Faculty Profiles - YANAI Hiroyuki

Papers - YANAI Hiroyuki

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根治性、機能性、整容性を兼ね備えた乳房温存術式

桧垣健二, 鵜垣伸也, 小野田正, 高倉範尚, 樋口富美, 影本正之, 柳井広之, 松浦博夫

乳癌の臨床 2002

進行・再発乳癌に対するHerceptinの使用経験

桧垣健二, 畝大, 藤原康弘, 鵜垣伸也, 原野雅生, 佐々木寛, 小野田正, 塩崎滋弘, 高倉範尚, 柳井広之, 松浦博夫

広島医学 2002

内視鏡的切除後に外科的追加切除を施行した早期大腸癌症例の検討

中川昌浩, 横田恭子, 岡本賢三, 仁科慎一, 久松倫子, 岡本裕子, 石井泰史, 有吉正憲, 河本博文, 長島不二夫, 杉原徹, 井上純一, 柴田醇, 柳井広之, 松浦博夫

社会保険広島市民病院医誌 17 ( 1 ) 106-113 2001.3

放射線治療が奏効し長期生存した噴門部進行胃癌の１例

谷為乃扶子, 影本正之, 樋口富美, 本山由紀子, 松浦明子, 太田辰, 浦島正喜, 柳井広之, 松浦博夫, 二宮基樹

広島医学 2001

Sentinel Node Biopsyによる腋窩非郭清手術の適応拡大

桧垣健二, 松川啓義, 今田孝子, 小野田正, 塩崎滋弘, 高倉範尚, 樋口富美, 影本正之, 柳井広之, 松浦博夫

乳癌の臨床 2001

MorbidityとQOLからみた乳癌に対する直視下腋窩郭清と内視鏡下腋窩郭清の比較検討

桧垣健二, 小野田正, 松川啓義, 徳永尚之, 清水秀二, 滝正樹, 高倉範尚, 影本正之, 柳井広之, 松浦博夫

乳癌の臨床 16 ( 1 ) 74 - 82 2001

乳癌に対する乳房温存手術の適応拡大を目指して

桧垣健二, 柳井広之, 松浦博夫

広島医学 2001

A case of intra-abdominal desmoplastic small round cell tumor

YANAI Hiroyuki, MATSUMOTO Manabu, FURUTANI Masumi

The Journal of the Japanese Society of Clinical Cytology 39 ( 4 ) 254 - 257 2000.7

S1667 小腸間膜病変（化骨性腸間膜炎）

松浦博夫, 柳井広之, 小林直広

病院病理 2000

乳癌に対する腋窩非郭清手術の術後成績

桧垣健二, 岡村進介, 森多克行, 吉鷹知也, 大崎悟, 小野田正, 塩崎滋弘, 影本正之, 柳井広之, 松浦博夫

乳癌の臨床 2000

空腸原発内分泌細胞癌の１例

竹中龍太, 友田純, 槙殿知穂, 村上敬子, 近藤淳一, 吉岡敏文, 坂田達朗, 廣田滋, 大川尚臣, 淵本定儀, 柳井広之

Gastroenterol Endosc 2000

Two Cases of Intracranial Metastatic Malignant Melanoma.

YAMASHITA Shiro, MORIYAMA Eiji, BECK Hiroichi, IWADO Eiji, YANAI Hiroyuki

Japanese Journal of National Medical Services 54 ( 8 ) 365 - 369 2000

Language：Japanese Publisher：Japanese Society of National Medical Services

Two cases of intracranial metastatic malignant melanoma are reported. Both patients were males of sixties with known primary skin malignant melanomas. Magnetic resonance imagings showed intracranial lesions, which were high intense in T1 WI, low intense in T2 WI and enhanced after Gd-DTPA adminisration. These findings were characteristic for intracranial malignat melanomas.<br>Treatment design consisted of intra-arterial chemotherapy with CDDP and ACNU, follwed by surgical resection and/or radiosurgery. In the first case, intratumoral hemorrhage occurred 40 hours after the intra-arterial chemotherapy and emergent craniotomy, instead of radiosurgery, was performed. The second patient underwent tumor removal on the following day after the chemotherapy. Both patients died of systemic metastases 2 and 3 months after the treatment, respectively.<br>Malignant melanomas are prone to metastasize to any organs including brain. Patients with malignant melanoma usually have short life expectancy, so the aim of treatment is focused on the maintenance of the QOL as long as possible. So, vigorous treatment should be carried out whenever necessary. Finally, spontaneous hemorrhage into intracranial malignant melanoma have been frequently observed. As shown in our case 1, treatment modalities might enhanced the risk of intratumoral hemorrhage. Care should be taken to avoid this serious complication

DOI： 10.11261/iryo1946.54.365

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劇症型Ｇ群溶連菌感染症の１例

松浦博夫, 柳井広之, 藤井誠志

診断病理 2000

Cyno-EBV (EBV-related herpesvirus from cynomolgus macaques) induces rabbit malignant lymphomas and their tumor cell lines frequently show specific chromosomal abnormalities Reviewed

K Hayashi, HL Chen, H Yanai, TR Koirala, N Ohara, N Teramoto, T Oka, T Yoshino, K Takahashi, K Miyamoto, K Fujimoto, Y Yoshikawa, T Akagi

LABORATORY INVESTIGATION 79 ( 7 ) 823 - 835 1999.7

Language：English Publishing type：Research paper (scientific journal) Publisher：LIPPINCOTT WILLIAMS & WILKINS

Malignant lymphoma (ML) induction in rabbits by Epstein-Barr virus (EBV)-related herpesvirus of cynomolgus (Cyno-EBV) is reported. Twenty-seven of 30 (90%) rabbits inoculated intravenously with Cyno-EBV-producing simian (cynomolgus) lymphocyte cell line (Ts-B6) cells developed ML between 45 and 115 days after inoculation. The peroral inoculation of Ts-B6 cells induced ML in only 2 of 10 (20%) rabbits (75 to 85 days). Five of 6 (83%) rabbits injected with cell-free pellets from Ts-B6 cultures also developed ML (27 to 122 days). Antibody response to the viral capsid antigen of EBV was also detected in sera from rabbits inoculated with Ts-B6. ML of the large cell or mixed type infiltrated diffusely in many organs, frequently involving the spleen, liver, kidneys, heart, and less frequently the lungs, lymph nodes, brain, eyes, gastrointestinal tract, thymus, and bone marrow. A chromosomal analysis of five lymphoma cell lines established from tumor-bearing rabbits revealed the rabbit karyotype. Three of these cell lines showed the chromosomal abnormalities with 12q- or t (7p+:12q-). EBV-encoded small RNA-1 and EBV-associated nuclear antigen 1 were expressed in Ts-B6 cells, the tumor tissues, and all rabbit cell lines by in situ hybridization and by immunofluorescence tests, respectively. EBV DNA was also detected in Ts-B6 cells and rabbit lymphoma cell lines by polymerase chain reaction and Southern blot analysis. The Southern blots of EBV termini revealed oligoclonal bands in the Cyno-EBV-induced rabbit lymphomas. No lymphoma was induced by the inoculation of B95-8 (EBV-producing cells) or peripheral leukocytes from normal cynomolgus (controls). These data suggest that the high rate of lymphoma induction in rabbits may be caused not by human EBV (B95-8) but by Cyno-EBV from Ts-B6 cells. A sequence analysis of the IR1 (BamHIW) region of Cyno-EBV revealed that this region is quite similar to that of herpesvirus Macaca fascicularis 1,which is a causative agent for a monkey model of AIDS-retated lymphomas. The present rabbit model of lymphoma with specific chromosomal abnormalities is very useful to clarify the role of EBV in human EBV-associated lymphoma and provides a means for studying prophylactic and therapeutic regimens.

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Lymphoepithelioma-like carcinoma of the uterine crervix-Case Report-

HAYASE Ryoji, YAMAMOTO Masahiko, YANAI Hiroyuki

17 ( 1 ) 78 - 81 1999.6

CD95 ligand is expressed in Reed-Sternberg cells of Hodgkin's disease Reviewed

Sakuma, I, T Yoshino, K Omonishi, R Nishiuchi, N Teramoto, H Yanai, K Kawahara, Kubonishi, I, Y Matsuo, T Akagi

PATHOLOGY INTERNATIONAL 49 ( 2 ) 103 - 109 1999.2

Language：English Publishing type：Research paper (scientific journal) Publisher：BLACKWELL SCIENCE ASIA

Reed-Sternberg (RS) cells and their mononuclear variants, Hodgkin's (H) cells, are considered to be the neoplastic cells of Hodgkin's disease (HD). The cellular origin of H-RS cells remains the subject of considerable controversy, although most recent papers have claimed that H-RS cells are of B cell origin, Recently, however, it has been reported that some H-RS cells express granzyme B, as observed in cytotoxic T cells and/or natural killer cells, which also express CD95 ligand (FasL/APO-1L). In the present study, the expression of CD95L and granzyme B in H-RS cells of HD was investigated, CD95L was detected in H-RS cells in five of nine HD cases (one case of lymphocyte-rich classical HD, two of these cases of nodular sclerosis type, and two of four cases of mixed cellularity type), All three examined HD cell lines expressed CD95L in the cytoplasm, although cell surface expression was seen only in L428 cells, Three HD cases expressed both CD95L and granzyme B. It was concluded that CD95L is frequently expressed in H-RS cells, which is one of their notable characteristics; albeit it seems to be irrespective of cell lineage.

DOI： 10.1046/j.1440-1827.1999.00830.x

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99mTc-GSA肝シンチの核医学指標と肝線維化との関連についての検討

河野良寛, 安藤由智, 生口俊浩, 中川富夫, 柳井広之, 平木祥夫

日本医学放射線学会雑誌 59 ( 2 ) S245 - S245 1999.2

Heterogeneity of dendritic cells in human superficial lymph node: In vitro maturation of immature dendritic cells into mature or activated interdigitating reticulum cells Reviewed

Kiyoshi Takahashi, Kenji Asagoe, Jin Zaishun, Hiroyuki Yanai, Tadashi Yoshino, Kazuhiko Hayashi, Tadaatsu Akagi

American Journal of Pathology 153 ( 3 ) 745 - 755 1998

Language：English Publishing type：Research paper (scientific journal) Publisher：American Society for Investigative Pathology Inc.

A two-color immunofluorescent analysis indicated that dendritic cells (DCs) in the human axillar lymph nodes (ie, lymph nodal DCs (LnDCs)) can be classified into three subsets. The first subset consists of CD1a+/CD86(- or dim)/CD83(- or dim) nondendriform DCs found mainly in lymph sinuses, the second is of CD1a-/CD86+/CD83+ dendriform DCs scattered in normal T zones, and the third is of large CD1a(bright)/CD86+/CD83+ dendriform DCs occasionally found in hyperplastic T zones. A three-color flow cytometric analysis, immunoperoxidase staining, and electron microscopic observation indicated that the majority of LnDCs corresponded to the first subset, which showed distinctive characteristics of DCs but did not fulfill the ultrastructural criteria for interdigitating reticulum cells (IDCs) and did not contain Birbeck granules. When LnDCs were cultured for 7 days, they became large CD1a(dim)/CD86+/CD83+ dendriform cells, which formed large complexes with many T cells and exhibited distinctive ultrastructural features of interdigitating reticulum cells, LnDCs cultured in the presence of granulocyte/macrophage colony-stimulating factor became markedly larger CD1a(bright)/CD86+/CD83+ dendriform cells forming large complexes with numerous T cells. These findings suggest that cells of the first subset represent immature LnDCs just migrating from epidermis, those of the second subset represent interdigitating reticulum cells, and those of the third subset represent interdigitating reticulum cells probably stimulated with certain immunostimulatory cytokines such as granulocyte/macrophage colony- stimulating factor. It is also suggested that either the second or the third subsets of LnDCs are derived from the first subset.

DOI： 10.1016/S0002-9440(10)65618-0

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Analysis of the Genome of an Epstein-Barr-Virus (EBV)-Related Herpesvirus in a Cynomolgus Monkey Cell Line (Si-IIA) Reviewed

Hideo Ino, Kazuhiko Hayashi, Hiroyuki Yanai, Norihiro Teramoto, Tirtha Raj Koirala, Hong-Li Chen, Takashi Oka, Tadashi Yoshino, Kiyoshi Takahashi, Tadaatsu Akagi

Acta Medica Okayama 51 ( 4 ) 207 - 212 1997.8

Language：English Publishing type：Research paper (scientific journal)

A simian cell line, Si-IIA, harboring Epstein-Barr-virus (EBV) -related herpesvirus (Si-IIA-EBV), produces malignant lymphoma in rabbits when administered by intravenous inoculation. In this study, we analyzed the Si-IIA-EBV genome and compared it with human EBV and herpesvirus macaca fascicularis 1 (HVMF 1 ), which is associated with B-cell lymphoma developing in SIV-infected immunosuppressed monkeys. DNA from Si-IIA-EBV was amplified by the polymerase chain reaction using three different primer pairs complementary to human EBV (B95-8) DNA
two of the primer pairs covered part of the long internal repeat 1 region (IR 1) and the third covered part of the BRRF 1 region. Direct sequencing of the three PCR products revealed that Si-IIA-EBV DNA had about 82% nucleotide homology to the human EBV DNA in all three regions and 92.4% homology to HVMF1 in the IR1 region. The blotting pattern by Southern blot analysis was different between Si-IIA-EBV and human EBV.

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Malignant lymphoma induction of rabbits with oral spray of Epstein-Barr virus-related herpesvirus from Si-IIA cells (HTLV-II-transformed Cynomolgus cell line): A possible animal model for Epstein-Barr virus infection and subsequent virus-related tumors in humans Reviewed

Tirtha Raj Koirala, Kazuhiko Hayashi, Hong-Li Chen, Hideo Ino, Naoyuki Kariya, Hiroyuki Yanai, Chitta Ranjan Choudhury, Tadaatsu Akagi

Pathology International 47 ( 7 ) 442 - 448 1997

Language：English Publishing type：Research paper (scientific journal) Publisher：Blackwell Publishing

Malignant lymphoma (ML) was induced in eight of nine rabbits inoculated by oral spray of the cell-free pellets from Si-IIA culture (HTLV-II- transformed leukocyte cell line of the Cynomolgus-producing Epstein-Barr virus (EBV)-related herpesvirus) after 64-141 days. None of the rabbits inoculated with EBV from B-95-8 cells or HTLV-II from MOT cells developed ML. Malignant lymphomas were usually of diffuse, large-cell or mixed type. HTLV- II infection was excluded by the polymerase chain reaction (PCR) and the particle agglutination teat. EBV-encoded RNA-1 and EBV-related DNA were detected in the tumor tissues by in situ hybridization and PCR, respectively. Anti-viral capsid antigen of EBV antibody (anti-VCA) was observed 3 weeks after oral inoculation of Si-IIA cell-free pellets. Polymerase chain reaction revealed continuous detection of EBV-related virus DNA in the peripheral blood leukocytes from 3 days after oral inoculation. These results show that ML induced orally with Si-IIA cell-free pellets was caused by EBV-related herpesvirus harbored by Si-IIA cells. Oral spray of EBV from B-95-8 also induced EBV infection in rabbits, which was confirmed both by the presence of anti-VCA and by PCR. These oral infection and malignant lymphoma induction systems of rabbit using EBV-related virus from Si-IIA or human EBV are useful animal models for the study of EBV infection and EBV-related lymphomas in humans.

DOI： 10.1111/j.1440-1827.1997.tb04522.x

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