研究者詳細 - 大塚　文男

論文 - 大塚　文男

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Clinical ineffectiveness of latamoxef for Stenotrophomonas maltophilia infection 査読国際誌

Hagiya H, Tasaka K, Sendo T, Otsuka F

Infect Drug Resist 8 353 - 7 2015年

Actinomyces turicensis bacteremia secondary to pyometra 査読

Hagiya H, Ogawa H, Takahashi Y, Kimura K, Hasegawa K, Otsuka F.

Intern Med 54 ( 21 ) 2775 - 7 2015年

Neurosyphilis Is a Long-forgotten Disease but Still a Possible Etiology for Dementia 査読

Hagiya H, Deguchi K, Kawada K, Otsuka F

Intern Med 54 ( 21 ) 2769 - 73 2015年

Cytomegalovirus as an Insidious Pathogen Causing Duodenitis 査読

Hagiya H, Iwamuro M, Tanaka T, Hanayama Y, Otsuka F

Acta Med Okayama 69 ( 5 ) 319 - 23 2015年

Relationships between causes of fever of unknown origin and inflammation markers: a multicenter collaborative retrospective study 査読

Naito T, Torikai K, Mizooka M, Mitsumoto F, Kanazawa K, Ohno S, Morita H, Ukimura A, Mishima N, Otsuka F, Ohyama Y, Nara N, Murakami K, Mashiba K, Akazawa K, Yamamoto K, Tanei M, Yamanouchi M, Senda S, Tazuma S, Hayashi J

Intern Med 54 ( 16 ) 1989 - 94 2015年

Tetanus in a 19-year-old Japanese Woman 査読

Hagiya H, Hirayama T, Ugawa T, Otsuka F

Intern Med 54 ( 14 ) 1825 - 1825 2015年

Relapsing Polychondritis Followed Up with FDG-PET 査読

Hagiya H, Waseda K, Otsuka F.

Intern Med 54 ( 13 ) 1675 - 6 2015年

Eagle's Syndrome Manifesting as Chronic Swallowing Pain 査読

Hagiya H, Waseda K, Ogawa H, Otsuka F

Intern Med 54 ( 10 ) 1321 - 1321 2015年

CT visualising infective vegetation. 国際誌

Hideharu Hagiya, Kou Hasegawa, Kikuko Asano, Fumio Otsuka

BMJ case reports 2014 2014年12月

Gingival overgrowth caused by vitamin C deficiency associated with metabolic syndrome and severe periodontal infection: a case report. 査読国際誌

Kazuhiro Omori, Yoshihisa Hanayama, Koji Naruishi, Kentaro Akiyama, Hiroshi Maeda, Fumio Otsuka, Shogo Takashiba

Clinical case reports 2 ( 6 ) 286 - 95 2014年12月

記述言語：英語掲載種別：研究論文（学術雑誌）

It has been suggested that vitamin C deficiency/scurvy is associated with gingival inflammatory changes; however, the disorder is very infrequently encountered in the modern era. Here, we report a case of extensive gingival overgrowth caused by vitamin C deficiency associated with metabolic syndrome and severe periodontal infection.

DOI： 10.1002/ccr3.114

PubMed

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Aortic vascular graft infection caused by Cardiobacterium valvarum: a case report. 査読国際誌

Hideharu Hagiya, Susumu Kokeguchi, Hiroko Ogawa, Tomohiro Terasaka, Kosuke Kimura, Koichi Waseda, Yoshihisa Hanayama, Kaori Oda, Hisatoshi Mori, Toru Miyoshi, Fumio Otsuka

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20 ( 12 ) 804 - 9 2014年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SPRINGER JAPAN KK

A 53-year-old man with a past medical history of total arch replacement surgery and severe aortic regurgitation presented with a 1-month history of persistent general malaise, anorexia, body weight loss and night sweats. His recent history included gingival hyperplasia for 6 years, gingivitis after tooth extraction 3 years before, prolonged inflammatory status for 4 months, fundal hemorrhage and leg tenderness for 2 months. A pathogen was detected from blood culture, but conventional microbiological examination failed to identify the pathogen. The organism was eventually identified as Cardiobacterium valvarum by 16S rRNA analysis, and the patient was diagnosed with infective endocarditis and prosthetic vascular graft infection. The patient received intravenous antibiotic therapy using a combination of ceftriaxone and levofloxacin for 5 weeks and was discharged with a good clinical course.
C. valvarum is a rare human pathogen in clinical settings. Only 10 cases have been reported to date worldwide, and therefore, the clinical characteristics of C. valvarum infection are not fully known. This is a first well-described case of C. valvarum infection in Japan, and further, a first report of aortic prosthetic vascular graft infection worldwide. Identification of C. valvarum is usually difficult due to its phenotypic characteristics, and molecular approaches would be required for both clinicians and microbiologists to facilitate more reliable diagnosis and uncover its clinical picture more clearly. (C) 2014, Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.jiac.2014.07.008

Web of Science

PubMed

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Pantoea dispersa bacteremia caused by central line-associated bloodstream infection

Hideharu Hagiya, Fumio Otsuka

BRAZILIAN JOURNAL OF INFECTIOUS DISEASES 18 ( 6 ) 696 - 697 2014年11月

Mycotic abdominal aortic aneurysm caused by Campylobacter fetus: a case report and literature review. 国際誌

Hideharu Hagiya, Mitsuaki Matsumoto, Hiroshi Furukawa, Tomoko Murase, Fumio Otsuka

Annals of vascular surgery 28 ( 8 ) 1933.e7-1933.e14 2014年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：ELSEVIER SCIENCE INC

Campylobacter spp. usually cause gastrointestinal infections, but among them, Campylobacter fetus is a well-known organism causing mycotic abdominal aortic aneurysm (MAAA), which requires proper surgical intervention and antibiotic therapy. We report a 65-year-old man who was successfully treated by an in situ operation using a rifampicin (RFP)-bonded J-Graft for C. fetus-induced MAAA. We performed a review of the English literature on MAAA caused by C. fetus and summarized the results of the cases (28 cases). All but 2 of the patients (92.9%) were men. Blood culture and arterial wall culture were positive in 63% and 73.1% of the cases, respectively. Aneurysm rupture was seen in half of the patients, and approximately half of those patients died. Among the 18 patients who underwent in situ graft replacement, only 1 patient (5.6%) died after surgery. Antibiotic therapy was performed for more than 1 month in most cases, and overall mortality rate was 25.9% (7 of 27 cases, 3 deaths before the operation and 4 deaths after surgery). Although extra-anatomic bypass has been conventionally performed after complete resection of an MAAA, the utility of in situ surgery has generally been recognized. Our review suggests that the in situ operation can be a choice also in cases of C. fetus-associated MAAA. Furthermore, our case suggested the clinical utility of a newly manufactured prosthetic graft, J-Graft, for such surgical treatment.

DOI： 10.1016/j.avsg.2014.06.072

Web of Science

PubMed

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Clinical Utility of String Test as A Screening Method for Hypermucoviscosity-phenotype Klebsiella pneumonia 査読国際誌

Hagiya H, Watanabe N, Maki M, Murase T, Otsuka F

Acute Medicine & Surgery 1 ( 4 ) 245 - 246 2014年10月

Emergence of third-generation cephalosporin-resistant Enterobacteriacae at a Japanese critical care setting 査読国際誌

Hagiya H, Murase T, Suzuki M, Otsuka F, Shibayama K

Acute Medicine & Surgery 1 ( 4 ) 256 - 258 2014年10月

Melatonin counteracts BMP-6 regulation of steroidogenesis by rat granulosa cells. 査読国際誌

Nakamura E, Otsuka F, Terasaka T, Inagaki K, Hosoya T, Tsukamoto-Yamauchi N, Toma K, Makino H

J Steroid Biochem Mol Biol 143 233 - 9 2014年9月

Vasohibin-1 deficiency enhances renal fibrosis and inflammation after unilateral ureteral obstruction 査読国際誌

Watatani H, Maeshima Y, Hinamoto N, Yamasaki H, Ujike H, Tanabe K, Sugiyama H, Otsuka F, Sato Y, Makino H

Physiol Rep 2 ( 6 ) 2014年6月

Retroperitoneal bronchogenic cyst: a rare incidentaloma discovered in a juvenile hypertensive patient. 査読国際誌

Tomohiro Terasaka, Fumio Otsuka, Kanako Ogura-Ochi, Tomoko Miyoshi, Kenichi Inagaki, Yasuyuki Kobayashi, Yasutomo Nasu, Hirofumi Makino

Hypertension research : official journal of the Japanese Society of Hypertension 37 ( 6 ) 595 - 7 2014年6月

【市中感染型MRSAの動向と対処法】ST8/non-USA300株による全身播種性市中感染型MRSA感染症の1例

萩谷英大, 久恒順三, 森本直樹, 大塚文男, 菅井基行

化学療法の領域 30 ( 5 ) 779 - 787 2014年4月

記述言語：日本語出版者・発行元：(株)医薬ジャーナル社

市中感染型メチシリン耐性黄色ブドウ球菌(CA-MRSA)は重症感染症を引き起こす起炎菌として知られているが、遺伝子的に多様であり、さまざまなタイプが世界中に分布している。本症例は、multilocus sequence type 8、IV型SCCmec(staphylococcal cassette chromosome mec)、III型コアグラーゼ陽性、Panton-Valentine leukocidinおよびarginine catabolic mobile element陰性の単一株により発症した全身播種性の重症CA-MRSA感染症のまれな一例である。筋骨格系を中心に全身に感染巣を形成しており、遺伝学的に同一のCA-MRSAを患者の異なる11部位より検出した。わが国におけるCA-MRSAの疫学および病原性は未解明である部分が多いが、本症例でもCA-MRSAの高病原性が示唆された。今後さらなる解析が期待される。(著者抄録)

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本態性高血圧の初期治療における第一選択薬決定のアルゴリズム作成と有用性の検討

萱野由佳, 三好智子, 水島孝明, 花山宜久, 黒田真生, 尾上洋, 相良英憲, 座間味義人, 大塚文男, 名倉弘哲

Progress in Medicine 34 ( 3 ) 527 - 536 2014年3月

記述言語：日本語出版者・発行元：(株)ライフ・サイエンス

本態性高血圧症は本邦において極めて患者数の多い疾患であり、その治療は食事・運動療法に加えて薬物治療が重要である。『高血圧治療ガイドライン2009』では、本態性高血圧に対する5種類の第一選択薬であるカルシウム拮抗薬、アンジオテンシンII受容体拮抗薬、アンジオテンシン変換酵素阻害薬、β遮断薬、利尿薬が提示されている。本態性高血圧の初期治療での薬剤選択に際して医師が考慮すべき事項は極めて煩雑であり、医師の処方薬決定を困難にしている。本研究では、本態性高血圧初期治療における処方決定に役立つためのアルゴリズムの作成を試みた。さらに、調査対象となる総合内科医師と保険薬剤師にアルゴリズムを配付し、一定の試用期間後にアルゴリズムの使用感に関する有用性の評価を実施したところ、本アルゴリズムは総合内科医師、保険薬剤師それぞれから高い評価を得た。また、医師の処方決定時の思考をおおむね反映していることが検証できた。したがって、作成したアルゴリズムは医師の処方決定の理解の手助けとなる可能性が示唆された。加えて、本アルゴリズムは薬剤師が処方解析を行ううえでもその有用性は高いと考えられた。(著者抄録)

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