURNAL OF RADIATION RESEARCH 44 ( 2 ) 95 - 99 2003.6

Language：English Publishing type：Research paper (scientific journal) Publisher：JAPAN RADIATION RESEARCH SOC

An increased systemic production of oxygen-free radicals by activated inflammatory cells is thought to be involved in the pathophysiology of asthma. The aim of this study is to evaluate the clinical effects of radon and thermal therapy on asthma in relation to antioxidant enzymes and lipid peroxide. Radon and thermal therapy were performed once a week. All subjects went to a hot bathroom with a high concentration of radon, and nasal inhalation of vapor from a hot spring was performed for 40 min once a day under conditions of high humidity. The room temperature was 48degreesC; the room radon concentration was 2,080 Bq/m(3). Blood samples were collected at 2 h, 14, and 28 days after the first therapy. A blood sample also was collected before the first therapy (at body temperature and background radon level) to be used as the control. The forced expiratory volume in one second (%FEV1) was significantly increased 28 days after the first therapy. Oil day 28, the catalase (CAT) activity was significantly increased in comparison with the control. The superoxide dismutase (SOD) activity was significantly increased compared to the control after first inhalation. On days 14 and 28, the lipid peroxide level was significantly decreased in comparison with the control. In conclusion, the present pilot study has shown that radon and thermal therapy improved the pulmonary function of asthmatics by increasing the reduced activities of antioxidant enzymes.

DOI： 10.1269/jrr.44.95

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MRIにおける画像の再構成

加藤博和, 花元克巳, 黒田昌宏, 澁谷光一, 川崎祥二

岡山大学医学部保健学科紀要 13 ( 2 ) 77 - 82 2003.3

Protein kinaseの阻害剤であるH89はBHK21細胞とtsAF8細胞の温熱耐性の発現を促進する(H89, a Protein Kinase Inhibitor, Promotes the Development of Thermotolerance in BHK21 and tsAF8 Cells)

澁谷光一, 小畑文香, 上江洲美緒, 小林貴子, 松下利, 川崎祥二, 花元克巳, 加藤博和, 黒田昌宏, 浅海淳一, 平木祥夫

日本ハイパーサーミア学会誌 19 ( 4 ) 187 - 194 2003

Language：English Publisher：(一社)日本ハイパーサーミア学会

BHK21細胞とtsAF8細胞を用いてprotein kinaseの阻害剤であるCalphostin CとH89の,温熱耐性の発現に及ぼす効果を検討した.その結果,いずれの細胞においてもCalphostin Cによって温熱耐性の発現が阻害された.H89では0.05μMの濃度では温熱耐性の発現が阻害されたが,2.5μMでは逆に発現が促進された.Calphostin CはPKCを特異的に阻害し,H89は主にPKAを阻害するが濃度が高くなるとPKGも阻害する.温熱耐性の発現はPKCとPKAにより阻害されるが,PKGによって促進されることが示唆された

DOI： 10.3191/thermalmedicine.19.187

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Papers - HANAMOTO Katsumi