研究者詳細 - 柳井　広之

論文 - 柳井　広之

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当院におけるテレパソロジーの現状.

森谷恭子, 藤村紀行, 羽原利幸, 櫛田あけみ, 園部宏, 柳井広之, 大森昌子

広島県臨床検査技師会誌 100 31 - 33 2007年

高血圧の精査にて発見されたNSE産生性副腎平滑筋肉腫の一例.

後藤順子, 大塚文男, 小寺亮, 稲垣兼一, 三好智子, 大谷寛之, 鈴木二郎, 三村由香里, 小倉俊郎, 那須保友, 柳井広之, 槇野博史

日本内分泌学会雑誌 83 242 - 245 2007年

化学療法が無効であったが、MPA療法が有効であった子宮体癌IVb期の一例.

清水美幸, 関典子, 児玉順一, 舛本明生, 松尾環, 中村圭一郎, 本郷淳司, 平松祐司, 柳井広之

日本産科婦人科学会中国四国合同地方部会雑誌 55 ( 3 ) 99 - 103 2007年

Radiofrequency ablation of normal lungs after pulmonary artery embolization with use of degradable starch microspheres: Results in a porcine model 査読

Takao Hiraki, Hideo Gobara, Jun Sakurai, Hidefumi Mimura, Takashi Mukai, Soichiro Hase, Toshihiro Iguchi, Hiroyasu Fujiwara, Nobuhisa Tajiri, Hiroyuki Yanai, Tadashi Yoshino, Susumu Kanazawa

JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY 17 ( 12 ) 1991 - 1998 2006年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：LIPPINCOTT WILLIAMS & WILKINS

PURPOSE: The present study was performed to evaluate the effect of pulmonary artery embolization on radiofrequency (RF) ablation of normal porcine lungs.
MATERIALS AND METHODS: RF ablation zones (n = 34) were created in the normal lungs of five domestic pigs (five zones in each of the first two pigs and eight zones in each of the remaining three pigs) with an expandable multitined electrode with use of bilateral thoracotomy. RF ablation was performed without pulmonary artery embolization (group 1, n = 8), immediately after embolization (group 2, n = 11),15 minutes after embolization (group 3, n = 7), and 30 minutes after embolization (group 4, n = 8) with degradable starch microspheres. Among them, 12 ablation zones were excluded from this study because they were considerably limited by the presence of the pleura or large bronchi. The remaining 22 zones were included (n = 7, n = 5, n = 4, and n = 6 in groups 1, 2, 3, and 4, respectively). Coagulation necrosis volumes in the ablation zones were measured and compared among the groups.
RESULTS: Coagulation necrosis volumes were 0.9 +/- 0.5 cm(3), 2.1 +/- 0.4 cm(3), 2.1 +/- 1.0 cm(3), and 1.9 +/- 0.6 cm(3) in groups 1, 2, 3, and 4, respectively. Groups 2-4 showed significantly larger coagulation volumes than group 1 (P = .012, P = .023, and P = .010 in groups 2, 3, and 4, respectively).
CONCLUSION: Pulmonary artery embolization contributed to larger volumes of coagulation necrosis after RF ablation of normal lungs.

DOI： 10.1097/01.RVI.0000251152.12254.AC

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Follicular lymphoma frequently originates in the salivary gland. 査読国際誌

Satoko Nakamura, Koichi Ichimura, Yumiko Sato, Shigeo Nakamura, Hirokazu Nakamine, Hiroshi Inagaki, Yoshito Sadahira, Koichi Ohshima, Sumie Sakugawa, Eisaku Kondo, Hiroyuki Yanai, Nobuya Ohara, Tadashi Yoshino

Pathology international 56 ( 10 ) 576 - 83 2006年10月

記述言語：英語掲載種別：研究論文（学術雑誌）

The aim of the present study was to examine the clinicopathological presentations of follicular lymphomas (FL) of the salivary glands, as compared to mucosa-associated lymphoid tissue (MALT) lymphomas. A total of 27 primary salivary gland lymphomas were examined: 6 FL (five, grade 1; one, grade 2); 19 MALT lymphomas; and two diffuse large B-cell lymphomas. The FL patients ranged in age from 24 to 73 years, with a mean of 49 years, which was younger than that of MALT patients (mean: 64 years; P < 0.05). Four of the six FL arose from the submandibular gland, which was the origin of only five out of a total of 19 MALT lymphomas. One FL patient was in clinical stage (CS) IE, two in CS IIE, and two in CS III and IV. As regards the MALT lymphoma patients, 13 (68%) were in CS IE and five (26%) in CS IIE. None of the FL patients had clinical diagnosis of autoimmune disease but eight MALT lymphoma patients had autoimmune disease. The present study found a relatively high incidence of FL in the salivary glands. The observed differences in age of onset, background of autoimmune disease, and lesion site suggests that the pathogenesis of FL may differ from that of MALT lymphoma.

DOI： 10.1111/j.1440-1827.2006.02011.x

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Calcifying fibrous tumor arising from the heart 査読

Hisayuki Shigematsu, Yoshifumi Sano, Shingo Kasahara, Hiroyuki Yanai, Hiroshi Date

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY 132 ( 3 ) 2006年9月

Accurate diagnosis of musculoskeletal lesions by core needle biopsy 査読

G Mitsuyoshi, N Naito, A Kawai, T Kunisada, A Yoshida, H Yanai, S Dendo, T Yoshino, S Kanazawa, T Ozaki

JOURNAL OF SURGICAL ONCOLOGY 94 ( 1 ) 21 - 27 2006年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：WILEY-LISS

Background: Percutaneous needle biopsy has many advantages over open biopsy in the treatment of neoplasms. However, the accuracy of needle biopsy in the diagnosis of musculoskeletal lesions has not yet been established. Here, we evaluate the accuracy and limitations of the procedure for musculloskeletal lesions.
Methods: The diagnoses of 163 needle biopsies (bone, 91; soft tissue, 72) performed on 157 consecutive patients using a Jamshidi needle or an Ostycut needle for bone lesions, or a Tru-cut needle for soft tissue lesions were compared with the final diagnoses made by open biopsy and/or a definitive operation.
Results: One hundred forty-three specimens (88%) were determined to be adequate for histological examination. Obtaining undamaged cores from very hard bony lesions or sclerotic cyst walls proved difficult. A pathologist with experience in musculoskeletal lesions was able to differentiate malignant tumors from benign lesions in 97% of the cases (bone, 100%; soft tissue, 94%) and arrive at a specific diagnosis in 88% (bone, 96%; soft tissue, 78%) when adequate cores were obtained. Differentiating a well-differentiated liposarcoma from a benign lipoma and inflammatory lesions from benign tumorous conditions, was difficult. The overall accuracy was 77% (bone, 85%; soft tissue, 68%). There was no morbidity related to the procedure.
Conclusion: The results indicate that needle biopsy is safe and accurate for diagnosing musculoskeletal lesions.

DOI： 10.1002/jso.20504

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Mutations of epidermal growth factor receptor and K-ras genes in adenosquamous carcinoma of the lung 査読

S Toyooka, Y Yatabe, M Tokumol, K Ichimura, H Asano, K Tomii, H Yanai, H Date, T Mitsudomi, N Shimizu

INTERNATIONAL JOURNAL OF CANCER 118 ( 6 ) 1588 - 1590 2006年3月

p53 protein transduction therapy: Successful targeting and inhibition of the growth of the bladder cancer cells 査読

Miyabi Inoue, Kazuhito Tomizawa, Masayuki Matsushita, Yun-Fei Lu, Teruhiko Yokoyama, Hiroyuki Yanai, Atsushi Takashima, Hiromi Kumon, Hideki Matsui

European Urology 49 ( 1 ) 161 - 168 2006年1月

記述言語：英語掲載種別：研究論文（学術雑誌）

Introduction: Virus-mediated gene therapy for bladder cancer has some problems, such as efficiency of gene delivery and safety issues. We have reported that poly-arginine peptide (11R) has the ability to increase protein transduction in cells. Here, we show that p53 protein transduction using 11R is useful for targeting to bladder tumors and suppressing the growth of bladder cancer cells. Materials and methods: An 11R-fused p53 protein (11R-p53) was transduced in bladder cancer cell lines (J82 and T24) to evaluate the anti-tumor effect. Cell viability was assessed by performing the 4-[3-(4-iodophenyl)-2-(4- nitrophenyl)-2H-5-tetrazolio]-1,3-benzene disulfonate (WST) assay. To investigate whether 11R-p53 enhanced the effect on anti-cancer drug-dependent apoptosis of bladder cancer cells, the cell lines were cotreated with 11R-p53 and cis-diaminedichloroplatinum (CDDP). Apoptotic cells were identified using Hoechst staining. To investigate the efficiency of protein transduction mediated by 11R in bladder tumors in vivo, SCID mice were transplanted with J82 cells in the bladder and 11R-GFP was transurethrally transduced into the bladder. The transduction of 11R-GFP in the tumor was examined by confocal microscopy. Results: 11R-p53 inhibited the growth of both J82 and T24 cells in a dose-dependent manner. The transduction of 11R-p53 enhanced CDDP-dependent induction of apoptosis. Transurethral application of 11R-GFP resulted in transduction of GFP in bladder tumors but not in the normal bladder epithelium or subepithelial tissues. Conclusion: The present results suggest that p53 protein transduction therapy may be a promising method for the treatment of bladder cancer. © 2005 Elsevier B.V. All rights reserved.

DOI： 10.1016/j.eururo.2005.08.019

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乳癌術前化学療法の効果判定における画像診断われわれが経験した病理判定と画像診断の不一致症例について

松岡順治, 田渕陽子, 伊藤充矢, 小野亮子, 今田孝子, 元木崇之, 松川啓義, 大森昌子, 柳井広之, 猶本良夫, 田中紀章

岡山医学会雑誌 2006年

Expression of phosphorylated Ser70 of Bcl-2 correlates with malignancy in human colorectal neoplasms. 査読国際誌

Eisaku Kondo, Takayoshi Miyake, Masao Shibata, Toshikazu Kimura, Hiromi Iwagaki, Shin-Ichi Nakamura, Takehiro Tanaka, Nobuya Ohara, Koichi Ichimura, Takashi Oka, Hiroyuki Yanai, Futoshi Shibasaki, Tadashi Yoshino

Clinical cancer research : an official journal of the American Association for Cancer Research 11 ( 20 ) 7255 - 63 2005年10月

記述言語：英語

PURPOSE: Bcl-2 is a model apoptosis suppressor postulated to promote tumorigenesis. Recently, it has been reported that Bcl-2 undergoes phosphoregulation of its Ser70 to substantially alter its molecular function. Previous studies further suggest that such phospho-Bcl-2 regulation may influence tumor progression in colorectal and other cancers; however, phosphorylation status of the Ser70 of Bcl-2 (pSer70) in vivo in tumors remains obscure. To elucidate this question that may suggest the biological role, we molecularly screened a panel of human colorectal adenomas and adenocarcinomas for endogenous expression of pSer70 Bcl-2. EXPERIMENTAL DESIGN: An antibody specific against pSer70 Bcl-2 was generated for thorough immunohistochemical examination of paraffin-embedded tumor specimens, allowing detection of the endogenously expressed antigen among a range of Bcl-2-positive colorectal neoplasms, including 75 tubular adenomas, 114 adenocarcinomas, and 15 cases of cancer in adenomas. RESULTS: Loss of pSer70 Bcl-2 expression was observed in adenocarcinomas in a differentiation-dependent manner (positivities: well differentiated 63%, moderately differentiated 52%, and poorly differentiated 12%), whereas tubular adenomas maintained their expression (positivity 88%). Interestingly, an inverse correlation was found between expression of pSer70 Bcl-2 and Ki-67 antigen in those cases of cancer in adenoma (P < 0.01). It was further observed that loss of pSer70 Bcl-2 expression was associated with significantly shorter survival (P < 0.05) and correlated with clinical stages and lymph node metastasis (P < 0.05 and P < 0.05, respectively). CONCLUSIONS: Loss of pSer70 Bcl-2 expression is closely linked to biological aggressiveness in colorectal tumors and represents a statistically significant molecular index for prognosis of patients with these tumors.

DOI： 10.1158/1078-0432.CCR-05-0274

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A case of monoclonal immunoglobulin light- and heavy-chain deposition disease exhibiting atypical deposition with fibrillary structures, successfully treated with chemotherapy 査読

A Nakatsuka, Y Maeshima, A Sarai, H Yanai, H Sugiyama, Y Yamasaki, H Makino

CLINICAL NEPHROLOGY 64 ( 3 ) 221 - 227 2005年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：DUSTRI-VERLAG DR KARL FEISTLE

We report a case of light and heavy chain deposition disease (LHCDD), a rather rare monoclonal immunoglobulin deposition disease (MIDD) with successful therapeutic effect. A 58-year-old woman suffered from proteinuria and renal insufficiency (serum creatinine 1.0 mg/dl, creatinine clearance 49.2 ml/min) in February 2003. In serum and urine samples, monoclonal IgG-kappa was detected. A bone marrow aspiration showed a slightly hypocellular marrow and plasma cell population was increased to 7.0%. Renal histological findings revealed lobulated glomeruli with nodular lesions on light microscopy, characteristic findings of MIDD. Intense deposition of IgG heavy chains in the linear pattern in the glomerular and tubular basement membranes was observed. Immunohistochemistry revealed both kappa and lambda light chain depositions in glomeruli. Electron-microscopic examination revealed fine granular electron-dense deposits accompanied by microfibrils. Based on these findings, this patient was diagnosed as LHCDD. She received three courses of melphalan and prednisone chemotherapy, resulting in disappearance of proteinuria, prevention of renal functional deterioration and the decrease of monoclonal immunoglobulin. This case clearly demonstrates that the earlier and accurate diagnosis and initiation of chemotherapy at the early stage with serum creatinine level below 4.0 mg/dl are necessary to improve renal and patient outcome.

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多発性の後腹膜神経節細胞腫(ganglioneuroma)の１例.

平木隆夫, 三村秀文, 柳井広之, 郷原英夫, 向井敬, 長谷聡一郎, 藤原寛康, 金澤右

臨床放射線 50 ( 3 ) 425 - 429 2005年

記述言語：日本語出版者・発行元：金原出版(株)

31歳男.右側腹部痛を契機に腹部CTにて右後腹膜腫瘍を認めた.腫瘍マーカーに異常を認めず,副腎皮質ホルモン関連検査にも異常はなく,カテコラミン関連検査にも異常を認めなかった.CT所見では右腎臓と肝の間に12×8×12cmの境界明瞭,辺縁整で一部が分葉状の腫瘍を認め,周囲への浸潤傾向は認められなかった.MRIではT1強調像では内部均一,T2強調像では内部不均一な被膜様構造を持つ腫瘍像を呈し,血管造影所見では乏血管性で腫瘍血管の明らかな不整像は認めなかった.ガリウムシンチでは腫瘍への集積像は認められなかった.手術により2つの腫瘍が接して生じていたことが確認され,病理組織学的に神経節細胞腫と診断された

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充実部分を伴う子宮広間膜腫瘍（いわゆる傍卵巣腫瘍）の二例.

関典子, 児玉順一, 中村洋二郎, 中村圭一郎, 本郷淳司, 水谷靖司, 平松祐司, 柳井広之

日本産科婦人科学会中国四国合同地方部会雑誌 53 264 - 269 2005年

大腸癌1,026例の臨床病理学的検討

小野田正, 小林直広, 大野聡, 元木崇之, 原野雅生, 佐々木, 寛, 青木秀樹, 塩崎滋弘, 桧垣健二, 池田俊行, 二宮基樹, 高倉範尚, 柳井広之, 松浦博夫

広島医学 2003年

Sentinel Node Biopsy(SNB)に基づいた腋窩非郭清手術の現状と問題点

桧垣健二, 黒田, 新士, 窪田, 康浩, 原野, 雅生, 佐々木, 寛, 二宮, 基樹, 高倉, 範尚, 影本正之, 柳井, 広之, 松浦, 博夫

乳癌の臨床 18 ( 6 ) 515 - 522 2003年

記述言語：日本語出版者・発行元：(株)篠原出版新社

Sentinel Node Biopsy(SNB)に基づいた腋窩非郭清手術の現状と問題点を検討した.対象は,腫瘍径が3cm以下の臨床的に腋窩リンパ節がないと判断された乳癌195例であった.術中の迅速病理検査の転移陰性は149例で,腋窩の非郭清手術が施行され,術後のもどしHE染色検査で8例(4.1%)が転移陽性と修正された.最終的に141例(72.3%)が腋窩郭清を省略し,46例(23.6%)にレベル2の腋窩郭清が施行された.腋窩非郭清手術後に腋窩リンパ節の再発は認めず,遠隔転移を149例中1例(0.7%)に認め,乳房温存手術後の温存乳房再発は133例中1例(0.8%)で腋窩再手術が行われたが,摘出リンパ節に転移は認めなかった.偽陰性症例8例は放射線照射が選択された.術後の経過観察期間は3.5〜39.0ヵ月(平均19.0ヵ月)で全例健在である.SNBに基づいた非郭清手術の実施では偽陽性症例の減少させることが必要と考えられた

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タモキシフェン投与中の女性に生じた子宮内膜ポリープ内carcinosarcoma.

柳井, 広之, 松浦, 博夫

岡山外科病理雑誌 2003年

急性壊死性好酸球性心筋炎の一剖検例

柳井広之, 松浦博夫, 白神邦浩

病理と臨床 2002年

Ovarian stromal tumor with minor sex cord elementsの１例

柳井広之, 松浦博夫

岡山外科病理雑誌 2002年

卵巣外発生と考えられた莢膜細胞腫の１例

柳井広之

日本婦人科腫瘍学会雑誌 2002年

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