Faculty Profiles - NASU Yasutomo

MISC - NASU Yasutomo

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ステロイド療法が奏効した後腹膜線維症の1例 : 第49回四国地方会

横山光彦, 那須良次, 那須保友

日本泌尿器科學會雜誌 83 ( 2 ) 267 - 267 1992.2

HISTOPATHOLOGICAL STUDY OF METALLOTHIONEIN IN BLADDER CANCER AND RENAL CELL CARCINOMA

Saika Takashi, Tsushima Tomoyasu, Nasu Yasutomo, Akebi Naoki, Noda Masatoshi, Kobashi Kenji, Matsumura Yousuke, Ohmori Hiroyuki

The Japanese Journal of Urology 83 ( 5 ) 636 - 642 1992

Publisher：The Japanese Urological Association

Metallothionein (MT) is a low molecularmetal binding protein with multiple biological functions. Recently, MT has been implicated as a factor involved in resistance to anticancer drugs, which presumably inactivates anticancer drugs, including cisplatin, and doxorubicin. In this report, we investigated the relationship of MT expression with the clinical features in bladder cancer and renal cell carcinoma. In 35 cases of bladder cancer, 10 cases of renal cell carcinoma and 3 cases of normal mucosa of bladder, the expression of MT was immunohistologically examined by avidinebiotin-peroxidase (ABC) staining of paraffin-embedded tissue specimens with anti-MT antibody. Intense MT expression was noted in all cases of normal mucosa of bladder. MT was detected in 10 of 35 cases of bladder cancer, with the incidence of MT expression being significantly higher increases with lower pathological tumor grade. MT was detected in 8 of 10 cases of renal cell carcinoma, and all of the their normal renal tubules showed more intense staining. A number of hypotheses can be proposed from these observations. First, our observation of decreased MT expression in poorly differentiated carcinomas, which are the more proliferating tumors, this suggests correlation of MT expression with proliferative status of cancer. Second, the higher incidence of MT expression in renal cell carcinoma than in bladder cancer may suggest that it is a factorresponsible for the lower efficacy of chemo-therapy in renal cell carcinoma than in bladder cancer.

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PROPHYLACTIC INTRAVESICAL INSTILLATION THERAPY IN PATIENTS WITH SUPERFICIAL BLADDER CANCER:Results of a Randomized Prospective Study

Tsushima Tomoyasu, Tanahashi Toyoko, Namba Katsuichi, Shiraga Tsuyoshi, Takamoto Hitoshi, Araki Tohru, Takeda Katsuji, Asahi Toshihiko, Akaeda Teruaki, Nasu Yasutomo, Abeki Naoki, Noda Masatoshi, Saika Takashi, Ohmori Hiroyuki, Kobashi Kenji, Ozaki Yujiro, Matsumura Yosuke

The Japanese Journal of Urology 83 ( 8 ) 1314 - 1321 1992

Publisher：The Japanese Urological Association

A randomized prospective study was conducted for the purpose of investigating the efficacy of intravesical chemoprophylaxis of superficial bladder cancers. Eligible patients were randomized into three groups: 1) adriamycin (ADM) group; intravesical instillation with 50mg of ADM dissolved in 100ml physiological saline, 2) mitomycin C (MMC) group; intravesical instillation with 30mg of MMC dissolved in 100ml of physiological saline, 3) control group; transurethral resection or transurethral coagulation only. The characteristic features of our protocol consisted of frequent (six times) instillations of the drugs within two weeks after transurethral resection, followed by instillations on two consecutive days at four-week intervals for two years. Furthermore, large quantities (100ml) of instillation fluid containing relatively low concentrations of the drugs (500&mu;g/ml for ADM or 300&mu;g/ml for MMC) were employed. One hundred and forty-four patients have been submitted to the study; 110 patients were fully evaluable for recurrence and 34 patients were eliminated as non-evaluable patients. The cumulative five-year non-recurrence rates of the patients with multiple tumors were 32% in the MMC group, 25% in the ADM group and 7% in the control group. The cumulative non-recurrence rates of the ADM and MMC groups were significantly higher than that of the control group. It is considered that this instillation therapy with ADM and MMC is useful for preventing the recurrence of superficial bladder cancers.

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1989年十全病院泌尿器科入院・手術統計 : 第203回岡山地方会

那須保友, 門田晃一, 小野憲昭, 水野全裕

日本泌尿器科學會雜誌 82 ( 1 ) 172 - 172 1991.1