Faculty Profiles - TAKIGAWA Masaharu

Papers - TAKIGAWA Masaharu

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THE DIFFERENCE BETWEEN THE EFFECTS OF SINGLE AND DOUBLE APPLICATIONS OF 12-O-TETRADECANOYLPHORBOL-13-ACETATE, A POTENT TUMOR PROMOTER, ON POLYAMINE METABOLISM AND NUCLEIC-ACID SYNTHESIS IN MOUSE EPIDERMIS Reviewed

M TAKIGAWA, RC SIMSIMAN, RK BOUTWELL

CARCINOGENESIS 4 ( 1 ) 5 - 7 1983

INHIBITION OF MOUSE SKIN TUMOR PROMOTION AND OF PROMOTER-STIMULATED EPIDERMAL POLYAMINE BIOSYNTHESIS BY ALPHA-DIFLUOROMETHYLORNITHINE Reviewed

M TAKIGAWA, AK VERMA, RC SIMSIMAN, RK BOUTWELL

CANCER RESEARCH 43 ( 8 ) 3732 - 3738 1983

POLYAMINE BIOSYNTHESIS AND SKIN TUMOR PROMOTION - INHIBITION OF 12-O-TETRADECANOYLPHORBOL-13-ACETATE-PROMOTED MOUSE SKIN TUMOR-FORMATION BY THE IRREVERSIBLE INHIBITOR OF ORNITHINE DECARBOXYLASE ALPHA-DIFLUOROMETHYLORNITHINE Reviewed

M TAKIGAWA, AK VERMA, RC SIMSIMAN, RK BOUTWELL

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 105 ( 3 ) 969 - 976 1982

RESTORATION BY CYCLIC-AMP OF THE DIFFERENTIATED PHENOTYPE OF CHONDROCYTES FROM DEDIFFERENTIATED CELLS PRETREATED WITH RETINOIDS Reviewed

M TAKIGAWA, T TAKANO, F SUZUKI

MOLECULAR AND CELLULAR BIOCHEMISTRY 42 ( 3 ) 145 - 153 1982

SIMULATION OF THE INITIAL-STAGE OF ENDOCHONDRAL OSSIFICATION - INVITRO SEQUENTIAL CULTURE OF GROWTH CARTILAGE CELLS AND BONE-MARROW CELLS Reviewed

F SUZUKI, T TAKASE, M TAKIGAWA, A UCHIDA, Y SHIMOMURA

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 78 ( 4 ) 2368 - 2372 1981

Effects of parathyroid hormone and cyclic AMP analogues on the activity of ornithine decarboxylase and expression of the differentiated phenotype of chondrocytes in culture Reviewed

M. Takigawa, T. Takano, F. Suzuki

Journal of Cellular Physiology 106 ( 2 ) 259 - 268 1981

Language：English Publishing type：Research paper (scientific journal)

Parathyroid hormone (PTH) greatly increased the level of adenosine 3′,5′ cyclic monophosphate (cAMP) in rabbit costal chondrocytes in culture 2 minutes after its addition. PTH, as well as N6 O2' dibutyryl adenosine 3′,5′ cyclic monophosphate (DBcAMP) and 8 Bromo adenosine 3′,5′ cyclic monophosphate (8 Br‐cAMP) induced ornithine decarboxylase (ODC
L‐ornithine carboxylyase
EC 4.1.1.17), which reached a maximum 4 hours after their addition. Neither cAMP, N6 O2′ dibutyryl guanosine 3′,5′ cyclic monophosphate (DBcGMP), nor sodium butyrate increased the activity of the enzyme. PTH had no effect on DNA synthesis, while DBcAMP and 8 Br‐cAMP decreased DNA synthesis. Expression of the differentiated phenotype of chondrocytes in culture was also induced by PTH, DBcAMP, and 8 Br‐cAMP, but not by cAMP, DBcGMP, or sodium butyrate, as judged by morphological change. Glycosaminoglycan synthesis, a characteristic of the cartilage phenotype, began to increase 8 hours after addition of PTH or DBcAMP, reaching a plateau 32 hours after their addition. These findings suggest that PTH induces increase of ODC activity and expression of the differentiated phenotype of chondrocytes through increase of cAMP and that induction of ODC is closely related to expression of the differentiated phenotype of chondrocytes. Copyright © 1981 Wiley‐Liss, Inc.

DOI： 10.1002/jcp.1041060212

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ROLE OF POLYAMINES IN EXPRESSION OF THE DIFFERENTIATED PHENOTYPE OF CHONDROCYTES IN CULTURE Reviewed

T TAKANO, M TAKIGAWA, F SUZUKI

MEDICAL BIOLOGY 59 ( 5-6 ) 423 - 427 1981

POLYAMINE AND DIFFERENTIATION - INDUCTION OF ORNITHINE DECARBOXYLASE BY PARATHYROID-HORMONE IS A GOOD MARKER OF DIFFERENTIATED CHONDROCYTES Reviewed

M TAKIGAWA, H ISHIDA, T TAKANO, F SUZUKI

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 77 ( 3 ) 1481 - 1485 1980

Changes in polyamine metabolism of rat liver after administration of D-galactosamine : Favorable effects of putrescine administration on galactosmaine-induced hepatic injury. Reviewed

Daikuhara, Y, Tamada, F, Takigawa, M, Takeda, Y, Mori, Y

Gastroenterology 77 123 - 132 1980

Induction by parathyroid hormone of ornithine decarboxylase in rabbit costal chondrocytes in culture. Reviewed

Takigawa, M, Watanabe, R, Ishida, H, Asada, A, Suzuki, F

J.Biochem. 85 311 - 314 1979

The role of putrescine in cell proliferation on the skin of mice induced by ethyl-phenylpropiolate. Reviewed

Takigawa, M, Inoue, H, Gohda, E, Asada, A, Takeda, Y, Mori, Y

Exp.Mol.Pathol. 27 183 - 196 1977

Effect of DL-α-hydrazino-δ-aninovalerric acid,an inhibitor of ornithine decarboxlase,on polyamine metabolism in isoproterenol-stimulated mouse parotid glands. Reviewed

Inoue, H, Kato, Y, Takigawa, M, Adachi K, Takeda, Y

J.Biochem. 77 879 - 893 1975

軟骨培養細胞株の樹立。 Invited

滝川正春

組織培養 15 165 - 169 1900

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Papers - TAKIGAWA Masaharu