Faculty Profiles - MIMURA Yukari

MISC - MIMURA Yukari

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中枢性尿崩症で発症し，汎下垂体機能低下を来したgerminomaの１例

稲垣兼一, 大塚文男, 松井利浩, 鈴木二郎, 武田昌也, 三好智子, 加納義浩, 岸田雅之, 三村由香里, 小倉俊郎, 市村浩一, 景山甚郷, 槇野博史

日本内分泌学会雑誌 2005

Aldosterone regulation for 18 years in a case of primary aldosteronism

T Miyoshi, F Otsuka, T Ogura, J Suzuki, K Inagaki, M Takeda, M Kishida, Y Mimura, A Nagai, H Makino

AMERICAN JOURNAL OF HYPERTENSION 17 ( 6 ) 546 - 548 2004.6

Recent trends of hyperuricemia and obesity in Japanese male adolescents, 1991 through 2002

T Ogura, K Matsuura, Y Matsumoto, Y Mimura, M Kishida, F Otsuka, K Tobe

METABOLISM-CLINICAL AND EXPERIMENTAL 53 ( 4 ) 448 - 453 2004.4

Language：English Publisher：W B SAUNDERS CO

The aim of the present study was to determine the change of serum uric acid (UA) levels in male adolescents and to characterize the relationship between UA levels and obesity or its related factors. This study was conducted in 17,155 students at enrollment in Okayama University from 1991 through 2002, in which the mean serum UA level as a whole was 5.64 +/- 0.009 mg/dL (mean +/- SEM) and the incidence of hyperuricemia (greater than or equal to7.6 mg/dL) was 4.13%. Serum UA levels were correlated with obesity-related indicators, including body mass index (BMI; r = 0.282, P < .0001) and skin-fold thickness (r = 0.286, P < .0001). The incidence of hyperuricemia was increased in parallel with BMI. In the last 4 years (1999 through 2002) of the study period, serum UA levels (5.76 mg/dL) and the incidence of hyperuricemia (4.5%) were significantly increased compared with those in the earlier period (1991 through 1994: 5.50 mg/dL and 3.5%, respectively). However, BMI has been rather gradually decreased throughout 12-year observation in all the subjects. Hyperuricemia was related to the presence of other risk factors, including hypercholesterolemia, liver function abnormality, and hypertension. The frequencies of such abnormalities were higher than euuricemic subjects and this trend was notable in the most recent students enrolled from 1999 through 2002. Hyperuricemia was even found in the group of non-obese male adolescents. Taking into consideration that hyperuricemia is associated with a high prevalence of lifestyle-related diseases in adults, it is of great importance to prevent hyperuricemia at the early stage in Japanese adolescents. (C) 2004 Elsevier Inc. All rights reserved.

DOI： 10.1016/j.metabol.2003.11.017

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Languages using in journals concerning judgment/diagnosis doing by Yogo teacher and its objects

( 12 ) 15 - 26 2004

Issues and Challenges in Yogo Diagnosis for Yogo Teacher : Consideration from Nuesing Diagnosis

Ksai Atsuko, Okada Kanako, Mimura Yukari, Tokuyama Michiko

Bulletin of the Faculty of Education, Hirosaki University 92 167 - 171 2004

養護教諭の行う養護診断の確立に向けて医学領域における「診断」から考える

三村由香里, 岡田加奈子, 葛西敦子, 徳山美智子

日本保健医療行動科学学会年報 19 217 - 223 2004

蝶形骨洞内に発生した異所性ACTH産生下垂体腺腫の１例

鈴木二郎, 大塚文男, 武田昌也, 三好智子, 稲垣謙一, 岸田雅之, 三村由香里, 小倉俊郎, 橋本浩三, 槇野博史

ホルモンと臨床 52 6 - 10 2004

妊娠中に顕在化した周期性クッシング病の一例

大塚文男, 三好智子, 鈴木二郎, 稲垣謙一, 武田昌也, 岸田雅之, 三村由香里, 小倉俊郎, 景山甚郷, 橋本浩三, 槇野博史

ACTH RELATED PEPRIDES 15 187 - 193 2004

Language：Japanese Publisher：間脳・下垂体・副腎系研究会

19歳女.妊娠後33週より高血圧・蛋白尿が出現し,35週には浮腫と体重増加を伴う妊娠中毒症を呈した.食事療法と安静によって妊娠36週に経腟分娩で男児を出産した.しかし,出産後も体重増加と高血圧が持続し,産後4ヵ月には尿路結石にも罹患した.血中ACTH高値とコルチゾール高値を認めたためクッシング症候群を疑い,入院となった.精査によりクッシング病と診断し,外来で経過観察を続けた.クッシング徴候が臨床的に増悪したため,経蝶形骨洞的下垂体腫瘍摘出術を施行した.摘出した下垂体腫瘍は免疫組織学的にACTH産生性腺腫であった.現在は長時間作用ドパミンアゴニストであるカベルゴリンによる後療法を行い経過観察中であるが再発は認めていない

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A lethal complication, acute necrotizing pancreatitis, of Turner's syndrome with primary hyperparathyroidism

K Masayuki, O Fumio, M Yukari, O Toshio, M Hirofumi

ENDOCRINE JOURNAL 50 ( 6 ) 835 - 836 2003.12

Hypothyroidism associated with anti-human chorionic gonadotropin antibodies secondarily produced by gonadotropin in a case of idiopathic hypothalamic hypogonadism

T Ogura, Y Mimura, F Otsuka, M Kishida, K Yokota, J Suzuki, A Nagai, S Hirakawa, H Makino, K Tobe

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION 26 ( 11 ) 1128 - 1135 2003.11

Language：English Publisher：EDITRICE KURTIS S R L

We report a 22-yr-old male patient with idiopathic hypothalamic hypogonadism who showed secondary resistance to gonadotropin (Gn) therapy over 3 yr after successful treatment with hCG combined with human menopausal Gn. The patient simultaneously developed subclinical hypothyroidism. Endocrine examination revealed low levels of testosterone (0.3 ng/ml), free T-4 (0.91 ng/dl), and increased levels of TSH (31.1 muU/ml) in the serum. Serum autoantibodies to thyroid gland were all negative. Interestingly, thyroid function was improved after discontinuation of Gn therapy. In vitro assays by immunoprecipitation using (125)l-hCG or (125)l-TSH elucidated the presence of anti-hCG antibody in the serum 13 months after commencement of Gn therapy but anti-TSH antibody was not detected in the serum. Furthermore, the anti-hCG antibody specifically bound to hCG but not to other glycoproteins including TSH and FSH based on a competitive displacement assay. Bioassays using porcine thyroid cells revealed that the serum gamma-globulin fraction enables the suppression of cyclic AMP (cAMP) synthesis stimulated by TSH. Our findings suggest that anti-hCG and/or anti-idiotypic hCG antibodies induced by hCG therapy impaired TSH-dependent cAMP production through interfering with binding of TSH to its receptor, and this resulted in subclinical hypothyroidism in this patient. (C) 2003, Editrice Kurtis.

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Role of bradykinin in renoprotective effects by angiotensin II type 1 receptor antagonist in salt-sensitive hypertension

K Yokota, M Kishida, T Ogura, J Suzuki, F Otsuka, Y Mimura, M Takeda, Y Nakamura, H Makino

HYPERTENSION RESEARCH 26 ( 3 ) 265 - 272 2003.3

Language：English Publisher：JAPANESE SOC HYPERTENSION CENT ACADEMIC SOC, PUBL OFFICE

To elucidate whether bradykinin is involved in the renoprotective effect produced by angiotensin II type 1 receptor antagonist (AT1A) in chronic salt-sensitive hypertension, Dahl salt-sensitive rats receiving a high-salt (8%) diet were treated either with an AT1A (candesartan, 1 mg/kg/day), a bradykinin B2 receptor antagonist (BKB2A; FR172357, 30 mg/kg/day) or a combination of AT1A and BKB2A for 7 weeks. None of the treatments changed the markedly increased systolic blood pressure induced by a high-salt diet. However, chronic treatment with AT1A significantly improved the histological hallmarks of renal damage-i.e., glomerular sclerosis and cell proliferation-despite the presence of severe hypertension. This beneficial action of AT1A was abolished by the concomitant administration of BKB2A. In agreement with these histologically based findings, increases in levels of creatinine clearance induced by AT1A were also reversed back to the basal levels when BKB2A was administered in conjunction with AT1A. Furthermore, urinary excretions of nitrate plus nitrite and prostaglandin E-2 increased moderately in response to the administration of AT1A alone, but not in combination with BKB2A. Thus, the blockade of bradykinin signaling abrogates the renoprotective actions of the angiotensin II type 1 (AT1) receptor antagonism. Collectively, these data show that when AT1 action is chronically blocked, endogenous bradykinin plays a pivotal role in preventing the progression of glomerular injury in salt-sensitive hypertension.

DOI： 10.1291/hypres.26.265

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Relationship between adrenomedullin and vasopressin-aquaporin system under general anesthesia

T Ogura, K Morita, M Takeuchi, F Otsuka, T Iwasaki, K Oe, K Matsuura, K Tobe, Y Mimura, M Kishida, H Makino, M Hirakawa

HORMONE RESEARCH 59 ( 1 ) 30 - 34 2003

Language：English Publisher：KARGER

Aim:The roles of adrenomedullin (AM) in body fluid balance under general anesthesia were investigated. Methods: Time course changes in plasma osmolality, AM, arginine vasopressin (AVP), and urinary aquaporin 2 (AQP2) in 17 patients undergoing abdominal surgery under general anesthesia were examined. Results: Increases in plasma AM levels were observed in parallel with increases in the levels of urinary AQP2/creatinine (Cr) before induction and 90 and 180 min after initiation of anesthesia. Significant correlations between plasma AM and urinary AQP2/Cr (r = 0.62, p < 0.0001) as well as urinary AVP/Cr and AQP2/Cr (r = 0.60, p < 0.0001) were uncovered. Multivariate stepwise analysis identified plasma AM as the critical independent factor affecting urinary AQP2/Cr level. Conclusion: A novel correlation of AM and AQP2 which overlays an AVP-AQP2 system may play a key role in fluid homeostasis during general anesthesia. Copyright (C) 2003 S. Karger AG, Basel.

DOI： 10.1159/000067933

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岡山大学における養護教諭養成カリキュラムの開発

高橋香代, 伊藤武彦, 三村由香里, 河内信子, 小出彌生, 門田新一郎

教科教育学研究 21 145 - 158 2003

学校保健の現場における看護的支援を要する児童・生徒の実態とこれからの支援のあり方

岡田加奈子, 三村由香里

リハビリテーション看護研究 2003

Issue and challenge in Yogo diagnosis.

Atsuko K, Okada K, Mimura Y, Tokuyama M

Japanease Journal of School Health 2003

Learning Needs with Respect to Curriculum of Nursing in Yogo teacher Training at Schools of Education

FUKUDA Hiromi, AMANO Atsuko, OKADA Kanako, HONDA Yuko, MATSUSHIMA Noriko, SHIBAKI Misako, TSUMURA Naoko, KOIDE Yayoi, MIMURA Yukari, NAKAMURA Tomoko, NISHIZAWA Yoshiko

Japanese journal of school health 45 ( 4 ) 331 - 342 2003

Learning Needs with Respect to Curriculum of Nursing in Yogo teacher Training at Schools of Education

FUKUDA Hiromi, AMANO Atsuko, OKADA Kanako, HONDA Yuko, MATSUSHIMA Noriko, SHIBAKI Misako, TSUMURA Naoko, KOIDE Yayoi, MIMURA Yukari, NAKAMURA Tomoko, NISHIZAWA Yoshiko

Japanese journal of school health 45 ( 4 ) 331 - 342 2003

Relationship between reduced serum IGF-I levels and accumulation of visceral fat in Japanese men

M Kunitomi, J Wada, K Takahashi, Y Tsuchiyama, Y Mimura, K Hida, N Miyatake, M Fujii, S Kira, K Shikata, H Makino

INTERNATIONAL JOURNAL OF OBESITY 26 ( 3 ) 361 - 369 2002.3

Language：English Publisher：NATURE PUBLISHING GROUP

OBJECTIVE: To investigate whether the changes in IGF-1 concentrations after weight reduction in Japanese overweight men are associated with changes in visceral and subcutaneous fat.
DESIGN: Cross-sectional and longitudinal clinical intervention study with exercise education.
SUBJECTS: One-hundred and twelve Japanese overweight men aged 30-59y (body mass index (BMI) 28.4+/-2.5 kg/m(2)) and 33 normal-weight men aged 30-39y (BMI 22.1+/-1.5 kg/m(2)) at baseline. From the participants, 56 randomly selected overweight men (BMI 28.8+/-2.8) were further enrolled into a 1 y exercise program.
MEASUREMENTS: Fat distribution was evaluated by visceral fat M and subcutaneous fat (S) areas measured with computed tomography scanning at umbilical levels, metabolic parameters and hormones including insulin, leptin and IGF-1 at baseline and after 1 y.
RESULTS: In 112 overweight subjects at baseline, insulin (10.5+/-5.0 muUl/ml) and leptin (6.4+/-3.7 ng/ml) significantly correlated with both V (r=0.260, P=0.0073; r=0.410, P<0.0001) and S areas (r=0.377, P<0.0001; r=0.613, P<0.0001), respectively. IGF-1 (156.8+/-48.7 muU/ml) significantly and negatively correlated with V area (r= -0.242, P=0.0125)and age (r= - 0.192, P=0.0480). In normal-weight men aged 30-39y (n=33) and age-matched subjects (n=30) selected from the 112 overweight men, the serum IGF-1 further tightly correlated with V area (r= - 0.467, P<0.0001). Visceral fat area and age were independently related to serum IGF-1 levels by multiple regression analysis. By intervention with exercise education, 56 overweight subjects showed an increase in daily steps (6224+/-2781 to 7898+/-4141 steps/day) and reduction of BMI (28.8+/-2.8 to 27.7+/-2.9). DeltaIGF-1 significantly correlated with DeltaV area (r= - 0.432, P = 0.0009) but not with DeltaS area or DeltaBMI.
CONCLUSION: The present study indicated a negative correlation between IGF-1 levels and visceral fat at baseline as well as an association between the reduction in visceral fat and increase in IGF-1 levels after an exercise intervention.

DOI： 10.1038/sj/ijo/0801899

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Basedow病で発症し中枢性甲状腺機能低下に移行した1型糖尿病の一例

永瀬亮, 臼井仁美, 松田充浩, 大石徹也, 四方賢一, 槇野博史, 小倉俊郎, 三村由香里, 和田淳

糖尿病 45 ( 2 ) 162 - 162 2002.2

Japanese family with glucocorticoid-remediable aldosteronism diagnosed by long-polymerase chain reaction

K Yokota, T Ogura, M Kishida, J Suzuki, F Otsuka, Y Mimura, T Oishi, M Hirata, K Tobe, H Makino

HYPERTENSION RESEARCH 24 ( 5 ) 589 - 594 2001.9

Language：English Publisher：JAPANESE SOC HYPERTENSION CENT ACADEMIC SOC, PUBL OFFICE

We report a Japanese family with glucocorticoid-remediable aldosteronism (GRA) in whom gene abnormality was identified by the long-polymerase chain reaction (PCR) method. The proband was a 21-year-old female incidentally found to have high blood pressure (173/107 mmHg). Laboratory tests showed hypokalemia (3.7 mmol/l), and high plasma aldosterone concentration (PAC, 234 pg/ml) with suppressed plasma renin activity (PRA, < 0.1 ng/ml/h). The circadian rhythm pattern and the results of a rapid adrenocorticotrophic hormone (ACTH) test indicated ACTH-dependent changes in PAC. Imaging studies showed no adrenal mass on either side. A dexamethasone (Dexa) suppression test (1.0 mg/day orally for 7 days) showed a marked decrease of PAC 2 days after administration, and this decreased level was maintained throughout Dexa administration. High blood pressure and hypokalemia also improved during Dexa treatment. The proband's younger sister was 19 years old and had hypertension, PAC of 231 pg/ml, and PRA < 0.1 ng/ml/h. The mother was 53 years old and had hypertension, PAC of 98.5 pg/ml, and PRA < 0.1 ng/ml/h. The proband's elder sister was a 22-year-old normotensive with PAC of 110 pg/ml and PRA of 0.1 ng/ml. Long-PCR was performed for detection of the chimeric gene associated with GRA, using DNA samples from all four cases and two normal control subjects. Although the aldosterone synthase gene was expressed among all DNA samples, the chimeric gene was detected only in the proband, her younger sister and her mother. Our clinical data and genetic investigation confirmed the presence of GRA in this Japanese family.

DOI： 10.1291/hypres.24.589

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