研究者詳細 - 成瀬　恵治

論文 - 成瀬　恵治

分割表示 177 件中 41 - 60 件目／全件表示 >>

Role of TRPC3 and TRPC6 channels in the myocardial response to stretch: Linking physiology and pathophysiology. 査読

Yamaguchi Y, Iribe G, Nishida M and Naruse K

Progress in Biophysics & Molecular Biology 130 ( Pt B ) 264 - 272 2017年11月

Effects of simulated ischemia on the transmural differences in the Frank-Starling relationship in isolated mouse ventricular cardiomyocytes 査読

Khokhlova A, Iribe G, Yamaguchi Y, Naruse K and Solovyova O

Progress in Biophysics and Molecular Biology, Progress in biophysics and biophysical chemistry 130 ( Pt B ) 323 - 332 2017年11月

Simultaneous mapping of multiple proteins in heart using matrix-assisted laser desorption/ionization imaging mass spectrometry 査読

Takahashi K, Naruse K

European Heart Journal 38 ( Suppl 1 ) ehx501.45 2017年8月

Effect of Oxidative Stress on Cardiovascular System in Response to Gravity 査読

Ken Takahashi, Hiroki Okumura, Rui Guo, Keiji Naruse

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 18 ( 7 ) 2017年7月

記述言語：英語出版者・発行元：MDPI AG

Long-term habitation in space leads to physiological alterations such as bone loss, muscle atrophy, and cardiovascular deconditioning. Two predominant factors-namely space radiation and microgravity-have a crucial impact on oxidative stress in living organisms. Oxidative stress is also involved in the aging process, and plays important roles in the development of cardiovascular diseases including hypertension, left ventricular hypertrophy, and myocardial infarction. Here, we discuss the effects of space radiation, microgravity, and a combination of these two factors on oxidative stress. Future research may facilitate safer living in space by reducing the adverse effects of oxidative stress.

DOI： 10.3390/ijms18071426

Web of Science

PubMed

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Imaging of Cell Mechanics under High Gravity by Rotational Microscope

Masatoshi Morimatsu, Ken Takahashi, Ayano Fujita, Keiji Naruse

BIOPHYSICAL JOURNAL 112 ( 3 ) 271A - 272A 2017年2月

Effects of bepridil on stretch-activated BKca channels and stretch-induced extrasystoles in isolated chick hearts. 査読

Jin H, Iribe G and Naruse K

Physiological Research 66 ( 3 ) 459 - 465 2017年

Dynamic Remodeling of the Heart and Blood Vessels: Implications of Health and Disease 査読

Ken Takahashi, Hulin Piao, Keiji Naruse

Mechanobiology: Exploitation for Medical Benefit 175 - 189 2016年11月

記述言語：英語掲載種別：論文集(書籍)内論文出版者・発行元：wiley

Long-term exposure to pressure/volume overload of the heart due to hypertension or aortic stenosis induces pathological hypertrophy and remodeling, and eventually causes heart failure. This process accompanies pathological phenomena such as inflammation, apoptosis, and arrhythmia. On the other hand, physical exercise promotes physiological hypertrophy and remodeling of the heart, thereby enhancing cardiac performance. Interestingly, recent research has suggested that enhancement of heart function is a result not only of physiological hypertrophy of pre-existing cardiomyocytes, but also of cardiac stem cell activation and myocyte formation. Furthermore, exercise improves exacerbated cardiac function in heart diseases, including dilated cardiomyopathy (DCM) and myocardial infarction (MI). The suggested mechanisms of action of exercise remedies for these diseases include angiogenesis, cardiac resynchronization, and inhibition of inflammatory cytokines. However, excessive exercise can cause arrhythmogenic remodeling and sudden death. In this chapter, we elaborate the mechanisms of hypertrophy and remodeling under physiological and pathological conditions and discuss future directions for coping with pathological hypertrophy and remodeling.

DOI： 10.1002/9781118966174.ch11

Scopus

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Induced NCX1 overexpression attenuates pressure overload-induced pathological cardiac remodelling 査読

Yoshihiro Ujihara,Keiichiro Iwasaki,Satomi Takatsu,Ken Hashimoto,Keiji Naruse*,Satoshi Mohri,Yuki Katanosaka*

Cardiovascular Research, Cardioscience 111 ( 4 ) 348 - 361 2016年9月

Transplantation of dental pulp stem cells suppressed inflammation in sciatic nerves by promoting macrophage polarization towards anti-inflammation phenotypes and ameliorated diabetic polyneuropathy. 査読

Omi M, Hata M, Nakamura N, Miyabe M, Kobayashi Y, Kamiya H, Nakamura J, Ozawa S, Tanaka Y, Takebe J, Matsubara T, Naruse K

Journal of diabetes investigation 7 ( 4 ) 485 - 496 2016年7月

Innovation of vascular engineering by mechanomedicine 査読

Ken Takahashi, Keiji Naruse

Vascular Engineering: New Prospects of Vascular Medicine and Biology with a Multidiscipline Approach 283 - 296 2016年1月

記述言語：英語掲載種別：論文集(書籍)内論文出版者・発行元：Springer Japan

This article describes how physical forces contribute to development, physiology, and pathology of vascular cells, focusing on endothelial cells and vascular smooth muscle cells. Based on these basic understandings of the mechanobiology, we discuss mechanomedicine, an application of the mechanobiology to medicine. Basic knowledge about cellular responses, such as cellular signal transduction pathway, gene expression, and cytoskeletal remodeling, to mechanical stimuli is important for understanding the pathology of vascular diseases including atherosclerosis. Introducing the knowledge of the vascular mechanobiology will not only contribute to the development of regenerative medicine using pluripotent stem cells but also provide a way to prevent diseases caused by thromboembolisms, such as myocardial and cerebral infarctions.

DOI： 10.1007/978-4-431-54801-0_15

Scopus

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[Response to mechanical stimulus and cardiovascular homeostasis.] 査読

Takahashi K, Naruse K

Clin Calcium 26 ( 12 ) 1671 - 1676 2016年

Mechanical Stretch on Human Skin Equivalents Increases the Epidermal Thickness and Develops the Basement Membrane 査読

Tokuyama E, Nagai Y, Takahashi K, Naruse K

PLoS One 10 ( 1 ) e0141989 - e0141989 2015年11月

Transient receptor potential melastatin-4 is involved in hypoxia-reoxygenation injury in the cardiomyocytes. 査読

Piao H, Takahashi K, Yamaguchi Y, Wang C, Liu K, Naruse K

PLoS One 10 ( 4 ) e0121703 - e0121703 2015年4月

A simple method for decreasing the liquid junction potential in a flow-through-type differential pH sensor probe consisting of pH-FETs by exerting spatiotemporal control of the liquid junction. 査読

Yamada A, Mohri S, Nakamura M, Naruse K

Sensors (Basel) 15 ( 4 ) 7898 - 7912 2015年4月

Development of a Fluidic Gripper for Isolated Cardiomyocytes 査読

Yohei Yamaguchi, Yasuyo Yamaguchi, Shuichi Wakimoto, Gentaro Iribe, Keiji Naruse

Proc. of The 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society 110 - 110 2015年

Real-time imaging of ATP release induced by mechanical stretch in human airway smooth muscle cells. 査読

Takahara N, Ito S, Furuya K, Naruse K, Aso H, Kondo M, Sokabe M and Hasegawa Y

Am J Respir Cell Mol Biol 51 ( 6 ) 772 - 782 2014年12月

Ca2+ influx and ATP release mediated by mechanical stretch in human lung fibroblasts. 査読

Murata N, Ito S, Furuya K, Takahara N, Naruse K, Aso H, Kondo M, Sokabe M and Hasegawa Y

Biochem Biophys Res Commun 453 ( 1 ) 101 - 105 2014年10月

The significant role of Na⁺/Ca²⁺ exchanger 1 on local Ca²⁺ control beneath T-tubule membrane 査読

Ujihara Yoshihiro, Iwasaki Keiichiro, Takatsu Satomi, Hashimoto Ken, Naruse Keiji, Mohri Satoshi, Katanosaka Yuki

生体医工学 52 212 - O-213 2014年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Japanese Society for Medical and Biological Engineering

Na⁺/Ca²⁺ exchanger (NCX1) is essential Ca²⁺ regulator of myocyte Ca²⁺ homeostasis and specially localized at transverse tubules (T-tubules) membrane. T-tubules are invaginations of the sarcolemma and critical for myocyte contraction, especially as the main site of excitation-contraction coupling. Therefore, T-tubule disorganization is linked to decreased contractility in heart failure, but the molecular mechanism is not clear. We analyzed the alteration of T-tubule structure and Ca2+ handling during the progression of heart failure after transverse aortic constriction (TAC)-surgery, using cardiac-specific and inducible NCX1 transgenic mice. In progression of cardiac dysfunction, sarcoplasmic reticulum Ca²⁺ ATPase and NCX1 activity were down-regulated before T-tubule disorganization. The inducing NCX1 overexpression after TAC-surgery prevented T-tubule disorganization and contractile dysfunction under prolonged pressure-overload, with improvement of myocyte Ca²⁺ handling. These results suggest that local Ca²⁺ control beneath the T-tubule membrane is crucial for the maintenance of myocyte structure and function, in which NCX1 has a pivotal role.

DOI： 10.11239/jsmbe.52.O-212

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Paper-based diagnostic devices for estimating human sperm motility 査読

Koji Matsuura, Wenqian Li, Kuan-Hung Chen, Yuka Asano, Keiji Naruse, Chao-Min Cheng

Transactions of Japanese Society for Medical and Biological Engineering 52 551 - O-552 2014年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Japan Soc. of Med. Electronics and Biol. Engineering

Low-cost paper-based diagnostic device for human sperm motility has developed to know sperm motility without consulting fertility clinics. We compared the signal pattern of the paper-based sperm motility assay using 4-channel pattern (cross) and 2-channel pattern (line) papers, and investigated difference in signal patterns using some tetrazorium salts for the assay. Using these two paper patterns, we can examine whether human sperm motility in semen is more than 50% or 0%. XTT and WST-8 reagents treated paper-based device can be used. We concluded that MTT treated line pattern paper is suitable for the purpose to reduce the cost of the device.

DOI： 10.11239/jsmbe.52.O-551

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Effects of axial stretch on mitochondrial reactive oxygen species in cardiac myocytes 査読

Gentaro Iribe, Keiko Kaihara, Keiji Naruse

Transactions of Japanese Society for Medical and Biological Engineering 52 44 2014年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Japan Soc. of Med. Electronics and Biol. Engineering

Myocardium contracts against ventricular wall stretch that comes along with ventricular filling. Mitochondria generate required ATP for myocardial contraction. It is well known that mitochondrial ATP production process is one of the sources of reactive oxygen species (ROS). ROS are known as toxic molecules, but also important physiological regulators of intracellular signaling pathways. In the present study, we investigate the relation between myocardial stretch and mitochondrial ROS production, and discuss the role of mitochondria on myocardial response to stretch. Isolated mouse ventricular myocytes were exposed to 10% axial stretch using carbon fiber technique. ROS production was studied using DCF-loaded cells. Axial stretch significantly increased ROS production. Applying 5 μM mitochondrial metabolic uncoupler FCCP blunted the response, indicating mitochondrial ROS production is stretch-sensitive. The present results suggest that stretch enhances electron transport chain to prepare for the more ATP production for the more preloaded, namely, the more energy-consuming contraction.

DOI： 10.11239/jsmbe.52.SY-44

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