研究者詳細 - 吉田　竜介

MISC - 吉田　竜介

分割表示 111 件中 61 - 80 件目／全件表示 >>

Analysis of taste responsiveness of subsets of receptor cells in the mouse single fungiform taste bud

R. Yoshida, T. Yasuo, Y. Murata, M. Jyotaki, Y. Ninomiya

CHEMICAL SENSES 33 ( 2 ) J11 - J11 2008年2月

マウスII型味細胞の発火頻度依存性ATP放出

村田芳博, 吉田竜介, 安尾敏明, 柳川右千夫, 小幡邦彦, 植野洋志, Margolskee, R.F, 二ノ宮裕三

日本味と匂学会誌 15 ( 3 ) 381 - 384 2008年

ATP release from type II taste cells depending on firing rate

Yoshihiro Murata, Ryusuke Yoshida, Toshiaki Yasuo, Yuchio Yanagawa, Kunihiko Obata, Hiroshi Ueno, Robert F. Margolskee, Yuzo Ninomiya

NEUROSCIENCE RESEARCH 61 S178 - S178 2008年

Abnormal taste perception in mine lacking the Type 3 IP3 Receptor

Chihiro Hisatsune, Keiko Yasumatsu, Hiromi Takahashi-Iwanaga, Naoko Ogawa, Yukiko Kuroda, Ryusuke Yoshida, Yuzo Ninomiya, Katsuhiko Mikoshiba

NEUROSCIENCE RESEARCH 61 S249 - S249 2008年

Analysis of signal transductions for umami taste by single fiber recordings in the chorda tympani nerve of T1R3-and TRPM5-KO mice

Keiko Yasumatsu, Ryusuke Yoshida, Robert F. Margolskee, Yuzo Ninomiya

NEUROSCIENCE RESEARCH 61 S179 - S179 2008年

Different response properties among cell types of taste receptor cells

Ryusuke Yoshida, Yoshihiro Murata, Toshiaki Yasuo, Masashi Jyotaki, Yuchio Yanagawa, Kunihiko Obata, Hiroshi Ueno, Robert F. Margolskee, Yuzo Ninomiya

NEUROSCIENCE RESEARCH 61 S248 - S248 2008年

味細胞の細胞型と応答特性

植野洋志, 吉田竜介

日本味と匂学会誌 15 ( 3 ) 285 - 288 2008年

II型およびIII型味細胞の発火頻度依存性ATP放出

村田芳博, 吉田竜介, 安尾敏明, 柳川右千夫, 小幡邦彦, 植野洋司, Margolskee Robert F, 二ノ宮裕三

日本生理学会大会発表要旨集 2008 ( 0 ) 167 - 167 2008年

出版者・発行元：一般社団法人日本生理学会

Taste signals are transmitted from taste cells to gustatory nerve fibers through chemical synapses. Taste cells are morphologically classified into four types: I, II, III and basal cells. Among them, chemical synapses are observed only in type III cells with putative sour receptors. However, sweet, bitter and umami receptors are expressed in type II cells, and the mechanisms have not been elucidated. Recent reports have highlighted the role of ATP as a key neurotransmitter. Here we tried to detect ATP release from single taste cells with action potentials in mouse fungiform papillae. The action potentials were recorded with the electrode basolaterally attached to a cell. When an increase in the firing rate was observed in response to a tastant, the electrode solution was applied for luciferase assay to determine the ATP. Type II and III cells express gustducin and glutamic acid decarboxylase (GAD67), respectively. We identified these cell types with transgenic mice expressing GFP in gustducin- or GAD67-positive cells. When Type II cells responded to saccharin or quinine, ATP was detected in a firing rate-dependent manner. When Type III cells increased the firing rate by application of HCl, ATP was below the detection limit. The results suggest that the amount of ATP released from taste cells differ with the response properties, or that type III cells release another neurotransmitter. <b>[J Physiol Sci. 2008;58 Suppl:S167]</b>

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塩味、酸味、苦味物質混合によるマウス鼓索神経甘味応答の修飾

安松啓子, 大栗弾宏, 吉田竜介, DAMAK Sami, MARGOLSKEE Robert F, 二ノ宮裕三

日本味と匂学会誌 = The Japanese journal of taste and smell research 14 ( 3 ) 387 - 390 2007年12月

T1R3-KOマウスにおけるうま味物質に対する条件付け味覚嫌悪学習

城崎慎也, 川東由利子, 中島清人, 重村憲徳, 安松啓子, 吉田竜介, MARGOLSKEE Robert F., 二ノ宮裕三

日本味と匂学会誌 = The Japanese journal of taste and smell research 14 ( 3 ) 379 - 382 2007年12月

単一味蕾中の複数の味受容細胞は様々な応答特性を持つ

吉田竜介, 安尾敏明, 村田芳博, 安松啓子, 重村憲徳, 二ノ宮裕三

Journal of Oral Biosciences 49 ( Supplement ) 171 2007年8月

マウス味細胞の味刺激応答とATP放出

村田芳博, 安尾敏明, 吉田竜介, 二ノ宮裕三

Journal of Oral Biosciences 49 ( Supplement ) 172 2007年8月

活動電位を発生する味細胞は味覚情報伝達経路の起始点となりうる

吉田竜介, 安松啓子, 二ノ宮裕三

日本味と匂学会誌 = The Japanese journal of taste and smell research 14 ( 2 ) 163 - 170 2007年8月

記述言語：日本語出版者・発行元：日本味と匂学会

味覚受容体を発現するII型味細胞はシナプスを特たないとされる。では神経への味の情報伝達はどのようになされているのであろうか?このメカニズムの解明が、現在、緊急の課題であり、味覚研究における最大の謎となっている。近年、ATP受容体P2X2/X3ノックアウトマウスの味応答の消失の発見に始まり、活動電位依存的なATPの放出も報告されるに至り、II型味細胞から神経への情報伝達の道筋が徐々に明らかになってきた。我々は、旧来より、味細胞から、神経への情報伝達の仕組みについて明らかにするため、神経の再生過程や、味細胞の応答特性や発現遺伝子との関連、神経線維の応答特性との関連を追及してきた。その結果、活動電位を発生する味細胞の応答は、そのまま神経へ伝達されている可能性が高く、味細胞の活動電位の発現が、味覚情報伝達に重要であることが示唆された。

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その他リンク： http://search.jamas.or.jp/link/ui/2008064681

甘味感受性に影響する温度依存的なTrpm5の働き

重村憲徳, 安松啓子, 吉田竜介, 二ノ宮裕三

低温生物工学会誌 = Cryobiology and cryotechnology 53 ( 1 ) 53 - 55 2007年6月

記述言語：日本語出版者・発行元：低温生物工学会

Trpm5, calcium-activated cation channel of the TRP superfamily, is highly expressed in taste buds of the tongue, where it has a key role in the perception of sweet, umami and bitter tastes. Activation of Trpm5 occurs downstream of the activation of G-protein-coupled taste receptors and is proposed to generate a depolarizing potential in the taste receptor cells. Factors that modulate Trpm5 activity are therefore expected to influence taste. Here we show that Trpm5 is a highly temperature-sensitive, heat-activated channel: inward Trpm5 currents increase steeply at temperatures between 15 and 35 degrees C. Heat activation is due to a temperature-dependent shift of the activation curve, in analogy to other thermosensitive TRP channels. Moreover, we show that increasing temperature between 15 and 35 degrees C markedly enhances the gustatory nerve response to sweet compounds in wild-type but not in Trpm5 knockout mice. The strong temperature sensitivity of Trpm5 may underlie known effects of temperature on perceived taste in humans, including enhanced sweetness perception at high temperatures and 'thermal taste`, the phenomenon whereby heating or cooling of the tongue evoke sensations of taste in the absence of tastants.

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その他リンク： http://search.jamas.or.jp/link/ui/2008081022

Analysis of salt taste signal transduction using salty peptides and KT-1 cells

T. Ookura, K. Yasumatsu, Y. Ito, R. Yoshida, T. Kawai, Y. Kusakabe, Y. Shindo, A. Hino, Y. Ninomiya

CHEMICAL SENSES 32 ( 2 ) J2 - J2 2007年2月

Behavioral analysis of responses to sweet substances in T1R3-KO mice

S. Shirosaki, R. Yoshida, N. Shigemura, K. Yasumatsu, R. F. Margolskee, Y. Ninomiya

CHEMICAL SENSES 32 ( 2 ) J5 - J6 2007年2月

Temperature dependency of the chorda tympani nerve response to sweeteners in C57BL/6N and BALB/c mice

T. Ohkuri, K. Yasumatsu, R. Yoshida, N. Shigemura, Y. Ninomiya

CHEMICAL SENSES 32 ( 2 ) J5 - J5 2007年2月

Relation of polymorphisms of ENaC Subunits to mouse strain differences in amiloride sensitive salt responses

N. Shigemura, T. Ohkuri, C. Sadamitsu, K. Yasumatsu, R. Yoshida, G. K. Beauchamp, A. Bachimanov, Y. Ninomiya

CHEMICAL SENSES 32 ( 2 ) J6 - J6 2007年2月

Response properties of NaCl responsive taste cells in mouse fungiform papillae: Amiloride-sensitive and insensitive taste cells

R. Yoshida, T. Ohkuri, K. Yasumatsu, N. Shigemura, Y. Ninomiya

CHEMICAL SENSES 32 ( 2 ) J6 - J6 2007年2月

Association between polymorphism of the sweet receptor gene, Tas1r3 and gurmarin sensitivity

K. Sanematsu, K. Yasumatsu, R. Yoshida, N. Shigemura, Y. Ninomiya

CHEMICAL SENSES 32 ( 2 ) J5 - J5 2007年2月

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