研究者詳細 - 樋口　仁

論文 - 樋口　仁

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The clinical advantage of nasal high-flow in respiratory management during procedural sedation: A scoping review on the application of nasal high-flow during dental procedures with sedation. 査読国際誌

Shinji Kurata, Takuro Sanuki, Hitoshi Higuchi, Takuya Miyawaki, Seiji Watanabe, Shigeru Maeda, Shuntaro Sato, Max Pinkham, Stanislav Tatkov, Takao Ayuse

The Japanese dental science review 58 179 - 182 2022年11月

記述言語：英語掲載種別：研究論文（学術雑誌）

Structured summary: Rationale: Nasal high-flow (NHF), a new method for respiratory management during procedural sedation, has greater advantages than conventional nasal therapy with oxygen. However, its clinical relevance for patients undergoing oral maxillofacial surgery and/or dental treatment remains uncertain and controversial, due to a paucity of studies. This scoping review compared and evaluated NHF and conventional nasal therapy with oxygen in patients undergoing oral maxillofacial surgery and/or dental treatment. Materials and methods: A literature search of two public electronic databases was conducted, and English writing randomized controlled trials (RCTs) of nasal high flow during dental procedure with sedation reviewed. The primary and secondary outcomes of interest were the incidence of hypoxemia and hypercapnia during sedation and the need for intervention to relieve upper airway obstruction, respectively. Results: The search strategy yielded 7 studies, of which three RCTs met our eligibility criteria, with a total of 78 patients. Compared with conventional nasal therapy with oxygen, NHF significantly reduced the incidence of hypoxemia and hypercapnia during procedural sedation. Conclusion: NHF can maintain oxygenation and possibly prevent hypercapnia in patients undergoing dental treatment. Additional RCTs are needed to clarify and confirm these findings.

DOI： 10.1016/j.jdsr.2022.05.003

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Capsaicin May Improve Swallowing Impairment in Patients with Amyotrophic Lateral Sclerosis: A Randomized Controlled Trial. 査読

Tomoko Higashi, Naomichi Murata, Maki Fujimoto, Saki Miyake, Masahiko Egusa, Hitoshi Higuchi, Shigeru Maeda, Takuya Miyawaki

Acta medica Okayama 76 ( 2 ) 179 - 186 2022年4月

記述言語：英語掲載種別：研究論文（学術雑誌）

Patients with neurodegenerative diseases are at an increased risk of dysphagia and aspiration pneumonia. In this study, we examined whether ingestion of capsaicin prior to swallowing changes the temporal dynamics of swallowing in such patients. In a crossover, randomized controlled trial, 29 patients with neurodegenerative diseases were given a soluble wafer containing 1.5 μg capsaicin or an identical placebo 20 min prior to testing. For evaluation with video fluoroscopy (VF), patients consumed a barium-containing liquid plus thickening material. The durations of the latency, elevating and recovery periods of the hyoid were assessed from VF. Overall, no significant differences were observed in the duration of each period between capsaicin and placebo treatments. However, reductions in the latency and elevating periods were positively correlated with baseline durations. In subgroup analyses, that correlation was observed in patents with amyotrophic lateral sclerosis (ALS) but not in patients with Parkinson's disease. The consumption of wafer paper containing capsaicin before the intake of food may be effective in patients with dysphagia related with certain neurodegenerative diseases, particularly ALS patients. Further studies will be needed to validate this finding.

DOI： 10.18926/AMO/63412

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Reply 招待国際誌

Hitoshi Higuchi, Kumiko Takaya-Ishida, Saki Miyake, Maki Fujimoto, Yukiko Nishioka, Shigeru Maeda, Takuya Miyawaki

Journal of Oral and Maxillofacial Surgery 79 ( 11 ) 2181 - 2182 2021年11月

知的障害者の安全な麻酔管理を目指して招待査読

樋口仁

日本歯科麻酔学会雑誌 49 ( 4 ) 158 - 157 2021年10月

Patient satisfaction with deep versus light/moderate sedation for non-surgical procedures 査読国際誌

Hiroshi Hoshijima, Hitoshi Higuchi, Aiji Sato (Boku), Makiko Shibuya, Yoshinari Morimoto, Toshiaki Fujisawa, Kentaro Mizuta

Medicine 100 ( 36 ) e27176 - e27176 2021年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Ovid Technologies (Wolters Kluwer Health)

BACKGROUND: Deep sedation relieves a patient's anxiety and stress during the procedure by inducing patient unconsciousness. However, it remains unclear whether deep sedation actually improves patient satisfaction with the procedure. Therefore, we performed a systematic review and meta-analysis to compare the satisfaction of patients undergoing deep sedation with that of those undergoing light/moderate sedation during non-surgical procedures. METHODS: A comprehensive literature search was performed using electronic databases (search until September 2020). The primary outcome was whether patient satisfaction was higher after deep sedation or light/moderate sedation. The secondary outcome was the relative safety of deep sedation compared with light/moderate sedation in terms of oxygen saturation, systolic blood pressure, and heart rate. The tertiary outcomes were the relative procedure and recovery times for deep versus light/moderate sedation.Data from each of the trials were combined, and calculations were made using DerSimonian and Laird random effects models. The pooled effect estimates for patient satisfaction were evaluated using relative risk (RR) with the 95% confidence interval (CI). The pooled effect estimates for continuous data are expressed as weighted mean difference with the 95% CI. We assessed heterogeneity with the Cochrane Q statistic and the I2 statistic. The risk of bias assessment and Grading of Recommendations Assessment, Development and Evaluation approach were used as the quality assessment method. RESULTS: After removing unrelated studies and applying the exclusion criterion, 5 articles satisfied the inclusion criteria. Patient satisfaction was significantly higher in those who received deep sedation compared with light/moderate sedation (relative risk = 1.12; 95% CI, 1.04-1.20; P = .003; Cochrane Q = 25.0; I2 = 76%).There was no significant difference in oxygen saturation, systolic blood pressure, heart rate, and procedure times according to whether the procedures were performed under deep or light/moderate sedation. However, the recovery time was significantly prolonged in patients under deep sedation. CONCLUSIONS: Our meta-analysis suggests that deep sedation resulted in improved patient satisfaction compared with light/moderate sedation. Deep sedation is recommended for patients undergoing procedures because it improves patient satisfaction. However, respiration and circulation should be carefully monitored both intra-operatively and postoperatively.

DOI： 10.1097/md.0000000000027176

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Comparison of Oxygen Saturation Between Nasal High-Flow Oxygen and Conventional Nasal Cannula in Obese Patients Undergoing Dental Procedures With Deep Sedation: A Randomized Crossover Trial 査読国際誌

Hitoshi Higuchi, Kumiko Takaya-Ishida, Saki Miyake, Maki Fujimoto, Yukiko Nishioka, Shigeru Maeda, Takuya Miyawaki

Journal of Oral and Maxillofacial Surgery 79 ( 9 ) 1842 - 1850 2021年9月

担当区分：筆頭著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Elsevier BV

PURPOSE: In anesthetic management, it is widely accepted that obese patients are more likely to suffer airway obstructions and reductions in arterial oxygen saturation (SpO2). Therefore, it is important to take special measures to prevent oxygen desaturation during the deep sedation of obese patients. This clinical study examined whether the use of nasal high-flow systems (NHFS) keep higher SpO2 and reduced hypoxemia than conventional nasal cannula during the deep sedation of obese patients with intellectual disabilities for dental treatment. MATERIALS AND METHODS: Eighteen obese patients (body mass index: >25) with intellectual disabilities who underwent dental sedation were enrolled. In each case, sedation was induced using propofol and maintained at a bispectral index of 50 to 70. The subjects were randomly assigned to the control oxygen administration (5 L/min via a nasal cannula) or NHFS (40% O2, 40 L/min, 37 °C) arm in alternate shifts as a crossover trial. The primary endpoint was the minimum SpO2 value, and the incidence of hypoxemia during dental treatment was also evaluated. RESULTS: The mean minimum SpO2 value was significantly higher in the NHFS arm than in the control arm (95.8 ± 2.1 % vs 93.6 ± 4.1 %, P = 0.0052, 95% confidence interval: 0.608-3.947). Hypoxemic episodes (SpO2: ≤94%) occurred 3 cases (16.7%) in the NHFS arm and 11 cases (61.1%) in the control arm (P = 0.0076, odds ratio: 0.127, 95% confidence interval 0.0324 - 0.630). CONCLUSION: NHFS resulted in higher minimum SpO2 and reduced hypoxemia than nasal cannula in obese patients during deep sedation for dental treatment.

DOI： 10.1016/j.joms.2021.04.004

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歯科用局所麻酔剤アーティカイン塩酸塩 (アルチカイン塩酸塩)・アドレナリン酒石酸水素塩注射剤 (OKAD01) の安全性および血中薬物動態の検討 (第Ⅰ相, 単施設, 非盲検試験) 査読

樋口仁, 若杉優花, 川瀬明子, 前田茂, 宮脇卓也

日本歯科麻酔学会雑誌 49 ( 3 ) 81 - 96 2021年7月

担当区分：筆頭著者,　責任著者記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本歯科麻酔学会

【要約】 緒言 : アーティカイン塩酸塩 (アルチカイン塩酸塩) は, 歯科治療に際して世界的に広く使用されているアミド型の局所麻酔薬であるが, 現在日本では薬事承認を受けていない. そこで本邦での歯科用アルチカイン製剤 (OKAD01) の導入を目指し, OKAD01を日本人の口腔粘膜下に投与した際の安全性および血中薬物動態を検討するため, 日本人を対象としたOKAD01の第Ⅰ相試験を行った. 方法 : 健康な日本人成人男性を対象とした. OKAD01 1カートリッジ (1.7ml) および3カートリッジ (5.1ml) を口腔粘膜下にそれぞれ6名ずつに投与した. OKAD01投与前, 投与終了15, 30, 60分後, および2, 4, 12, 24時間後の血漿中アルチカイン濃度の測定を行った. またOKAD01投与前, 投与後に臨床検査, バイタルサインなどの測定を行い, OKAD01投与による有害事象を検討した. 結果 : 1カートリッジ群の薬物動態パラメータ値 [平均値±標準偏差 (最小値-最大値)] は, 最高血中薬物濃度 (Cmax) が374.35±97.65 (252.7-514.5) ng/ml, 最高血中薬物濃度到達時間 (Tmax) が0.25±0.00 (0.25-0.25) hであった. また3カートリッジ群では, Cmaxが694.00±175.23 (517.9-970.4) ng/ml, Tmaxが0.42±0.13 (0.25-0.5) hであった. 有害事象は1カートリッジ群に｢頭痛｣が1件認められたが, OKAD01との因果関係はなしと判断された. 結論 : OKAD01を日本人の口腔粘膜に投与した際のCmaxは, 本治験の安全域とした5.0 μg/ml未満であることが確認された. また, OKAD01に関連した有害事象は認められず, OKAD01は, 20歳以上の健常日本人男性に対して忍容性が認められ, 安全性に問題はないと考えられた.

DOI： 10.24569/jjdsa.49.3_81

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プロポフォールによる日帰り全身麻酔において覚醒遅延がみられた抗てんかん薬多剤併用療法患者の1例査読

若杉優花, 川瀬明子, 宇治田仁美, 濵岡緑, 樋口仁, 前田茂, 宮脇卓也

日本歯科麻酔学会雑誌 49 ( 1 ) 1571 - 3 2021年1月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：一般社団法人日本歯科麻酔学会

Patients with intellectual disabilities frequently have concomitant epilepsy requiring medication with multiple antiepileptic drugs. Some previous studies have reported a drug interaction between propofol and antiepileptics. We report an outpatient with a delayed emergence from a general anesthesia with propofol that was attributed to multi-drug therapy for epilepsy. The patient was a 44-year-old man who was scheduled to undergo dental treatment requiring two sessions of ambulatory anesthesia using propofol. His preoperative tests were normal, including a routine blood examination, liver and kidney function, ECG and chest radiograph. He was receiving multiple antiepileptic drugs for the treatment of epilepsy. Anesthesia was induced using propofol, remifentanil, and rocuronium bromide. After the discontinuation of propofol administration, spontaneous eye opening and a response to verbal commands were both delayed, occurring about 1 hour after the first session of general anesthesia and about 1.5 hours after the second session. The patient was not obese, and his perioperative liver and renal functions were normal. Hypothermia and central nervous system (CNS) abnormalities caused by sequela were both ruled out. He had been receiving multiple antiepileptic drugs, so synergistic effects at propofol's site of action in the CNS were suspected as the main cause of the delayed emergence. Furthermore, hypovolemia could have resulted in an elevated blood level of propofol and its delayed metabolism/excretion, delaying the emergence from sedation. We could not identify a clear cause because we did not measure the blood concentrations of the antiepileptics or propofol in the patient. In the presently reported patient, a drug interaction between propofol and antiepileptics was thought to be a possible cause of the delayed emergence from sedation.

DOI： 10.24569/jjdsa.49.1_1

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Pulmonary Aspiration During Induction of General Anesthesia 査読国際誌

Reina Hayashi, Shigeru Maeda, Taninishi Hideki, Hitoshi Higuchi, Takuya Miyawaki

Anesthesia Progress 67 ( 4 ) 214 - 218 2020年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：American Dental Society of Anesthesiology (ADSA)

Perioperative pulmonary aspiration of gastric contents can induce complications of varying severity, including aspiration pneumonitis or pneumonia, which may be lethal. A 34-year-old man with no significant medical history presented to Okayama University Hospital for extraction of the third molars and incisive canal cystectomy under general anesthesia. He experienced pulmonary aspiration of clear stomach fluid during mask ventilation after induction. After aspiration occurred, the patient was immediately intubated, and suctioning was performed through the endotracheal tube (ETT). An anteroposterior (AP) chest radiograph was obtained that demonstrated atelectasis in the left lower lobe, in addition to increased peak airway pressures being noted, although SpO2 remained at 96% to 99% at an FiO2 of 1.0. The decision was made to proceed, and the scheduled procedures were completed in approximately 2 hours. A repeat AP chest radiograph obtained at the end of the operation revealed improvement of the atelectasis, and no residual atelectasis was observed on the next day. Although the patient reported following standard preoperative fasting instructions (no fluids for 2 hours preoperatively), more than 50 mL of clear fluid remained in his stomach. Because vomiting can occur despite following NPO guidelines, the need for continued vigilance by anesthesia providers and proper timely management is reinforced.

DOI： 10.2344/anpr-67-02-03

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Dexmedetomidine inhibits LPS-induced inflammatory responses through peroxisome proliferator-activated receptor gamma (PPARγ) activation following binding to α2 adrenoceptors 査読

Maki Fujimoto, Hitoshi Higuchi, Yuka Honda-Wakasugi, Saki Miyake, Yukiko Nishioka, Akiko Yabuki-Kawase, Shigeru Maeda, Takuya Miyawaki

European Journal of Pharmacology 892 173733 2020年11月

Metabolic alterations caused by the mutation and overexpression of the Tmem135 gene 査読

Wei-Hua Lee, Vijesh J Bhute, Hitoshi Higuchi, Sakae Ikeda, Sean P Palecek, Akihiro Ikeda

Experimental Biology and Medicine 245 ( 17 ) 1571 - 1583 2020年11月

知的障害を伴ったGlenn術後患者の静脈内鎮静法の経験査読

宇治田仁美, 若杉優花, 中納麻衣, 西岡由紀子, 樋口仁, 前田茂, 宮脇卓也

日本歯科麻酔学会雑誌 48 ( 4 ) 138 - 140 2020年10月

記述言語：日本語出版者・発行元：(一社)日本歯科麻酔学会

症例は9歳6ヵ月男児で、乳歯4歯の晩期残存を認めたが、複雑心奇形の合併、最重度の知的障害および身体障害により通法下での抜歯が困難であるため、麻酔管理下での抜歯を目的に当科を紹介され受診した。浸潤麻酔は1/8万アドレナリン含有2%リドカインを生理食塩液で2倍に希釈したものを総量1.2mL投与した。術中に体動が再度出現した際はケタミンを5mgずつ静脈内投与した。スケーリング終了後、酸素投与量を2L/minに減量し、聴診器にて肺音が正常であることを確認した。その25分後、開眼、体動によって覚醒を確認し、心拍数は126回/分、SpO2は87%と術前と変わりないことを確認した後に酸素投与量を1L/minとして退室した。鎮痛指示はカロナール細粒150mgを処方したが、痛がる様子がなかったため内服させなかった。その後も経過良好のため翌日退院となった。

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Assessing the Effectiveness of Combined Analgesics for Bilateral Ramus Osteotomies 査読

Shigeru Maeda, Hitoshi Higuchi, Maki Fujimoto, Saki Miyake, Yuka Honda-Wakasugi, Takuya Miyawaki

Anesthesia Progress 67 ( 3 ) 140 - 145 2020年9月

Assessing the Effectiveness of Combined Analgesics for Bilateral Ramus Osteotomies

Shigeru Maeda, Hitoshi Higuchi, Maki Fujimoto, Saki Miyake, Yuka Honda-Wakasugi, Takuya Miyawaki

Anesthesia progress 67 ( 3 ) 140 - 145 2020年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：NLM (Medline)

Pain management is important for alleviating patients' suffering and early recovery. Although analgesic combinations are known to be effective, a comparison of the effectiveness of different combinations has never been performed specifically for ramus osteotomy procedures. Therefore, the purpose of this observational retrospective cohort study was to identify an effective combination for pain management throughout the intraoperative and immediate postoperative period for patients undergoing bilateral ramus osteotomy procedures. Inclusion criteria consisted of patients who had undergone bilateral mandibular ramus osteotomies over a 2-year period. The analyzed predictor variables included patient gender, age, body weight, operation, anesthetic method, duration of operation, intraoperative use of fentanyl, nonsteroidal anti-inflammatory drugs (NSAIDs), and intravenous acetaminophen administered in the operating room at the end of the surgery. The outcome variable was the necessity for additional rescue analgesics (yes/no) in the recovery room. Bivariate statistics and multivariate analysis were computed with a p-value of &lt
0.05. The study sample was comprised of 78 patients requiring bilateral mandibular ramus osteotomies. From the multivariate analysis, the combination of NSAIDs-acetaminophen-fentanyl was an independent factor for no additional rescue analgesics during the first 1 hour after bilateral ramus osteotomies, indicating that the combination is significantly effective for bilateral ramus osteotomies compared with the other combinations. Considering that this study consisted of a small sample size, the results of this study suggest that some of the combinations, particularly NSAIDs-acetaminophen-fentanyl, are more effective than NSAIDs alone for postoperative pain control immediately following bilateral ramus osteotomy procedures.

DOI： 10.2344/anpr-67-01-05

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大腿骨低形成・特異顔貌症候群患者の全身麻酔経験査読

松田怜奈, 濱岡緑, 三宅沙紀, 若杉優花, 樋口仁, 前田茂, 宮脇卓也

日本歯科麻酔学会雑誌 48 ( 2 ) 57 - 59 2020年4月

記述言語：日本語出版者・発行元：(一社)日本歯科麻酔学会

17歳女性。開口障害があり、開口量は10mm程度であった。夜間睡眠時に一時的な呼吸停止を認めた既往があり、睡眠時無呼吸の疑いを指摘されていた。開口障害に対して開口量改善および睡眠時無呼吸の改善を目的に下顎骨延長術の実施が検討され、それに先立ち今回、全身麻酔下での筋突起切除術が予定された。麻酔管理上の問題として、骨格異常と小顎による気道確保困難および気管挿管困難が危惧されたが、自発呼吸が残る程度に適度な鎮静を図ったうえで、気管支ファイバースコープを用いて意識下挿管することにより安全な気道管理が行えた。

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Multi-drug therapy for epilepsy influenced bispectral index after a bolus propofol administration without affecting propofol's pharmacokinetics: a prospective cohort study 査読国際誌

Matsuri Kodama, Hitoshi Higuchi, Minako Ishii-Maruhama, Mai Nakano, Yuka Honda-Wakasugi, Shigeru Maeda, Takuya Miyawaki

Scientific Reports 10 ( 1 ) 1578 - 1578 2020年1月

歯科麻酔専門医・認定医における深鎮静の現状認識調査報告査読

渋谷真希子, 佐藤會士[朴], 樋口仁, 星島宏, 森本佳成, 藤澤俊明, 日本歯科麻酔学会歯科麻酔医のための深鎮静ガイドライン策定小部会

日本歯科麻酔学会雑誌 48 ( 1 ) 22 - 29 2020年1月

記述言語：日本語出版者・発行元：(一社)日本歯科麻酔学会

日本歯科麻酔学会歯科麻酔専門医全員292名と歯科麻酔認定医資格のみ有する歯科麻酔医から無作為に抽出した308名を対象として、2018年8月に電子メールにより深鎮静に対する現状意識に関するアンケート調査を実施した。回答率は40.2%であり、歯科麻酔専門医が154名、歯科麻酔認定医資格のみを有する者が87名であった。所属する施設で深鎮静が行われていた割合は71.4%であった。アメリカ麻酔学会(ASA)の呼びかけや刺激に対する反応から見た鎮静深度区分(「ASA鎮静深度区分」)とRamsay's sedation scaleを融合かつ改変して鎮静深度スコア1〜6を作成し、回答者が考える深鎮静の深度範囲を調査した結果、「ASA鎮静深度区分」で中等度鎮静に属するスコア5-aを「最浅」と選択したものが多く(40.7%)、「最深」と考えるスコアはスコア5-cとスコア6がそれぞれ41.9%、36.1%で拮抗するなど、「最浅」「最深」ともにその範囲の選択は多様であった。

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歯科麻酔医の深鎮静に関する施設実態調査報告査読

渋谷真希子, 佐藤會士[朴], 樋口仁, 星島宏, 森本佳成, 藤澤俊明, 日本歯科麻酔学会歯科麻酔医のための深鎮静ガイドライン策定小部会

日本歯科麻酔学会雑誌 47 ( 4 ) 158 - 164 2019年10月

記述言語：日本語出版者・発行元：(一社)日本歯科麻酔学会

歯科麻酔医が勤務する歯科施設を対象に深鎮静管理に関するアンケート調査を行った。その結果、189施設中109施設(57.7%)から回答が得られた。深鎮静の定義に関しては56.9%の施設で共通した定義がなく、また、定義のある施設でも文書化されているのは10.6%であった。実際に深鎮静を行っている施設は76.1%であった。気道管理に関わる偶発症を経験した施設の割合は、重複を含め、喉頭痙攣が12.0%、誤嚥が24.1%、気管挿管やBag-valve-maskによる対応を要した気道閉塞・呼吸抑制が36.1%であった。今回の検討ではスタッフ間で深鎮静に対する共通した認識があるとは限らないことや、意識下鎮静と比べ偶発症のリスクが高い可能性が示唆された。

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Locally injected ivabradine inhibits carrageenan-induced pain and inflammatory responses via hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. 査読国際誌

Saki Miyake, Hitoshi Higuchi,Yuka Honda-Wakasugi, Maki Fujimoto, Hotaka Kawai, Hitoshi Nagatsuka, Shigeru Maeda, Takuya Miyawaki

PLoS One 14 ( 5 ) e0217209 2019年5月

Marshall-Smith症候群患児の全身麻酔経験査読

中納麻衣, 藤本磨希, 三宅沙紀, 谷村博史, 樋口仁, 前田茂, 宮脇卓也

日本歯科麻酔学会雑誌 47 ( 2 ) 47 - 49 2019年4月

記述言語：日本語出版者・発行元：(一社)日本歯科麻酔学会

症例は10歳男児で、生後1ヵ月時に中顔面の低形成、多関節拘縮、尿道下裂、小下顎症、体幹が細いことなどから染色体検査を受け、Marshall-Smith症候群の診断を受けた。今回、正中過剰埋伏歯に対して抜歯術が予定された。酸素6L/minを吸入させ、プロポフォール20mgを投与し、引き続き10mg/kg/hで持続的に投与した。気道確保の後、セボフルランを3%の濃度で開始し、徐々に人工呼吸に移行した。その後セボフルラン濃度を5%に変更し、McGRATH MACで愛護的に喉頭展開を試みたところ声帯が確認でき、挿管可能と判断した。術中はプロポフォールとフェンタニルで維持した。手術終了後、自発呼吸の回復および十分な覚醒を確認した後、抜管を行った。抜管に際して、骨折を誘発するような体動および興奮は認めなかった。周術期を通して経皮的動脈血酸素飽和度の低下はみられず、術後も経過良好のため翌日退院となった。

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