Faculty Profiles - NAKANO Michiyo

MISC - NAKANO Michiyo

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Streptococcus mutans形態決定遺伝子と齲蝕原性との関連について

柳田可奈子, 高島由紀子, 藤田一世, 仲野道代

岡山歯学会雑誌 32 ( 2 ) 82 - 82 2013.12

Streptococcus mutans GbpAのバイオフィルム形成における役割

松三友紀, 藤田一世, 高島由紀子, Arifah Chieko Ardin, 仲野道代

岡山歯学会雑誌 32 ( 2 ) 82 - 83 2013.12

重度両側性辰顎口蓋裂患者に対し、上顎両側犬歯のTransport distraction osteogenesisを用いて良好な治療結果を得た一例

古森紘基, 柳田剛志, 松村達志, 柳田可奈子, 仲野道代, 飯田征二, 上岡寛, 山城隆

岡山歯学会雑誌 32 ( 2 ) 79 - 80 2013.12

ウーロン茶ポリフェノールの齲蝕抑制効果とそのメカニズム

仲野道代

Journal of Oral Biosciences Supplement 2013 105 - 105 2013.9

Characterization of ammonium transporter operon in Streptococcus mutans and its role in biofilm formation

ARDIN Arifah Chieko, NAKANO Michiyo, FUJITA Kazuyo, NAKANO Kazuhiko

51 ( 2 ) 171 - 171 2013.4

Relationship between bacteriocin production and biofilm formation in Streptococcus mutans

NAGAYAMA Kayoko, NAKANO Michiyo, ARDIN Arifah Chieko, FUJITA Kazuyo, NAKANO Kazuhiko

51 ( 2 ) 169 - 169 2013.4

Streptococcus mutansにおける細胞膜輸送に関連する調節遺伝子の分布

森川優子, 高島由紀子, Ardin Arifah Chieko, 藤田一世, 仲野道代

小児歯科学雑誌 51 ( 2 ) 283 - 283 2013.4

Streptococcus mutansのプロテオーム解析による表層タンパク発現メカニズムの検討

松三友紀, 稲垣暁子, 藤田一世, 仲野道代

小児歯科学雑誌 51 ( 2 ) 168 - 168 2013.4

乳酸菌種によるバイオフィルム形性能の検討

藤田一世, 松三友紀, 高島由紀子, 仲野道代

小児歯科学雑誌 51 ( 2 ) 170 - 170 2013.4

混合歯列期における突発性のエナメル質形成不全への対応

高木淳史, 平野慶子, 仲野道代

小児歯科学雑誌 51 ( 2 ) 254 - 254 2013.4

Streptococcus mutansのグルカン結合タンパクCの構造による性状の比較

高島由紀子, 藤田一世, 仲野道代

小児歯科学雑誌 51 ( 2 ) 281 - 281 2013.4

Streptococcus mutans形態決定遺伝子と齲蝕原性との関連について

柳田可奈子, 藤田一世, 永山佳代子, 仲野道代

小児歯科学雑誌 51 ( 2 ) 282 - 282 2013.4

Streptococcus mutansのグルカン結合タンパクCの機能領域の特定

高島由紀子, 仲野道代, 藤田一世

小児歯科学雑誌 51 ( 1 ) 109 - 110 2013.3

犬の歯肉縁下プラークにおけるPorphyromonas gulaeの線毛タンパクの多様性と歯周状態との関連に対する臨床的検討

山崎由衛, 仲野道代, 仲野和彦, 野村良太

小児歯科学雑誌 51 ( 1 ) 108 - 108 2013.3

Streptococcus mutans GbpA欠失による表層タンパクの発現の変化

松三友紀, 仲野道代, 藤田一世, 稲垣暁子

小児歯科学雑誌 51 ( 1 ) 108 - 109 2013.3

突発性のエナメル質形成不全に伴い多数歯の埋伏を認めた症例

高木淳史, 仲野道代

小児歯科学雑誌 51 ( 1 ) 106 - 106 2013.3

小児口腔内から分離された乳酸菌の齲蝕原性の検討

藤田一世, 仲野和彦, 仲野道代

小児歯科学雑誌 51 ( 1 ) 111 - 111 2013.3

Streptococcus mutans形態決定遺伝子mreCの分子生物学的解析

柳田可奈子, 仲野道代, 藤田一世, 永山佳代子

小児歯科学雑誌 51 ( 1 ) 109 - 109 2013.3

【小児歯科の夢を語る】「小児歯科の夢を語る」ぜひ、小児歯科医になろうよ!

新谷誠康, 仲野道代, 福本敏, 有田信一

小児歯科臨床 18 ( 1 ) 15 - 51 2013.1

Distribution and molecular characterization of Porphyromonas gulae carrying a new fimA genotype

Yoshie Yamasaki, Ryota Nomura, Kazuhiko Nakano, Hiroaki Inaba, Masae Kuboniwa, Norihiko Hirai, Mitsuyuki Shirai, Yukio Kato, Masaru Murakami, Shuhei Naka, Soichi Iwai, Michiyo Matsumoto-Nakano, Takashi Ooshima, Atsuo Amano, Fumitoshi Asai

VETERINARY MICROBIOLOGY 161 ( 1-2 ) 196 - 205 2012.12

Language：English Publisher：ELSEVIER SCIENCE BV

Porphyromonas gulae is a gram-negative black-pigmented anaerobe which is known to be a pathogen for periodontitis in dogs. Approximately 41 kDa filamentous appendages on the cell surface (FimA) encoded by the fimA gene are regarded as important factors associated with periodontitis. The fimA genotype was classified into two major types and strains in type B were shown to be more virulent than those in type A. In the present study, we characterized a strain with a novel fimA genotype and designated it as type C. The putative amino acid sequence was shown to be similar to the genotype IV fimA of Porphyromonas gingivalis, a major pathogen of human periodontitis. Analyses using an oral squamous cell carcinoma cell line derived from tongue primary lesions revealed that the type C strain inhibited proliferation and scratch closure more than genotype A and B strains. In addition, experiments using a mouse abscess model demonstrated that the type C strain could induce much higher systemic inflammation when compared with strains of the other genotypes. Furthermore, molecular analyses of oral swab specimens collected from dogs demonstrated that the detection frequencies of P. gulae and the genotype C in the periodontitis group were significantly higher than those in the periodontally healthy group. These results suggest that FimA of P. gulae is diverse with the virulence of genotype C strains the highest and that molecular identification of genotype C P. gulae could be a possible useful marker for identifying dogs at high risk of developing periodontitis. (C) 2012 Elsevier B.V. All rights reserved.

DOI： 10.1016/j.vetmic.2012.07.026

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