研究者詳細 - 柳井　広之

論文 - 柳井　広之

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Ectopic thyroid tissue in the adrenal gland: CT and MRI findings 査読

A. Tada, T. Tanaka, A. Takamoto, H. Yanai, S. Sato, S. Kanazawa

DIAGNOSTIC AND INTERVENTIONAL IMAGING 97 ( 3 ) 371 - 373 2016年3月

Actual Status of Involvement of Helicobacter pylori Infection That Developed Gastric Cancer from Group A of ABC (D) Stratification - Study of Early Gastric Cancer Cases That Underwent Endoscopic Submucosal Dissection 査読

Ko Miura, Hiroyuki Okada, Yoshiyasu Kouno, Hiromitsu Kanzaki, Masaya Iwamuro, Keisuke Hori, Masahide Kita, Seiji Kawano, Yoshiro Kawahara, Takehiro Tanaka, Hiroyuki Yanai

DIGESTION 94 ( 1 ) 17 - 23 2016年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：KARGER

Background/Aims: Patients who are Helicobacter pylori antibody negative and have normal pepsinogen (PG) levels (group A of ABC (D) stratification) are considered unlikely to develop gastric cancer. This study aimed to clarify the involvement (uninfection, present infection or previous infection) of H. pylori in group A patients with early gastric cancer who underwent endoscopic submucosal dissection (ESD) by examining their background gastric mucosa endoscopically and histologically. Methods: This study included 166 patients with gastric cancer who were treated by ESD. Patients were classified according to PG levels and H. pylori antibody titers. Three biopsies (greater curvature of the antrum, lesser curvature of the middle corpus and greater curvature of the middle corpus) from group A were histologically analyzed and compared with those of groups B, C, D and after eradication). Results: In group A (34 patients), 32 patients had endoscopic atrophy (group A'). Histological neutrophil activity, chronic inflammation and atrophy scores were lower in group A' than in other groups. Group A' scores were similar to those of the after eradication group. Conclusion: Most of the group A patients with early gastric cancer were not uninfected with H. pylori, but had previous infections, thus carrying carcinogenic risk. (C) 2016 S. Karger AG, Basel

DOI： 10.1159/000446771

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耳下腺に発生した mammary analogue secretory carcinoma の 1 例 ― 形態的特徴と鑑別診断を中心に― 査読

那須篤子, 畠榮, 藤田勝, 山内豊子, 中村聡子, 田中健大, 市村浩一, 柳井広之

日本臨床細胞学会雑誌 55 ( 2 ) 112 - 118 2016年

記述言語：日本語出版者・発行元：(公社)日本臨床細胞学会

背景:耳下腺に発生したmammary analogue secretory carcinoma(以下MASC)の1例を経験したので細胞像を中心に報告する。症例:60歳代、男性。左耳前部の腫脹を主訴に他院を受診。超音波検査にて左耳下腺内に約3cmの腫瘍を認め、穿刺吸引細胞診を施行、悪性判定となり、手術目的で当院紹介受診となった。穿刺吸引細胞診では、乳頭状構造を示す細胞集塊やライトグリーン淡染性で豊富な細胞質を有する細胞が疎な結合性を呈し散見された。これらの細胞の核は偏在し、一部の細胞では細胞質内小腺腔(intracytoplasmic lumina、以下ICL)を認めた。ICLや腺腔内の貯留物質は、パパニコロウ染色では淡い桃色を呈し、Hema-color染色では、異染性を呈した。細胞学的には、腺房細胞癌や低悪性度篩状嚢胞腺癌、腺癌の鑑別が困難であった。結論:腺房細胞癌や低悪性度篩状嚢胞腺癌、腺癌の鑑別が困難であったが、MASCというまれな組織型と診断された。腺房細胞癌様の細胞が認められた場合は、鑑別診断の一つとしてMASCを念頭に置くことが肝要であると考えられた。(著者抄録)

DOI： 10.5795/jjscc.55.112

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前眼房水に浸潤した節外性 NK/T 細胞リンパ腫鼻型の 1 例査読

那須篤子, 市村浩一, 畠榮, 柳井広之, 藤田勝, 濵田香菜, 田中健大, 吉野正

日本臨床細胞学会雑誌 55 ( 2 ) 89 - 93 2016年

記述言語：日本語出版者・発行元：(公社)日本臨床細胞学会

背景:前眼房水に浸潤した節外性NK/T細胞リンパ腫、鼻型(extranodal NK/T cell lymphoma、nasal type、以下ENKL)の1例を経験したので細胞所見を中心に報告する。症例:50歳代、男性。発熱、食思不振、全身倦怠感を主訴として他院を受診。肝生検にて、ENKL、Stage IVBと診断され、当院を紹介受診。その後、左前眼房の混濁があり、前眼房水の細胞診が施行された。検体量が少量なためCyto Richを用いて液状化検体細胞診(liquid based cytology、以下LBC法)で標本を作製した。標本には長く伸びた核を有し、核の切れ込みなどの異型を示すリンパ球様細胞が多く認められた。また細胞質の一方が突起様に伸びたhand mirror様の形態を呈した細胞も観察された。肝生検、骨髄clot sectionの免疫組織化学的検索でCD3ε、CD56が陽性、ISHでEBERが陽性であり、前眼房水検体の免疫細胞化学的検索でも同様の結果であったためENKLの浸潤と診断した。結論:ENKLの細胞は細胞診形態でHand mirror cellとして出現することがある。ENKLの診断は、免疫染色とあわせて総合的に判断することが必要であり、LBC法はそのために有効であった。(著者抄録)

DOI： 10.5795/jjscc.55.89

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小児の頭蓋内髄膜腫術後肺転移の一例

今井みどり, 濱田香菜, 那須篤子, 井上博文, 藤田勝, 田中健大, 柳井広之

岡山県臨床細胞学会誌 35 30 - 33 2016年

記述言語：日本語出版者・発行元：岡山県臨床細胞学会

背景髄膜腫は中年女性に多く15歳未満の小児に起こる割合は0.57%と稀である。一般的に、髄膜腫は摘出によって完治の期待できる生物学的悪性度の低い腫瘍として扱われているが、極めて稀に遠隔転移をすることがある。今回我々は小児の頭蓋内髄膜腫術後肺転移の一例を経験したので、文献的考察を加えて報告する。症例患者は10歳未満の女児。てんかん発作、左下肢麻痺を主訴に来院。右前頭葉に直径5.5cmの腫瘍を認め、開頭術を施行し乳頭型髄膜腫と診断された。頭蓋内に2回の再発を繰り返し、他院にてサイバーナイフを施行。初発から3年後、胸部CTにて両肺野に多発性結節を認め、胸腔鏡下で右肺2ヶ所切除し、髄膜腫の転移と診断された。その後2回の化学療法を受け、翌年に右肺区域切除、3ヵ月後に左肺部分切除。その後経過観察中である。右肺区域切除時の迅速検査材料から捺印標本を作製した。腫瘍細胞は上皮様結合を示し、島状の集塊で観察された。細胞質は好酸性、核は類円形で明瞭な核小体を有し、粗顆粒状のクロマチンが均等に分布していた。迅速組織標本では、淡明な卵円形核と好酸性細胞質を有する細胞の増殖が観察された。腫瘍細胞は血管を含む結合織で区画されたwhorl formationを呈し、散在性に砂粒体を認める髄膜皮性髄膜腫の像であった。結論髄膜腫の頭蓋外に遠隔転移をする割合は0.1%と言われている。稀とはいえ、髄膜腫の遠隔転移が起こりうる可能性を認識しておく必要がある。(著者抄録)

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涙腺から発生したと考えられた導管癌の1例査読

田中顕之, 田中健大, 松本洋, 柳井広之, 吉野正

診断病理 33 ( 3 ) 254 - 258 2016年

高アンドロゲン/高エストロゲン血症およびpseudo-Meigs症候群を呈し，性索間質腫瘍が疑われた卵巣類内膜腺癌の一例査読

田中梓菜, 関典子, 西田傑, 春間朋子, 小川千加子, 楠本知行, 中村圭一郎, 増山寿, 柳井広之, 平松祐司

日本婦人科腫瘍学会雑誌 34 ( 2 ) 112 - 118 2016年

Peutz-Jeghers syndromeに合併した子宮頸部最小偏倚型粘液性腺癌の二例査読

田中梓菜, 中西美恵, 澤田麻里, 永井あや, 柳井広之, 早瀬良二

日本婦人科腫瘍学会雑誌 34 ( 2 ) 134 - 143 2016年

Feasibility of Neoadjuvant Ad-REIC Gene Therapy in Patients with High-Risk Localized Prostate Cancer Undergoing Radical Prostatectomy 査読

Hiromi Kumon, Katsumi Sasaki, Yuichi Ariyoshi, Takuya Sadahira, Motoo Araki, Shin Ebara, Hiroyuki Yanai, Masami Watanabe, Yasutomo Nasu

CTS-CLINICAL AND TRANSLATIONAL SCIENCE 8 ( 6 ) 837 - 840 2015年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：WILEY-BLACKWELL

In a phase I/IIa study of in situ gene therapy using an adenovirus vector carrying the human REIC/Dkk-3 gene (Ad-REIC), we assessed the inhibitory effects of cancer recurrence after radical prostatectomy (RP), in patients with high risk localized prostate cancer (PCa). After completing the therapeutic interventions with initially planned three escalating doses of 1.0 x 10(10), 1.0 x 10(11), and 1.0 x 10(12) viral particles (VP) in 1.0-1.2 mL (n = 3, 3, and 6), an additional higher dose of 3.0 x 10(12) VP in 3.6 mL (n = 6) was further studied. Patients with recurrence probability of 35% or more within 5 years after RP as calculated by Kattan's nomogram, were enrolled. They received two ultrasound-guided intratumoral injections at 2-week intervals, followed by RP 6 weeks after the second injection. Based on the findings of MRI and biopsy mapping, as a rule, one track injection to the most prominent cancer area was given to initial 12 patients and 3 track injections to multiple cancer areas in additional 6 patients. As compared to the former group, biochemical recurrence-free survival of the latter showed a significantly favorable outcome. Neoadjuvant Ad-REIC, mediating simultaneous induction of cancer selective apoptosis and augmentation of antitumor immunity, is a feasible approach in preventing cancer recurrence after RP. (199)

DOI： 10.1111/cts.12362

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エトポシドとシスプラチンの併用療法(EP療法)が著効し組織学的CRが得られた肝原発小細胞癌の1切除例

秋元悠, 堤康一郎, 加藤博也, 幡英典, 榮浩行, 内田大輔, 友田健, 松本和幸, 野間康宏, 山本直樹, 堀口繁, 原田亮, 岡田裕之, 柳井広之, 八木孝仁, 山本和秀

日本消化器病学会雑誌 112 ( 11 ) 2024 - 2034 2015年11月

記述言語：日本語出版者・発行元：(一財)日本消化器病学会

52歳女性。主訴は右上腹部痛。巨大な肝腫瘤と多発性肝腫瘤、胆嚢壁肥厚を認め、EUS-FNAにて小細胞癌と診断。エトポシド、シスプラチン併用療法が著効したため、根治目的に肝中央二区域・胆管切除術、胆嚢摘出術施行。病理では泡沫細胞の集簇を認め、viableな腫瘍細胞は認めなかった。画像、病理所見より、肝原発小細胞癌と最終診断した。化学療法著効後に根治切除でき、組織学的CRが得られた貴重な1例である。(著者抄録)

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[Radical surgery after successful chemotherapy in a case of primary small cell carcinoma of the liver]. 査読

Yutaka Akimoto, Koichiro Tsutsumi, Hironari Kato, Hidenori Hata, Hiroyuki Sakae, Daisuke Uchida, Takeshi Tomoda, Kazuyuki Matsumoto, Yasuhiro Noma, Naoki Yamamoto, Shigeru Horiguchi, Ryo Harada, Hiroyuki Okada, Hiroyuki Yanai, Takahito Yagi, Kazuhide Yamamoto

Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 112 ( 11 ) 2024 - 34 2015年11月

記述言語：日本語掲載種別：研究論文（学術雑誌）

A 52-year-old woman was admitted to our hospital with right upper quadrant pain with gallbladder wall thickening and multiple liver tumors. Endoscopic ultrasound-guided biopsy revealed small cell carcinomas of both the gallbladder and liver. After 10 cycles of chemotherapy with etoposide and cisplatin, marked shrinkage of the tumors was evident on computed tomography. The patient subsequently underwent hepatectomy and resection of the extrahepatic bile duct and gallbladder with curative intent. Although no viable tumor cells were found in the resected specimens, we confirmed phagocytosis of tumor cells killed by chemotherapy in the resected liver specimen. Therefore, we suspected that the patient had primary small cell carcinoma of the liver that had been successfully treated. This is a rare case of primary small cell carcinoma of the liver that showed pathological complete response to chemotherapy with etoposide and cisplatin.

DOI： 10.11405/nisshoshi.112.2024

PubMed

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Diagnostic value of Thallium-201 scintigraphy in differentiating malignant bone tumors from benign bone lesions 査読

Ryota Inai, Takayoshi Shinya, Akihiro Tada, Shuhei Sato, Tomohiro Fujiwara, Ken Takeda, Toshiyuki Kunisada, Hiroyuki Yanai, Toshifumi Ozaki, Susumu Kanazawa

ANNALS OF NUCLEAR MEDICINE 29 ( 8 ) 674 - 681 2015年10月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SPRINGER

This retrospective study aims to evaluate the diagnostic capacity of thallium-201 (201Tl) scintigraphy for differentiating malignant bone tumors from benign bone lesions.
Between January 2006 and December 2012, 279 patients with bone lesions (51 malignant and 228 benign) underwent 201Tl scintigraphy before treatment. To evaluate 201Tl uptake, we investigated tumor-to-background contrast (TBC) as well as TBC washout rate (WR). The differences of TBC on early and delayed images and WR were estimated by the Mann-Whitney U test. Receiver operating characteristic (ROC) analyses were used to determine the cut-off TBC values for differentiating malignant bone tumors from benign bone lesions.
There were statistically significant differences in median TBC between malignant tumors and benign lesions. These differences occurred for early imaging (1.57 vs. 0.09, p < 0.001) as well as for delayed imaging (0.83 vs. 0.07, p < 0.001). However, there was no statistical difference in WR between malignant tumors and benign lesions (44 vs. 43 %, NS). The chosen TBC cut-off value was 0.68 for early imaging and 0.38 for delayed imaging. Using these cut-off values, the prediction of malignancy had a 77 % sensitivity, 74 % specificity, and 75 % accuracy for early imaging and an 80 % sensitivity, 76 % specificity, and 77 % accuracy for delayed imaging.
201Tl scintigraphy may have the ability to distinguish malignant bone tumors from benign bone lesions.

DOI： 10.1007/s12149-015-0990-6

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Xp11.2転座型腎癌の3例

井上陽介, 高本篤, 佐々木克己, 森聰博, 有吉勇一, 小林泰之, 荒木元朗, 江原伸, 渡邉豊彦, 那須保友, 柳井広之, 黒田直人

西日本泌尿器科 77 ( 増刊 ) 142 - 142 2015年10月

腎盂原発明細胞腺癌の一例

浜田香菜, 那須篤子, 今井みどり, 松岡博美, 原田和恵, 井上博文, 藤田勝, 田中顕之, 田中健大, 市村浩一, 大森昌子, 柳井広之

日本臨床細胞学会雑誌 54 ( Suppl.2 ) 692 - 692 2015年10月

胸水に出現したEwing肉腫の一例

原田和恵, 藤田勝, 松岡博美, 今井みどり, 井上博文, 那須篤子, 浜田香菜, 田中顕之, 田中健大, 柳井広之

日本臨床細胞学会雑誌 54 ( Suppl.2 ) 628 - 628 2015年10月

超音波内視鏡下穿刺吸引法(EUS-FNA)における採取材料の色調と細胞学的特異性

井上博文, 藤田勝, 松岡博美, 今井みどり, 那須篤子, 浜田香菜, 原田和恵, 伏見聡一郎, 市村浩一, 田中顕之, 田中建大, 大森昌子, 柳井広之

日本臨床細胞学会雑誌 54 ( Suppl.2 ) 587 - 587 2015年10月

Clinicopathological heterogeneity in ovarian clear cell adenocarcinoma: a study on individual therapy practice 査読

Yuji Matsuo, Hironori Tashiro, Hiroyuki Yanai, Takuya Moriya, Hidetaka Katabuchi

MEDICAL MOLECULAR MORPHOLOGY 48 ( 3 ) 146 - 154 2015年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SPRINGER JAPAN KK

Ovarian clear cell adenocarcinoma (CCA) has been believed to be a lethal histological subtype of an epithelial ovarian adenocarcinoma (EOA); its precursor has been assumed to be endometriosis. However, it has been reported that CCAs occasionally exhibit different clinical behaviors, suggesting that CCAs might not belong to a single category. We focused on CCAs combined with other histological types of EOAs; we re-evaluated the pathology of 46 CCAs and divided them into two subgroups: 35 CCAs alone (pure-type CCAs); and 11 CCAs with other histological types, endometrioid adenocarcinomas (EAs) or/and serous adenocarcinomas (SAs) (mixed-type CCAs). Immunohistochemical analysis for expression of ARID1A, p53, PTEN, Annexin 4, hepatocyte nuclear factor-1 beta (HNF-1 beta), and WT-1 was employed. We identified that patients with endometriosis were younger than those without endometriosis in pure-type CCAs (P < 0.005). In mixed-type CCAs, the immunohistochemical-staining patterns revealed internal transition of each histological component. In pure-type CCAs, expressions of ARID1A and p53 were mutually altered, and altered expression of p53 was associated with worse prognosis than that of ARID1A (P < 0.001). Our results provide evidence that CCAs would have clinicopathological heterogeneity, determining the patient's prognosis. Furthermore, immunohistochemical analysis may shed light on the selection of appropriate treatment, including chemotherapy.

DOI： 10.1007/s00795-014-0090-z

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Both a visual and a semiquantitative analysis for differentiating benign from malignant chondrogenic bone tumors using Tc-99m (V) DMSA scintigraphy: a prospective study 査読

Takayoshi Shinya, Shuhei Sato, Toshiyuki Kunisada, Ryota Inai, Hiroyuki Yanai, Toshifumi Ozaki, Susumu Kanazawa

NUCLEAR MEDICINE COMMUNICATIONS 36 ( 8 ) 802 - 807 2015年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：LIPPINCOTT WILLIAMS & WILKINS

ObjectiveThe aims of this prospective study were to assess the relationship between tumor aggressiveness and Tc-99m (V) dimercaptosuccinic acid (DMSA) uptake in chondrogenic bone tumors and the value of Tc-99m (V) DMSA scintigraphy for differentiating benign from malignant tumors.MethodsTwenty-four patients with chondrogenic tumors (19 benign and five malignant) underwent Tc-99m DMSA (V) scintigraphy. Radiopharmaceutical uptake was classified using a three-point scale to allow a visual-only analysis, and a tumor-to-background contrast (TBC) was computed using regions of interest to provide a semiquantitative analysis. Spearman's correlation coefficient was used to assess the correlation between tumor aggressiveness and TBC. The difference in TBC between benign and malignant tumors was analyzed with the Mann-Whitney U-test. An appropriate cutoff value of TBC was chosen for the diagnosis of malignancy of a tumor using receiver operating characteristic analysis.ResultsSix benign tumors showed negative uptake (uptake score 0), whereas 13 benign tumors showed positive uptake (n=10 uptake score 1; n=3 uptake score 2). All chondrosarcomas showed positive uptake (n=2 uptake score 1; n=3 uptake score 2). A significant correlation was found between tumor aggressiveness and TBC. A significant difference was seen in TBC between benign and malignant tumors. With the chosen cutoff value of TBC equal to 0.611, the sensitivity was 80.0%, specificity was 78.9%, the positive predictive value was 50.0%, and the negative predictive value was 93.8%.ConclusionTc-99m (V) DMSA scintigraphy may have the potential to improve diagnostic methods for detecting chondrosarcomas using visual and/or semiquantitative analyses.

DOI： 10.1097/MNM.0000000000000328

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Simultaneous immunostaining with anti-S100P and anti-SV40 antibodies revealed the origin of BK virus-infected decoy cells in voided urine samples 査読

S. Ariyasu, H. Yanai, M. Sato, Y. Shinno, K. Taniguchi, I. Yamadori, Y. Miki, Y. Sato, T. Yoshino, K. Takahashi

CYTOPATHOLOGY 26 ( 4 ) 250 - 255 2015年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：WILEY-BLACKWELL

BackgroundMethods for determining the origin of BK virus (BKV)-infected cells (decoy cells) in clinical urine samples have not been established although they could enhance the diagnosis of BKV infection in immunocompromised patients.
MethodsWe performed simultaneous immunostaining with anti-S100P (a urothelial marker) and anti-SV40 antibodies in 66 clinical urine samples exhibiting SV40 positivity and a decoy-cell appearance on Papanicolaou staining. The clinical voided urine samples included seven cases of renal transplantation, 47 cases of cancer therapy and 12 cases of non-neoplastic disease. SurePath liquid-based cytology was used for the urine samples.
ResultsBKV-infected cells were categorized as SV40(+)/S100P(+) and SV40 (+)/S100p(-). SV40(+)/S100P(-) cells were found in 55 cases (83.4%); nine cases (13.6%) carried both SV40(+)/S100P(-) and SV40(+)/S100P(+) cells. The former were identified as BKV infection in renal tubules and the latter in both the renal tubules and urothelial epithelia. The remaining two cases (3.0%) had only SV40(+)/S100P(+) cells of urothelial origin.
ConclusionSimultaneous immunostaining with anti-S100P and anti-SV40 is a useful method for determining the origin of BKV-infected cells in clinical urine samples from immunocompromised patients such as renal transplantation recipients.

DOI： 10.1111/cyt.12213

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A Paraganglioma in a Hypertensive Patient with Unilateral Renal Hypoplasia 査読

Tomohiro Terasaka, Hideharu Hagiya, Kosuke Kimura, Takahiro Nada, Eri Nakamura, Yoshihisa Hanayama, Hitoshi Sugiyama, Yasuyuki Kobayashi, Hiroyuki Yanai, Fumio Otsuka

ACTA MEDICA OKAYAMA 69 ( 2 ) 119 - 122 2015年4月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：OKAYAMA UNIV MED SCHOOL

We report the case of a 46-year-old hypertensive Japanese female with renal insufficiency related to unilateral renal hypoplasia. The patient was found to have developed paraganglioma in the retroperitoneal space over a 5-year period. Catecholamine-producing tumors are not usually recognized as conditions associated with renal hypoplasia. Our long-term observation of the patient eventually led us to the diagnosis of paraganglioma. In hypertensive patients with chronic kidney disease, not only the renin-angiotensin-aldosterone system but also catecholamine activity may be involved, particularly in the patients whose cases are complicated with unilateral renal hypoplasia.

DOI： 10.18926/AMO/53341

<柳井 広之>

論文 - 柳井 広之

<柳井　広之>

論文 - 柳井　広之