Faculty Profiles - YANAI Hiroyuki

Papers - YANAI Hiroyuki

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Ad-REIC gene therapy: Promising results in a patient with metastatic CRPC following chemotherapy Reviewed

Hiromi Kumon, Katsumi Sasaki, Yuichi Ariyoshi, Takuya Sadahira, Shin Ebara, Takao Hiraki, Susumu Kanazawa, Hiroyuki Yanai, Masami Watanabe, Yasutomo Nasu

Clinical Medicine Insights: Oncology 9 ( 9 ) 31 - 38 2015.3

Language：English Publishing type：Research paper (scientific journal) Publisher：Libertas Academica Ltd.

A 63-year-old man with metastatic castration-resistant prostate cancer (CRPC) was successfully treated for two years with in situ gene therapy using an adenovirus vector carrying the human REIC/Dkk‑3 gene (Ad-REIC), following chemotherapy. Ad-REIC mediates simultaneous induc-tion of cancer-selective apoptosis and augmentation of antitumor immunity, and a Phase I/IIa clinical study on Ad-REIC has been conducted at Okayama University Hospital since January 2011. At the time of enrollment in December 2012, the patient presented with rapid progression of lymph node (LN) metastases. Two scheduled Ad-REIC injections and 10 additional Ad-REIC injections into metastatic pelvic and para-aortic LNs under CT guidance, with an average four weeks’ interval, exhibited the potent direct and indirect effects of Ad-REIC as a therapeutic cancer vaccine. During the next 12 months, three additional injections into para-aortic LNs showing regrowth achieved adequate control of all metastatic LNs with prostate-specific antigen (PSA) decline, without any particular adverse events.

DOI： 10.4137/CMO.S23252

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A case of cardiac amyloidosis with ventricular flutter of first symptom

Ono Tamaki, Morita Hiroshi, Kimura Tomonari, Tokioka Koji, Nakagawa Kouji, Nishii Nobuhiro, Nagase Satoshi, Nakamura Kazuhumi, Ito Hiroshi, Tanaka Takehiro, Yanai Hiroyuki, Ando Midori, Yutani Chikao

Shinzo 47 ( suppl-1 ) 33 - 37 2015

膀胱粘膜下傍神経節腫の2例

小田晋輔, 伏見聡一郎, 山口隆廣, 伊藤利洋, 大枝忠史, 市川孝治, 柳井広之, 國友忠義, 中本周, 松川昭博

鳥取医学雑誌 42 ( 3-4 ) 147 - 152 2014.12

Language：Japanese Publisher：(公社)鳥取県医師会

われわれは膀胱に発生した傍神経節腫の2例を経験した。症例1は90歳代女性。血尿の精査中、膀胱鏡で右壁に3cm大の粘膜下腫瘍が認められ、経尿道的膀胱腫瘍切除術(transurethral resection of bladder tumor:TURBT)を施行された。症例2は70歳代男性。胸部大動脈瘤術後の経過観察中に、Computed tomography(CT)検査にて膀胱腫瘍を指摘され、膀胱鏡を行ったところ新たに別の粘膜下腫瘍が認められTURBTを施行された。2例とも病理組織学的に傍神経節腫と診断された。膀胱に発生する傍神経節腫はまれであり、文献的考察を加えて報告する。(著者抄録)

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切除縁評価法の問題点切除縁評価法の問題点悪性骨腫瘍

国定俊之, 武田健, 藤原智洋, 柳井広之, 尾崎敏文

日本整形外科学会雑誌 88 ( 9 ) 588 - 594 2014.9

Language：Japanese Publisher：(公社)日本整形外科学会

2005年〜2011年に治療した初診時遠隔転移を認めない高悪性骨腫瘍52例を対象に、最近の症例について検討し、悪性骨腫瘍の切除縁評価法に関する疑問点・問題点について検討した。組織型は骨肉腫34例、軟骨肉腫12例、Ewing肉腫3例等であった。52例の切除縁評価は2cm wide margin以上45例、1cm wide margin 4例、marginal margin以下3例であった。1cm wide marginとなった4例は血管温存目的(2例)および術前化学療法効果著効例での関節温存目的(2例)であった。marginal margin以下となった3例は骨盤発生、脊椎発生、大腿骨巨大腫瘍で、広範囲切除縁確保が困難であった。再発は4例に認め、2cm wide margin以上1例、marginal margin以下3例であった。最初の問題点は反応層の定義で、反応層をもう少し詳細に分類する必要がある。2番目の問題点は術前画像での切除縁設定の基準を決めることで、全国で統一した安全な切除縁設定の基準を決める必要があると思われた。

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Other Link： https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2014&ichushi_jid=J01133&link_issn=&doc_id=20141006030026&doc_link_id=%2Ffj2ortho%2F2014%2Fs08809%2F005%2F0588-0594%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Ffj2ortho%2F2014%2Fs08809%2F005%2F0588-0594%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Fatal glioblastoma after Gamma Knife radiosurgery for arteriovenous malformation in a child Reviewed

Koichi Yoshida, Tomotsugu Ichikawa, Kazuhiko Kurozumi, Hiroyuki Yanai, Keisuke Onoda, Isao Date

JOURNAL OF CLINICAL NEUROSCIENCE 21 ( 8 ) 1453 - 1455 2014.8

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER SCI LTD

We describe a fatal case of glioblastoma multiforme that was induced by Gamma Knife radiosurgery (GKS; Elekta AB, Stockholm, Sweden) for an arteriovenous malformation (AVM). A 4-year-old girl presented with repeated convulsions. Imaging studies revealed an AVM located in the right thalamus. One year after initial symptoms, GKS was performed to obliterate the nidus. The maximum and marginal radiation doses were 32 and 16 Gy, respectively. Seventy months after GKS, the patient represented with severe headache. MRI showed a poorly demarcated tumor with heterogeneous gadolinium enhancement in the right thalamus and adjacent to the white matter of the temporal lobe. After a generalised convulsion, the patient deteriorated into a deep coma. CT scans showed severe brain swelling with intratumoral hemorrhage. An emergency craniotomy was performed, and the hematoma was removed. During this surgery, a tumor mass, which was found adjacent to the hematoma, was resected. Microscopic examination revealed glioblastoma multiforme. Despite intensive treatment, the patient died 1 month after surgery. A GKS-induced secondary tumor is a rare but serious complication. It is important to be aware of the adverse effects of GKS, including secondary neoplasms, before its clinical application, especially in young patients. (C) 2014 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.jocn.2013.10.039

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直腸癌術後尿管再発の１例

松本聖, 稲田涼, 近藤喜太, 母里淑子, 岸本浩行, 江原伸, 戸田博子, 柳井広之, 永坂岳司, 藤原俊義

癌の臨床 60 ( 5 ) 549 - 554 2014

Language：Japanese Publisher：(株)篠原出版新社

尿管再発は大腸癌において頻度の低い再発形式である。今回直腸癌術後に血尿を契機に発見された左尿管再発を経験したので報告する。患者は80代男性。2007年1月、上部直腸癌に対して低位前方切除術を施行。病理診断にて中分化管状腺癌(pT4aN0M0、pStage II)と診断。2011年9月、血尿を認め、膀胱および左尿管に腫瘍を指摘。膀胱腫瘍に対してはTUR-BTを、また尿管腫瘍に対しては左腎尿管摘出術を施行。組織診断では膀胱腫瘍は、原発性尿路上皮癌と診断。また尿管腫瘍は腸管由来の分化型腺癌を認め、直腸癌の尿管再発と診断。その後、膀胱癌の局所再発および直腸癌の肺・膀胱内再発をきたすも、2012年5月、癒着性イレウスによる嘔吐に伴う誤嚥性肺炎により永眠された。(著者抄録)

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2014&ichushi_jid=J00297&link_issn=&doc_id=20141203210011&doc_link_id=%2Fad7gnrsc%2F2014%2F006005%2F011%2F0549-0554%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fad7gnrsc%2F2014%2F006005%2F011%2F0549-0554%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

膵Solid-pseudopapillary neoplasm(clear cell variant)の一例

濱田香菜, 那須篤子, 井上博文, 今井みどり, 松岡博美, 藤田勝, 市村浩一, 柳井広之

日本臨床細胞学会岡山支部会誌 32 29 - 32 2013.12

Language：Japanese Publisher：岡山県臨床細胞学会

背景超音波内視鏡下穿刺吸引細胞診(以下EUS-FNA)において、膵solid-pseudopapillary neoplasm(以下SPN)のclear cell variantを経験したので報告する。症例 40歳代、男性。造影CTにて膵尾部に約17mm大の腫瘤を指摘。EUS-FNAが施行され、比較的均一な、小型類円形の偏在核を有する形質細胞様の腫瘍細胞が、単在性あるいは小集塊で多数認められた。多くの腫瘍細胞の細胞質に細胞質内空胞が見られ、集塊内部や腫瘍細胞近傍にライトグリーン好染性の球状無構造物が観察された。集塊の結合性は緩く、一部でロゼット様配列を示し、細い血管結合織を軸とする集塊も見られた。以上の所見より細胞診では膵神経内分泌腫瘍が疑われた。組織学的検索においても、生検材料、手術材料ともに膵神経内分泌腫瘍との診断を得たが、その後の再検討により、SPN(clear cell variant)と診断された。結論 SPNは男性に発生する頻度は低く、組織学的にも膵神経内分泌腫瘍と鑑別困難な場合があり、細胞診判定に苦慮した。本亜型の特徴所見である細胞質内空胞を認識することが組織型推定への手がかりとなる。(著者抄録)

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Predictive factors for acute and late urinary toxicity after permanent interstitial brachytherapy in Japanese patients Reviewed

Ryuta Tanimoto, Kensuke Bekku, Norihisa Katayama, Yasuyuki Kobayashi, Shin Ebara, Motoo Araki, Mitsuhiro Takemoto, Hiroyuki Yanai, Yasutomo Nasu, Hiromi Kumon

International Journal of Urology 20 ( 8 ) 812 - 817 2013.8

Language：English Publishing type：Research paper (scientific journal)

To describe the frequency of and to determine predictive factors associated with Radiation Therapy Oncology Group urinary toxicity in prostate brachytherapy patients. Methods: From January 2004 to April 2011, 466 consecutive Japanese patients underwent permanent iodine-125-seed brachytherapy (median follow up 48 months). International Prostate Symptom Score and Radiation Therapy Oncology Group toxicity data were prospectively collected. Prostate volume, International Prostate Symptom Score before and after brachytherapy, and postimplant analysis were examined for an association with urinary toxicity, defined as Radiation Therapy Oncology Group urinary toxicity of Grade1 or higher. Logistic regression analysis was used to examine the factors associated with urinary toxicity. Results: The rate of Radiation Therapy Oncology Group urinary toxicity grade1 or higher at 1, 6, 12, 24, 36 and 48 months was 67%, 40%, 21%, 31%, 27% and 28%, respectively. Grade2 or higher urinary toxicity was less than 1% at each time-point. International Prostate Symptom Score was highest at 3 months and returned to normal 12 months after brachytherapy. On univariate analysis, patients with a larger prostate size, greater baseline International Prostate Symptom Score, higher prostate V100, higher prostate V150, higher prostate D90 and a greater number of seeds had more acute urinary toxicities at 1 month and 12 months after brachytherapy. On multivariate analysis, significant predictors for urinary toxicity at 1 month and 12 months were a greater baseline International Prostate Symptom Score and prostate V100. Conclusions: Most urinary symptoms are tolerated and resolved within 12 months after prostate brachytherapy. Acute and late urinary toxicity after brachytherapy is strongly related to the baseline International Prostate Symptom Score and prostate V100. © 2013 The Japanese Urological Association.

DOI： 10.1111/iju.12050

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Smear cytology findings of large cell neuroendocrine carcinoma of the uterine cervix Reviewed

Naoto Kuroda, Yukari Wada, Kaori Inoue, Masahiko Ohara, Keiko Mizuno, Makoto Toi, Azusa Tanaka, Yoji Wani, Hiroyuki Yanai

DIAGNOSTIC CYTOPATHOLOGY 41 ( 7 ) 636 - 639 2013.7

Language：English Publishing type：Research paper (scientific journal) Publisher：WILEY-BLACKWELL

Large cell neuroendocrine carcinoma (LCNEC) of the uterine cervix is a rare tumor. Moreover, there are only three reports to date that have focused on the cytologic findings of cervical LCNEC. We report the case of a 59-year-old Japanese woman with cervical LCNEC combined with small cell carcinoma (SmCC). Cytologic specimens from the uterine cervix demonstrated large cells with coarse chromatin and prominent nucleoli. Frequent mitotic figures were also observed. Curettage of the uterine endometrium revealed an endometrioid adenocarcinoma with squamous differentiation; i.e., an adenoacanthoma. Histologic examination of surgically resected uterine cervical tissue revealed LCNEC with minor foci of SmCC. Neuroendocrine differentiation in LCNEC was confirmed by immunohistochemistry for synaptophysin and CD56. Cytotechnologists or pathologists need to consider a differential diagnosis of LCNEC while examining cervical cytologic specimens; therefore, it is important to correctly identify the cytologic characteristics of this tumor. Diagn. Cytopathol. 2013. (c) 2011 Wiley Periodicals, Inc.

DOI： 10.1002/dc.21834

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Clinicopathologic analysis of IgG4-related skin disease Reviewed

Yasuharu Sato, Mai Takeuchi, Katsuyoshi Takata, Kyotaro Ohno, Noriko Iwaki, Yorihisa Orita, Naoe Goto, Akira I. Hida, Toshiyuki Iwamoto, Naoko Asano, Toshihiro Ito, Hiroyuki Hanakawa, Hiroyuki Yanai, Tadashi Yoshino

Modern Pathology 26 ( 4 ) 523 - 532 2013.4

Language：English Publishing type：Research paper (scientific journal)

IgG4-related disease is a recently recognized systemic syndrome characterized by mass-forming lesions with lymphoplasmacytic infiltration, increase in the number of IgG4 + cells in affected tissues and elevation of serum IgG4 levels. In 2009, we were the first to report skin lesions in patients with IgG4-related disease, but no large case series has been reported and clinicopathological findings remain unclear. To clarify these features, we herein report 10 patients (9 men and 1 woman
median age, 64 years
age range, 46-81 years) with IgG4-related skin disease. All patients had erythematous and itchy plaques or subcutaneous nodules on the skin of the head and neck, particularly in the periauricular, cheek, and mandible regions, except for one patient, whose forearm and waist skin were affected. In addition, eight patients had extracutaneous lesions: these were found on the lymph nodes in six patients, the lacrimal glands in three patients, the parotid glands in three patients, and the kidney in one patient. Histologically examined extracutaneous lesions were consistent with IgG4-related disease
five of six lymph node lesions showed progressively transformed germinal centers-type IgG4-related lymphadenopathy. Cases of IgG4-related skin disease were classified into two histological patterns: those exhibiting a nodular dermatitis pattern and those with a subcutaneous nodule pattern. The infiltrate was rich in plasma cells, small lymphocytes, and eosinophils
the majority of the plasma cells were IgG4 +. The IgG4 + cell count was 49-396 per high-power field (mean±s.d., 172±129), with an IgG4 +/IgG + cell ratio ranging from 62 to 92%. Serum IgG4 levels were elevated in all examined patients. In conclusion, patients with IgG4-related skin disease had uniform clinicopathology. Lesions were frequently present on the skin of the periauricular, cheek, and mandible regions, and were frequently accompanied by IgG4-related lymphadenopathy. © 2013 USCAP, Inc. All rights reserved.

DOI： 10.1038/modpathol.2012.196

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A case of synovial sarcoma with brain metastasis treated with surgical resection and stereotactic radiosurgery Reviewed

Yoshihiro Otani, Tomotsugu Ichikawa, Kazuhiko Kurozumi, Hiroyuki Yanai, Toshiyuki Kunisada, Toshifumi Ozaki, Isao Date

Neurological Surgery 41 ( 3 ) 255 - 262 2013.3

Language：Japanese Publishing type：Research paper (scientific journal)

Synovial sarcomas compromise between 5 to 10% of all soft tissue sarcomas in adults. Synovial sarcoma commonly occurs in the vicinity of the large joints and cranial metastasis is rare. Here, we describe a case with intracranial metastases of a synovial sarcoma A 41-year-old woman was admitted to our department with sensory aphasia. She had a history of a left inguinal synovial sarcoma and underwent surgery and chemotherapy for primary and metastatic lesions Head MRI revealed three gadolinium-enhancing lesions in the left frontal, parietal and parietotemporal lobe Gross total resection was achieved in the left parietotemporal lesion and pathological diagnosis was synovial sarcoma. Two weeks after surgery, she received cyber-knife radiosurgery and her neurological deficit was almost completely resolved Intracranial metastatic synovial sarcoma is rare. Surgical resection and stereotaxic radiosurgery was very effective in the present case.

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A case of synchronous thyroid papillary carcinoma and colon cancer of the neck node

Nomura Tsunehisa, Miyoshi Kazuya, Nishie Manabu, Iwakawa Kazuhide, Yanai Hiroyuki, Sonobe Hiroshi, Tanaka Katsuhiro

Official Journal of the Japan Association of Endocrine Surgeons and the Japanese Society of Thyroid Surgery 30 ( 3 ) 226 - 231 2013

１型神経線維腫症の異型神経線維腫を背景に発生した低悪性度悪性末梢神経鞘腫瘍の1例 Reviewed

田中梓菜, 黒田直人, 柳井広之, 岩田純

診断病理 30 ( 1 ) 19 - 22 2013

当院で治療した子宮体癌患者319症例の疫学的調査 Reviewed

春間朋子, 中村圭一郎, 福島千加子, 楠本知行, 関典子, 柳井広之, 平松祐司

日本婦人科腫瘍学会雑誌 31 ( 4 ) 137 - 142 2013

膣転移で発見された悪性傍神経節種の１例

多賀茂樹, 早瀬良二, 柳井広之

日本婦人科腫瘍学会雑誌 31 ( 1 ) 14 - 17 2013

乳頭状卵管過形成を伴う卵巣漿液性境界悪性腫瘍の一例

黒田直人, 田中梓菜, 柳井広之

日本婦人科病理学会誌 4 ( 2 ) 97 - 99 2013

胃底腺型胃癌の1例 Reviewed

田中健大, 市村浩一, 柳井広之, 吉野正

診断病理 30 ( 1 ) 62 - 65 2013

外科的摘出および定位放射線治療が有用であった転移性滑膜肉腫の1例

大谷理浩, 市川智継, 黒住和彦, 柳井広之, 国定俊之, 尾崎敏文, 伊達勲

Neurological Surgery 41 ( 3 ) 255 - 262 2013

A case of primary gallbladder choriocarcinoma with a rapidly aggressive course after surgery

Naoyuki Tokunaga, Masaru Inagaki, Yuji Kimura, Koji Kitada, Hiromi Iwagaki, Hiroyuki Yanai

Japanese Journal of Gastroenterological Surgery 46 ( 4 ) 268 - 274 2013

Language：Japanese Publishing type：Research paper (scientific journal)

A 75-year-old man complaining of right upper quadrant abdominal pain visited another hospital, and the acute cholecystitis was suspected based on ultrasonogram (US) and computer tomography (CT) scans. He was introduced our hospital for further examination and surgical treatment. Enhanced CT scan showed a circumferential wall thickness in the middle third of the gallbladder, and revealed the abcess formation outside the gallbladder wall, too. The clinical diagnosis of suppurative cholecystitis was made, and an urgent cholecystectomy was performed. Histopathological examination incidentally showed a moderately or poorly differentiated adenocarcinoma mixed with multinucleated syncytial trophoblasts. Immunohistochemistry revealed positive staining for HCG in the trophoblastic-cell component. According to the pathological diagnosis, we performed second operation immediately for the necessity of additional hepatectomy and lymph node dissection, but radical excision was immposible because of diffuse peritoneal dissemination and multiple liver metastasis. The patient survived only about four months following the first surgery. Primary gallbladder choriocarcinoma is exceedingly rare, and the prognosis is poorer than typical gallbladder adenocarcinoma in the literature. We report a case of gallbladder choriocarcinoma which demonstrated a rapidly aggressive course after cholecystectomy. © 2013 The Japanese Society of Gastroenterological Surgery.

DOI： 10.5833/jjgs.2012.0195

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Primary signet-ring cell/histiocytoid carcinoma of the axilla expressing human epidermal growth factor receptor 2 Reviewed

Tomoko Miyake, Osamu Yamasaki, Maho Sugiu, Toshihisa Hamada, Masaki Otsuka, Hiroyuki Yanai, Yoshiko Morishita, Keiji Iwatsuki

JOURNAL OF DERMATOLOGY 39 ( 12 ) 1038 - 1040 2012.12

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