Faculty Profiles - TANAKA Takehiro

MISC - TANAKA Takehiro

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Langerhans cell histiocytosisにおける活性化型PTPN6(SHP-1)pY536の発現

村上一郎, 岡剛史, 桑本聡, 加藤雅子, 堀江靖, 林一彦, 佐藤妃映, 北村雄太, 鷲尾佳奈, 神農陽子, 田中健大, 市村浩一, 大原信哉, 柳井広之, 高橋聖之, 吉野正

日本病理学会会誌 99 ( 1 ) 2010

壊死性リンパ節炎におけるCD30発現とその分子生物学的意義の検索

國友知義, 田端哲也, 高田尚良, 佐藤康晴, 守都敏晃, 田村麻衣子, 市村浩一, 田中健大, 吉野正

日本病理学会会誌 98 ( 1 ) 400 - 400 2009.3

悪性リンパ腫の新WHO分類.

吉野正, 田中健大

検査と技術 37 ( 2 ) 150 - 153 2009

超効率的タンパクデリバリーシステムを応用した多重分子標的による新規悪性グリオーマ増殖抑制法の解析(Potent synergy of dual anti-tumor peptides for growth suppression of human glioblastoma cell lines)

田中健大, 近藤英作, 大原信哉, 市村浩一, 吉川和宏, 上田龍三, 吉野正

日本癌学会総会記事 67回 315 - 316 2008.9

消化管濾胞性リンパ腫.

吉野正, 佐藤康晴, 市村浩一, 田中健大, 高田尚良, 守都敏晃, 大西尚子, 田村麻衣子, 岡田裕之, 河原祥朗, 竹中龍太, 田利晶

胃と腸 43 ( 7 ) 1039 - 1046 2008

A case of Hodgkin's lymphoma with difficult diagnosis

TAKATA Katsuyoshi, NOSE Souichirou, HAMAYA Kazuo, ICHIMURA Kouichi, TANAKA Takehiro, SATO Yasuharu, MORITO Toshiaki, YOSHINO Tadashi

24 ( 3 ) 344 - 347 2007.7

田中健大, 吉野正

日本臨床 65 178 - 181 2007.1

除菌無効胃MALTリンパ腫の分子病理的特徴.

守都敏晃, 佐藤康晴, 高田尚良, 田中健大, 市村浩一, 吉野正

胃と腸 42 ( 8 ) 1191 - 1197 2007

Clinicopathology of MALT lymphoma

Takehiro Tanaka, Tadashi Yoshino

Nippon rinsho. Japanese journal of clinical medicine 65 178 - 181 2007

Expression of vascular endothelial growth factor in malignant mesothelioma

Keisuke Aoe, Akio Hiraki, Takehiro Tanaka, Ken-Ichi Gemba, Koji Taguchi, Tomoyuki Murakami, Naoko Sueoka, Toshiaki Kamei, Hiroshi Ueoka, Kazuro Sugi, Tadashi Yoshino, Takumi Kishimoto

ANTICANCER RESEARCH 26 ( 6C ) 4833 - 4836 2006.11

Language：English Publisher：INT INST ANTICANCER RESEARCH

Malignant mesothelioma is the most common primary pleural neoplasm. Angiogenesis is an important component of a variety of pathological processes, including carcinogenesis and tumor metastases. Vascular endothelial growth factor (VEGF) is the most potent known endothelial, cell specific mitogen. The authors assessed the relation between VEGF expression and clinicopathological variables or overall survival, in malignant mesothelioma. We studied 37 patients with malignant pleural mesothelioma and found that 36 out of 37 (97.3%) malignant mesothelioma samples were stained positively for VEGF. An increased expression of VEGF was observed in the epithelioid type compared with the other histological types of malignant mesothelioma, including the biphasic and sarcomatoid types. No statistically significant association was observed between VEGF expression and gender, age, or clinical stage. Furthermore, the expression of VEGF did not impact on the survival of patients with malignant mesothelioma. Although VEGF expression might be important for tumor development and maintenance, it was not identified as a prognostic factor in malignant mesothelioma.

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縦隔腫瘤と心嚢液貯留を呈したtri-lineage phenotypic LBLの一例

藤井昌学, 吉田功, 尾瀬功, 濱本泰, 片岡正明, 野上尚之, 小松原一雄, 西村理恵子, 寺本典弘, 田中健大, 市村浩一, 吉野正

臨床血液 47 ( 9 ) 1273 - 1273 2006.9

機能性ペプチドを用いた多重分子標的法による新規悪性グリオーマ増殖抑制法の解析

田中健大, 近藤英作, 吉川和宏, 吉野正

日本病理学会会誌 95 ( 1 ) 311 - 311 2006.4

腸管悪性リンパ腫の分子病理学的特徴.

吉野正, 市村浩一, 佐久川純枝, 佐藤由美子, 田中健大, 佐藤康晴

胃と腸 41,3,295-303 2006

ペプチドデリバリーシステムを応用した癌抑制遺伝子機能の回復による悪性腫瘍増殖抑制へのアプローチ

近藤英作, 田中健大, 瀬戸加大, 吉川和宏, 吉野正

日本病理学会会誌 94 ( 1 ) 234 - 234 2005.3

Induction and prevention of virus-associated malignant lymphoma by serial transmission of EBV-related virus from cynomolgus by blood transfusion in rabbits

TR Koirala, K Hayashi, ZS Jin, S Onoda, T Tanaka, W Oda, K Ichimura, N Ohara, T Oka, M Yamada, T Yoshino

ACTA MEDICA OKAYAMA 58 ( 2 ) 67 - 74 2004.4

Language：English Publisher：OKAYAMA UNIV MED SCHOOL

Epstein-Barr virus (EBV)-related herpesvirus (Si-IIA-EBV) was serially transmitted for 3 passages from rabbit to rabbit of the opposite sex by blood transfusion, which subsequently induced virus-associated rabbit lymphomas. The virus could be transmitted by transfusion with 15-20 ml of whole blood (7/7) or irradiated blood (1/6) from the EBV-related virus-infected rabbits, but there was no transmission with transfusion of cell-free plasma (0/6) from the infected rabbits. Passive anti-EBV-VCA IgG (x 20 similar to x 10) titers decreased during the first 1 - 2 weeks in the transfused rabbits. The virus-transmitted rabbits showed a gradual increase in antibody titers ranging from peak titers of X 640 to x 2560 after 3 weeks of transfusion. The recipient origin of malignant lymphoma that developed in the first rabbit transfused by infected blood was confirmed by chromosomal analysis. This rabbit model thus shows that EBV-related herpesvirus is serially transmissible by blood transfusion and that transmission can not be completely prevented by irradiation of blood, but removal of blood cells is the best way to prevent transmission of EBV-related virus. Therefore, this animal model provides a convenient in vivo system for studies of the prevention and therapy of transfusion -related transmission of EBV and EBV-associated lymphoproliferative diseases in immunocompromised human beings.

DOI： 10.18926/AMO/32097

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胃MALTリンパ腫の除菌後の経過と分子基盤 ?病理の立場から?.

吉野正, 市村浩一, 佐藤由美子, 田中健大, 佐久川純枝, 高田晋一, 山崎理恵, 中村聡子, 小田和歌子, 中谷陽子, 高畑浩之

胃と腸 39,3,295-301 2004

Therapeutic trials for a rabbit model of EBV-associated Hemophagocytic Syndrome (HPS): Effects of vidarabine or CHOP, and development of Herpesvirus papio (HVP)-negative lymphomas surrounded by HVP-infected lymphoproliferative disease

K Hayashi, H Joko, TR Koirala, S Onoda, ZS Jin, M Munemasa, N Ohara, W Oda, T Tanaka, T Oka, E Kondo, T Yoshino, K Takahashi, M Yamada, T Akagi

HISTOLOGY AND HISTOPATHOLOGY 18 ( 4 ) 1155 - 1168 2003.10

Language：English Publisher：F HERNANDEZ

Epstein-Barr virus-associated hemophagocytic syndrome (EBV-AHS), which is often associated with fatal infectious mononucleosis or T-cell lymphoproliferative diseases (LPD), is a distinct disease characterized by high mortality. Treatment of patients with EBV-AHS has proved challenging. To develop some therapeutic interventions for EBV-AHS, we examined the effectiveness of an antiviral agent (vidarabine) or chemotherapy (CHOP), using a rabbit model for EBV-AHS.
Fourteen untreated rabbits were inoculated intravenously with cell-free virions of the EBV-Iike virus Herpesvirus papio (HVP). All of the rabbits died of HVP-associated (LPD) and hemophagocytic syndrome (HPS) between 21 and 31 days after inoculation. Furthermore, three HVP-infected rabbits treated with vidarabine died between days 23 and 28 after inoculation, and their clinicopathological features were no different from those of untreated rabbits, indicating that this drug is not effective at all to treat HVP-induced rabbit LPD and HPS.
Three of the infected rabbits that were treated with one course, with an incomplete set of three courses, or with three full courses of CHOP treatment died of HVP-induced LPD and HPS with a bleeding tendency and/or with opportunistic infections. They died on the 26th, 62nd and 105th day after virus inoculation, respectively. CHOP treatment transiently suppressed the HVP-induced LPD and contributed to the prolonged survival time of two infected rabbits. However, it did not remove all of the HVP-infected cells from the infected rabbits, and residual HVP-infected lymphocytes caused recurrences of rabbit LPD and HPS. The most interesting finding of this experiment was observed in the infected rabbit with the longest survival time of 105 days: HVP-negative lymphomas surrounded by HVP-induced LPD developed in the larynx and ileum of this rabbit, causing an obstruction of the lumen. We concluded that these were not secondary lymphomas caused by CHOP treatment, because no suspicious lesions were detected in three uninfected rabbits that were treated with three courses of CHOP for 120 days. It is therefore necessary to clarify the mechanism by which HVP-negative lymphomas associated with HVP-induced LPD can develop.
Our data from therapeutic trials using EBV-AHS animal models indicate that vidarabine is not effective as an agent to treat HVP-infected rabbits, and even the cytotoxic chemotherapy of CHOP is not sufficient to cure the HVP-infected rabbits or to prolong the survival time of infected rabbits. Further studies will therefore be required to develop better therapies to treat EBV-AHS.

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Rabbit model for human EBV-associated hemophagocytic syndrome (HPS) - Sequential autopsy analysis and characterization of IL-2 dependent cell lines established from herpesvirus papio-induced fatal rabbit lymphoproliferative diseases with HPS

K Hayashi, ZS Jin, S Onoda, H Joko, N Teramoto, N Ohara, W Oda, T Tanaka, YX Liu, TR Koirala, T Oka, E Kondo, T Yoshino, K Takahashi, T Akagi

AMERICAN JOURNAL OF PATHOLOGY 162 ( 5 ) 1721 - 1736 2003.5

Language：English Publisher：AMER SOC INVESTIGATIVE PATHOLOGY, INC

Epstein-Barr virus-associated hemophagocytic syndrome (EBV-AHS) is often associated with fatal infectious mononucleosis or T-cell lymphoproliferative diseases (LPD). To elucidate the true nature of fatal LPD observed in Herpesvirus papio (HVP)-induced rabbit hemophagocytosis, reactive or neoplastic, we analyzed sequential development of HVP-induced rabbit LPD and their cell lines. All of the seven Japanese White rabbits inoculated intravenously with HVP died of fatal LPD 18 to 27 days after inoculation. LPD was also accompanied by hemophagocytic syndrome (HPS) in five of these seven rabbits. Sequential autopsy revealed splenomegaly and swollen lymph nodes, often accompanied by bleeding, which developed in the last week. Atypical lymphoid cells infiltrated many organs with a "starry sky" pattern, frequently involving the spleen, lymph nodes, and liver. HVP-small RNA-1 expression in these lymphoid cells was clearly demonstrated by a newly developed in situ hybridization (ISH) system. HVP-ISH of immunomagnetically purified lymphoid cells from spleen or lymph nodes revealed HVP-EBER1+ cells in each CD4+, CD8+, or CD79a+ fraction. Hemophagocytic histiocytosis was observed in the lymph nodes, spleen, bone marrow, and thymus. HVP-DNA was detected in the tissues and peripheral blood from the infected rabbits by PCR or Southern blot analysis. Clonality analysis of HVP-induced LPD by Southern blotting with TCR gene probe revealed polyclonal bands, suggesting polyclonal proliferation. Six IL-2-dependent rabbit T-cell lines were established from transplanted scid mouse tumors from LPD. These showed latency type I/II HVP infection and had normal karyotypes except for one line, and three of them showed tumorigenicity in nude mice. These data suggest that HVP-induced fatal LPD in rabbits is reactive polyclonally in nature.

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