Faculty Profiles - YANAI Hiroyuki

Papers - YANAI Hiroyuki

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Huge Primary Cardiac Undifferentiated Pleomorphic Sarcoma. Reviewed

Ryo Karasudani, Norihiko Nakanishi, Masahiro Tabata, Hiroyuki Yanai

Internal medicine (Tokyo, Japan) 2023.11

有安早苗, 田中慎一, 福田由美子, 中桐智香子, 山代承子, 佐藤正和, 表梨華, 柳井広之

日本臨床細胞学会雑誌 62 ( Suppl.2 ) 541 - 541 2023.10

A Case of Uterine Tumor Resembling Ovarian Sex Cord Tumor With Prominent Myxoid Features. Reviewed International journal

Koki Ise, Zen-Ichi Tanei, Yoshitaka Oda, Satoshi Tanikawa, Hirokazu Sugino, Yusuke Ishida, Masumi Tsuda, Yuko Gotoda, Kunihiko Nishiwaki, Hiroyuki Yanai, Tadashi Hasegawa, Kazuo Nagashima, Shinya Tanaka

International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 2023.6

Language：English Publishing type：Research paper (scientific journal)

Uterine tumor resembling ovarian sex cord tumor (UTROSCT) is a rare tumor with low malignant potential that commonly occurs in middle age. Although more than 100 cases have been reported to date, myxoid morphology is not well documented. Here, we present a 75-yr-old woman with abnormal vaginal bleeding, with an 8-cm mass in the uterine corpus detected by irregular, high-intensity signaling on T2-weighted imaging. The uterine mass had a glistening mucinous appearance on gross examination. Microscopically, most of the tumor cells were floating in the myxoid stroma. The tumor cells formed clusters or nests with abundant cytoplasm, while some exhibited trabecular or rhabdoid appearances. Immunohistochemically, tumor cells were positive for pancytokeratin (AE1/AE3), α-smooth muscle actin, CD10, progesterone receptor, and some sex cord markers such as calretinin, inhibin, CD56, steroidogenic factor-1. Electron microscopy demonstrated epithelial and sex cord differentiation. This tumor was negative for JAZF1-JJAZ1 fusion gene that is frequently found in low-grade endometrial stromal sarcoma. Fusion genes related to UTROSCT, including NCOA2/3, were not detected by reverse transcription polymerase chain reaction. The present case suggests that UTROSCT should be included in the differential diagnosis of myxoid uterine tumors.

DOI： 10.1097/PGP.0000000000000949

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Utility of Comprehensive Genomic Profiling for Precise Diagnosis of Pediatric-Type Diffuse High-Grade Glioma. Reviewed

Keigo Makino, Yoshihiro Otani, Kentaro Fujii, Joji Ishida, Shuichiro Hirano, Yasuki Suruga, Kana Washio, Kenji Nishida, Hiroyuki Yanai, Shuta Tomida, Daisuke Ennishi, Isao Date

Acta medica Okayama 77 ( 3 ) 323 - 330 2023.6

Language：English

In the current World Health Organization classification of central nervous system tumors, comprehensive genetic and epigenetic analyses are considered essential for precise diagnosis. A 14-year-old male patient who presented with a cerebellar tumor was initially diagnosed with glioblastoma and treated with radiation and concomitant temozolomide chemotherapy after resection. During maintenance temozolomide therapy, a new contrast-enhanced lesion developed in the bottom of the cavity formed by the resection. A second surgery was performed, but the histological findings in specimens from the second surgery were different from those of the first surgery. Although genome-wide DNA methylation profiling was conducted using frozen tissue for a precise diagnosis, the proportion of tumor cells was insufficient and only normal cerebellum was observed. We then performed comprehensive genetic analysis using formalin-fixed paraffin-embedded sections, which revealed MYCN amplification without alteration of IDH1, IDH2, or Histone H3. Finally, the patient was diagnosed with pediatric-type diffuse high-grade glioma, H3-wildtype and IDH-wildtype. In conclusion, comprehensive genetic and epigenetic analysis should be considered in pediatric brain tumor cases.

DOI： 10.18926/AMO/65502

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Like a shot-through manubrium: A rare presentation of skeletal tuberculosis. Reviewed International journal

Tomohiro Fujiwara, Hiroyuki Yanai, Hideharu Hagiya

Clinical case reports 11 ( 5 ) e7119 2023.5

Language：English

A 22-year-old Vietnamese woman presented with anterior chest swelling. Computed tomography revealed an osteolytic lesion in the manubrium, whereas MRI showed an extra-osseous expansion. A needle biopsy showed granuloma formation, whereas a 3-week mycobacterial culture indicated Mycobacterium tuberculosis infection. Manubrium/sternum involvement in tuberculosis is extremely rare but should be considered.

DOI： 10.1002/ccr3.7119

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片側下腿に発生した多発性グロムス腫瘍の一例

徳田貴大, 藤原智洋, 近藤彩奈, 国定俊之, 中田英二, 西村碧フィリーズ, 柳井広之, 尾崎敏文

中国・四国整形外科学会雑誌 35 ( 1 ) 47 - 51 2023.4

Language：Japanese Publisher：中国・四国整形外科学会

症例は21歳男性で、左下腿脛骨外側部のグロムス腫瘍切除術後2ヵ月経過した時点で左下腿の疼痛が再燃した。MRIでは左脛骨前面、脛骨後面、脛腓間、腓骨周囲に多発性の腫瘤を認め、これら全病変を辺縁切除した。病理検査では全てグロムス腫瘍と診断され、術後1年の時点で疼痛の再燃や腫瘍の再発は認めず、趣味のダンスも再開している。

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子宮頸部腺癌のWHO分類第5版(2020)は生検診断においても有効か

川上史, 柳井広之, 南口早智子, 美山優, 安田政実, 寺本典弘, 岩本雅美, 清川貴子, 三上芳喜

日本病理学会会誌 112 ( 1 ) 255 - 255 2023.3

Probability scoring system of intravascular large B-cell lymphoma for the application of random skin biopsy: A retrospective cohort study. Reviewed International journal

Mikiko Takigawa, Osamu Yamasaki, Hayato Nomura, Tomoko Miyake, Hiroyuki Yanai, Shin Morizane

JAAD international 9 146 - 152 2022.12

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Intravascular large B-cell lymphoma (IVLBCL) is rare and fatal when diagnosed late in the disease course. Random skin biopsy (RSB) is useful for early diagnosis, but criteria for its application are not well established. OBJECTIVE: To develop an IVLBCL-probability scoring system for stratifying patients and investigate its feasibility and capability for RSB application. METHODS: A retrospective cohort of 77 consecutive patients with suspected IVLBCL who underwent RSB was included in this study. All patients were classified into 3 IVLBCL-probability groups according to the IVLBCL-probability scoring system comprising the following 4 components: general symptoms, organ-specific symptoms, serum soluble-interleukin-2 receptor levels, and serum lactate-dehydrogenase levels. RESULTS: The high (score 7-10), intermediate (score 4-6) and low (score 1-3) IVLBCL-probability groups contained 32, 30, and 15 patients, respectively. All 5 patients with IVLBCL were stratified into the high IVLBCL probability group. Accuracies in the diagnosis of IVLBCL were 100%, 100%, and 93.8% for the low, intermediate, and high IVLBCL-probability groups. The positive detection rate in the high IVLBCL-probability group increased to 9.4% from 3.9% across all groups. CONCLUSIONS: The newly-developed IVLBCL-probability scoring system has good capability for stratification of patients and could allow limiting application of RSB for diagnosis only to high-probability groups.

DOI： 10.1016/j.jdin.2022.09.005

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A critical review of "uterine leiomyoma" with subsequent recurrence or metastasis: A multicenter study of 62 cases. Reviewed International journal

Sakiko Sanada, Kimio Ushijima, Hiroyuki Yanai, Yoshiki Mikami, Yoshihiro Ohishi, Hiroaki Kobayashi, Hironori Tashiro, Mikio Mikami, Shingo Miyamoto, Hidetaka Katabuchi

The journal of obstetrics and gynaecology research 48 ( 12 ) 3242 - 3251 2022.12

Language：English Publishing type：Research paper (scientific journal)

AIM: Histopathologic diagnosis of a subset of uterine smooth muscle tumors is challenging. We report a critical review regarding the clinicopathological point of view of 62 cases of subsequently recurred or metastasized leiomyoma. METHODS: Medical records and glass slides of 62 cases of uterine smooth muscle tumor diagnosed as leiomyoma, which subsequently recurred or metastasized, were critically reviewed by pathologists specializing in gynecologic pathology and oncology. RESULTS: In 47 (75.8%) of 62 cases, the diagnosis of leiomyoma was confirmed, including 11 intravascular leiomyomatosis (IVL) and benign metastasizing leiomyoma (BML). In 29 cases (46.8%) laparoscopic surgery was performed, of which morcellator without a bag was employed in 23 cases. Fifteen cases (24.2%) appeared to be underestimated and were re-classified as smooth muscle tumor of uncertain malignant potential (STUMP), leiomyosarcoma, or other malignant mesenchymal tumors. Recurrences in seven cases (11.3%) were interpreted to be a malignant transformation, and one STUMP recurred as STUMP. CONCLUSION: The recurrence or metastasis in cases of "leiomyoma" is attributed to iatrogenic or under-evaluation of primary tumors, although a subset of cases is a rare example of biological progression.

DOI： 10.1111/jog.15426

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腫瘍用人工骨頭による股関節置換術を施行した転移性前立腺癌の1例

和田里章悟, 久住倫宏, 藤原智洋, 山本哲也, 柳井広之, 白石裕雅, 徳永素, 窪田理沙, 市川孝治, 津島知靖

西日本泌尿器科 85 ( 2 ) 47 - 51 2022.12

Language：Japanese Publisher：(一社)西日本泌尿器科学会

症例は57歳,男性。腰部と右大腿部の痛みを主訴に近医を受診した。単純X線写真での骨硬化像とPSA高値から骨転移を伴う前立腺癌を疑われ当科紹介となった。初診時,PSAは433ng/dLであり直腸診で前立腺は石様硬に触れた。画像検査では腰椎,仙骨,恥骨,右大腿骨頸部から転子部にかけて転移を疑う像を認めたが,リンパ節腫大と他臓器の占拠性病変はなかった。初診より7日目に経直腸式前立腺生検の迅速病理で腺癌の組織を確認し,即時の外科的去勢術を施行した。病理結果を以てGleason score 4+5の前立腺癌cT3bN0M1bと診断した。腰椎及び仙骨と右大腿骨の転移性骨腫瘍にはそれぞれ30Gyの放射線治療とビスフォスフォネート製剤の投与を行い,外来通院でアビラテロン内服を開始した。初診より5ヵ月後,PSAは低下傾向にあったが,右大腿骨頸部の病的骨折により入院となった。Activities of Daily Livingが著しく低下し,骨腫瘍切除術と腫瘍用人工骨頭による再建術を施行した。荷重部の転移性骨腫瘍については切迫骨折のリスクを評価し,免荷を指示するかあるいは,病的骨折を発症する前の外科的介入も検討する必要がある。(著者抄録)

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特徴的な細胞所見が確認できた胃癌子宮転移の一例 Reviewed

安村早優美, 山口祐菜, 那須篤子, 今井みどり, 本山由紀子, 田中健大, 柳井広之

岡山県臨床細胞学会誌 40 24 - 26 2022.12

Language：Japanese Publisher：岡山県臨床細胞学会

背景:子宮内膜の二次性腫瘍は子宮外を原発とする腫瘍の子宮内膜への転移であり,極めて稀である.二次性腫瘍としては婦人科原発や乳癌の小葉癌,胃癌が多い.今回,特徴的な細胞所見が確認できた胃癌子宮転移の一例を報告する.症例:40代,女性.3型進行胃癌の疑いで精査のために他院より紹介受診した.CTにて胃体下部から胃角部大彎を中心に約7cm大の壁肥厚病変や卵巣の低度腫大が認められ,胃生検,子宮腟部細胞診,子宮体部細胞診が施行された.胃生検では,卵円形に腫大した核と粘液に富む胞体をもつ異型細胞が索状あるいは孤在性に増殖しており,印環細胞癌と診断された.子宮腟部,子宮体部細胞診では異型が強く,細胞質内に粘液を大量に含み,核が偏在し,いわゆる印環細胞癌の特徴を示す異型細胞が多数存在しており,これらの所見と既往歴から,胃癌の子宮転移と推定した.結語:子宮の二次性腫瘍の中でも,細胞診標本中に腫瘍細胞を認めることは稀であるが,今回の症例では子宮腟部,子宮体部細胞診にて胃生検と同様に印環細胞型の異型の強い腺癌細胞が孤在性または集塊で出現しており,臨床情報と併せて転移性腫瘍の診断が可能であった.(著者抄録)

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S100P/Ki-67二重免疫染色は上部尿路細胞診の補助手段になりえるか組織学的基礎検討

有安早苗, 田中慎一, 福田由美子, 中桐智香子, 山代承子, 佐藤正和, 表梨華, 柳井広之

日本臨床細胞学会雑誌 61 ( Suppl.2 ) 533 - 533 2022.10

The utility of DNA methylation analysis in elderly patients with pilocytic astrocytoma morphology. Reviewed International journal

Yasuki Suruga, Kaishi Satomi, Yoshihiro Otani, Kentaro Fujii, Joji Ishida, Atsuhito Uneda, Nobushige Tsuboi, Keigo Makino, Shuichiro Hirano, Naoya Kemmotsu, Ryoji Imoto, Ryo Mizuta, Yusuke Tomita, Takao Yasuhara, Kana Washio, Hiroyuki Yanai, Yuko Matsushita, Yuko Hibiya, Akihiko Yoshida, David Capper, Koichi Ichimura, Isao Date

Journal of neuro-oncology 160 ( 1 ) 179 - 189 2022.9

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: Pilocytic astrocytoma (PA) is a circumscribed low-grade astrocytic glioma, generally considered to be associated with a good prognosis. However, a subset of PA patients shows unfavorable outcomes. In this study, we retrospectively reviewed PA patients and performed further molecular analysis, such as DNA methylation profiling, to identify prognostic factors. METHODS: We analyzed 29 histologically-confirmed PA patients from a single center from 2002 to 2021 and conducted integrated molecular analyses among elderly PA patients since age was an independent prognostic factor for poor outcomes. RESULTS: The median age at diagnosis was 14 years (range 3-82 years) and 4 patients (14%) were elderly (patients ≥ 60 years old). Age over 60 was associated with poor progression-free survival and overall survival. We performed DNA methylation analysis on 2 of the 4 elderly patients. Both cases were histologically diagnosed as PA, but DNA methylation profiling revealed one as high-grade astrocytoma with piloid features (all methylation class scores were below 0.3 in both v11b4 and v12.5) and the other as glioblastoma, IDH-wildtype (score was over 0.5 in both v11b4 and v12.5), using the German Cancer Research Center methylation profiling classifiers and t-SNE analysis. CONCLUSIONS: Elderly patients with PA morphology showed unfavorable outcomes in this cohort. In those patients, further molecular analysis and DNA methylation profiling revealed the possibility of high-grade astrocytic tumors, including newly defined entities.

DOI： 10.1007/s11060-022-04131-3

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Site-specific differences in T lymphocyte composition of the gastric mucosa after Helicobacter pylori eradication. Reviewed International journal

Masaya Iwamuro, Takahide Takahashi, Natsuki Watanabe, Makoto Abe, Hiroyuki Sakae, Yoshiyasu Kono, Hiromitsu Kanzaki, Takehiro Tanaka, Seiji Kawano, Fumio Otsuka, Yoshiro Kawahara, Hiroyuki Yanai, Hiroyuki Okada

Medicine 101 ( 34 ) e30241 2022.8

Language：English Publishing type：Research paper (scientific journal)

In our earlier work, we revealed that inflammation of the lesser curvature of the gastric body and antrum could constitute independent risk factors for gastric cancer development, while inflammation of the greater curvature was not. The aims of this study were as follows: first, to reveal the differences between T lymphocyte populations of the gastric antrum and the greater and lesser curvatures of the gastric body in patients after Helicobacter pylori eradication; second, to analyze the correlation between the composition of the stomach-resident T lymphocytes and time from H. pylori eradication; and third, to evaluate the sex differences in T lymphocyte subsets after H. pylori eradication. To investigate site-specific differences in stomach-resident T lymphocytes after H. pylori eradication, we performed flow cytometry analysis on samples taken from the gastric antrum, greater curvature of the gastric body, and lesser curvature of the gastric body of 20 patients. We also analyzed the correlation between the composition of the stomach-resident T lymphocytes and the time from H. pylori eradication. The lymphocyte subsets of the antrum and lesser curvature of the body were similar. In contrast, compared to those in the greater curvature of the gastric body, CD4+/CD3+ lymphocyte subsets (43.8 ± 19.4% vs 31.7 ± 14.6%) were elevated in the lesser curvature of the body, whereas CD8+/CD3+ (67.1 ± 21.3% vs 80.4 ± 12.0%), CD7+/CD3+ (91.2 ± 4.6% vs 93.7 ± 3.8%), CCR4+/CD3+ (7.7 ± 8.1% vs 10.4 ± 7.0%), CD45RA+/CD3+CD4+ (27.2 ± 24.8% vs 39.5 ± 20.8%), and CD45RA+/CD3+CD4- (14.2 ± 11.1% vs 18.7 ± 11.5) were lower. Linear regression analysis showed a negative correlation between the time after H. pylori eradication and CD4+/CD3+ (P < .05, R2 = 0.198). There were no significant differences between men and women with respect to the lymphocyte populations. These results indicate that there are site-specific differences in lymphocyte composition in the stomach after H. pylori eradication.

DOI： 10.1097/MD.0000000000030241

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Genomic Profiling of a Case of Glioneuronal Tumor with Neuropil-like Islands. Reviewed

Nobushige Tsuboi, Joji Ishida, Yosuke Shimazu, Hisanori Edaki, Atsuhito Uneda, Yoshihiro Otani, Kentaro Fujii, Kazuhiko Kurozumi, Daisuke Ennishi, Hiroyuki Yanai, Isao Date

Acta medica Okayama 76 ( 4 ) 473 - 477 2022.8

Language：English

Glioneuronal tumor with neuropil-like islands (GNTNI) is a very rare subtype of glioneuronal tumor. We present a case of a 62-year-old man with GNTNI. Two adjacent lesions in the left parietal lobe were removed by left parietal craniotomy. The histological findings were glial cell proliferation and scattered rosettes consisting of synaptophysin-positive and NeuN-positive cells, leading to the diagnosis of GNTNI. Target sequencing revealed a genetic alteration similar to glioblastoma, IDH-wild type, which suggested adjuvant therapies. There are few previous reports on the treatment of this disease, and the patient should be followed carefully.

DOI： 10.18926/AMO/63907

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18F-FDG-PET/CTで集積の乏しい低異型度子宮内膜間質肉腫の1例

丸山拓夢, 蟹江悠一郎, 丸川洋平, 檜垣文代, 児島克英, 柳井広之, 依田尚之, 平木隆夫

臨床放射線 67 ( 8 ) 887 - 891 2022.8

Language：Japanese Publisher：金原出版(株)

症例は40歳代女性で、検診目的に産婦人科を受診し、子宮腫瘍を指摘されたため、精査加療目的に当院紹介となった。MRIではT1強調像で均一な低信号、T2強調像で均一な中間的高信号、拡散強調像で高信号、ADCの低下を認めた。MRI上、低異型度子宮内膜間質肉腫(low-grade ESS)を疑ったが、当院受診2ヵ月前に全身検索目的で撮像された18F-FDG-PET/CTにて腫瘤に異常高集積を認めなかったため、静脈内平滑筋腫症を否定できなかった。肉腫の可能性を考慮して開腹子宮全摘術、両側付属器切除術を施行した。病理所見では、細胞質の乏しい短紡錘形細胞の増殖がみられ、螺旋動脈様の小血管が規則的に介在しており、部分的に筋層に分け入るような浸潤像も認められ、low-grade ESSに特徴的な所見であった。

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2022&ichushi_jid=J01565&link_issn=&doc_id=20220823130017&doc_link_id=10.18888%2Frp.0000002037&url=https%3A%2F%2Fdoi.org%2F10.18888%2Frp.0000002037&type=%E5%8C%BB%E6%9B%B8.jp_%E3%82%AA%E3%83%BC%E3%83%AB%E3%82%A2%E3%82%AF%E3%82%BB%E3%82%B9&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

A Case of a Solitary Cortical Tuber with No Other Manifestations of Tuberous Sclerosis Complex Mimicking Focal Cortical Dysplasia Type II with Calcification. Reviewed

Kakeru Hosomoto, Tatsuya Sasaki, Koji Kawai, Yosuke Okazaki, Yuki Hyodo, Takashi Shibata, Susumu Sasada, Takao Yasuhara, Katsuhiro Kobayashi, Hiroyuki Yanai, Isao Date

Acta medica Okayama 76 ( 3 ) 323 - 328 2022.6

Language：English

Cortical tubers are one of the typical intracranial manifestations of tuberous sclerosis complex (TSC). Multiple cortical tubers are easy to diagnose as TSC; however, a solitary cortical tuber without any other cutaneous or visceral organ manifestations can be confused with other conditions, particularly focal cortical dysplasia. We report a surgical case of refractory epilepsy caused by a solitary cortical tuber mimicking focal cortical dysplasia type II, and describe the radiological, electrophysiological, and histopathological findings of our case.

DOI： 10.18926/AMO/63742

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Regulatory T cells induce a suppressive immune milieu and promote lymph node metastasis in intrahepatic cholangiocarcinoma. Reviewed International journal

Daisuke Konishi, Yuzo Umeda, Kazuhiro Yoshida, Kunitoshi Shigeyasu, Shuya Yano, Tomohiro Toji, Sho Takeda, Ryuichi Yoshida, Kazuya Yasui, Tomokazu Fuji, Kazuyuki Matsumoto, Hiroyuki Kishimoto, Hiroyuki Michiue, Fuminori Teraishi, Hironari Kato, Hiroshi Tazawa, Hiroyuki Yanai, Takahito Yagi, Ajay Goel, Toshiyoshi Fujiwara

British journal of cancer 127 ( 4 ) 757 - 765 2022.5

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Emerging evidence indicates that immunogenicity plays an important role in intrahepatic cholangiocarcinoma (ICC). Herein, we systematically evaluated the clinical relevance of immunogenicity in ICC. METHODS: Highly immunogenic ICCs identified in the public dataset and the Cancer Immunome Atlas (TCIA) were assessed to determine the prognostic impact of immunogenicity in ICC and key components after curative resection. We also investigated the clinical relevance of the immune milieu in ICC. RESULTS: Using the Gene Expression Omnibus dataset 89749 and TCIA, we identified CD8+/forkhead box P3 (FoxP3)+ tumour-infiltrating lymphocytes (TILs), T-cell immunoglobulin and mucin domain 3 (TIM-3) and human leukocyte antigen-A (HLA-A) in highly immunogenic ICCs. Immunohistochemical analysis of the in-house cohort showed that intratumoral FoxP3+ TILs correlated with CD8+ TILs (P = 0.045, Fisher's exact test) and that high FoxP3+/CD8+ ratio (FCR) was an important marker for poor survival (P < 0.001, log-rank test). Furthermore, the FCR was higher in tumour-free lymph nodes in ICCs with lymph node metastases than in those without lymph node metastases (P = 0.003, Mann-Whitney U test). CONCLUSIONS: FCR should be considered an important biomarker that represents the immune environment of ICC based on its potentially important role in tumour progression, especially lymph node metastasis.

DOI： 10.1038/s41416-022-01838-y

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AYA世代の脳腫瘍病理小児、AYA世代の脳腫瘍に対する網羅的メチル化解析を用いた診断の有用性と限界

大谷理浩, 藤井謙太郎, 石田穣治, 坪井伸成, 鷲尾佳奈, 柳井広之, 里見介史, 市村幸一, 伊達勲

Brain Tumor Pathology 39 ( Suppl. ) 076 - 076 2022.5

甲状腺sclerosing mucoepidermoid carcinoma with eosinophiliaの一例

園部宏, 福田由美子, 中桐智香子, 村本将太, 山代承子, 表梨華, 柳井広之

日本臨床細胞学会雑誌 61 ( Suppl.1 ) 213 - 213 2022.5

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Papers - YANAI Hiroyuki