Faculty Profiles - TAKIGAWA Masaharu

Papers - TAKIGAWA Masaharu

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A FACTOR IN CONDITIONED MEDIUM OF RABBIT COSTAL CHONDROCYTES INHIBITS THE PROLIFERATION OF CULTURED ENDOTHELIAL-CELLS AND ANGIOGENESIS INDUCED BY B-16 MELANOMA - ITS RELATION WITH CARTILAGE-DERIVED ANTITUMOR FACTOR (CATF) Reviewed

M TAKIGAWA, E SHIRAI, M ENOMOTO, HO PAN, F SUZUKI, T SHIIO, Y YUGARI

BIOCHEMISTRY INTERNATIONAL 14 ( 2 ) 357 - 363 1987.2

THE EFFECT OF PARATHYROID-HORMONE (1-34) ON CYCLIC-AMP LEVEL, ORNITHINE DECARBOXYLASE ACTIVITY, AND GLYCOSAMINOGLYCAN SYNTHESIS OF CHRONDROCYTES FROM MANDIBULAR CONDYLAR CARTILAGE, NASAL SEPTAL CARTILAGE, AND SPHENO-OCCIPITAL SYNCHONDROSIS IN CULTURE Reviewed

T TAKANO, M TAKIGAWA, E SHIRAI, K NAKAGAWA, M SAKUDA, F SUZUKI

JOURNAL OF DENTAL RESEARCH 66 ( 1 ) 84 - 87 1987.1

Effects of various tumor promoters on expression of cartilage phenotypes in rabbit costal chondrocytes in culture Reviewed

Masaharu Takigawa, Koji Tajima, Keisuke Fukuo, Hirota Fujiki, Fujio Suzuki

Journal of Biochemistry 101 ( 2 ) 397 - 404 1987

Language：English Publishing type：Research paper (scientific journal) Publisher：Oxford University Press

12-O-Tetradecanoylphorbol-13-acetate (TPA), a skin tumor-promoting phorbol ester, and teleocidin and aplysiatoxin, which are potent tumor promoters in mouse skin but are chemically unrelated to phorbol esters, induced change of cultured rabbit costal chondrocytes from a polygonal to a fibroblastic shape and inhibited glycosaminoglycan (GAG) synthesis and metachromatic matrix formation in these cells. The potencies of teleocidin and aplysiatoxin to inhibit GAG synthesis were almost the same as that of TPA. On the other hand, Tween 60 and cantharidin, weak mouse skin tumor promoters, phenobarbital, a liver tumor promoter, and saccharin, a bladder tumor promoter, had no effect on the morphology or GAG synthesis of cultured chondrocytes. Like TPA, teleocidin and aplysiatoxin increased DNA and RNA syntheses of chondrocytes. Parathyroid hormone (PTH) and dibutyryl cyclic AMP reversed the morphological and histochemical changes caused by a 4-day treatment with teleocidin or aplysiatoxin as well as with TPA, reversal being apparent after 2 days. PTH increased intracellular cyclic AMP after 2 min in chondrocytes pretreated with teleocidin or aplysiatoxin as well as with TPA. PTH also increased ornithine decarboxylase [ODC
EC 4.1.1.17] activity in these chondrocytes after 4 h. These results show that retention of responsiveness to PTH is a typical characteristic of chondrocytes dedifferentiated by treatment with TPA-type tumor promoters such as TPA, teleocidin and aplysiatoxin. The results also suggest that ODC induction mediated by elevation of cyclic AMP plays an important role in re-differentiation of teleocidin- and aplysiatoxin-treated chondrocytes. © 1987 The Journal of Biochemistry.

DOI： 10.1093/oxfordjournals.jbchem.a121924

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COMPARISON OF INHIBITION BY A TUMOR PROMOTER (12-O-TETRADECANOYLPHORBOL-13-ACETATE) OF EXPRESSION OF THE DIFFERENTIATED PHENOTYPE OF CHONDROCYTES IN RABBIT COSTAL CHONDROCYTES IN CULTURE WITH INHIBITION BY RETINOIC ACID Reviewed

K FUKUO, M TAKIGAWA, K TAJIMA, M ENOMOTO, Y KUMAHARA, F SUZUKI

JOURNAL OF BIOCHEMISTRY 99 ( 2 ) 385 - 396 1986.2

TUMOR PROMOTER-INDUCED REFRACTORY STATE AGAINST ORNITHINE DECARBOXYLASE INDUCTION BY 12-O-TETRADECANOYLPHORBOL-13-ACETATE IN MOUSE EPIDERMIS Reviewed

M TAKIGAWA, RC SIMSIMAN, RK BOUTWELL

CANCER RESEARCH 46 ( 1 ) 106 - 112 1986.1

Differential effects of parathyroid hormone and somatomedin-like growth factors on the sizes of proteoglycan monomers and their synthesis in rabbit costal chondrocytes in culture

Yuji Hiraki, Yasutaka Yutani, Masaharu Takigawa, Yukio Kato, Fujio Suzuki

BBA - Molecular Cell Research 845 ( 3 ) 445 - 453 1985.6

Language：English Publishing type：Research paper (scientific journal)

In the proteoglycans extracted from rabbit costal chondrocytes in culture, two populations of proteoglycans were distinguished by density gradient centrifugation under dissociative conditions. The major component was the faster sedimenting population (proteoglycan I), the putative 'cartilage-specific' proteoglycans, and the minor component was the slower sedimenting population (proteoglycan II). The monomeric size of proteoglycan I was closely related to the differentiation-state of chondrocytes and was a good marker of the differentiated chondrocytes. Treatment of the cultures with parathyroid hormone (PTH) induced an increase in the monomeric size of proteoglycan I. This increase was ascribed to an increase in the molecular size of the glycosaminoglycan chain in proteoglycan I. On the other hand, somatomedin-like growth factors, such as multiplication-stimulating activity (MSA) and cartilage-derived factor (CDF), did not affect the size of proteoglycan I, while they markedly stimulated the synthesis of proteoglycan I. In contrast, treatment with nonsomatomedin growth factors, such as fibroblast growth factor (FGF) and epidermal growth factor (EGF), resulted in not only a decrease in glycosaminoglycan synthesis but also a slight decrease in size of proteoglycan I. However, synthesis and size of proteoglycan II were little affected by these agents. Thus, the present study clearly shows that PTH and somatomedin-like growth factors have differential functions in bringing about the expression of the differentiated phenotype of chondrocytes: PTH influences chain elongation and termination of glycosaminoglycans in proteoglycan I, while somatomedin-like growth factors affect primarily the synthesis and secretion of proteoglycan I. © 1985.

DOI： 10.1016/0167-4889(85)90210-1

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INDUCTION OF SPERMIDINE SPERMINE N1-ACETYLTRANSFERASE BY PARATHYROID-HORMONE IN RABBIT COSTAL CHONDROCYTES IN CULTURE Reviewed

MATSUIYUASA, I, S OTANI, S MORISAWA, M TAKIGAWA, M ENOMOTO, F SUZUKI

JOURNAL OF BIOCHEMISTRY 97 ( 1 ) 387 - 390 1985

CARTILAGE-DERIVED ANTI-TUMOR FACTOR (CATF) INHIBITS THE PROLIFERATION OF ENDOTHELIAL-CELLS IN CULTURE Reviewed

M TAKIGAWA, E SHIRAI, M ENOMOTO, Y HIRAKI, M FUKUYA, F SUZUKI, T SHIIO, Y YUGARI

CELL BIOLOGY INTERNATIONAL REPORTS 9 ( 7 ) 619 - 625 1985

DIFFERENTIAL-EFFECTS OF PARATHYROID-HORMONE AND SOMATOMEDIN-LIKE GROWTH-FACTORS ON THE SIZES OF PROTEOGLYCAN MONOMERS AND THEIR SYNTHESIS IN RABBIT COSTAL CHONDROCYTES IN CULTURE Reviewed

Y HIRAKI, Y YUTANI, M TAKIGAWA, Y KATO, F SUZUKI

BIOCHIMICA ET BIOPHYSICA ACTA 845 ( 3 ) 445 - 453 1985

STIMULATION BY GLUCOCORTICOIDS OF THE DIFFERENTIATED PHENOTYPE OF CHONDROCYTES AND THE PROLIFERATION OF RABBIT COSTAL CHONDROCYTES IN CULTURE Reviewed

T TAKANO, M TAKIGAWA, F SUZUKI

JOURNAL OF BIOCHEMISTRY 97 ( 4 ) 1093 - 1100 1985

DIFFERENTIATION AND DE-DIFFERENTIATION OF CULTURED CHONDROCYTES - INCREASE IN MONOMERIC SIZE OF CARTILAGE-SPECIFIC PROTEOGLYCANS BY DIBUTYRYL CYCLIC-AMP AND COMPLETE INHIBITION OF THEIR SYNTHESIS BY RETINOIC ACID Reviewed

Y HIRAKI, Y YUTANI, M FUKUYA, M TAKIGAWA, F SUZUKI

BIOCHEMISTRY INTERNATIONAL 10 ( 2 ) 267 - 272 1985

EFFECTS OF SYNTHETIC ANALOGS AND FRAGMENTS OF BOVINE PARATHYROID-HORMONE ON ADENOSINE-3',5'-MONOPHOSPHATE LEVEL, ORNITHINE DECARBOXYLASE ACTIVITY, AND GLYCOSAMINOGLYCAN SYNTHESIS IN RABBIT COSTAL CHONDROCYTES IN CULTURE - STRUCTURE-ACTIVITY RELATIONS Reviewed

T TAKANO, M TAKIGAWA, E SHIRAI, F SUZUKI, M ROSENBLATT

ENDOCRINOLOGY 116 ( 6 ) 2536 - 2542 1985

STUDIES ON CHONDROCYTES FROM MANDIBULAR CONDYLAR CARTILAGE, NASAL SEPTAL CARTILAGE, AND SPHENO-OCCIPITAL SYNCHONDROSIS IN CULTURE .1. MORPHOLOGY, GROWTH, GLYCOSAMINOGLYCAN SYNTHESIS, AND RESPONSIVENESS TO BOVINE PARATHYROID-HORMONE (1-34) Reviewed

M TAKIGAWA, M OKADA, T TAKANO, H OHMAE, M SAKUDA, F SUZUKI

JOURNAL OF DENTAL RESEARCH 63 ( 1 ) 19 - 22 1984

Cartilage derived anti-tumor factor(CATF) : A high morecular weight in cartilage extract inhibits tumor growth. Reviewed

Suzuki, F, Takigawa, M, Hiraki, Y, Kato, Y, Fukuo, K. Shiio, T, Yugari, Y

J.Bone Mineral Metab. 2 231 - 235 1984

CYTOSKELETON AND DIFFERENTIATION - EFFECTS OF CYTOCHALASIN B AND COLCHICINE ON EXPRESSION OF THE DIFFERENTIATED PHENOTYPE OF RABBIT COSTAL CHONDROCYTES IN CULTURE Reviewed

M TAKIGAWA, T TAKANO, E SHIRAI, F SUZUKI

CELL DIFFERENTIATION 14 ( 3 ) 197 - 204 1984

INHIBITION OF POLYAMINE SYNTHESIS AND PROLIFERATION IN MOUSE L-CELLS BY DL-ALPHA-HYDRAZINO-DELTA-AMINOVALERIC ACID, AN INHIBITOR OF ORNITHINE DECARBOXYLASE Reviewed

E GOHDA, M TAKIGAWA, H INOUE, Y KATO, Y DAIKUHARA, Y TAKEDA

JOURNAL OF BIOCHEMISTRY 94 ( 1 ) 97 - 106 1983

PURIFICATION OF 12-O-TETRADECANOYLPHORBOL-13-ACETATE-INDUCED ORNITHINE DECARBOXYLASE FROM MOUSE EPIDERMIS Reviewed

FW PERRELLA, M TAKIGAWA, RK BOUTWELL

INTERNATIONAL JOURNAL OF BIOCHEMISTRY 15 ( 7 ) 885 - 889 1983

A bioassay for parathyroid hormone using rabbit costal chondrocytes in culture. Reviewed

Takano, T, Takigawa, M, Suzuki, F

Jpn.J.Oral.Biol. 25 394 - 397 1983

RESTORATION BY PARATHYROID-HORMONE AND DIBUTYRYL-CYCLIC-AMP OF EXPRESSION OF THE DIFFERENTIATED PHENOTYPE OF CHONDROCYTES INHIBITED BY A TUMOR PROMOTER, 12-0-TETRADECANOYLPHORBOL-13-ACETATE Reviewed

M TAKIGAWA, K FUKUO, T TAKANO, F SUZUKI

CELL DIFFERENTIATION 13 ( 4 ) 283 - 291 1983

ROLE OF POLYAMINES IN EXPRESSION OF THE DIFFERENTIATED PHENOTYPE OF CHONDROCYTES - EFFECT OF DL-ALPHA-HYDRAZINO-DELTA-AMINOVALERIC ACID (DL-HAVA), AN INHIBITOR OF ORNITHINE DECARBOXYLASE, ON CHONDROCYTES TREATED WITH PARATHYROID-HORMONE Reviewed

T TAKANO, M TAKIGAWA, F SUZUKI

JOURNAL OF BIOCHEMISTRY 93 ( 2 ) 591 - 598 1983

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