研究者詳細 - 樋口　仁

論文 - 樋口　仁

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Hyperoxia reduces salivary secretion by inducing oxidative stress in mice 査読国際誌

Tajiri A, Higuchi H, Miyawaki T

Archives of Oral Biology 98 38 - 46 2019年2月

Remifentanil suppresses increase in interleukin-6 mRNA in the brain by inhibiting cyclic AMP synthesis 査読

Maeda S, Andoh T, Onishi R, Tomoyasu Y, Higuchi H, Miyawaki T.

Journal of Anesthesia 32 ( 5 ) 731 - 739 2018年8月

The effect of Tmem135 overexpression on the mouse heart. 査読

Lewis SA, Takimoto T, Mehrvar S, Higuchi H, Doebley AL, Stokes G, Sheibani N, Ikeda S, Ranji M, Ikeda A.

PLoS One 13 ( 8 ) e0201986 2018年8月

In vitro changes in the proportion of protein-unbound-free propofol induced by valproate. 査読

Ishii-Maruhama M, Higuchi H, Nakanou M, Honda-Wakasugi Y, Yabuki-Kawase A, Maeda S, Miyawaki T

Journal of Anesthesia 32 ( 5 ) 688 - 693 2018年7月

Intellectual disability is a risk factor for delayed emergence from total intravenous anaesthesia 査読

Higuchi H, Maeda S, Ishii-Maruhama M, Honda-Wakasugi Y, Yabuki-Kawase A, Miyawaki T

Journal of Intellectual disability Research 62 ( 3 ) 217 - 224 2017年11月

Capnography Prevents Hypoxia during Sedation for Dental Treatment: A Randomized Controlled Trial 査読

Kumiko Takaya, Hitoshi Higuchi, Minako Ishii-Maruhama, Akiko Yabuki-Kawase, Yuka Honda, Yumiko Tomoyasu, Shigeru Maeda, Takuya Miyawaki

JDR Clinical & Translational Research, 2 ( 2 ) 158 - 167 2017年4月

Clinical Analysis of Analgesics and Steroids Use for Extraction of Teeth in Patients with Intellectual Disability Under General Anesthesia 査読国際誌

Shigeru Maeda, Yuka Honda, Hiroshi Tanimura, Yumiko Tomoyasu, Hitoshi Higuchi, Naomichi Murata, Masahiko Egusa, Takuya Miyawaki

The Open Dentistry Journal 11 181 - 186 2017年3月

口腔腫瘍術後疼痛に対する経静脈的自己調節鎮痛 (IV-PCA) の有用性の検討査読

三宅沙紀, 樋口仁, 大西梨恵子, 谷村博史, 高谷久美子, 本田優花, 川瀬明子, 前田茂, 宮脇卓也

日本歯科麻酔学会雑誌 45 ( 1 ) 17 - 22 2017年1月

Anesthetic management of a child with diamond-Blackfan Anemia and cyanotic congenital heart disease undergoing cleft lip repair

Yukiko Nishioka, Hiroshi Tanimura, Rieko Onishi, Yuka Honda-Wakasugi, Akiko Yabuki-Kawase, Hitoshi Higuchi, Shigeru Maeda, Takuya Miyawaki

Journal of Japanese Dental Society of Anesthesiology 45 ( 5 ) 669 - 671 2017年

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：Japanese Dental Society of Anesthesiology

Diamond-Blackfan anemia (DBA) is a rare congenital form of pure red cell aplasia that is often complicated by congenital anomalies such as craniofacial anomalies and heart disease. We report a case of cleft lip repair performed under general anesthesia in a child with DBA. The patient was a male aged 12 years old, 95.8cm in height, and 12.8 kg in body weight He had anemia, a double-outlet right ventricle (DORV), and coarctation of the aorta (CoA). He had been treated with the administration of prednisolone and red blood cell transfusion for the anemia. Because steroid therapy increases the risk of infection, he was unable to undergo a radical operation for DORV. He exhibited cyanosis with an SpO2 of 75% under 2//min oxygen, and we considered tracheal intubation to be difficult because of the craniofacial anomaly. Before the induction of anesthesia, his SpO2 was 76%. Anesthesia was induced with thiopental. Because tracheal intubation was difficult, we performed oral intubation using a video laryngoscope. Anesthesia was maintained with oxygen, air, sevoflurane, and fentanyL To prevent infective endocarditis (IE), we administered ampicillin just before the operation, and 2% lidocaine with 1/240, 000 adrenalin was used for local anesthesia Under mechanical ventilation with the pressure mode, the FIO2 was kept at 0.5 to maintain the SpO2 at around 75%. In the present case, we needed to manage respiration and circulation because of cyanotic congenital heart disease, to take measures because of a difficult tracheal intubation, to prevent IE, and to prepare for red blood cell transfusion for anemia As a result, we were able to manage the general condition of a child with Diamond-Blackfan anemia and cyanotic congenital heart disease during general anesthesia safely without any complications.

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Mouse Tmem135 mutation reveals a mechanism involving mitochondrial dynamics that leads to age-dependent retinal pathologies 査読

Wei-Hua Lee, Hitoshi Higuchi, Sakae Ikeda, Erica L Macke, Tetsuya Takimoto, Bikash R Pattnaik, Che Liu, Li-Fang Chu, Sandra M Siepka, Kathleen J Krentz, C Dustin Rubinstein, Robert F Kalejta, James A Thomson, Robert F Mullins, Joseph S Takahashi, Lawrence H Pinto, Akihiro Ikeda

eLife 5 e19264 2016年11月

Female Patients Require a Higher Propofol Infusion Rate for Sedation 査読国際誌

Shigeru Maeda, Yumiko Tomoyasu, Hitoshi Higuchi, Yuka Honda, Minako Ishii-Maruhama, and Takuya Miyawaki

Anesthesia Progress 63 ( 2 ) 67 - 70 2016年8月

Effect of a low dose of midazolam on high blood pressure in dental patients: A randomised, double-blind, placebo-controlled, two-centre study

Yoshihisa Watanabe, Hitoshi Higuchi, Minako Ishii-Maruhama, Yuka Honda, Akiko Yabuki-Kawase, Ayaka Yamane-Hirano, Yumiko Tomoyasu, Shigeru Maeda, Takuya Miyawaki

British Journal of Oral and Maxillofacial Surgery 54 ( 4 ) 443 - 448 2016年5月

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）出版者・発行元：Churchill Livingstone

Some patients have transient hypertension before dental treatment as a result of anxiety and stress. Midazolam is an anxiolytic, and thought to be effective for the management of this sort of transient hypertension. We have evaluated in a randomised, controlled trial whether a low dose of midazolam can lower blood pressure in dental patients to an acceptable level without excessive sedation. Suitable patients were randomised to be given midazolam (trial group) or physiological saline (control group) intravenously. Blood pressure, heart rate, degree of anxiety, and amount of sedation were measured before and after injection. After injection, blood pressure in the trial group significantly decreased to clinically acceptable levels compared with controls. The degree of anxiety in the trial group was also significantly less than that in the control group, but there were no significant differences in sedation. These results suggest that injection of a low dose of midazolam stabilises the blood pressure of dental patients with transient hypertension.

DOI： 10.1016/j.bjoms.2016.02.006

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知的障害を有する肥満患者の静脈内鎮静法下歯科治療における経鼻高流量酸素供給システム (Optiflow) の使用経験査読

大西梨恵子, 樋口仁, 川瀬明子, 丸濱美菜子, 本田優花, 前田茂, 宮脇卓也

日本歯科麻酔学会雑誌 44 ( 2 ) 207 - 209 2016年4月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：(一社)日本歯科麻酔学会

症例は40歳男性で、重度の知的障害を有しておりコミュニケーションが不可能であったため、通常の方法では歯科治療のみならず診察も行うことができなかった。半年に1度の頻度で静脈内鎮静法下での定期検診を受けていた。静脈路確保が困難であることから、麻酔前投薬としてジュースにミダゾラムを混ぜて内服させた。入眠後は舌根沈下することが多かったため、入眠直後より経鼻エアウェイを挿入するとともに経鼻カニューラから酸素を投与したが頻繁にSpO2は90〜95%になった。過去の経過を踏まえ、静脈内鎮静法中の低酸素血症を予防するために、経鼻高流量酸素供給システム(Optiflow)を用いることを計画した。歯科処置中は気道確保を容易に行うことができ、気道閉塞および呼吸状態の異常を認めることはなく、経鼻エアウェイを使用する必要もなかった。歯科治療中のSpO2は終始98〜99%で推移した。プロポフォール投与終了後60分で覚醒し、ミダゾラム投与2時間45分後に帰宅した。術後合併症はなかった。

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Effect of a low dose of midazolam on high blood pressure indental patients: a randomised, double-blind,placebo-controlled, two-centre study 査読

Yoshihisa Watanabe, Hitoshi Higuchi, Minako Ishii-Maruhama, Yuka Honda, Akiko Yabuki-Kawase, Ayaka Yamane-Hirano, Yumiko Tomoyasu, Shigeru Maeda,Takuya Miyawaki

British Journal of Oral and Maxillofacial Surgery 54 ( 4 ) 443 - 448 2016年3月

Effect of carbamazepine or phenytoin therapy on blood level of intravenously administered midazolam: a prospective cohort study 査読

Tomato Hayashi, Hitoshi Higuchi, Yumiko Tomoyasu, Minako Ishii?Maruhama, Shigeru Maeda, Takuya Miyawaki

Journal of Anesthesia 30 ( 1 ) 166 - 169 2016年2月

Airway management using a nasal high flow system (Optiflow™) during intravenous sedation for dental treatment in an obese patient with intellectual disability

Rieko Onishi, Hitoshi Higuchi, Akiko Kawase, Minako Maruhama, Yuka Honda, Shigeru Maeda, Takuya Miyawaki

Journal of Japanese Dental Society of Anesthesiology 44 ( 2 ) 207 - 209 2016年

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：Japanese Dental Society of Anesthesiology

Intravenous sedation (IVS) is useful for the dental treatment of patients with intellectual disability (ID). However, in obese patients, difficulties in airway management can easily lead to oxygen desaturation. Nasal high-flow systems (NHFS) are a new type of device that can supply oxygen at a high flow rate. Several recent studies have shown that the use of an NHFS is very effective for preventing oxygen desaturation, and we have used an NHFS for airway management during IVS for a dental procedure in a patient with severe obesity and ID. Use of the NHFS was approved by the institutional review board of Okayama University Hospital, and written informed consent was obtained from the patient's parents. The dental treatment was planned for a 40-year-old male patient (height: 170 cm
body weight : 92.1 kg
body mass index : 31.8) with ID. He had experienced several oxygen desaturation episodes during previous dental sedations because of difficulties encountered during airway management. At this time, the NHFS (Optiflow™) was used for airway management during IVS. Fifty-minutes after the oral administration of 25 mg of midazolam, propofol was continuously infused at a dose of 1.0 μg/ml of the target effect site concentration. The sedation level was maintained at a bispectral index value of 50-70 by adjusting the target concentration of propofol. Initially, 40% oxygen was administered at a rate of 20 l/min via the NHFS. The flow volume was gradually increased up to 50 l/min, and high-flow oxygen was supplied throughout the dental treatment. Neither airway obstruction nor oxygen desaturation was observed during the dental treatment, resulting in no complications such as airway injury. This case suggests that NHFS enabled easy airway management during IVS for dental treatment in an obese patient.

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The inhibitory effect of locally injected dexmedetomidine on carrageenan-induced nociception in rats 査読

Yuka Honda, Hitoshi Higuchi, Yoshikazu Matsuoka, Akiko Yabuki-Kawase, Minako Ishii-Maruhama, Yumiko Tomoyasu, Shigeru Maeda, Hiroshi Morimatsu, Takuya Miyawaki

European Journal of Pharmacology 764 215 - 219 2015年10月

Effect of dexmedetomidine injected into the oral mucosa in combination with lidocaine on local anesthetic potency in humans: a crossover double-blind study. 査読国際誌

Ayaka Yamane, Hitoshi Higuchi, Yumiko Tomoyasu, Minako Ishii-Maruhama, Shigeru Maeda, Takuya Miyawaki

Journal of oral and maxillofacial surgery 73 ( 4 ) 616 - 621 2015年4月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

PURPOSE: Recently, attention has been paid to dexmedetomidine, a selective α-2 adrenoceptor agonist, as a possible additive for local anesthesia. However, the effect of locally injected dexmedetomidine on the anesthetic action in humans has not fully been clarified. Thus, the purpose of the present study was to evaluate the effect of dexmedetomidine injected into the oral mucosa in combination with lidocaine on local anesthetic potency in humans. MATERIALS AND METHODS: Twenty healthy volunteers were included in the present crossover double-blinded study. Lidocaine solution or lidocaine plus dexmedetomidine solution was submucosally injected into the alveolar mucosa in a crossover and double-blinded manner. The local anesthetic effect of the solutions was evaluated by measuring the current perception threshold (CPT) in the oral mucosa for 120 minutes after injection. Furthermore, the sedation level, blood pressure, and heart rate of the volunteers were evaluated. For statistical analysis, the Wilcoxon signed rank test and 2-way repeated measures analysis of variation were used. RESULTS: The CPT was increased with the 2 solutions and peaked 10 minutes after injection. CPT values 10 and 20 minutes after injection of lidocaine plus dexmedetomidine solution were considerably higher than those with lidocaine solution. The duration of an important increase in the CPT after injection with lidocaine plus dexmedetomidine solution was longer than that with lidocaine. Furthermore, the area under the time curve of CPT was considerably higher with lidocaine plus dexmedetomidine solution than with lidocaine solution. No volunteer showed a change in sedation level, blood pressure, or heart rate after injection with either test solution throughout the experiment. CONCLUSION: The present study showed that a combination of dexmedetomidine plus lidocaine considerably enhances the local anesthetic potency of lidocaine without any major influences on the cardiovascular system when locally injected into the oral mucosa.

DOI： 10.1016/j.joms.2014.09.029

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Independent factors affecting recovery time after sedation in patients with intellectual disabilities. 査読国際誌

Shigeru Maeda, Yumiko Tomayasu, Hitoshi Higuchi, Minako Ishii-Maruhama, Ayaka Yamane, Akiko Yabuki, Yuka Honda, Masahiko Egusa, Takuya Miyawaki

The open dentistry journal 31 146 - 149 2015年3月

記述言語：英語掲載種別：研究論文（学術雑誌）

Purpose : The purpose of this study was to identify independent factors associated with prolonged recovery time after intravenous sedation for dental treatment in patients with intellectual disabilities. Methods : This study was designed as a prospective cohort study. Participants were patients with intellectual disabilities, for whom sedation for dental treatment was planned in Okayama University Hospital. The outcome variable was recovery time. The predictor variables were patient background, antiepileptic and psychotropic drugs, and anesthesia-related variables. Factors affecting the outcome were examined with multiple regression analysis. Results : We enrolled 260 cases in this study. Oral midazolam was a strong independent determinant in prolonged recovery time. Teeth extraction, short treatment time and lower body mass index were significant independent predictors of prolonged recovery time. Conclusion : Oral midazolam is a clear independent determinant of prolonged recovery time after sedation, while psychotropic drugs and antiepileptic drugs were not independent determinants in this study.

DOI： 10.2174/1874210601509010146

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Independent predictors of delay in emergence from general anesthesia 査読

Shigeru Maeda, Yumiko Tomoyasu, , Hitoshi Higuchi, Minako Ishii-Maruhama, Masahiko Egusa, Takuya Miyawaki

Anesthesia Progress 62 ( 1 ) 8 - 13 2015年3月

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