Faculty Profiles - MIMURA Yukari

MISC - MIMURA Yukari

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Alterations of renal V1 and V2 receptors in spontaneously hypertensive rats and doca-salt hypertensive rats using computerized quantification for macro-autoradiogram

Yukari Mimura, Toshio Ogura, Hideo Kataoka, Teisuya Oishi, Naoko Asano, Masayuki Kishida, Takayoshi Yamauchi, Norio Ogawa, Hirofumi Makino

Research Communications in Molecular Pathology and Pharmacology 95 ( 1 ) 43 - 56 1997

Language：English

We previously examined the precise localization of vasopressin (VP) V1 and V2 receptors in the rat kidney using in vitro macro- and micro- autoradiography (ARG), and established the methodology of quantification for macro-ARG. In this study, to elucidate the role of VP in hypertension, we investigated the change within V1 and V2 receptors in the kidney of spontaneously hypertensive rats (SHR) and deoxycorticosterone acetate (DOCA)- salt hypertensive rats at different hypertensive stages. In SHR, although medullary V1 and V2 receptors decreased compared with age-matched Wistar- Kyoto (WKY) rats at the developmental hypertensive stage, these receptors increased once hypertension was established. Conversely, in DOCA-salt hypertensive rats, both renal V1 and V2 receptors decreased with elevated blood pressure. Therefore, expression of renal V1 and V2 receptors proved to be different between two models of hypertension, SHR and DOCA-salt hypertensive rats, when their blood pressure increases. In DOCA-salt hypertensive rats, renal V1 and V2 receptors may be down-regulated secondary to the high blood VP level. In SHR, the increase in renal V1 and V2 receptors may have a role in the development of high blood pressure in this strain of rats.

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A patient with sarcoidosis associated with recurrent urolithiasis and tubular injury caused by calcium deposition

Yukari Mimura, Yohei Maeshima, Toshio Ogura, Naoki Kashihara, Kenji Kawabata, Nobuhiko Hayakawa, Yoshio Nagake, Kazue Hironaka, Hirofumi Makino, Zensuke Ota, Jingo Kageyama

Japanese Journal of Nephrology 38 ( 3 ) 141 - 145 1996

Language：English

A 38-year-old woman was hospitalized in January, 1994 with renal dysfunction and hypercalcemia. Before admission, she was diagnosed as having urolithiasis, and had been treated twice with extracorporeal shock wave lithotripsy (ESWL). Ophthalmologically, she exhibited iritis and secondary glaucoma. Hypercalcemia, an extremely low titer of parathyroid hormone (PTH), and elevation of angiotensin-converting enzyme (ACE) and lysozyme activity were noted. These findings suggested sarcoidosis, although the chest X-ray showed only fibrotic changes. Hypercalcemia was suspected of having been caused secondarily by sarcoidosis. Since her laboratory data also showed renal dysfunction and abnormal unnalysis, a renal biopsy was performed. The histological findings indicated a tubular and interstitial disorder without glomerular abnormality
calcium deposition, which was detected by X-ray energy dispersive analysis, was observed in the tubular cytoplasm. Administration of prednisolone alleviated the renal dysfunction and decreased the elevation of ACE activity and lysozyme level of the blood. Sarcoidosis is sometimes associated with hypercalcemia, but rarely with renal dysfunction. These findings suggested that sarcoidosis may be associated with renal dysfunction due to tubular injury caused by calcium deposition in the tubules, and that glucocorticoid therapy was effective for these disorders.

DOI： 10.14842/jpnjnephrol1959.38.141

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A patient with sarcoidosis associated with recurrent urolithiasis and tubular injury caused by calcium deposition

Yukari Mimura, Yohei Maeshima, Toshio Ogura, Naoki Kashihara, Kenji Kawabata, Nobuhiko Hayakawa, Yoshio Nagake, Kazue Hironaka, Hirofumi Makino, Zensuke Ota, Jingo Kageyama

Japanese Journal of Nephrology 38 ( 3 ) 141 - 145 1996

Language：English

DOI： 10.14842/jpnjnephrol1959.38.141

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Effect of vasopressin V1- and V2-receptor stimulation on blood pressure in DOCA-salt hypertensive rats.

Mimura Yukari, Ogura Toshio, Yamauchi Takayoshi, Otsuka Fumio, Oishi Tetsuya, Harada Kazushi, Hashimoto Masami, Ota Zensuke

Acta Medica Okayama 49 ( 4 ) 187 - 194 1995.8

Effect of vasopressin V1-and V2-receptor stimulation on blood pressure in DOCA-salt hypertensive rats. (共著)

Mimura Yukari, Ogura Toshio, Yamauchi Takayoshi, Otsuka Fumio, Oishi Tetsuya, Harada Kazushi, Hashimoto Masami, Ota Zensuke

Acta Med Okayama 49 ( 4 ) 187 - 194 1995.8

In vitro micro-autoradiography of atrial natriuretic peptide in biopsy specimens from patients with renal diseases. (jointly worked)

Ogura T, Asano N, Katayama E, Oishi T, Mimura Y, Hironaka K, Kashihara N, Makino H, Ota Z, Ogawa N

Journal of Medicine 25 203 - 217 1994

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