Faculty Profiles - YOSHIDA Ryusuke

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ATP release from type II taste cells depending on firing rate

Yoshihiro Murata, Ryusuke Yoshida, Toshiaki Yasuo, Yuchio Yanagawa, Kunihiko Obata, Hiroshi Ueno, Robert F. Margolskee, Yuzo Ninomiya

NEUROSCIENCE RESEARCH 61 S178 - S178 2008

Abnormal taste perception in mine lacking the Type 3 IP3 Receptor

Chihiro Hisatsune, Keiko Yasumatsu, Hiromi Takahashi-Iwanaga, Naoko Ogawa, Yukiko Kuroda, Ryusuke Yoshida, Yuzo Ninomiya, Katsuhiko Mikoshiba

NEUROSCIENCE RESEARCH 61 S249 - S249 2008

Analysis of signal transductions for umami taste by single fiber recordings in the chorda tympani nerve of T1R3-and TRPM5-KO mice

Keiko Yasumatsu, Ryusuke Yoshida, Robert F. Margolskee, Yuzo Ninomiya

NEUROSCIENCE RESEARCH 61 S179 - S179 2008

Different response properties among cell types of taste receptor cells

Ryusuke Yoshida, Yoshihiro Murata, Toshiaki Yasuo, Masashi Jyotaki, Yuchio Yanagawa, Kunihiko Obata, Hiroshi Ueno, Robert F. Margolskee, Yuzo Ninomiya

NEUROSCIENCE RESEARCH 61 S248 - S248 2008

味細胞の細胞型と応答特性

植野洋志, 吉田竜介

日本味と匂学会誌 15 ( 3 ) 285 - 288 2008

Firing rate dependent ATP release from type II and type III taste cells in mice

Murata Yoshihiro, Yoshida Ryusuke, Yasuo Toshiaki, Yanagawa Yuchio, Obata Kunihiko, Ueno Hiroshi, Margolskee Robert F, Ninomiya Yuzo

Proc Annu Meet PSJ 2008 ( 0 ) 167 - 167 2008

Publisher：一般社団法人日本生理学会

Taste signals are transmitted from taste cells to gustatory nerve fibers through chemical synapses. Taste cells are morphologically classified into four types: I, II, III and basal cells. Among them, chemical synapses are observed only in type III cells with putative sour receptors. However, sweet, bitter and umami receptors are expressed in type II cells, and the mechanisms have not been elucidated. Recent reports have highlighted the role of ATP as a key neurotransmitter. Here we tried to detect ATP release from single taste cells with action potentials in mouse fungiform papillae. The action potentials were recorded with the electrode basolaterally attached to a cell. When an increase in the firing rate was observed in response to a tastant, the electrode solution was applied for luciferase assay to determine the ATP. Type II and III cells express gustducin and glutamic acid decarboxylase (GAD67), respectively. We identified these cell types with transgenic mice expressing GFP in gustducin- or GAD67-positive cells. When Type II cells responded to saccharin or quinine, ATP was detected in a firing rate-dependent manner. When Type III cells increased the firing rate by application of HCl, ATP was below the detection limit. The results suggest that the amount of ATP released from taste cells differ with the response properties, or that type III cells release another neurotransmitter. <b>[J Physiol Sci. 2008;58 Suppl:S167]</b>

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Modulation of sweet taste responses by addition of NaCl, HCl and QHCl in the chorda tympani nerve of wild type and TRPM5-KO mice

YASUMATSU Keiko, OHKURI Tadahiro, YOSHIDA Ryusuke, DAMAK Sami, MARGOLSKEE Robert F, NINOMIYA Yuzo

The Japanese journal of taste and smell research 14 ( 3 ) 387 - 390 2007.12

Conditioned taste aversion for umami substances in T1R3-knockout mice

SHIROSAKI Shinya, KAWATO Yuriko, NAKASHIMA Kiyohito, SHIGEMURA Noriatsu, YASUMATSU Keiko, YOSHIDA Ryusuke, MARGOLSKEE Robert F., NINOMIYA Yuzo

The Japanese journal of taste and smell research 14 ( 3 ) 379 - 382 2007.12

単一味蕾中の複数の味受容細胞は様々な応答特性を持つ

吉田竜介, 安尾敏明, 村田芳博, 安松啓子, 重村憲徳, 二ノ宮裕三

Journal of Oral Biosciences 49 ( Supplement ) 171 2007.8

マウス味細胞の味刺激応答とATP放出

村田芳博, 安尾敏明, 吉田竜介, 二ノ宮裕三

Journal of Oral Biosciences 49 ( Supplement ) 172 2007.8

Taste receptor cells with action potentials as an initiation site for the gustatory information transduction pathway

YOSHIDA Ryusuke, YASUMATSU Keiko, NINOMIYA Yuzo

The Japanese journal of taste and smell research 14 ( 2 ) 163 - 170 2007.8

The Role of Trpm5 in Thermal Sensitivity of Sweet Taste

SHIGEMURA Noriatsu, YASUMATSU Keiko, YOSHIDA Ryusuke, NINOMIYA Yuzo

Cryobiology and cryotechnology 53 ( 1 ) 53 - 55 2007.6

Language：Japanese Publisher：Japanese Society for Cryobiology and Cryotechnology

Trpm5, calcium-activated cation channel of the TRP superfamily, is highly expressed in taste buds of the tongue, where it has a key role in the perception of sweet, umami and bitter tastes. Activation of Trpm5 occurs downstream of the activation of G-protein-coupled taste receptors and is proposed to generate a depolarizing potential in the taste receptor cells. Factors that modulate Trpm5 activity are therefore expected to influence taste. Here we show that Trpm5 is a highly temperature-sensitive, heat-activated channel: inward Trpm5 currents increase steeply at temperatures between 15 and 35 degrees C. Heat activation is due to a temperature-dependent shift of the activation curve, in analogy to other thermosensitive TRP channels. Moreover, we show that increasing temperature between 15 and 35 degrees C markedly enhances the gustatory nerve response to sweet compounds in wild-type but not in Trpm5 knockout mice. The strong temperature sensitivity of Trpm5 may underlie known effects of temperature on perceived taste in humans, including enhanced sweetness perception at high temperatures and 'thermal taste`, the phenomenon whereby heating or cooling of the tongue evoke sensations of taste in the absence of tastants.

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Other Link： http://search.jamas.or.jp/link/ui/2008081022

Analysis of salt taste signal transduction using salty peptides and KT-1 cells

T. Ookura, K. Yasumatsu, Y. Ito, R. Yoshida, T. Kawai, Y. Kusakabe, Y. Shindo, A. Hino, Y. Ninomiya

CHEMICAL SENSES 32 ( 2 ) J2 - J2 2007.2

Behavioral analysis of responses to sweet substances in T1R3-KO mice

S. Shirosaki, R. Yoshida, N. Shigemura, K. Yasumatsu, R. F. Margolskee, Y. Ninomiya

CHEMICAL SENSES 32 ( 2 ) J5 - J6 2007.2

Temperature dependency of the chorda tympani nerve response to sweeteners in C57BL/6N and BALB/c mice

T. Ohkuri, K. Yasumatsu, R. Yoshida, N. Shigemura, Y. Ninomiya

CHEMICAL SENSES 32 ( 2 ) J5 - J5 2007.2

Relation of polymorphisms of ENaC Subunits to mouse strain differences in amiloride sensitive salt responses

N. Shigemura, T. Ohkuri, C. Sadamitsu, K. Yasumatsu, R. Yoshida, G. K. Beauchamp, A. Bachimanov, Y. Ninomiya

CHEMICAL SENSES 32 ( 2 ) J6 - J6 2007.2

Response properties of NaCl responsive taste cells in mouse fungiform papillae: Amiloride-sensitive and insensitive taste cells

R. Yoshida, T. Ohkuri, K. Yasumatsu, N. Shigemura, Y. Ninomiya

CHEMICAL SENSES 32 ( 2 ) J6 - J6 2007.2

Association between polymorphism of the sweet receptor gene, Tas1r3 and gurmarin sensitivity

K. Sanematsu, K. Yasumatsu, R. Yoshida, N. Shigemura, Y. Ninomiya

CHEMICAL SENSES 32 ( 2 ) J5 - J5 2007.2

Polymorphisms of ENaC subunits relate to mouse strain differences in amiloride sensitive salt responses

Noriatsu Shigemura, Tadahiro Ohkuri, Chiharu Sadamitsu, Keiko Yasumatsu, Ryusuke Yoshida, Gary K. Beauchamp, Alexander A. Bachmanov, Yuzo Ninomiya

NEUROSCIENCE RESEARCH 58 S217 - S217 2007

マウス茸状乳頭味細胞のATP放出

村田芳博, 安尾敏明, 吉田竜介, 二ノ宮裕三

日本味と匂学会誌 14 ( 3 ) 391 - 394 2007

Language：Japanese Publisher：日本味と匂学会

味細胞の応答とそれに伴うATP放出の関係を明らかにした。マウス(C57BL/6N)の舌を摘出した。味細胞の応答記録はルーズパッチ記録法で行った。サッカリン刺激で応答する味細胞に当てた記録電極の内液にはATPが検出され、ATPは味細胞が放出したもと考えられた。サッカリン刺激によるATP放出は、味細胞が発する活動電位の頻度が上昇することで生じ、その放出量はスパイク頻度が上昇する程度に依存した。このことは、味刺激で誘発される味細胞の活動電位がATP放出に重要な役割を担っていることが示唆された。味細胞が発する活動電位はパネキシン1の開口に関与する可能性が考えられた。

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2007&ichushi_jid=J04102&link_issn=&doc_id=20071228200037&doc_link_id=%2Fcw7jasts%2F2007%2F001403%2F047%2F0391-0394%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fcw7jasts%2F2007%2F001403%2F047%2F0391-0394%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

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