Faculty Profiles - NASU Yasutomo

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両側睾丸腫瘍の1例 : 第191回岡山地方会

那須保友, 石戸則孝, 荒巻謙二, 城仙泰一郎

日本泌尿器科學會雜誌 80 ( 7 ) 1087 - 1087 1989.7

腎腫瘍を思わせた腎カルブンケルの2例 : 第191回岡山地方会

石戸則孝, 那須保友, 荒巻謙二, 城仙泰一郎

日本泌尿器科學會雜誌 80 ( 7 ) 1084 - 1084 1989.7

経皮的腎切石術の経験(第185回岡山地方会)

那須保友, 公文裕巳, 赤木隆文, 津島知靖

日本泌尿器科學會雜誌 80 ( 4 ) 614 - 614 1989.4

女性尿失禁に対する手術経験(第83回広島地方会)

那須保友, 林俊秀, 荒巻謙二, 城仙泰一郎

日本泌尿器科學會雜誌 80 ( 2 ) 301 - 301 1989.2

膀胱憩室扁平上皮癌の1例 : 泌尿器科領域における血中SCC抗原測定の意義(第84回広島地方会)

林俊秀, 那須保友, 荒巻謙二, 城仙泰一郎

日本泌尿器科學會雜誌 80 ( 2 ) 305 - 305 1989.2

CLINICAL STUDY ON PAP, γ-SM AND PA AS TUMOR : MARKERS IN PROSTATIC CANCER PATIENTS

Ohashi Teruhisa, Akagi Takafumi, Irie Shin, Obama Tsuneaki, Nasu Yasutomo, Tohjoh Shunji, Takeda Katsuji, Yoshimoto Jun, Matsumura Yosuke, Ohmori Hiroyuki

The Japanese Journal of Urology 78 ( 8 ) 1403 - 1408 1987.8

Language：Japanese Publisher：The Japanese Urological Association

Prostatic acid phosphatase (PAP), γ-seminoprotein (γ-Sm) and prostatic specific antigen (PA) were determined by double antibody radioimmunoassay and enzyme immunoassay in 97 patients with prostatic cancer (the untreated: 35, the treated: 62), 316 with prostatic hypertrophy, 41 with bladder cancer and 138 with other benign urological diseases to assess the clinical usefulness as a tumor marker. Positive rates of PAP, γ-Sm and PA levels were 74.3%, 73.1% and 79.4%, respectively, in patients with untreated prostatic cancer, while those were 2.8%, 12.5% and 12.3%, respectively, in patients with prostatic hypertrophy. Although the highest sensitivity was found in PA levels, the highest specificity was shown by PAP levels. A slight correlation was found between PAP and PA, but no significant correlation was present with γ-Sm. The positive rate in untreated prostatic cancer patients increased by the combination assay of these three markers, and moreover, different variations of these markers were noted with various therapies in prostaitc cancer patients. These data suggested that the combination assay of these markers was useful for diagnosis and monitoring of prostatic cancer patients.

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A new anti-cancer agent, bestrabucil (KM 2210): I, concentration in serum and tissue in urogenital tumors

Y. Nasu, M. Saegusa, M. Hara, J. Ochi, T. Akagi, T. Obama, T. Tsushima, J. Yoshimoto, Y. Ozaki, Y. Matsumura

Japanese Journal of Cancer and Chemotherapy 14 ( 4 ) 1116 - 1121 1987

ANDROGEN-PRODUCING ADRENOCORTICAL ADENOMA : A CASE REPORT

Nasu Yasutomo, Takeda Katsuji, Kumon Hiromi, Morioka Masaaki, Ohashi Teruhisa, Ohmori Hiroyuki

The Japanese Journal of Urology 78 ( 2 ) 346 - 350 1987

Language：Japanese Publisher：The Japanese Urological Association

A case of androgen producing adrenocortical adenoma is reported. Patient was 31-year-old woman, who was admitted to our hospital with the complaints of hypertrichosis, amenorrhea, hypertension and general fatigue. Diurnal rhythm of cortisol secretion disappeared. Plasma ACTH was not detected and no responce was observed in dexamethasone suppression test and rapid ACTH test. Moreover, plasrna testosterone, DHEA, DHEA-S and urinary 17-KS were high. CT-scan and scintigram revealed the presence of left adrenal tumor and left adrenalectomy was performed. Microscopic examination revealed no malignant findings and tumor was regarded as adrenocortical adenoma. Electronmicroscopic findings did not indicate definitely the presence or absence of the malignancy. Tissue concentration of testosterone was high but not so high as that of adrenal cancer. Differentiation between adrenocortical adenoma and cancer was difficult by endocrinological analysis.

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PROPHYLACTIC INTRAVESICAL INSTILLATION THERAPY WITH ADRIAMYCIN (ADM) AND MITOMYCIN C (MMC) IN PATIENTS WITH SUPERFICIAL BLADDER CANCER

Ozaki Yujiro, Tsushima Tomoyasu, Nasu Yasutomo, Akagi Takafumi, Obama Tsuneaki, Matsumura Yosuke, Ohmori Hiroyuki

The Japanese Journal of Urology 77 ( 9 ) 1493 - 1500 1986.9

Language：Japanese Publisher：The Japanese Urological Association

Intravesical instillation of Adriamycin (ADM) and Mitomycin C (MMC) was carried out for the purpose of prophylaxis of the recurrence of superficial bladder cancers after TUR or TUC. The eligible patients were allocated at random into the following 3 groups (ADM, MMC and control), for solitary or multiple tumors of bladder. 1) No treatment. 2) Intravesical instillation with ADM: 50mg of ADM in 100ml saline solution. 3) Intravesical instillation with MMC: 30mg of MMC in 100ml saline solution. The drugs were given 6 times by instillations in 2 weeks after TUR or TUC, and there after for 2 days continuously every 4 weeks for 2 years. In total 134 patients were investigated. Of them 103 patients were evaluable and 31 were eliminated as non-evaluable patients. The cumulative non-recurrence rate was 73.6% in the ADM group, 63.4% in the MMC group and 22.5% in the control group after following up for 24 months. The cumulative non-recurrence rates of the 2 instilled groups (ADM, MMC) are significantly higher than that of the control group. The side effects were relatively mild. We consider that this instillation therapy with Adriamycin and Mitomycin C is useful for preventing the recurrence of bladder cancers.

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ISOANTIGENS ABH IN BLADDER TUMORS AS AN INDICATOR OF MALIGNANT POTENTIAL : IV. Correlation with Thomsen-Friedenreich Antigen and CEA

Nasu Yasutomo, Kumon Hiromi, Matsumura Yousuke, Ohmori Hiroyuki

The Japanese Journal of Urology 77 ( 9 ) 1511 - 1518 1986.9

Language：Japanese Publisher：The Japanese Urological Association

We studied prognostic significance of blood group ABH (BGA) and Thomen-Friedenreich antigen (T-antigen) and carcinoembryonic antigen (CEA) in 86 patients, who had initially low stage transitional cell carcinoma of the bladder and had been followed for 3 to 8 years. BGA and CEA were detected by the peroxidase-antiperoxidase method (PAP), and T-antigen by the T-specific lectin (Peanut agglutinin) immuno-peroxidase method using paraffin section. Staining patterns of BGA by PAP were classified into 5 types as follows: TypeI: Stained homogeneously and as intensely as normal urothelium. TypeII: Stained homogeneously but less intensely than normal urothelium. TypeIIIa: Stained non-homogeneously with negative area (less than 50%). TypeIIIb: Stained non-homogeneously with negative area (more than 50%). TypeIV: Stained negatively with no positive area. No correlation was found between histological grade and BGA staining patterns. CEA was detected in 10 of 86 (11.6%) superficial tumors and was detected at a higher incidence in grade 3 bladder tumors. Recurrence rate of the cases with type IIIb, V is higher than that with other types. Moreover, all cases (10 cases) with invasive recurrence belonged to type IIIb, IV. T-antigen expression was also significantly related to subsequent recurrence with invasion. CEA was less effective than BGA in predicting clinical course. Of these markers, BGA is the most reliable indicator of biological behaviors of future recurrent tumors as a single marker system. In combination study, any combination did not enhance the accuracy compared with BGA alone. Consequently, cases with BGA expression of type IIIb or IV and T-antigen expression of cryptic T-antigen negative have been proved to be high risk groups for invasive recurrence.

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ISOANTIGENS ABH IN BLADDER TUMORS AS AN INDICATOR OF MALIGNANT POTENTIAL : Criteia for the Loss of BGA Based on the Staining Pattern by PAP Method and its Correlation with CEA and Fibronectin

Nasu Yasutomo

The Japanese Journal of Urology 77 977 - 987 1986

Language：Japanese Publisher：The Japanese Urological Association

The analysis of the blood group isoantigen (BGA) in bladder tumor is valuable for the prediction of malignant potential. We have employed PAP method to detect the loss of BGA and made classification of staining patterns of BGA. In order to obtain clinically valuable and useful criteria for the loss of BGA, 129 bladder tumors including 86 superficial tumors were examined. Carcinoembryonic antigen (CEA) and fibronectin (FN) were also detected in the same tissue by PAP method and clinical usefulness was investigated in the correlation with the loss of BGA. BGA staining pattern was classified into 5 types as follows, Type I: Stained homogeneously as intensely as normal urothelium. Type II: Stained homogeneously but less intensely than normal urothelium. Type III-a: Stained non-homogeneously with negative area. (less than 50%) Type III-b: Stained non-homogeneously with negative area. (more than 50%) Type IV: Stained negatively with no positive area. No correlation was found between histological grade and BGA staining pattern. CEA was detected in 13 of all 129 tumors (10.1%) and in 10 of 86 superficial tumors (11.6%). CEA was detected at a high incidence in grade 3 bladder tumors. Negative rate of tissue FN was 26.6% in all cases and was correlated with histological stage. Analysis of the loss of BGA is the most valuable for the prediction of malignant potential of bladder tumor especially in low stage, because out of 86 cases of low stage bladder tumor all 10 cases with subsequent invasive recurrence belonged to type III-b or type IV. In conclusion, it was possible to propose new criteria for the loss of BGA i.e., type I & type II: positive, type III-a: borderline, type III-b & type IV: negative.

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Intravesical chemotherapy with 4'-EPI-adriamycin in patients with superficial bladder tumors (randomized study)

31 ( 12 ) 2215 - 2218 1985.12

尿路性器悪性腫瘍における血中及び尿中TPAの意義

東條俊司, 大橋輝久, 入江伸, 古川雅人, 那須保友, 松村陽右, 大森弘之

日本泌尿器科學會雜誌 76 ( 11 ) 1725 - 1725 1985.11

膀胱腫瘍におけるABO-isoantigenの意義 : PAP法による染色パターンの分類ならびにT-antigenとの関連性

那須保友, 赤木隆文, 公文裕巳, 松村陽右, 大森弘之

日本泌尿器科學會雜誌 76 ( 11 ) 1702 - 1703 1985.11

T24細胞のクローニング法による異質性の検討

津島知靖, 小浜常昭, 那須保友, 赤木隆文, 尾崎雄治郎, 松村陽右, 大森弘之

日本泌尿器科學會雜誌 76 ( 11 ) 1702 - 1702 1985.11

膀胱腫瘍における ABO-isoantigen の意義. その4 : 酵素抗体法による検討

那須保友, 公文裕巳, 松村陽右, 大森弘之

日本泌尿器科學會雜誌 75 ( 11 ) 1818 - 1818 1984.11

Clinical evaluation of serum and urine CEA levels determined by RIA kit “Daiichi” in genitourinary cancer.

大橋輝久, 那須保友, 大森弘之, 平木祥夫, 青野要, あき山隆夫, 松島紀志夫, 広中孝作, 宮野秀昭

西日本泌尿器科 46 ( 6 ) 1984

ISOANTIGENS ABH IN BLADDER TUMORS AS AN INDICATOR OF MALIGNANT POTENTIAL : II. Results of a Long-term Follow-up and Technical Problems

Kumon Hiromi, Nasu Yasutomo, Matsumura Yosuke, Ohmori Hiroyuki

The Japanese Journal of Urology 75 731 - 738 1984

Language：Japanese Publisher：The Japanese Urological Association

We studied prognostic significance of ABH isoantigens in 22 patients who was initially with grade 1, stage O-A transitional cell carcinoma of the bladder. The presence or absence of the antigens in these carcinomas was previously reported. In a follow-up study, of 9 cases devoided of the antigens, 4 progressed to fatal conditions, one to grade 3 lesion, 3 showed one or more local recurrences and one no recurrence. On the other hand, of 13 cases with the antigens, 7 showed no tumor recurrence for at least 5 years and 6 showed recurrence which were confined only to the submucosal layer. These results indicate that the analysis of isoantigens is most valuable for predicting malignant potential of transitional cell carcinoma. Concerning how to detect the antigens, we compared the commonly used specific red-cell adherence test with immunofluorescence, immunoperoxidase and scanning immunoelectron microscopy. The immnuoperoxidase method was found to be far superior to others in several points including sensitivity and reproducibility.

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ISOANTIGENS ABH IN BLADDER TUMORS AS AN INDICATOR OF MALIGNANT POTENTIAL : III. Detection of PAP Method and A Classification of Staining Pattern

Nasu Yasutomo, Kumon Hiromi, Matsumura Yosuke, Ohmori Hiroyuki

The Japanese Journal of Urology 75 ( 5 ) 739 - 743 1984

Language：Japanese Publisher：The Japanese Urological Association

We employed the peroxidase-antiperoxidase method (PAP) to detect the Blood Group Antigens (BGA) in bladder tumors, PAP was found to be satisfactory in the staining specificity, sensitivity and reproducivility. H-antigen could also be detected successfully. Staining patterns of BGA by PAP were examined in 58 cases of bladder tumors with various histological grade and classified into four types ; Type I: Stained homogeneously and as intensely as normal urothelium. Type II: Stained homogeneously but less intensely than normal urothelium. Type III: Stained non-homogeneously with scattered negative areas. Type IV: Stained negatively with no positive areas.

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TUR-P と Lithotripsy 併用による前立腺結石の摘出 : 第172回岡山地方会

荒木徹, 那須保友, 津川昌也

日本泌尿器科學會雜誌 75 ( 3 ) 536 - 537 1984

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