Faculty Profiles - YOSHIDA Ryusuke

MISC - YOSHIDA Ryusuke

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カプサイシンはマウス味覚神経応答を糖特異的に増強する

岩田周介, 吉田竜介, 高橋慎平, 安尾敏明, 諏訪部武, 硲哲崇, 二ノ宮裕三, 二ノ宮裕三

Journal of Oral Biosciences Supplement (Web) 2023 2023

研究室紹介 Invited

吉田竜介

日本味と匂学会誌 29 ( 2 ) 113 - 116 2022.11

持続的な甘味刺激が唾液分泌量に及ぼす影響

山田蘭子, 杉本皓, 田中祐貴, 北川佳祐, 古寺寛志, 足立れいみ, 市川知香, 松岸諒, 森慧太郎, 桑原実穂, 萬田陽介, 兒玉直紀, 吉田竜介, 皆木省吾

日本補綴歯科学会誌 14 ( 中国・四国支部学術大会特別号 ) 22 - 22 2022.8

Capsaicin enhances responses of the gustatory nerve to sugars and salt in mice

岩田周介, 岩田周介, 吉田竜介, 高井信吾, 實松敬介, 實松敬介, 實松敬介, 重村憲徳, 重村憲徳, 二ノ宮裕三, 二ノ宮裕三

Journal of Oral Biosciences Supplement (Web) 2022 2022

発酵乳成分におけるマウスの味覚応答の解析

山瀬裕子, 黄海, 美藤純弘, 美藤純弘, 美藤純弘, 江草正彦, 宮脇卓也, 吉田竜介, 吉田竜介, 吉田竜介

岡山歯学会雑誌 41 ( 2 ) 2022

発酵乳成分に対する味覚応答

山瀬裕子, 山瀬裕子, 黄海, 美藤純弘, 美藤純弘, 美藤純弘, 江草正彦, 宮脇卓也, 吉田竜介, 吉田竜介, 吉田竜介

日本神経化学会大会抄録集(Web) 65th 2022

唾液腺支配のラット上唾液核ニューロンに対する摂食亢進ペプチドの影響

美藤純弘, 佐藤匡, 藤田雅子, 小橋基, 市川博之, 吉田竜介

Journal of Oral Biosciences Supplement (Web) 2019 2019

Gustatory responses of taste receptor cells expressing fluorescent proteins in transgenic mice

Ryusuke Yoshida, Keiko Yasumatsu-Nakano, Keisuke Sanematsu, Noriatsu Shigemura, Yuzo Ninomiya

CHEMICAL SENSES 41 ( 9 ) E115 - E115 2016.11

Glucagon like peptide-1, sweet taste and metabolic modulation of peripheral taste information

Shingo Takai, Noriatsu Shigemura, Keiko Yasumatsu-Nakano, Mayuko Inoue, Shusuke Iwata, Ryusuke Yoshida, Robert F. Margolskee, Yuzo Ninomiya

CHEMICAL SENSES 41 ( 9 ) E128 - E128 2016.11

Intracellular acidification is involved in full activation of the sweet taste receptor by miraculin

Keisuke Sanematsu, Masayuki Kitagawa, Ryusuke Yoshida, Satoru Nirasawa, Noriatsu Shigemura, Yuzo Ninomiya

CHEMICAL SENSES 41 ( 9 ) E276 - E276 2016.11

味覚と健康栄養素センサー研究の現状と未来味覚受容体の機能(塩味と甘味)

重村憲徳, 吉田竜介, 安松啓子, 大栗弾宏, 岩田周介, 高井信吾, 上瀧将史, 仁木麻由, 實松敬介, 二ノ宮祐三

日本薬学会年会要旨集 136年会 ( 1 ) 206 - 206 2016.3

The function of glucagon-like peptide-1 in the mouse peripheral taste system

Shingo Takai, Ryusuke Yoshida, Keiko Yasumatsu, Noriatsu Shigemura, Yuzo Ninomiya

Journal of Oral Biosciences 58 ( 1 ) 10 - 15 2016.2

Publishing type：Book review, literature introduction, etc.

© 2015 Japanese Association for Oral Biology. Published by Elsevier B.V. All rights reserved. Background Several studies have demonstrated that some gut peptides known to be important in energy metabolism are expressed in mouse taste bud cells. However, the functions of these peptides in taste cells are still largely unknown. In the gut, one of these peptides, glucagon-like peptide-1 (GLP-1), which is known as the insulinotropic gut peptide, is secreted from enteroendocrine L-cells, which express as many taste molecules as those on the tongue. These taste transduction molecules are suggested to be involved in GLP-1 secretion from L-cells in response to various nutrient stimuli. GLP-1 is reported to function as a neurotransmitter via activation of its receptors expressed on the vagus nerve, thereby regulating insulin secretion. Highlight Consistent with this evidence from the gastrointestinal tract, recent studies have demonstrated that GLP-1 is secreted from mouse taste cells in response to taste compounds such as sugars, artificial sweeteners, and long-chain fatty acids. GLP-1 secreted from taste cells may activate particular types of gustatory nerve fibers because they express GLP-1 receptors and respond to GLP-1 administered via the femoral vein. Conclusion GLP-1 released from taste cells may be involved in transmission of sweet and lipid signals, thereby impacting animalsfeeding behavior in response to these important nutrient factors.

DOI： 10.1016/j.job.2015.09.002

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甘味受容体を起点とした口腔脳腸の味情報 : 内分泌連関と食調節 (特集第13回高付加価値食品開発のためのフォーラム)

吉田竜介, 二ノ宮裕三

食品加工技術 : 日本食品機械研究会誌 36 ( 1 ) 30 - 38 2016

ホルモンによる味覚(塩味・甘味)感受性調節

重村憲徳, 吉田竜介, 安松啓子, 大栗弾宏, 岩田周介, 高井信吾, 上瀧将史, 仁木麻由, 實松敬介, 二ノ宮裕三

日本生物工学会大会講演要旨集平成27年度 161 - 161 2015.9

口腔生理学分野の研究最前線Frontier in the field of Oral Physiology エンドカンナビノイドによる自己増幅的甘味増強とT1R3-非依存的甘味受容経路の存在

岩田周介, 吉田竜介, 重村憲徳, 二ノ宮裕三

Journal of Oral Biosciences Supplement 2015 115 - 115 2015.9

味細胞におけるエンドカンナビノイドを介した甘味応答の自己増幅

岩田周介, 吉田竜介, 重村憲徳, 二ノ宮裕三

Journal of Oral Biosciences Supplement 2015 295 - 295 2015.9

Involvement of CCK in normal gustatory responses to bitter compounds

Misa Shin, Keiko Yasumatsu, Shingo Takai, Noriatsu Shigemura, Ryusuke Yoshida, Soichi Takiguchi, Seiji Nakamura, Yuzo Ninomiya

CHEMICAL SENSES 40 ( 3 ) 259 - 260 2015.3

香辛料の味修飾作用及び消化管を介した代謝調節作用―3 ホルモンによる味覚修飾と摂食調節―アンジオテンシンIIと味覚―

重村憲徳, 吉田竜介, 安松啓子, 大栗弾宏, 岩田周介, 高井信吾, 上瀧将史, 仁木麻由, 實松敬介, 二ノ宮裕三

日本味と匂学会誌 21 ( 1 ) 49 - 53 2014.4

Involvement of multiple populations of taste cells and afferent neurons in umami taste detection

Y. Ninomiya, K. Yasumatsu, R. Yoshida

CHEMICAL SENSES 39 ( 1 ) 77 - 77 2014.1

味蕾から分泌される消化管ホルモンは味質特異的な情報伝達に関与する

高井信吾, 安松啓子, 岩田周介, 井上真由子, 吉田竜介, 重村憲徳, DRUCKER Daniel J, MARGOLSKEE Robert F, 二ノ宮裕三, 二ノ宮裕三

Journal of Oral Biosciences Supplement (Web) 2014 ROMBUNNO.SS11‐1 (WEB ONLY) 2014

Endogenous humoral modulators of behavioral preference for sweet and salty tastes

Yuzo Ninomiya, Mayu Niki, Ryusuke Yoshida, Noriatsu Shigemura

JOURNAL OF PHYSIOLOGICAL SCIENCES 63 S59 - S59 2013

食欲調節物質による甘味感受性の調節

吉田竜介, 二ノ宮裕三

日本薬理學雜誌 = Folia pharmacologica Japonica 139 ( 3 ) 131 - 131 2012.3

Inhibition of sweet taste responses by AM251, an antagonist of endocannabinoid receptors in db/db mice

NIKI Mayu, JYOTAKI Masafumi, YOSHIDA Ryusuke, NINOMIYA Yuzo

The Japanese journal of taste and smell research 18 ( 3 ) 255 - 258 2011.12

The taste organ is a target for orexigenic and anorexic mediators

Yuzo Ninomiya, Mayu Niki, Tadahiro Ohkuri, Masafumi Jyotaki, Ryusuke Yoshida

CHEMICAL SENSES 36 ( 1 ) E2 - E2 2011.1

Expression of G alpha subunits in sweet and umami taste cells in mice

Ryusuke Yoshida, Aya Miyauchi, Robert F. Margolskee, Yuzo Ninomiya

NEUROSCIENCE RESEARCH 71 E154 - E154 2011

Modulation of sweet sensitivity by endogenous leptin and endocannabinoid

Mayu Niki, Masafumi Jyotaki, Tadahiro Ohkuri, Ryusuke Yoshida, Yuzo Ninomiya

NEUROSCIENCE RESEARCH 71 E163 - E163 2011

Involvement of mGluRs in umami detection in mice

Yoko Kusuhara, Keiko Yasumatsu, Tadahiro Ohkuri, Ryusuke Yoshida, Katsumasa Maeda, Yuzo Ninomiya

NEUROSCIENCE RESEARCH 71 E358 - E358 2011

Humoral modulation of sweet taste sensitivities for energy homeostasis

Yuzo Ninomiya, Mayu Niki, Masafumi Jyotaki, Tadahiro Ohkuri, Ryusuke Yoshida

NEUROSCIENCE RESEARCH 71 E40 - E41 2011

Inhibition of sweet taste responses by AM251, an antagonist of endocannabinoid receptors in db/db mice

NIKI Mayu, OHKURI Tadahiro, JYOTAKI Masafumi, YOSHIDA Ryusuke, NINOMIYA Yuzo

The Japanese journal of taste and smell research 17 ( 3 ) 231 - 234 2010.12

Influence of GABA on taste responses of mouse taste cells

YASUO Toshiaki, YOSHIDA Ryusuke, YANAGAWA Yuchio, MARGOLSKEE Robert F, NINOMIYA Yuzo

The Japanese journal of taste and smell research 17 ( 3 ) 227 - 230 2010.12

マウス味細胞の味応答に対するGABAの影響

安尾敏明, 吉田竜介, 重村憲徳, 柳川右千夫, 二ノ宮裕三

Journal of Oral Biosciences 52 ( Supplement ) 100 2010.9

味蕾内におけるGABAの応答特性

安尾敏明, 吉田竜介, 堀尾奈央, 重村憲徳, 二ノ宮裕三

日本生理学雑誌 72 ( 2 ) 43 2010.2

GABA act as a modulator for sweet and bitter taste responses of mice taste bud cells

Toshiaki Yasuo, Ryusuke Yoshida, Noriatsu Shigemura, Robert Margolskee, Yuzo Ninomiya

JOURNAL OF PHYSIOLOGICAL SCIENCES 60 S143 - S143 2010

Endocannabinoids enhance sweet taste sensitivities in mice

Ryusuke Yoshida, Tadahiro Ohkuri, Masafumi Jyotaki, Toshiaki Yasuo, Nao Horio, Keiko Yasumatsu, Keisuke Sanematsu, Noriatsu Shigemura, Tsuneyuki Yamamoto, Robert F. Margolskee, Yuzo Ninomiya

NEUROSCIENCE RESEARCH 68 E389 - E390 2010

GABA influence on taste cell responses in mice

Toshiaki Yasuo, Ryusuke Yoshida, Noriatsu Shigemura, Robert F. Margolskee, Yuzo Ninomiya

NEUROSCIENCE RESEARCH 68 E384 - E384 2010

Single nucleotide polymorphisms (SNP) in taste sensor genes and perceptual diversity

Noriatsu Shigemura, Yoko Ogiwara, Keisuke Sanematsu, Misako Kawai, Ryusuke Yoshida, Yuzo Ninomiya

JOURNAL OF PHYSIOLOGICAL SCIENCES 60 S73 - S73 2010

PKD2L1 is associated with the sour taste transduction

Nao Horio, Ryusuke Yoshida, Keiko Yasumatsu, Yuchio Yanagawa, Yoshiro Ishimaru, Hiroaki Matsunami

NEUROSCIENCE RESEARCH 68 E385 - E385 2010

GABA functions as neurotransmitter in the mice taste buds

YASUO Toshiaki, YOSHIDA Ryusuke, HORIO Nao, SHIGEMURA Noriatsu, NINOMIYA Yuzo

The Japanese journal of taste and smell research 16 ( 3 ) 323 - 326 2009.12

Different Response Properties between Type II and Type III Taste Bud Cells in Mouse Fungiform Papillae

Ryusuke Yoshida, Toshiaki Yasuo, Yoshihiro Murata, Masashi Jyotaki, Yuchio Yanagawa, Kunihiko Obata, Hiroshi Ueno, Robert F. Margolskee, Yuzo Ninomiya

CHEMICAL SENSES 34 ( 7 ) A72 - A72 2009.9

Genetic and Molecular Basis of Individual Differences in Human Umami Taste Perception

Noriatsu Shigemura, Shinya Shirosaki, Keisuke Sanematsu, Yoko Ogiwara, Misako Kawai, Ryusuke Yoshida, Yuzo Ninomiya

CHEMICAL SENSES 34 ( 7 ) A63 - A63 2009.9

The role of taste bud cells on the coding of taste information

YOSHIDA Ryusuke, NINOMIYA Yuzo

The Japanese journal of taste and smell research 16 ( 2 ) 117 - 124 2009.8

Taste Signal Transnission from Fungiform Taste Bud Cells to Chorda Tympani Nerve Fibers in Mice

Ryusuke Yoshida, Yoshinori Murata, Toshiaki Yasuo, Keiko Yasumatsu, Noriatsu Shigemura, Yuzo Ninomiya

CHEMICAL SENSES 34 ( 3 ) E30 - E30 2009.3

Firing Frequency-Dependent ATP Release from Type II Taste Cells in Mice

Yoshihiro Murata, Ryusuke Yoshida, Toshiaki Yasuo, Yuchio Yanagawa, Kunihiko Obata, Hiroshi Ueno, Robert F. Margolskee, Yuzo Ninomiya

CHEMICAL SENSES 34 ( 2 ) J8 - J8 2009.2

Cell Types and Response Properties of Mouse Fungiform Taste Cells

Ryusuke Yoshida, Yoshihiro Murata, Toshiaki Yasuo, Masashi Jyotaki, Yuchio Yanagawa, Kunihiko Obata, Hiroshi Ueno, Robert F. Margolskee, Yuzo Ninomiya

CHEMICAL SENSES 34 ( 2 ) J2 - J2 2009.2

Sweet sensing for regulation of food intake

Yuzo Ninomiya, Keisuke Sanematsu, Masahumi Johtaki, Ryusuke Yoshida, Noriatsu Shigemura

JOURNAL OF PHARMACOLOGICAL SCIENCES 109 46P - 46P 2009

Functional analysis of T1R1/T1R3 umami taste receptor variants

Noriatsu Shigemura, Shinya Shirosaki, Keisuke Sanematsu, Yoko Ogiwara, Misako Kawai, Ryusuke Yoshida, Yuzo Ninomiya

NEUROSCIENCE RESEARCH 65 S176 - S176 2009

Responses of mouse fungiform taste cells to multiple bitter or sour taste compounds

Ryusuke Yoshida, Toshiaki Yasuo, Aya Miyauchi, Yuchio Yanagawa, Kunihiko Obata, Hiroshi Ueno, Robert F. Margolskee, Yuzo Ninomiya

NEUROSCIENCE RESEARCH 65 S175 - S175 2009

FUNCTIONAL EXPRESSION STUDY OF TAS1R1/TAS1R3 RECEPTOR VARIANTS ASSOCIATED WITH INDIVIDUAL DIFFERENCES IN HUMAN UMAMI TASTE SENSITIVITY

Noriatsu Shigemura, Shinya Shirosaki, Keisuke Sanematsu, Yoko Ogiwara, Misako Kawai, Ryusuke Yoshida, Yuzo Ninomiya

JOURNAL OF PHYSIOLOGICAL SCIENCES 59 488 - 488 2009

TASTE RESPONSIVENESS OF TYPE II AND III TASTE BUD CELLS IN MOUSE FUNGIFORM PAPILLAE

Ryusuke Yoshida, Toshiaki Yasuo, Yoshihiro Murata, Masashi Jyotaki, Yuchio Yanagawa, Kunihiko Obata, Hiroshi Ueno, Sami Damak, Robert F. Margolskee, Yuzo Ninomiya

JOURNAL OF PHYSIOLOGICAL SCIENCES 59 148 - 148 2009

Effects of antagonists for mGluRs on behavioral responses in C57BL/6 and T1R3-KO mice

SHIROSAKI Shinya, KAWATO Yuriko, NAKASHIMA Kiyohito, SHIGEMURA Noriatsu, YASUMATSU Keiko, YOSHIDA Ryusuke, MARGOLSKEE Robert F, NINOMIYA Yuzo

The Japanese journal of taste and smell research 15 ( 3 ) 293 - 296 2008.12

Modulation and Transmission of Sweet Taste Information for Energy Homeostasis

Yuzo Ninomiya, Ryusuke Yoshida, Yoshihiro Murata, Keiko Yasumatsu, Tadahiro Ohkuri, Shinya Shirosaki, Keisuke Sanematsu, Toshiaki Yasuo, Yuki Nakamura, Noriatsu Shigemura

CHEMICAL SENSES 33 ( 8 ) S23 - S23 2008.10

Firing Rate-Dependent ATP Release from Mouse Fungiform Taste Cells with Action Potentials

Yoshihiro Murata, Ryusuke Yoshida, Toshiaki Yasuo, Yuchio Yanagawa, Kunihiko Obata, Hiroshi Ueno, Robert F. Margolskee, Yuzo Ninomiya

CHEMICAL SENSES 33 ( 8 ) S128 - S128 2008.10

Multiple Receptor Systems for Umami Taste in Mice

Ryusuke Yoshida, Keiko Yasumatsu, Shinya Shirosaki, Yuriko Kawato, Yoshihiro Murata, Noriatsu Shigemura, Kiyohito Nakashima, Robert F. Margolskee, Yuzo Ninomiya

CHEMICAL SENSES 33 ( 8 ) S5 - S5 2008.10

GFPノックインマウスを用いたII型およびIII型味細胞の応答特性の解析

吉田竜介, 村田芳博, 安尾敏明, 上瀧将史, 安松啓子, 重村憲徳, 二ノ宮裕三

Journal of Oral Biosciences 50 ( Supplement ) 189 2008.9

II型味細胞は活動電位の頻度に依存してATPを放出する

村田芳博, 安尾敏明, 吉田竜介, 二ノ宮裕三

Journal of Oral Biosciences 50 ( Supplement ) 189 2008.9

単一味蕾内の複数の味細胞の応答特性

吉田竜介, 安尾敏明, 村田芳博, 上瀧将史, 二ノ宮裕三

日本生理学雑誌 70 ( 2 ) 59 2008.2

マウス茸状乳頭味細胞の活動電位依存性ATP放出

村田芳博, 安尾敏明, 吉田竜介, 二ノ宮裕三

日本生理学雑誌 70 ( 2 ) 60 2008.2

ATP release from mouse fungiform taste cells with action potentials

Y. Murata, T. Yasuo, R. Yoshida, Y. Ninomiya

CHEMICAL SENSES 33 ( 2 ) J11 - J11 2008.2

Analysis of taste responsiveness of subsets of receptor cells in the mouse single fungiform taste bud

R. Yoshida, T. Yasuo, Y. Murata, M. Jyotaki, Y. Ninomiya

CHEMICAL SENSES 33 ( 2 ) J11 - J11 2008.2

マウスII型味細胞の発火頻度依存性ATP放出

村田芳博, 吉田竜介, 安尾敏明, 柳川右千夫, 小幡邦彦, 植野洋志, Margolskee, R.F, 二ノ宮裕三

日本味と匂学会誌 15 ( 3 ) 381 - 384 2008

ATP release from type II taste cells depending on firing rate

Yoshihiro Murata, Ryusuke Yoshida, Toshiaki Yasuo, Yuchio Yanagawa, Kunihiko Obata, Hiroshi Ueno, Robert F. Margolskee, Yuzo Ninomiya

NEUROSCIENCE RESEARCH 61 S178 - S178 2008

Abnormal taste perception in mine lacking the Type 3 IP3 Receptor

Chihiro Hisatsune, Keiko Yasumatsu, Hiromi Takahashi-Iwanaga, Naoko Ogawa, Yukiko Kuroda, Ryusuke Yoshida, Yuzo Ninomiya, Katsuhiko Mikoshiba

NEUROSCIENCE RESEARCH 61 S249 - S249 2008

Analysis of signal transductions for umami taste by single fiber recordings in the chorda tympani nerve of T1R3-and TRPM5-KO mice

Keiko Yasumatsu, Ryusuke Yoshida, Robert F. Margolskee, Yuzo Ninomiya

NEUROSCIENCE RESEARCH 61 S179 - S179 2008

Different response properties among cell types of taste receptor cells

Ryusuke Yoshida, Yoshihiro Murata, Toshiaki Yasuo, Masashi Jyotaki, Yuchio Yanagawa, Kunihiko Obata, Hiroshi Ueno, Robert F. Margolskee, Yuzo Ninomiya

NEUROSCIENCE RESEARCH 61 S248 - S248 2008

味細胞の細胞型と応答特性

植野洋志, 吉田竜介

日本味と匂学会誌 15 ( 3 ) 285 - 288 2008

Firing rate dependent ATP release from type II and type III taste cells in mice

Murata Yoshihiro, Yoshida Ryusuke, Yasuo Toshiaki, Yanagawa Yuchio, Obata Kunihiko, Ueno Hiroshi, Margolskee Robert F, Ninomiya Yuzo

Proc Annu Meet PSJ 2008 ( 0 ) 167 - 167 2008

Publisher：一般社団法人日本生理学会

Taste signals are transmitted from taste cells to gustatory nerve fibers through chemical synapses. Taste cells are morphologically classified into four types: I, II, III and basal cells. Among them, chemical synapses are observed only in type III cells with putative sour receptors. However, sweet, bitter and umami receptors are expressed in type II cells, and the mechanisms have not been elucidated. Recent reports have highlighted the role of ATP as a key neurotransmitter. Here we tried to detect ATP release from single taste cells with action potentials in mouse fungiform papillae. The action potentials were recorded with the electrode basolaterally attached to a cell. When an increase in the firing rate was observed in response to a tastant, the electrode solution was applied for luciferase assay to determine the ATP. Type II and III cells express gustducin and glutamic acid decarboxylase (GAD67), respectively. We identified these cell types with transgenic mice expressing GFP in gustducin- or GAD67-positive cells. When Type II cells responded to saccharin or quinine, ATP was detected in a firing rate-dependent manner. When Type III cells increased the firing rate by application of HCl, ATP was below the detection limit. The results suggest that the amount of ATP released from taste cells differ with the response properties, or that type III cells release another neurotransmitter. <b>[J Physiol Sci. 2008;58 Suppl:S167]</b>

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Modulation of sweet taste responses by addition of NaCl, HCl and QHCl in the chorda tympani nerve of wild type and TRPM5-KO mice

YASUMATSU Keiko, OHKURI Tadahiro, YOSHIDA Ryusuke, DAMAK Sami, MARGOLSKEE Robert F, NINOMIYA Yuzo

The Japanese journal of taste and smell research 14 ( 3 ) 387 - 390 2007.12

Conditioned taste aversion for umami substances in T1R3-knockout mice

SHIROSAKI Shinya, KAWATO Yuriko, NAKASHIMA Kiyohito, SHIGEMURA Noriatsu, YASUMATSU Keiko, YOSHIDA Ryusuke, MARGOLSKEE Robert F., NINOMIYA Yuzo

The Japanese journal of taste and smell research 14 ( 3 ) 379 - 382 2007.12

単一味蕾中の複数の味受容細胞は様々な応答特性を持つ

吉田竜介, 安尾敏明, 村田芳博, 安松啓子, 重村憲徳, 二ノ宮裕三

Journal of Oral Biosciences 49 ( Supplement ) 171 2007.8

マウス味細胞の味刺激応答とATP放出

村田芳博, 安尾敏明, 吉田竜介, 二ノ宮裕三

Journal of Oral Biosciences 49 ( Supplement ) 172 2007.8

Taste receptor cells with action potentials as an initiation site for the gustatory information transduction pathway

YOSHIDA Ryusuke, YASUMATSU Keiko, NINOMIYA Yuzo

The Japanese journal of taste and smell research 14 ( 2 ) 163 - 170 2007.8

The Role of Trpm5 in Thermal Sensitivity of Sweet Taste

SHIGEMURA Noriatsu, YASUMATSU Keiko, YOSHIDA Ryusuke, NINOMIYA Yuzo

Cryobiology and cryotechnology 53 ( 1 ) 53 - 55 2007.6

Language：Japanese Publisher：Japanese Society for Cryobiology and Cryotechnology

Trpm5, calcium-activated cation channel of the TRP superfamily, is highly expressed in taste buds of the tongue, where it has a key role in the perception of sweet, umami and bitter tastes. Activation of Trpm5 occurs downstream of the activation of G-protein-coupled taste receptors and is proposed to generate a depolarizing potential in the taste receptor cells. Factors that modulate Trpm5 activity are therefore expected to influence taste. Here we show that Trpm5 is a highly temperature-sensitive, heat-activated channel: inward Trpm5 currents increase steeply at temperatures between 15 and 35 degrees C. Heat activation is due to a temperature-dependent shift of the activation curve, in analogy to other thermosensitive TRP channels. Moreover, we show that increasing temperature between 15 and 35 degrees C markedly enhances the gustatory nerve response to sweet compounds in wild-type but not in Trpm5 knockout mice. The strong temperature sensitivity of Trpm5 may underlie known effects of temperature on perceived taste in humans, including enhanced sweetness perception at high temperatures and 'thermal taste`, the phenomenon whereby heating or cooling of the tongue evoke sensations of taste in the absence of tastants.

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Other Link： http://search.jamas.or.jp/link/ui/2008081022

Analysis of salt taste signal transduction using salty peptides and KT-1 cells

T. Ookura, K. Yasumatsu, Y. Ito, R. Yoshida, T. Kawai, Y. Kusakabe, Y. Shindo, A. Hino, Y. Ninomiya

CHEMICAL SENSES 32 ( 2 ) J2 - J2 2007.2

Behavioral analysis of responses to sweet substances in T1R3-KO mice

S. Shirosaki, R. Yoshida, N. Shigemura, K. Yasumatsu, R. F. Margolskee, Y. Ninomiya

CHEMICAL SENSES 32 ( 2 ) J5 - J6 2007.2

Temperature dependency of the chorda tympani nerve response to sweeteners in C57BL/6N and BALB/c mice

T. Ohkuri, K. Yasumatsu, R. Yoshida, N. Shigemura, Y. Ninomiya

CHEMICAL SENSES 32 ( 2 ) J5 - J5 2007.2

Relation of polymorphisms of ENaC Subunits to mouse strain differences in amiloride sensitive salt responses

N. Shigemura, T. Ohkuri, C. Sadamitsu, K. Yasumatsu, R. Yoshida, G. K. Beauchamp, A. Bachimanov, Y. Ninomiya

CHEMICAL SENSES 32 ( 2 ) J6 - J6 2007.2

Response properties of NaCl responsive taste cells in mouse fungiform papillae: Amiloride-sensitive and insensitive taste cells

R. Yoshida, T. Ohkuri, K. Yasumatsu, N. Shigemura, Y. Ninomiya

CHEMICAL SENSES 32 ( 2 ) J6 - J6 2007.2

Association between polymorphism of the sweet receptor gene, Tas1r3 and gurmarin sensitivity

K. Sanematsu, K. Yasumatsu, R. Yoshida, N. Shigemura, Y. Ninomiya

CHEMICAL SENSES 32 ( 2 ) J5 - J5 2007.2

Polymorphisms of ENaC subunits relate to mouse strain differences in amiloride sensitive salt responses

Noriatsu Shigemura, Tadahiro Ohkuri, Chiharu Sadamitsu, Keiko Yasumatsu, Ryusuke Yoshida, Gary K. Beauchamp, Alexander A. Bachmanov, Yuzo Ninomiya

NEUROSCIENCE RESEARCH 58 S217 - S217 2007

マウス茸状乳頭味細胞のATP放出

村田芳博, 安尾敏明, 吉田竜介, 二ノ宮裕三

日本味と匂学会誌 14 ( 3 ) 391 - 394 2007

Language：Japanese Publisher：日本味と匂学会

味細胞の応答とそれに伴うATP放出の関係を明らかにした。マウス(C57BL/6N)の舌を摘出した。味細胞の応答記録はルーズパッチ記録法で行った。サッカリン刺激で応答する味細胞に当てた記録電極の内液にはATPが検出され、ATPは味細胞が放出したもと考えられた。サッカリン刺激によるATP放出は、味細胞が発する活動電位の頻度が上昇することで生じ、その放出量はスパイク頻度が上昇する程度に依存した。このことは、味刺激で誘発される味細胞の活動電位がATP放出に重要な役割を担っていることが示唆された。味細胞が発する活動電位はパネキシン1の開口に関与する可能性が考えられた。

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単一細胞応答の観点からみたマウス茸状乳頭味蕾の応答性

吉田竜介, 安尾敏明, 村田芳博, 上瀧将史, 二ノ宮裕三

日本味と匂学会誌 14 ( 3 ) 395 - 398 2007

Language：Japanese Publisher：日本味と匂学会

単一味蕾中に存在する複数の味細胞の基本味刺激(NaCl、HCl、サッカリン、キニーネ、MSG)に対する応答をルーズパッチ法にて記録し、それらを比較することで、個々の味蕾がどのような味覚情報を味神経へ伝達しているのかについて解析した。C57BL/6Nマウスの舌を摘出した。14個の味蕾から2個の異なる味細胞の応答を同時に、もしくは別々に記録することができた。6個の味蕾では2つの味細胞が同じ刺激で最大応答を示し、残りの8個の味蕾では2つの異なる味細胞は異なる刺激により最大応答を示した。28個の味細胞に対するエントロピー値は0.156±0.269、14個の味蕾のエントロピー値は0.378±0.310となり、両者の間には有意差が見られた。

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1P179 ATP release from mouse taste cells with action potentials in response to a tastant(Chemoreception,Poster Presentations)

Murata Yoshihiro, Yoshida Ryusuke, Yasuo Toshiaki, Yanagawa Yuchio, Obata Kunihiko, Ueno Hiroshi, Margolskee Robert F, Ninomiya Yuzo

Seibutsu Butsuri 47 ( 0 ) S68 2007

1P180 Differences in response properties among cell types of taste cells(Chemoreception,Poster Presentations)

Yoshida Ryusuke, Murata Yoshihiro, Yasuo Toshiaki, Jyotaki Masashi, Yanagawa Yuchio, Obata Kunihiko, Ueno Hiroshi, Margolskee Robert F, Ninomiya Yuzo

Seibutsu Butsuri 47 ( 0 ) S68 2007

Modulations of sweet taste responses by salts, acids and bitter compounds in the mouse chorda tympani nerve

Keiko Yasumatsu, Ryusuke Yoshida, Robert F. Margolskee, Yuzo Ninomiya

NEUROSCIENCE RESEARCH 58 S217 - S217 2007

Relation of polymorphisms of ENaC subunits to mouse strain differences in amiloride sensitive salt responses

SHIGEMURA Noriatsu, OHKURI Tadahiro, SADAMITSU Chiharu, YASUMATSU Keiko, YOSHIDA Ryusuke, BACHMANOV Alexander A., BEAUCHAMP Gary K., NINOMIYA Yuzo

The Japanese journal of taste and smell research 13 ( 3 ) 355 - 358 2006.12

Temperature dependency of the chorda tympani nerve response to sweeteners in C57BL/6N and BALB/c mice

OHKURI Tadahiro, YASUMATSU Keiko, YOSHIDA Ryusuke, SHIGEMURA Noriatsu, NINOMIYA Yuzo

The Japanese journal of taste and smell research 13 ( 3 ) 339 - 342 2006.12

Association between polymorphism of the sweet receptor gene, Tas1r3 and gurmarin-sensitivity

SANEMATSU Keisuke, YASUMATSU Keiko, YOSHIDA Ryusuke, SHIGEMURA Noriatsu, NINOMIYA Yuzo

The Japanese journal of taste and smell research 13 ( 3 ) 343 - 346 2006.12

Response properties of NaCl responsive taste cells in mouse fungiform papillae : Amiloride -sensitive and -insensitive taste cells

YOSHIDA Ryusuke, OHKURI Tadahiro, YASUMATSU Keiko, SHIGEMURA Noriatsu, NINOMIYA Yuzo

The Japanese journal of taste and smell research 13 ( 3 ) 351 - 354 2006.12

Analysis of salt taste signal transduction using salt taste enhancers and KT-1 cells

OOKURA Tetsuya, YASUMATSU Keiko, ITO Yumiko, YOSHIDA Ryusuke, KAWAI Takayuki, KUSAKABE Yuko, SHINDO Yoichiro, HINO Akihiro, NINOMIYA Yuzo

The Japanese journal of taste and smell research 13 ( 3 ) 279 - 280 2006.12

Behavioral analysis of responses to sweet substances in T1R3-KO mice

SHIROSAKI Shinya, SHIGEMURA Noriatsu, YOSHIDA Ryusuke, YASUMATSU Keiko, MARGOLSKEE Robert F., NINOMIYA Yuzo

The Japanese journal of taste and smell research 13 ( 3 ) 347 - 350 2006.12

Analysis of residual responses to umami compounds in the chorda tympani nerve fiber of T1R3- and TRPM5-KO mice

YASUMATSU Keiko, YOSHIDA Ryusuke, SHIGEMURA Noriatsu, DAMAK Sami, MARGOLSKEE Robert F., NINOMIYA Yuzo

The Japanese journal of taste and smell research 13 ( 3 ) 335 - 338 2006.12

Multiple receptors, transduction pathways and fiber types underlie umami taste in mice

K. Yasumatsu, R. Yoshida, N. Shigemura, S. Damak, R. F. Margolskee, Y. Ninomiya

CHEMICAL SENSES 31 ( 8 ) E88 - E89 2006.10

Functional roles of taste signals on regulation of food intake

Shigemura Noriatsu, Nakamura Yuki, Yoshida Ryusuke, Ninomiya Yuzo

The Japanese journal of taste and smell research 13 ( 2 ) 125 - 132 2006.8

Formation of taste neural coding channels

R Yoshida, N Shigemura, K Yasumatsu, Y Ninomiya

CHEMICAL SENSES 31 ( 1 ) J2 - J3 2006.1

Behavioral analysis of responses to quinine in Trpm5 KO mice

S Shirosaki, R Yoshida, N Shigemura, K Yasumatsu, RF Margolskee, Y Ninomiya

CHEMICAL SENSES 31 ( 1 ) J12 - J12 2006.1

NaCl induced responses of mouse fungiform taste cells: existence of amiloride sensitive and insensitive taste cells

Ryusuke Yoshida, Tadahiro Ohkuri, Keiko Yasumatsu, Noriatsu Shigemura, Yuzo Ninomiya

NEUROSCIENCE RESEARCH 55 S251 - S251 2006

Behavioral analysis of responses to quinine in TRPM5 KO mice

SHIROSAKI Shinya, SHIGEMURA Noriatsu, YOSHIDA Ryusuke, YASUMATSU Keiko, MARGOLSKEE Robert F., NINOMIYA Yuzo

The Japanese journal of taste and smell research 12 ( 3 ) 373 - 376 2005.12

Formation of taste neural coding channels

YOSHIDA Ryusuke, SHIGEMURA Noriatsu, YASUMATSU Keiko, NINOMIYA Yuzo

The Japanese journal of taste and smell research 12 ( 3 ) 259 - 262 2005.12

レプチンによる甘味感受性の修飾 (特集・味覚のメカニズムに迫る)

吉田竜介, 重村憲徳, 安松啓子

生体の科学 56 ( 2 ) 109 - 113 2005.3

Abstracts of the 27th Annual Meeting of the Japan Neuroscience Society and the 3rd Joint Meeting of the Japan Neuroscience Society and the Japanese Society for Neurochemistry (Neuro 2004) (vol 51, pg 219, 2005)

K Yasumatsu, N Shigemura, R Yoshida, S Damak, RF Margolskee, Y Ninomiya

NEUROSCIENCE RESEARCH 51 ( 2 ) 219 - 219 2005.2