研究者詳細 - 大塚　文男

論文 - 大塚　文男

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2型糖尿病初期治療における経口糖尿病降下薬の処方選択基準に関するアルゴリズムの作成と有用性の検討査読

塩見明日香、三好智子、村上和敏、水島孝明、黒田真生、尾上洋、相良英憲、座間味義人、大塚文男、名倉弘哲

ライフ・サイエンスProgress in Medicine 33 ( 10 ) 2261 - 2268 2013年10月

記述言語：日本語出版者・発行元：(株)ライフ・サイエンス

薬理作用の異なる薬剤が多数処方される2型糖尿病治療域において、ガイドラインを適切に理解し薬剤の適正使用を行うことは、臨床経験の少ない研修医や新人薬剤師にとっては困難であり、煩雑な知識を要する。そこで、2型糖尿病初期治療の選択基準となるアルゴリズムを糖尿病診療ガイドラインなどに基づき作成し、その有効性について研修医、総合内科医師、薬剤師にアンケートを実施した。アルゴリズムの有用性に関する評価では、研修医と総合内科医師の間で有意差は認められなかった。一方、薬剤師では、「本アルゴリズムの使用により、医師の処方意図や患者背景について考えるきっかけとなりましたか」との質問に対して、経験年数が6年以上の薬剤師の値に比べ、経験年数が1〜5年の薬剤師の方が有意に高い値を示した。したがって、アルゴリズムを作成し治療選択基準を図式化することで、経験年数の少ない薬剤師の迅速な理解向上に寄与できることが示唆された。(著者抄録)

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Melatonin receptor activation suppresses adrenocorticotropin production via BMP-4 action by pituitary AtT20 cells. 査読国際誌

Tsukamoto N, Otsuka F, Ogura-Ochi K, Inagaki K, Nakamura E, Toma K, Terasaka T, Iwasaki Y, Makino H

Mol Cell Endocrinol 375 ( 1-2 ) 1 - 9 2013年8月

Systemic varicella-zoster virus infection in two critically ill patients in an intensive care unit 査読国際誌

Hagiya H, Kimura M, Miyamoto T, Otsuka F

Virol J 10 225 - 225 2013年7月

Erdheim-Chester病が強く疑われた下垂体機能低下症の一例査読

三好智子、大塚文男、稲垣兼一、田中康司、越智可奈子、藤井一恭、藤井伸治、当真貴志雄、中村絵里、塚本尚子、武田昌也、三村由香里、小倉俊郎、景山甚郷、槇野博史

日本内分泌学会雑誌 89 ( suppl ) 21 - 23 2013年6月

GRK-6 mediates FSH action synergistically enhanced by estrogen and the oocyte in rat granulosa cells. 査読国際誌

Miyoshi T, Otsuka F, Shimasaki S

Biochemical and Biophysical Research Communications 434 ( 2 ) 401 - 6 2013年5月

Estrogen facilitates osteoblast differentiation by upregulating bone morphogenetic protein-4 signaling. 査読国際誌

Matsumoto Y, Otsuka F, Takano-Narazaki M, Katsuyama T, Nakamura E, Tsukamoto N, Inagaki K, Sada KE, Makino H

Steroids 78 ( 5 ) 513 - 20 2013年5月

中枢性尿崩症で発症したリンパ球性汎下垂体炎の1例査読

竹本玲加、大塚文男、森下美智子、森本尚孝、寺田洋明、斉藤信幸、正岡哲也、宮谷克也、田中健大

三豊総合病院雑誌 34 59 - 63 2013年4月

左眼瞼下垂を契機に診断された若年胃癌のトルコ鞍部転移の一例査読

稲垣兼一、当真貴志雄、中村絵里、越智可奈子、塚本尚子、三好智子、三村由香里、小倉俊郎、大塚文男、槇野博史

ACTH Related Peptides 24 56 - 58 2013年3月

Involvement of bone morphogenetic protein activity in somatostatin actions on ovarian steroidogenesis. 査読国際誌

Nakamura E, Otsuka F, Inagaki K, Tsukamoto N, Ogura-Ochi K, Miyoshi T, Toma K, Takeda M, Makino H

J Steroid Biochem Mol Biol 134 67 - 74 2013年3月

Rapid Progression of Graves' Ophthalmopathy Despite the Administration of Thiamazole

Takayuki Katsuyama, Masaya Takeda, Fumio Otsuka, Kishio Toma, Kenichi Inagaki, Ken-Ei Sada, Yukari Mimura, Toshio Ogura, Hirofumi Makino

Internal Medicine 52 ( 20 ) 2317 - 2320 2013年

Is wet swab superior to dry swab as an intranasal screening test? 査読国際誌

Hagiya H, Mio M, Murase T, Egawa K, Kokumai Y, Uchida T, Morimoto N, Otsuka F, Shiota S

J Intensive Care 1 ( 1 ) 10 - 10 2013年

Group a streptococcal meningitis in a patient with palmoplantar pustulosis 査読

Hagiya H, Otsuka F

Intern Med 52 ( 23 ) 2675 - 8 2013年

Disseminated Gonococcal Infection in An Elderly Japanese Man 査読

Hagiya H, Onishi N, Ebara H, Hanayama Y, Kokeguchi S, Nose M, Kusano N, Otsuka F

Intern Med 52 ( 23 ) 2669 - 73 2013年

Ineffectiveness of Daptomycin in the treatment of Septic Pulmonary Emboli and Persistent Bacteremia Caused by Methicillin-Resistant Staphylococcus aureus 査読

Hagiya H, Hagioka S, Otsuka F

Intern Med 52 ( 22 ) 2577 - 82 2013年

A Comprehensive Anaiysis of 1 74 Febri:e Patients Admitted to Okayama University Hospital 査読

Ryuko H, Otsuka F

Acta Med Okayama 67 ( 4 ) 227 - 37 2013年

Multifunctional bone morphogenetic protein system in endocrinology.

Fumio Otsuka

Acta medica Okayama 67 ( 2 ) 75 - 86 2013年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：OKAYAMA UNIV MED SCHOOL

New biological activities of bone morphogenetic proteins (BMPs) in the endocrine system have recently been revealed. The BMP system is composed of approximately 30 ligands and preferential combinations of type I and type II receptors. The BMP system not only induces bone formation but also plays unique tissue-specific roles in various organs. For instance, the ovarian BMP system is a physiological inhibitor of luteinization in growing ovarian follicles. In the ovary, the expression of oocyte-derived BMP-15 is critical for female reproduction. In the pituitary, BMP-4 is a key player for initial development of the anterior pituitary, while it is also functionally involved in some differentiated pituitary tumors, including prolactinoma and Cushing's disease. In the adrenal glands, BMP-6 and BMP-4 modulate aldosterone and catecholamine production, respectively, which contributes to a functional interaction between the cortex and medulla. In the present review, recent advances in BMP biology in the field of endocrinology are described and the possibility for clinical application of BMP activity is discussed.

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An in vivo role of bone morphogenetic protein-6 in aldosterone production by rat adrenal gland. 査読国際誌

Matsumoto Y, Otsuka F, Inagaki K, Tsukamoto N, Takano-Narazaki M, Miyoshi T, Nakamura E, Ogura-Ochi K, Takeda M, Makino H

J Steroid Biochem Mol Biol 132 ( 1-2 ) 8 - 14 2012年10月

Evaluation of weekly-reduction regimen of glucocorticoids in combination with cyclophosphamide for anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis in Japanese patients. 査読国際誌

Yoshinori Matsumoto, Ken-Ei Sada, Fumio Otsuka, Mariko Takano, Noriko Toyota, Koichi Sugiyama, Hiroshi Wakabayashi, Tomoko Kawabata, Hirofumi Makino

Rheumatology international 32 ( 10 ) 2999 - 3005 2012年10月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SPRINGER HEIDELBERG

The current therapeutic regimen recommended by the European League against Rheumatism (EULAR) for anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) is continuation of initially administered doses of glucocorticoids (GCs) in combination with cyclophosphamide (CYC) for 1 month followed by gradual tapering. Considering the adverse effects of GCs, another tapering regimen of GCs with CYC, which was characterized by tapering GCs weekly, was reported by the British Society of Rheumatology (weekly-reduction regimen). The aim of the present study is to evaluate the safety and efficacy of this weekly-reduction regimen for Japanese AAV patients in comparison with the monthly-reduction regimen recommended by the EULAR. We retrospectively reviewed medical records of adult patients newly diagnosed with AAV during the period from April 2000 to December 2010. The outcome measures were rates of remission, relapse, infection, and GC-induced diabetes mellitus during the first 12 months. Clinical data in the two groups and categorial variables with a possible relation to the outcomes were compared by using the t test and chi-square test, respectively. Twenty-four patients were enrolled in our study. All of the patients achieved remission, and the rates of relapse during the first 12 months were not statistically different between the two groups (P = 0.16). Patients treated with the weekly-reduction regimen were less liable to have infection (P = 0.03) and impaired glucose tolerance (P = 0.017), compared with those treated with the monthly-reduction regimen. A therapeutic strategy using the weekly-reduction regimen of GCs would be effective and would have fewer side effects than the monthly-reduction regimen.

DOI： 10.1007/s00296-011-2136-z

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Pro-apoptotic effects of imatinib on PDGF-stimulated pulmonary artery smooth muscle cells from patients with idiopathic pulmonary arterial hypertension. 国際誌

Kazufumi Nakamura, Satoshi Akagi, Aiko Ogawa, Kengo F Kusano, Hiromi Matsubara, Daiji Miura, Soichiro Fuke, Nobuhiro Nishii, Satoshi Nagase, Kunihisa Kohno, Hiroshi Morita, Takahiro Oto, Ryutaro Yamanaka, Fumio Otsuka, Aya Miura, Chikao Yutani, Tohru Ohe, Hiroshi Ito

International journal of cardiology 159 ( 2 ) 100 - 6 2012年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：ELSEVIER IRELAND LTD

BACKGROUND: Remodeling of the pulmonary artery by an inappropriate increase of pulmonary artery smooth muscle cells (PASMCs) is problematic in the treatment of idiopathic pulmonary arterial hypertension (IPAH). Effective treatment that achieves reverse remodeling is required. The aim of this study was to assess the pro-apoptotic effects of imatinib, a platelet-derived growth factor (PDGF)-receptor tyrosine kinase inhibitor, on PASMCs obtained from patients with IPAH. METHODS: PASMCs were obtained from 8 patients with IPAH undergoing lung transplantation. Cellular proliferation was assessed by (3)H-thymidine incorporation. Pro-apoptotic effects of imatinib were examined using TUNEL and caspase-3,7 assays and using transmission electron microscopy. RESULTS: Treatment with imatinib (0.1 to 10 μg/mL) significantly inhibited PDGF-BB (10 ng/mL)-induced proliferation of PASMCs from IPAH patients. Imatinib (1 μg/mL) did not induce apoptosis in quiescent IPAH-PASMCs, but it had a pro-apoptotic effect on IPAH-PASMCs stimulated with PDGF-BB. Imatinib did not induce apoptosis in normal control PASMCs with or without PDGF-BB stimulation. PDGF-BB induced phosphorylation of Akt at 15 min, and Akt phosphorylation was inhibited by imatinib in IPAH-PASMCs. Akt-I-1/2 (1 μmol/L), an Akt inhibitor, in the presence of PDGF-BB significantly increased apoptotic cells compared with the control condition. Thus, Akt-I-1/2 could mimic the effects of imatinib on PASMCs. CONCLUSION: Imatinib has anti-proliferative and pro-apoptotic effects on IPAH-PASMCs stimulated with PDGF. The inhibitory effect of imatinib on Akt phosphorylation induced by PDGF plays an important role in the pro-apoptotic effect.

DOI： 10.1016/j.ijcard.2011.02.024

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Regulatory role of kit ligand-c-kit interaction and oocyte factors in steroidogenesis by rat granulose cells. 査読国際誌

Miyoshi T, Otsuka F, Nakamura E, Inagaki K, Ogura-Ochi K, Tsukamoto N, Takeda M, Makino H

Mol Cell Endocrinol 358 ( 1 ) 18 - 26 2012年7月

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