研究者詳細 - 大塚　文男

論文 - 大塚　文男

分割表示 822 件中 541 - 560 件目／全件表示 >>

Clinical characteristics of febrile outpatients: Possible involvement of thyroid dysfunction in febrile tachycardia

Oka K, Hanayama Y, Sato A, Omura D, Yasuda M, Hasegawa K, Obika M and Otsuka F

Acta Med. Okayama 72 ( 5 ) 447 - 456 2018年10月

The Esophagus on Sight: Ultrasonography in Achalasia.

Yoshito Nishimura, Yuusaku Sugihara, Fumio Otsuka

JMA journal 1 ( 1 ) 71 - 72 2018年9月

Effect of the interaction of metformin and bone morphogenetic proteins on ovarian steroidogenesis by human granulosa cells 国際誌

Iwata N, Hasegawa T, Fujita S, Nagao S, Nakano Y, Nada T, Nishiyama Y, Hosoya T and Otsuka F

Biochem. Biopys. Res. Commun 503 ( 3 ) 1422 - 1427 2018年9月

Enterovaginal and colovesical fistulas as late complications of pelvic radiotherapy

Iwamuro M, Hasegawa K, Hanayama Y, Kataoka H, Tanaka T, Kondo Y, Otsuka F

J. Gen. Fam. Med 19 ( 5 ) 166 - 169 2018年9月

Thyroid Follicular Carcinoma in a Teenager: A Case Report

Oka K, Shien T and Otsuka F

J. Gen. Fam. Med 19 ( 5 ) 170 - 172 2018年9月

Manifestation of central diabetes insipidus in a patient with thyroid storm

Nakamichi A, Ocho K, Oka K, Yasuda M, Hasegawa K, Iwamuro M, Obika M, Rai K and Otsuka F

Intern. Med 57 ( 13 ) 1939 - 1942 2018年7月

Interaction between orexin A and bone morphogenetic protein system on progesterone biosynthesis by rat granulosa cells 国際誌

Fujita S, Hasegawa T, Nishiyama Y, Fujisawa S, Nakano Y, Nada T, Iwata N, Kamada Y, Masuyama H and Otsuka F

J. Steroid Biochem. Mol. Biol 181 73 - 79 2018年7月

Modulation of bone morphogenetic protein activity by melatonin in ovarian steroidogenesis.

Fumio Otsuka

Reproductive medicine and biology 17 ( 3 ) 228 - 233 2018年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：WILEY

Background: Melatonin regulates circadian and seasonal rhythms and the activities of hormones and cytokines that are expressed in various tissues, including the ovary, in which melatonin receptors are expressed. In the ovary, follicular growth occurs as a result of complex interactions between pituitary gonadotropins and autocrine and paracrine factors, including bone morphogenetic proteins (BMPs) that are expressed in the ovary. Methods: The effects of melatonin and BMPs on steroidogenesis were examined by using the primary cultures of rat granulosa cells. Main findings Results: It was shown that melatonin has antagonistic effects on BMP-6 actions in the granulosa cells, suggesting that melatonin is likely to contribute to balancing the biological activity of endogenous BMPs that maintain progesterone production and luteinization in the growing follicles. Similar interactions between melatonin and BMP-smad signaling also were shown in the mechanism of controlling ovarian steroidogenesis by other ligands. Conclusion: A new role of melatonin in the regulation of endocrine homeostasis in relation to BMP activity is introduced in this review.

DOI： 10.1002/rmb2.12089

Web of Science

PubMed

researchmap

Isolated follicle-stimulating hormone deficiency coincidentally diagnosed by hematospermia

Fujisawa S and Otsuka F

Intern. Med 57 ( 12 ) 1799 - 1799 2018年6月

Unilateral exophthalmos due to lymphomatous involvement

Yasuda M, M Iwamuro, Kimura K and Otsuka F

Intern. Med 57 ( 9 ) 1335 - 1335 2018年5月

RS3PE syndrome mimicking venous thrombosis

Nakano Y, Oka K, Horiguchi S and Otsuka F

J. Hosp. Gen. Med 14 ( 3 ) 223 - 224 2018年4月

Incretins modulate progesterone biosynthesis by regulating bone morphogenetic protein activity in rat granulosa cells 国際誌

Nishiyama Y,Hasegawa T, Fujita S, Iwata N, Nagao S, Hosoya T, Inagaki K, Wada Jun and Otsuka F

J. Steroid Biochem. Mol. Biol 178 82 - 88 2018年4月

Colonoscopy examination requires a longer time in patients with acromegaly than in other individuals

Iwamuro M, Yasuda M, Hasegawa K, Fujisawa S, Ogura-Ochi K, Sugihara Y, Harada K, Hiraoka S, Okada H and Otsuka F

Endocr. J 65 ( 2 ) 151 - 157 2018年2月

Far East scarlet-like fever masquerading as adult-onset Kawasaki disease

Ocho K, Iwamuro M, Hasegawa K, Hagiya H, Rai K, Yumoto T, Otsuka F

Intern. Med 57 ( 3 ) 437 - 440 2018年2月

Pneumatosis Cystoides Intestinalis

Yuusaku Sugihara, Keita Harada, Hiroko Ogawa, Fumio Otsuka, Hiroyuki Okada

Journal of Lung Health and Diseases 2018年2月

Severe Gastritis after Administration of Nivolumab and Ipilimumab

Nishimura Y, Yasuda M, Ocho K, Iwamuro M, Yamasaki O, Tanaka T, Otsuka F

Case Rep Oncol 11 ( 2 ) 549 - 556 2018年

Psoas abscess secondary to paravertebral inflammation 国際誌

Nishimura Y, Otsuka F

ID Cases 13 e00435 2018年

Interaction of Melatonin and BMP-6 in Ovarian Steroidogenesis. 国際誌

Fumio Otsuka

Vitamins and hormones 107 137 - 153 2018年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：ELSEVIER ACADEMIC PRESS INC

The bone morphogenetic protein (BMP) system in the ovary plays a physiological role as a luteinization inhibitor in growing follicles. BMP-6 secreted from oocytes and granulosa cells can exert an inhibitory effect on follicle-stimulating hormone (FSH) actions by suppressing adenylate cyclase activity downstream of the FSH receptor. The inhibition of FSH-induced progesterone production by BMP-6 is impaired by melatonin treatment in granulosa cells. Intracellular Smad signaling induced by BMP-6 is suppressed by melatonin, suggesting that melatonin has a regulatory role in BMP receptor signaling in granulosa cells. Since the expression of BMP-6 in granulosa cells is increased in patients with polycystic ovary syndrome, melatonin may play an important role in the maintenance of progesterone production by suppressing BMP-6 signaling, leading to the preservation of ovarian function.

DOI： 10.1016/bs.vh.2018.01.012

Web of Science

PubMed

researchmap

Diffuse intestinal ganglioneuromatosis showing multiple large bowel ulcers in a patient with neurofibromatosis type 1. 査読

Iwamuro M, Omote R, Tanaka T, Sunada N, Nada T, Kondo Y, Nose S, Kawaguchi M, Otsuka F, Okada H

Intern. Med 56 ( 24 ) 3287 - 3291 2017年12月

Rapid laboratory tests for Malaria detection in Japan.

Kashihara N, Iwamuro M, Kusano N, Otsuka F

J. Gen. Fam. Med 18 ( 6 ) 470 - 471 2017年12月

　前のページ - 次のページ　

<大塚 文男>

論文 - 大塚 文男

<大塚　文男>

論文 - 大塚　文男