研究者詳細 - 成瀬　恵治

論文 - 成瀬　恵治

分割表示 177 件中 21 - 40 件目／全件表示 >>

Systematic Understanding of Pathophysiological Mechanisms of Oxidative Stress-Related Conditions—Diabetes Mellitus, Cardiovascular Diseases, and Ischemia–Reperfusion Injury 査読

Wang M, Liu Y, Liang Y, Naruse K, Takahashi K

Frontiers in Cardiovascular Medicine 8 2021年4月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Frontiers Media SA

Reactive oxygen species (ROS) plays a role in intracellular signal transduction under physiological conditions while also playing an essential role in diseases such as hypertension, ischemic heart disease, and diabetes, as well as in the process of aging. The influence of ROS has some influence on the frequent occurrence of cardiovascular diseases (CVD) in diabetic patients. In this review, we considered the pathophysiological relationship between diabetes and CVD from the perspective of ROS. In addition, considering organ damage due to ROS elevation during ischemia–reperfusion, we discussed heart and lung injuries. Furthermore, we have focused on the transient receptor potential (TRP) channels and L-type calcium channels as molecular targets for ROS in ROS-induced tissue damages and have discussed about the pathophysiological mechanism of the injury.

DOI： 10.3389/fcvm.2021.649785

researchmap

Treatment of Oxidative Stress with Exosomes in Myocardial Ischemia 査読

Yun Liu, Mengxue Wang, Yin Liang, Chen Wang, Keiji Naruse, Ken Takahashi

International Journal of Molecular Sciences 22 ( 4 ) 1729 - 1729 2021年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：MDPI AG

A thrombus in a coronary artery causes ischemia, which eventually leads to myocardial infarction (MI) if not removed. However, removal generates reactive oxygen species (ROS), which causes ischemia–reperfusion (I/R) injury that damages the tissue and exacerbates the resulting MI. The mechanism of I/R injury is currently extensively understood. However, supplementation of exogenous antioxidants is ineffective against oxidative stress (OS). Enhancing the ability of endogenous antioxidants may be a more effective way to treat OS, and exosomes may play a role as targeted carriers. Exosomes are nanosized vesicles wrapped in biofilms which contain various complex RNAs and proteins. They are important intermediate carriers of intercellular communication and material exchange. In recent years, diagnosis and treatment with exosomes in cardiovascular diseases have gained considerable attention. Herein, we review the new findings of exosomes in the regulation of OS in coronary heart disease, discuss the possibility of exosomes as carriers for the targeted regulation of endogenous ROS generation, and compare the advantages of exosome therapy with those of stem-cell therapy. Finally, we explore several miRNAs found in exosomes against OS.

DOI： 10.3390/ijms22041729

researchmap

The inhibitory role of rab11b in osteoclastogenesis through triggering lysosome-induced degradation of c-Fms and RANK surface receptors. 査読

Tran MT, Okusha Y, Feng Y, Morimatsu M, Wei P, Sogawa C, Eguchi T, Kadowaki T, Sakai E, Okamura H, Naruse K, Tsukuba T, Okamoto K

Int J Mol Sci 21 ( 24 ) 9352 - 9352 2020年12月

In vitro Neo-Genesis of Tendon/Ligament-Like Tissue by Combination of Mohawk and a Three-Dimensional Cyclic Mechanical Stretch Culture System. 査読

Kataoka K, Kurimoto R, Tsutsumi H, Chiba T, ato T, Shishido K, Kato M, Ito Y, Cho Y, Hoshi O, Mimata A, Sakamaki Y, Nakamichi R, Lotz MK, Naruse K, Asahara H

Front Cell Dev Biol 8 2020年6月

Model of Ischemic Heart Disease and Video-Based Comparison of Cardiomyocyte Contraction Using hiPSC-Derived Cardiomyocytes. 査読

Liu Y, Liang Y, Wang M, Wang C, Wei H, Naruse K, Takahashi K

J Vis Exp 159 ( 159 ) e61104 2020年5月

Increased hydrostatic pressure induces nuclear translocation of DAF-16/FOXO in C. Elegans 査読国際誌

Watanabe N, Morimatsu M, Fujita A, Teranishi M, Sudevan S, Watanabe M, Iwasa H, Hata Y, Kagi H , Nishiyama M, Naruse K, Higashitani A

Biochem Biophys Res Commun 523 ( 4 ) 853 - 858 2020年3月

Elimination of fukutin reveals cellular and molecular pathomechanisms in muscular dystrophy-associated heart failure. 査読国際誌

Ujihara Y, Kanagawa M, Mohri S, Takatsu S, Kobayashi K, Toda T, Naruse K, Katanosaka Y

Nat Commun 10 ( 1 ) 5754 - 5754 2019年12月

Mechanical strain attenuates cytokine-induced ADAMTS9 expression via transient receptor potential vanilloid type 1. 査読国際誌

Exp Cell Res 383 ( 2 ) 111556 - 111556 2019年10月

Development of a model of ischemic heart disease using cardiomyocytes differentiated from human induced pluripotent stem cells. 査読

Wei H, Wang C, Guo R, Takahashi K, Naruse K

Biochemical and biophysical research communications 520 ( 3 ) 600 - 605 2019年10月

Spiral Trajectory Modulation of Rheotaxic Motile Human Sperm in Cylindrical Microfluidic Channels of Different Inner Diameters. 査読

Nishina S, Matsuura K, Naruse K

Acta medica Okayama 73 ( 3 ) 213 - 221 2019年6月

L-type calcium channel modulates mechanosensitivity of the cardiomyocyte cell line H9c2. 査読国際誌

Takahashi K, Hayashi S, Miyajima M, Omori M, Wang J, Kaihara K, Morimatsu M, Wang C, Chen J, Iribe G, Naruse K, Sokabe M

Cell Calcium 79 68 - 74 2019年5月

Cyclic stretch enhances reorientation and differentiation of 3-D culture model of human airway smooth muscle. 査読

Asano S, Ito S, Morosawa M, Furuya K, Naruse K, Sokabe M, Yamaguchi E, Hasegawa Y

Biochemistry and biophysics reports 16 32 - 38 2018年12月

TRPV2 is required for mechanical nociception and the stretch-evoked response of primary sensory neurons. 査読

Katanosaka K, Takatsu S, Mizumura K, Naruse K, Katanosaka Y

Scientific reports 8 ( 1 ) 16782 - 16782 2018年11月

Stretching of single DNA molecules caused by accelerating flow on a microchip. 査読

Hirano K, Iwaki T, Ishido T, Yoshikawa Y, Naruse K, Yoshikawa K

The Journal of chemical physics 149 ( 16 ) 165101 - 165101 2018年10月

Human gingival fibroblast feeder cells promote maturation of induced pluripotent stem cells into cardiomyocytes. 査読

Matsuda Y, Takahashi K, Kamioka H, Naruse K

Biochemical and biophysical research communications 503 ( 3 ) 1798 - 1804 2018年9月

Role of the TRPM4 Channel in Cardiovascular Physiology and Pathophysiology. 査読

Wang C, Naruse K, Takahashi K

Cells 7 ( 6 ) E62 - E62 2018年6月

TRPC3 participates in angiotensin II type 1 receptor-dependent stress-induced slow increase in intracellular Ca2+ concentration in mouse cardiomyocytes. 査読

Yamaguchi Y, Iribe G, Kaneko T, Takahashi K, Numaga-Tomita T, Nishida M, Birnbaumer L, Naruse K

The Journal of Physiological Sciences 68 ( 2 ) 153 - 164 2018年3月

Effects of Mechanical Stress on Periodontal Ligament 査読

Fujita Ayano, Morimatsu Masatoshi, Nishiyama Masayoshi, Takashiba Shogo, Naruse Keiji

BIOPHYSICAL JOURNAL 114 ( 3 ) 143A 2018年2月

The effects of load on transmural differences in contraction of isolated mouse ventricular cardiomyocytes. 査読

Khokhlova A, Iribe G, Katsnelson L, Naruse K, Solovyova O

J Mol Cell Cardiol 114 276 - 287 2018年1月

Mechano-sensitivity of mitochondrial function in mouse cardiac myocytes 査読

Iribe G, Kaihara K, Yamaguchi Y, Nakaya M, Inoue R and Naruse K

Progress in Biophysics and Molecular Biology, Progress in biophysics and biophysical chemistry 130 ( Pt B ) 315 - 322 2017年11月

　前のページ - 次のページ　

<成瀬 恵治>

論文 - 成瀬 恵治

<成瀬　恵治>

論文 - 成瀬　恵治