研究者詳細 - 大塚　文男

論文 - 大塚　文男

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Global public awareness of Castleman disease and TAFRO syndrome between 2015 and 2021: A Google Trends analysis 査読

Yoshito Nishimura, Midori Filiz Nishimura, David C. Fajgenbaum, Frits van Rhee, Yasuharu Sato, Fumio Otsuka

eJHaem 3 ( 3 ) 748 - 753 2022年4月

Hormonal trends in patients suffering from long COVID symptoms. 査読

Naruhiko Sunada, Hiroyuki Honda, Yasuhiro Nakano, Koichiro Yamamoto, Kazuki Tokumasu, Yasue Sakurada, Yui Matsuda, Toru Hasegawa, Yuki Otsuka, Mikako Obika, Yoshihisa Hanayama, Hideharu Hagiya, Keigo Ueda, Hitomi Kataoka, Fumio Otsuka

Endocrine journal 69 ( 10 ) 1173 - 1181 2022年4月

担当区分：最終著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）

Symptoms of long COVID are complex and long-lasting, and endocrine dysfunction might be involved in the underlying mechanisms. In this study, to clarify the hormonal characteristics of long COVID patients, laboratory data for patients who visited the outpatient clinic for long COVID were evaluated. A retrospective analysis was performed for patients who visited Okayama University Hospital during the period from Feb 2021 to Dec 2021 with focus on the interrelationships between major symptoms and endocrine data. Information and laboratory data were obtained from medical records for 186 patients. The patients had various symptoms, and the most frequent symptoms were general malaise, dysosmia/dysgeusia, hair loss, headache, dyspnea, and sleeplessness. Patients who were suffering from fatigue and dysosmia/dysgeusia were younger, while hair loss was more frequent in older and female patients. As for the characteristics of patients suffering from general fatigue, the scores of depression and fatigue were positively correlated with serum levels of cortisol and free thyroxin (FT4), respectively. Also, patients suffering from general fatigue had lower levels of serum growth hormone and higher levels of serum FT4, while patients with dysosmia/dysgeusia had a significantly lower level of serum cortisol. Serum thyrotropin (TSH) levels were higher and the ratios of FT4/TSH were lower in the initially severe cases, suggesting occult hypothyroidism. In addition, the ratios of plasma adrenocorticotropin to serum cortisol were decreased in patients with relatively high titers of serum SARS-CoV-2 antibody. Thus, hormonal changes seem to be, at least in part, involved in the persistent symptoms of long COVID.

DOI： 10.1507/endocrj.EJ22-0093

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Late-Onset Hypogonadism in a Male Patient with Long COVID Diagnosed by Exclusion of ME/CFS. 査読国際誌

Yoshiaki Soejima, Yuki Otsuka, Kazuki Tokumasu, Yasuhiro Nakano, Ko Harada, Kenta Nakamoto, Naruhiko Sunada, Yasue Sakurada, Kou Hasegawa, Hideharu Hagiya, Keigo Ueda, Fumio Otsuka

Medicina (Kaunas, Lithuania) 58 ( 4 ) 2022年4月

担当区分：最終著者記述言語：英語

After the acute phase of COVID-19, some patients have been reported to have persistent symptoms including general fatigue. We have established a COVID-19 aftercare clinic (CAC) to provide care for an increasing number of these patients. Here, we report the case of a 36-year-old man who developed post-COVID fatigue after acute infection with SARS-CoV-2. In the acute phase of COVID-19, the patient's fever resolved within four days; however, general fatigue persisted for three months, and he visited our CAC 99 days after the initial infection. Examination revealed a high Aging Male's Symptoms (AMS) score of 44 and low free testosterone (FT) level of 5.5 pg/mL, which meet the Japanese criteria of late-onset hypogonadism (LOH) syndrome. Imaging studies revealed an atrophic pituitary in addition to fatty liver and low bone mineral density. Anterior pituitary function tests showed a low follicle-stimulating hormonelevel and delayed reaction of luteinizing hormone (LH) after gonadotropin-releasing hormone (GnRH) stimulation, indicating the possibility of hypothalamic hypogonadism in addition to primary hypogonadism seen in patients with post-COVID-19 conditions. After the initiation of Japanese traditional medicine (Kampo medicine: hochuekkito followed by juzentaihoto), the patient's symptoms as well as his AMS score and serum FT level were noticeably improved. Furthermore, follow-up tests of GnRH stimulation revealed improvements in LH responsiveness. Although many patients have been reported to meet the criteria of ME/CFS such as our case, we emphasize the possibility of other underlying pathologies including LOH syndrome. In conclusion, LOH syndrome should be considered a cause of general fatigue in patients with post-COVID-19 conditions and herbal treatment might be effective for long COVID symptoms due to LOH (264 words).

DOI： 10.3390/medicina58040536

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Antimicrobial prescription practices for outpatients with uncomplicated cystitis in Japan. 査読国際誌

Misa Takahashi, Hideharu Hagiya, Tsukasa Higashionna, Yasuhiro Nakano, Kota Sato, Yuto Haruki, Mai Haruki, Hiroyuki Honda, Hiroko Ogawa, Keigo Ueda, Fumio Otsuka

Scientific reports 12 ( 1 ) 5921 - 5921 2022年4月

担当区分：最終著者記述言語：英語掲載種別：研究論文（学術雑誌）

To promote antimicrobial stewardship, we studied antimicrobial prescription rates for uncomplicated cystitis, a common outpatient disease requiring antibiotic treatment. This multicenter retrospective study was performed from January 1, 2018, to December 31, 2020, in Japan, targeting outpatients aged ≥ 20 years whose medical records revealed International Classification of Diseases (ICD-10) codes suggesting uncomplicated cystitis (N300). The data of 1445 patients were collected and that of 902 patients were analyzed. The overall median patient age was 71 years and a proportion of those aged less than 50 years was 18.8% with a female dominance (82.6%). Antimicrobials were prescribed for 884 patients (98.0%) and a total of 623 patients (69.1%) were treated with broad-spectrum drugs, including fluoroquinolones (36.0%), third-generation cephalosporins (29.9%) and faropenem (3.1%). A logistic regression model revealed that the broad-spectrum agents were significantly prescribed for the older patients, male patients, and those who visited internists. Recurrence was observed in 37 (4.1%) cases, and the multivariate analysis suggested any of age, sex, or antimicrobial types were not associated with the recurrence. Collectively, approximately two-thirds of antimicrobials prescribed for uncomplicated cystitis were broad-spectrum agents. The present data would be an indicator for antimicrobial prescriptions in uncomplicated cystitis in Japan.

DOI： 10.1038/s41598-022-09946-8

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Relationship between patients’ characteristics and efficacy of calcimimetics for primary hyperparathyroidism in the elderly

Koichiro Yamamoto, Yasuhiro Nakano, Kazuki Tokumasu, Hiroyuki Honda, Kou Hasegawa, Asuka Sato, Hiroko Ogawa, Mikako Obika, Yoshihisa Hanayama, Fumio Otsuka

Clinical Case Reports 10 ( 4 ) 2022年4月

Cat scratch disease without a history of cat exposure 国際誌

Kosuke Oka, Yume Takagi, Hideharu Hagiya, Fumio Otsuka

Clinical Case Reports 10 ( 4 ) e04816 2022年4月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Wiley

A patient complaining of swelling and tenderness in her left axilla was diagnosed with cat scratch disease despite no apparent history of cat exposure. Zoonosis can occur even in the absence of cat exposure because cat flea Ctenocephalides felis is also the vector of the pathogen through the flea feces.

DOI： 10.1002/ccr3.4816

PubMed

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その他リンク： https://onlinelibrary.wiley.com/doi/full-xml/10.1002/ccr3.4816

Half-and-Half Toenails

Koichiro Yamamoto, Fumio Otsuka

Mayo Clinic Proceedings 97 ( 4 ) 652 - 652 2022年4月

IFN-α投与が奏効したステロイド抵抗性Erdheim-Chester病の1例

庵谷紘美, 中野靖浩, 中本健太, 平佑貴, 山本紘一郎, 長谷川功, 三好智子, 小川弘子, 白羽英則, 大塚文男

日本内分泌学会雑誌 98 ( 1 ) 279 - 279 2022年4月

COVID-19後遺症契機に発見された2型糖尿病の1例

田中秀一, 本多寛之, 山本絋一郎, 高橋美砂, 長谷川功, 小比賀美香, 片岡仁美, 大塚文男

糖尿病 65 ( Suppl.1 ) S - 268 2022年4月

原発性副甲状腺機能亢進症に対するカルシウム受容体作動薬の効果と関連因子

山本紘一郎, 中野靖浩, 徳増一樹, 本多寛之, 長谷川功, 小比賀美香子, 三好智子, 小川弘子, 花山宜久, 大塚文男

日本内分泌学会雑誌 98 ( 1 ) 374 - 374 2022年4月

重度の化膿性胸鎖関節炎から発見された2型糖尿病の1例

高瀬了輔, 本多寛之, 中本健太, 平佑貴, 庵谷紘美, 中野靖浩, 長谷川功, 萩谷英大, 小比賀美香子, 片岡仁美, 大塚文男

日本内分泌学会雑誌 98 ( 1 ) 363 - 363 2022年4月

Cushing病術後にバセドウ病再燃と相対的副腎不全を来した1例

中野靖浩, 平佑貴, 中本健太, 庵谷紘美, 長谷川功, 大塚勇輝, 佐々木恵里佳, 岸田雅之, 大塚文男

日本内分泌学会雑誌 98 ( 1 ) 346 - 346 2022年4月

体動困難を契機に発見され副腎クリーゼを発症したACTH単独欠損症の1例

中野靖浩, 中本健太, 平佑貴, 庵谷紘美, 長谷川功, 大塚文男

日本内分泌学会雑誌 98 ( 1 ) 336 - 336 2022年4月

頭部外傷が契機と考えられる中枢性尿崩症の1例

山本紘一郎, 本多寛之, 田中秀一, 高橋美砂, 長谷川功, 中野靖浩, 大塚文男

日本内分泌学会雑誌 98 ( 1 ) 335 - 335 2022年4月

肝硬変と多発骨折を契機に診断されたFGF23関連低リン血症性骨軟化症の1例

須山敦仁, 山本紘一郎, 田中秀一, 孫麗那, 高橋美砂, 中野靖浩, 本多寛之, 長谷川功, 大塚文男

日本内分泌学会雑誌 98 ( 1 ) 325 - 325 2022年4月

経過中に難治性高血圧症を合併した血管型Ehlers-Danlos症候群の1例

長谷川功, 田中秀一, 山本紘一郎, 中野靖浩, 本多寛之, 萩谷英大, 冨田晃司, 戸田洋伸, 内田治仁, 平沢晃, 大塚文男

日本内分泌学会雑誌 98 ( 1 ) 322 - 322 2022年4月

コロナ・アフターケア(CAC)外来における後遺症の特徴と抗体価との関連

櫻田泰江, 砂田匠彦, 大塚勇輝, 徳増一樹, 中野靖浩, 本多寛之, 松田祐依, 大村大輔, 長谷川功, 萩谷英大, 小比賀美香子, 植田圭吾, 片岡仁美, 古川雅規, 大塚文男

日本内分泌学会雑誌 98 ( 1 ) 301 - 301 2022年4月

精巣副腎遺残腫瘍に関連し性腺機能低下を来した21-水酸化酵素欠損症の2例

山本紘一郎, 本多寛之, 中野靖浩, 徳増一樹, 長谷川功, 小比賀美香子, 花山宜久, 大塚文男

日本内分泌学会雑誌 98 ( 1 ) 401 - 401 2022年4月

精巣副腎遺残腫瘍に関連し性腺機能低下を来した21-水酸化酵素欠損症の2例

山本紘一郎, 本多寛之, 中野靖浩, 徳増一樹, 長谷川功, 小比賀美香子, 花山宜久, 大塚文男

日本内分泌学会雑誌 98 ( 1 ) 401 - 401 2022年4月

原発性副甲状腺機能亢進症に対するカルシウム受容体作動薬の効果と関連因子

山本紘一郎, 中野靖浩, 徳増一樹, 本多寛之, 長谷川功, 小比賀美香子, 三好智子, 小川弘子, 花山宜久, 大塚文男

日本内分泌学会雑誌 98 ( 1 ) 374 - 374 2022年4月

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