研究者詳細 - 久松　隆史

論文 - 久松　隆史

分割表示 130 件中 41 - 60 件目／全件表示 >>

Optimal timing for measuring the casual urine Na/K ratio using a single sample: insights from a comparison with 24-h urine samples. 招待査読国際誌

Takashi Hisamatsu

Hypertension research : official journal of the Japanese Society of Hypertension 48 ( 2 ) 849 - 851 2024年12月

CTG repeat length underlying cardiac events and sudden death in myotonic dystrophy type 1 査読国際誌

Hideki Itoh, Takashi Hisamatsu, Kazuhiko Segawa, Toshiaki Takahashi, Takumi Sato, Hiroto Takada, Satoshi Kuru, Chizu Wada, Mikiya Suzuki, Takuhisa Tamura, Shugo Suwazono, Koichi Kimura, Tsuyoshi Matsumura, Masanori P Takahashi

European Heart Journal Open 4 ( 5 ) oeae078 2024年8月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

AIMS: Myotonic dystrophy Type 1 (DM1) is caused by the expansion of CTG repeats (CTGn) in the DM1 protein kinase (DMPK) gene, while it remains unclear whether CTGn may be associated with the incidence of cardiac events or sudden death in Japan as well as Europe. The aim of this study was to investigate the association between CTGn and cardiac involvements. METHODS AND RESULTS: This cohort study included patients with DM1 who were retrospectively recruited from nine Japanese hospitals specializing in neuromuscular diseases. A total of 496 patients with DM1 who underwent a genetic test in the DMPK gene were analysed. Patients with congenital form or under 15 years old were excluded and patients were assigned into the quartiles. When we compared the incidence of cardiac events including advanced/complete atrioventricular block, pacemaker implantation, and ventricular tachycardias or mortality among four groups, patients with 1300 or longer CTGn experienced composite cardiac events [hazard ratio (HR): 3.19, 95% confidence interval (CI): 1.02-9.99, P = 0.014] more frequently and had significantly higher mortality rate (HR: 6.79, 95% CI: 2.05-22.49, P < 0.001) than those under 400 CTGn while the rate of sudden death was not significantly different. CONCLUSION: Regarding the cardiac events and mortality in patients with DM1, patients with 1300 or longer CTGn are at especially high risk.

DOI： 10.1093/ehjopen/oeae078

PubMed

researchmap

IoT技術を用いた家庭血圧管理研究の5年間の成果と時系列ビックデータ・AIを活用した今後の展望益田研究査読

久松隆史, 絹田皆子, 福田茉莉, 谷口かおり, 中畑典子, 神田秀幸

岡山医学会雑誌 136 ( 2 ) 57 - 62 2024年8月

Low-density lipoprotein particle profiles compared with standard lipids measurements in the association with asymptomatic intracranial artery stenosis. 査読国際誌

Thien Vu, Yuichiro Yano, Huy Kien Tai Pham, Rajib Mondal, Mizuki Ohashi, Kaori Kitaoka, Mohammad Moniruzzaman, Sayuki Torii, Akihiko Shiino, Atsushi Tsuji, Takashi Hisamatsu, Tomonori Okamura, Keiko Kondo, Aya Kadota, Yoshiyuki Watanabe, Kazuhiko Nozaki, Hirotsugu Ueshima, Katsuyuki Miura

Scientific reports 14 ( 1 ) 10765 - 10765 2024年5月

記述言語：英語掲載種別：研究論文（学術雑誌）

The Shiga Epidemiological Study of Subclinical Atherosclerosis was conducted in Kusatsu City, Shiga, Japan, from 2006 to 2008. Participants were measured for LDL-p through nuclear magnetic resonance technology. 740 men participated in follow-up and underwent 1.5 T brain magnetic resonance angiography from 2012 to 2015. Participants were categorized as no-ICAS, and ICAS consisted of mild-ICAS (1 to < 50%) and severe-ICAS (≥ 50%) in any of the arteries examined. After exclusion criteria, 711 men left for analysis, we used multiple logistic regression to examine the association between lipid profiles and ICAS prevalence. Among the study participants, 205 individuals (28.8%) had ICAS, while 144 individuals (20.3%) demonstrated discordance between LDL-c and LDL-p levels. The discordance "low LDL-c-high LDL-p" group had the highest ICAS risk with an adjusted OR (95% CI) of 2.78 (1.55-5.00) in the reference of the concordance "low LDL-c-low LDL-p" group. This was followed by the concordance "high LDL-c-high LDL-p" group of 2.56 (1.69-3.85) and the discordance "high LDL-c-low LDL-p" group of 2.40 (1.29-4.46). These findings suggest that evaluating LDL-p levels alongside LDL-c may aid in identifying adults at a higher risk for ICAS.

DOI： 10.1038/s41598-024-59523-4

PubMed

researchmap

Heart Rate Fragmentation, Ambulatory Blood Pressure, and Coronary Artery Calcification: A Population-Based Study. 査読国際誌

Yuichi Sawayama, Yuichiro Yano, Takashi Hisamatsu, Akira Fujiyoshi, Aya Kadota, Sayuki Torii, Keiko Kondo, Sayaka Kadowaki, Yosuke Higo, Akiko Harada, Yoshiyuki Watanabe, Yoshihisa Nakagawa, Katsuyuki Miura, Hirotsugu Ueshima

JACC. Asia 4 ( 3 ) 216 - 225 2024年3月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Little is known regarding whether ultra-rapid patterns of heart rate variability (eg, heart rate fragmentation [HRF]) are associated with coronary artery calcification (CAC) in a general population. OBJECTIVES: This study aimed to assess the association between HRF and CAC, and whether these associations are independent of systolic blood pressure (SBP) levels. METHODS: From SESSA (the Shiga Epidemiological Study of Subclinical Atherosclerosis), we used data from 24-hour ambulatory blood pressure monitoring to identify awake and asleep SBP levels, and data from concurrent 24-hour Holter monitoring to quantify HRF using the awake and asleep percentage of inflection points (PIP). CAC on computed tomography scanning was quantified using an Agatston score. We used multivariable binomial logistic regression to assess the associations of PIP and ambulatory SBP with the presence of CAC, as defined by Agatston score >0. RESULTS: Of the 508 participants in this study (mean age: 66.5 ± 7.3 years), 325 (64%) had CAC and 183 (36%) did not. In fully adjusted models of prevalent CAC that also included office SBP, the ORs with 95% CIs for awake PIP, awake SBP, asleep PIP, and asleep SBP were 1.23 (95% CI: 0.99-1.54), 1.40 (95% CI: 1.11-1.77), 1.31 (95% CI: 1.05-1.62), and 1.28 (95% CI: 1.02-1.60), respectively. There was no evidence of interaction between PIP and ambulatory SBP in association with CAC. Results were similar when other HRF indices instead of PIP were used. CONCLUSIONS: Higher HRF and SBP levels during sleep are each associated with the presence of CAC in a general male population.

DOI： 10.1016/j.jacasi.2023.10.004

PubMed

researchmap

Relationship Between Hemoglobin Concentration and Cardiovascular Disease Mortality in a 25-Year Follow-up Study of a Japanese General Population - NIPPON DATA90. 査読

Megumi Kawashima, Takashi Hisamatsu, Akiko Harada, Aya Kadota, Keiko Kondo, Yukiko Okami, Takehito Hayakawa, Yoshikuni Kita, Akira Okayama, Hirotsugu Ueshima, Tomonori Okamura, Katsuyuki Miura

Circulation journal : official journal of the Japanese Circulation Society 88 ( 5 ) 742 - 750 2024年2月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Deviations of hemoglobin from normal levels may be a factor in cardiovascular disease (CVD) risk; however, conclusive evidence is lacking. In addition, preclinical conditions may influence hemoglobin concentrations, but studies focusing on reverse causation are limited. Thus, we examined the relationship between hemoglobin concentrations and CVD mortality risk, considering reverse causation.Methods and Results: In a prospective cohort representative of the general Japanese population (1990-2015), we studied 7,217 individuals (mean age 52.3 years; 4,219 women) without clinical CVD at baseline. Participants were categorized into sex-specific hemoglobin quintiles (Q1-Q5) and data were analyzed using the Cox proportional hazards model adjusted for possible confounders. During a 25-year follow-up, 272 men and 334 women died from CVD. Adjusted hazard ratios for CVD mortality across sex-specific quintiles, using Q3 as the reference, were significantly higher for Q1 (1.40; 95% confidence interval [CI] 1.08-1.82) and Q5 (1.49; 95% CI 1.14-1.96), and remained significant after excluding deaths within the first 5 years of follow-up to consider reverse causation (1.35 [95% CI 1.02-1.79] and 1.45 [95% CI 1.09-1.94], respectively). A similar U-shaped association was seen between transferrin saturation levels and CVD mortality, but after excluding deaths within the first 5 years the association was significant only for Q1. CONCLUSIONS: Low and high hemoglobin concentrations were associated with an increased risk of CVD mortality.

DOI： 10.1253/circj.CJ-23-0725

PubMed

researchmap

Association of step counts with cognitive function in apparently healthy middle-aged and older Japanese men. 査読国際誌

Takeshi Shibukawa, Akira Fujiyoshi, Mohammad Moniruzzaman, Naoko Miyagawa, Aya Kadota, Keiko Kondo, Yoshino Saito, Sayaka Kadowaki, Takashi Hisamatsu, Yuichiro Yano, Hisatomi Arima, Ikuo Tooyama, Hirotsugu Ueshima, Katsuyuki Miura

Preventive medicine reports 38 102615 - 102615 2024年2月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Increasing physical activity may prevent cognitive decline. Previous studies primarily focused on older adults and used self-reported questionnaires to assess physical activity. We examined the relationship between step count, an objective measure of physical activity, and cognitive function in community-based middle-aged and older Japanese men. METHODS: The Shiga Epidemiological Study of Subclinical Atherosclerosis randomly recruited community-dwelling healthy men aged 40-79 years from Shiga, Japan, and measured their step counts over 7 consecutive days using a pedometer at baseline (2006-2008). Among men who returned for follow-up (2009-2014), we assessed their cognitive function using the Cognitive Abilities Screening Instrument (CASI) score. We restricted our analyses to those with valid 7-day average step counts at baseline and those who remained free of stroke at follow-up (n = 676). Using analysis of covariance, we calculated the adjusted means of the CASI score according to the quartiles of the average step counts. RESULTS: The mean (standard deviation) of age and unadjusted CASI score were 63.8 (9.1) years and 90.8 (5.8), respectively. The CASI score was elevated in higher quartiles of step counts (90.2, 90.4, 90.6, and 91.8 from the lowest to the highest quartile, respectively, [p for trend = 0.004]) in a model adjusted for age and education. Further adjustment for smoking, drinking, and other cardiovascular risk factors resulted in a similar pattern of association (p for trend = 0.005). CONCLUSION: In apparently healthy middle-aged and older Japanese men, a greater 7-day average step count at baseline was associated with significantly higher cognitive function score.

DOI： 10.1016/j.pmedr.2024.102615

PubMed

researchmap

全国の一般地域住民における最近の循環器疾患発症率 NIPPON DATA2010

門田文, 大久保孝義, 原田亜紀子, 高嶋直敬, 有馬久富, 二宮利治, 秦淳, 寳澤篤, 中村幸志, 東山綾, 大澤正樹, 久松隆史, 鳥居さゆ希, 岡見雪子, 近藤慶子, 宮本恵宏, 岡村智教, 上島弘嗣, 岡山明, 三浦克之

Journal of Epidemiology 34 ( Suppl. ) 122 - 122 2024年1月

High blood pressure in childhood and adolescence. 招待査読国際誌

Takashi Hisamatsu, Minako Kinuta

Hypertension research : official journal of the Japanese Society of Hypertension 47 ( 1 ) 203 - 205 2023年10月

The gut microbiota and coronary artery calcification in Japanese men. 査読国際誌

Yukiko Okami, Hisatomi Arima, Keiko Kondo, Zhang Hexun, Yuichiro Yano, Aya Kadota, Sayuki Torii, Takashi Hisamatsu, Akira Fujiyoshi, Sayaka Kadowaki, Yoshiyuki Watanabe, Akira Andoh, Yoshihisa Nakagawa, Hirotsugu Ueshima, Katsuyuki Miura for the SESSA Research Group

American heart journal 267 12 - 21 2023年10月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: The gut microbiota differs between patients with coronary artery disease (CAD) and healthy controls; however, it currently remains unclear whether these differences exist prior to the onset of CAD. We herein investigated the gut microbiota associated with subclinical coronary artery calcification (CAC) in a Japanese population. METHODS: A total of 663 Japanese men were enrolled in this cross-sectional study. Computed tomography and gut microbiology tests were performed, and CAC scores were calculated using the Agatston method. Participants were categorized into four groups based on their CAC scores: CAC = 0, 0 <CAC ≤100, 100 <CAC, and with a CAD history. The bacterial 16S ribosomal RNA gene was amplified, and DNA sequencing was conducted on a MiSeq System. QIIME2 and LEfSe were used to analyze the gut microbiota, and the results obtained were compared among the four CAC categories. RESULTS: The mean age of participants was 68.4 years (46-83 years). The numbers of participants in CAC = 0, 0 <CAC ≤100, 100 <CAC, and with a CAD history were 219, 200, 193, and 51, respectively. The medians of the Firmicutes to Bacteroidota ratio were 1.50, 1.52, 1.67, and 1.80 for each CAC category (P = 0.020). One standard deviation higher phylum Firmicutes, class Bacilli, and order Lactobacillales were associated with a 1.3- to 1.4-fold higher risk of CAD. These taxa were also associated with a higher CAC score category. The family Streptococcaceae and genus Streptococcus showed a higher risk of CAD. The order Enterobacterales and family Enterobacteriaceae correlated with CAC scores. The genus Blautia showed a preventive direction for CAD, but did not correlate with CAC scores. CONCLUSIONS: The gut microbiota significantly differed from the phylum to genus level in a manner that was dependent on CAC scores, even before the onset of CAD.

DOI： 10.1016/j.ahj.2023.09.009

PubMed

researchmap

Long-Term Effect of Smoking Ban Legislation on Hospitalization for Acute Coronary Syndrome. 招待査読

Takashi Hisamatsu, Minako Kinuta

Circulation journal : official journal of the Japanese Circulation Society 87 ( 11 ) 1686 - 1688 2023年9月

At-risk internet addiction and related factors among senior high school teachers in Japan based on a Nationwide survey. 査読国際誌

Mari Fukuda, Mohammad Chowdhury, Tanvir Turin Chowdhury, Hideki Tsumura, Rina Tsuchie, Minako Kinuta, Takashi Hisamatsu, Hideyuki Kanda

Neuropsychopharmacology reports 43 ( 4 ) 553 - 560 2023年7月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Internet addiction (IA) has been drawing attention to mental health. However, few reports have been found on the related factors of at-risk IA among regular workers by a nationwide survey. The study aimed to evaluate the characteristics of at-risk IA and identify related factors among senior high school teachers in Japan. METHODS: This survey was a cross-sectional survey of high schools across Japan in 2017. There were 3189 teachers (2088 males and 1098 female) who participated in this survey. The questionnaire asked about their devices, both the time and the activities of using their internet, and sociodemographic factors. IA was measured by the internet addiction test (IAT) by which 40-79 points were classified as at-risk IA, and more as IA. We compared the related factors of at-risk IA and non-IA using descriptive analysis and multivariable regression analysis. RESULTS: The rates of IA and at-risk IA were 0.09% (n = 3) and 6.91% (n = 220), respectively. At-risk IA was positively associated with activities on the internet for gaming, entertainment, net-surfing, and younger ages. In addition, the at-risk IA group had a longer time spent on the internet than the non-IA group. CONCLUSIONS: Around 7% of high school teachers are at-risk IA in this survey, though they have regular work. Our results suggest that at-risk IA may be reinforced not only by the active internet use such as gaming, but also by purposeless behaviors, such as net-surfing. Managing time on the internet may support preventing at-risk IA among senior high school teachers.

DOI： 10.1002/npr2.12350

PubMed

researchmap

Relationships of rapid eating with visceral and subcutaneous fat mass and plasma adiponectin concentration. 査読国際誌

Hideki Tsumura, Mari Fukuda, Takashi Hisamatsu, Rie Sato, Rina Tsuchie, Hideyuki Kanda

Scientific reports 13 ( 1 ) 11491 - 11491 2023年7月

記述言語：英語掲載種別：研究論文（学術雑誌）

Rapid eating has been demonstrated to be associated with obesity and overweight. However, few studies have characterized the separate relationships of eating speed with visceral and subcutaneous fat mass or circulating adiponectin concentration. We hypothesized that rapid eating is associated with the larger visceral fat tissue (VFT) area and lower adiponectin concentration, but not with the subcutaneous fat tissue (SFT) area in men and women. We performed a cross-sectional study of 712 adults aged 20-86 years (528 men and 184 women; mean ± SD age 59.36 ± 13.61 years). The participants completed a self-reported questionnaire, and underwent anthropometric and laboratory measurements and computed tomographic imaging of the abdomen as a part of annual medical check-ups. Multivariate linear regression analyses revealed that rapid eating was associated with larger visceral (B = 24.74; 95% CI 8.87-40.61, p = 0.002) and subcutaneous fat areas (B = 31.31; 95% CI 12.23-50.38, p = 0.001), lower adiponectin concentration (B = - 2.92; 95% CI - 4.39- - 1.46, p < 0.001), higher body mass index (BMI) (B = 2.13; 95% CI 1.02-3.25, p < 0.001), and larger waist circumference (B = 5.23; 95% CI 2.16-8.30, p < 0.001) in men, which is partially consistent with the hypothesis. In contrast, rapid eating was found to be associated only with BMI, and not with abdominal adipose area or adiponectin concentration in women, which is a result that is not consistent with the hypothesis. These results suggest that there is no difference in the association of rapid eating with VFT and SFT areas.

DOI： 10.1038/s41598-023-38623-7

PubMed

researchmap

Coronary Artery Calcium in Assessment of Atherosclerotic Cardiovascular Disease Risk and its Role in Primary Prevention. 招待査読

Takashi Hisamatsu, Minako Kinuta

Journal of atherosclerosis and thrombosis 30 ( 10 ) 1289 - 1302 2023年7月

担当区分：筆頭著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）

Coronary artery calcium (CAC), which is detected using computed tomography scanning, is a well-established indicator of subclinical atherosclerosis. The CAC score is independently associated with atherosclerotic cardiovascular disease (ASCVD) outcomes and provides improved predictive values for estimating the risk of ASCVD beyond traditional risk factors. Thus, CAC is considered to have important implications for reclassification as a decision aid among individuals in the preclinical phase and as the primary prevention of ASCVD. This review is focused on epidemiological evidence on CAC in asymptomatic population-based samples from Western countries and Japan. We also discuss the usability of CAC as a tool for assessing ASCVD risk and its role in the primary prevention of ASCVD. A lack of evidence for the CAC score in ASCVD risk assessment beyond traditional risk factors in populations other than those in Western countries (including Japan) warrants further investigation. Clinical trials are also necessary to demonstrate the usefulness and safety of CAC screening in the primary prevention of ASCVD.

DOI： 10.5551/jat.RV22009

PubMed

researchmap

Association of Arterial Stiffness and Atherosclerotic Burden With Brain Structural Changes Among Japanese Men. 査読国際誌

Nazar M Azahar, Yuichiro Yano, Aya Kadota, Akihiko Shiino, Ali H Syaifullah, Naoko Miyagawa, Keiko Kondo, Mohammad Moniruzzaman, Sayuki Torii, Hiroyoshi Segawa, Takashi Hisamatsu, Akira Fujiyoshi, Kazuhiko Nozaki, Ikuo Tooyama, Hirotsugu Ueshima, Katsuyuki Miura

Journal of the American Heart Association 12 ( 11 ) e028586 2023年5月

記述言語：英語掲載種別：研究論文（学術雑誌）

Background Little is known regarding whether arterial stiffness and atherosclerotic burden are each independently associated with brain structural changes. Simultaneous assessments of both arterial stiffness and atherosclerotic burden in associations with brain could provide insights into the mechanisms of brain structural changes. Methods and Results Using data from the SESSA (Shiga Epidemiological Study of Subclinical Atherosclerosis), we analyzed data among 686 Japanese men (mean [SD] age, 67.9 [8.4] years; range, 46-83 years) free from history of stroke and myocardial infarction. Brachial-ankle pulse wave velocity and coronary artery calcification on computed tomography scans were measured between March 2010 and August 2014. Brain volumes (total brain volume, gray matter, Alzheimer disease signature and prefrontal) and brain vascular damage (white matter hyperintensities) were quantified using brain magnetic resonance imaging from January 2012 through February 2015. In multivariable adjustment models including mean arterial pressure, when brachial-ankle pulse wave velocity and coronary artery calcification were entered into the same models, the β (95% CI) for Alzheimer disease signature volume for each 1-SD increase in brachial-ankle pulse wave velocity was -0.33 (-0.64 to -0.02), and the unstandardized β (95% CI) for white matter hyperintensities for each 1-unit increase in coronary artery calcification was 0.68 (0.05-1.32). Brachial-ankle pulse wave velocity and coronary artery calcification were not statistically significantly associated with total brain and gray matter volumes. Conclusions Among Japanese men, higher arterial stiffness was associated with lower Alzheimer disease signature volumes, whereas higher atherosclerotic burden was associated with brain vascular damage. Arterial stiffness and atherosclerotic burden may be independently associated with brain structural changes via different pathways.

DOI： 10.1161/JAHA.122.028586

PubMed

researchmap

Mendelian Randomization to Evaluate the Causal Effect of Serum Bilirubin on Atrial Fibrillation. 招待査読国際誌

Takashi Hisamatsu

Korean circulation journal 53 ( 7 ) 480 - 482 2023年5月

Non-missense variants of KCNH2 show better outcomes in type 2 long QT syndrome. 査読国際誌

Takanori Aizawa, Yuko Wada, Kanae Hasegawa, Hai Huang, Tomohiko Imamura, Jingshan Gao, Asami Kashiwa, Hirohiko Kohjitani, Megumi Fukuyama, Koichi Kato, Eri Toda Kato, Takashi Hisamatsu, Seiko Ohno, Takeru Makiyama, Takeshi Kimura, Minoru Horie

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 25 ( 4 ) 1491 - 1499 2023年3月

記述言語：英語掲載種別：研究論文（学術雑誌）

AIMS: More than one-third of type 2 long QT syndrome (LQT2) patients carry KCNH2 non-missense variants that can result in haploinsufficiency (HI), leading to mechanistic loss-of-function. However, their clinical phenotypes have not been fully investigated. The remaining two-thirds of patients harbour missense variants, and past studies uncovered that most of these variants cause trafficking deficiency, resulting in different functional changes: either HI or dominant-negative (DN) effects. In this study, we examined the impact of altered molecular mechanisms on clinical outcomes in LQT2 patients. METHODS AND RESULTS: We included 429 LQT2 patients (234 probands) carrying a rare KCNH2 variant from our patient cohort undergoing genetic testing. Non-missense variants showed shorter corrected QT (QTc) and less arrhythmic events (AEs) than missense variants. We found that 40% of missense variants in this study were previously reported as HI or DN. Non-missense and HI-groups had similar phenotypes, while both exhibited shorter QTc and less AEs than the DN-group. Based on previous work, we predicted the functional change of the unreported variants-whether they cause HI or DN via altered functional domains-and stratified them as predicted HI (pHI)- or pDN-group. The pHI-group including non-missense variants exhibited milder phenotypes compared to the pDN-group. Multivariable Cox model showed that the functional change was an independent risk of AEs (P = 0.005). CONCLUSION: Stratification based on molecular biological studies enables us to better predict clinical outcomes in the patients with LQT2.

DOI： 10.1093/europace/euac269

PubMed

researchmap

Association between proprotein convertase subtilisin/kexin type 9 (PCSK9) and subclinical cerebrovascular disease in the community. 査読国際誌

Ayako Kunimura, Yuichiro Yano, Takashi Hisamatsu, Sayuki Torii, Keiko Kondo, Aya Kadota, Akira Fujiyoshi, Tomonori Okamura, Yoshiyuki Watanabe, Akihiko Shiino, Kazuhiko Nozaki, Hirotsugu Ueshima, Katsuyuki Miura

European journal of neurology 30 ( 5 ) 1327 - 1334 2023年2月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a new target for reducing low-density lipoprotein cholesterol (LDL-C) and incident cardiovascular disease, including stroke. However, the clinical relevance of circulating PCSK9 levels have been poorly elucidated in the general population, particularly in association with subclinical cerebrovascular disease including cerebral small vessel disease (CSVD) and intracranial artery stenosis (ICAS). METHODS: In community-dwelling Japanese men (n = 526) aged 46-82 years without a history of cardiovascular disease, we assessed the associations of serum PCSK9 levels with the prevalence of CSVD and ICAS using magnetic resonance imaging. CSVD included lacunar infarction, deep and subcortical white matter hyperintensity, periventricular hyperintensity, and cerebral microbleeds. RESULTS: The median (interquartile range) age at baseline and serum PCSK9 levels were 69 (63 - 74) years and 240 (205-291) ng/mL, respectively. After adjusting for traditional cardiovascular risk factors including LDL-C, multivariable Poisson regression with robust error variance revealed a significant association between PCSK9 levels (per 1-SD) and ICAS (relative risks 1.18, 95% confidence intervals [CI] 1.02-1.37). Multivariable ordinal logistic regression for ICAS, with stenosis graded as mild (<50%) or moderate-severe (≥50%), revealed a similar association (common odds ratio 1.31, 95% CI 1.04-1.64). However, no significant association was observed between serum PCSK9 levels and CSVD. CONCLUSIONS: Higher circulating PCSK9 levels were independently associated with a ICAS prevalence but not with a CSVD prevalence. The quantification of circulating PCSK9 levels may help to identify individuals at high risk for cerebrovascular disease in the general population.

DOI： 10.1111/ene.15723

PubMed

researchmap

Association and dose-response relationship between exposure to alcohol advertising media and current drinking: a nationwide cross-sectional study of Japanese adolescents. 査読

Keita Yoshida, Hideyuki Kanda, Takashi Hisamatsu, Yuki Kuwabara, Aya Kinjo, Hisashi Yoshimoto, Teruna Ito, Hideaki Kasuga, Ruriko Minobe, Hitoshi Maesato, Maki Jike, Yuuki Matsumoto, Yuichiro Otsuka, Osamu Itani, Yoshitaka Kaneita, Susumu Higuchi, Yoneatsu Osaki

Environmental health and preventive medicine 28 58 - 58 2023年

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Underage drinking is a public health concern. However, few studies have examined the association between alcoholic beverage advertising and underage drinking, particularly in countries with low underage drinking rates, such as Japan. Therefore, we aimed to investigate the relationship between exposure to advertising in various media and alcohol drinking among Japanese adolescents. METHODS: We conducted a cross-sectional study involving 15,683 adolescents (51% girls) using data from a nationwide lifestyle survey in 2021 among junior and senior high schools across Japan. Media types were websites, stores, and public transportation. We defined current drinking as alcohol consumption of ≥1 day in the 30 days preceding the survey. Multivariable logistic regression was used to examine the association between exposure to alcohol advertisements and current drinking, adjusting for sex, grades, school area, lifestyle (bedtime and having fun at school), and addictive behaviors (smoking status and parents' alcohol consumption). RESULTS: The prevalence of current drinking was 2.2% (2.3% of boys and 2.0% of girls). Students who were exposed to any alcohol advertising media had higher odds of current drinking compared with those who were not (odds ratio, 1.48; 95% confidence interval [CI], 1.18-1.87). Students who were exposed to web, in-store, and public transportation advertisements had odds ratios of 1.44 (95% CI, 1.14-1.81), 1.62 (1.28-2.05), and 1.45 (1.06-1.98) of current drinking, respectively, compared with those who were not. The association of exposure to alcohol advertising media with the prevalence of current drinking was similar among boys and girls (all p for sex interaction >0.1), except for that of exposure to web advertisements; its association with current drinking was more pronounced in girls (p for sex interaction = 0.046). Exposure to a larger cumulative number of different alcohol advertising media was independently associated with a higher prevalence of current drinking among all students, boys, and girls (p-values for trend <0.001, 0.031, and <0.001, respectively; p for sex interaction = 0.085). CONCLUSIONS: We found an association with a dose-response relationship between exposure to alcohol advertisements and current drinking among adolescents in junior and senior high schools across Japan. Our findings highlight the need for further advertising regulations to prevent underage drinking.

DOI： 10.1265/ehpm.23-00127

PubMed

researchmap

Cross-sectional association of equol producing status with aortic calcification in Japanese men aged 40-79 years. 査読国際誌

Xiao Zhang, Akira Fujiyoshi, Aya Kadota, Keiko Kondo, Sayuki Torii, Yukiko Okami, Takashi Hisamatsu, Yuichiro Yano, Emma Barinas-Mitchell, Jared Magnani, Katsuyuki Miura, Hirotsugu Ueshima, Akira Sekikawa

Scientific reports 12 ( 1 ) 20114 - 20114 2022年11月

記述言語：英語掲載種別：研究論文（学術雑誌）

Equol is an isoflavone (ISF)-derived metabolite by the gut microbiome in certain individuals termed equol-producers (EP). Equol might be the critical anti-atherogenic component of ISFs. In a population-based study of 979 Japanese men aged 40-79 without cardiovascular (CVD) or chronic kidney disease, we measured the urinary levels of equol and ISFs. Aortic calcification (AC) in the entire aorta was assessed by electron-beam or multi-detector-row computed tomography. Subjects with log10 (urinary equol to daidzein concentration) > - 1.5 were classified as EP. EP was further classified as person with low- and high-equol. We analyzed the association between equol-producing status and AC presence, defined as AC score > 0, by the logistic regressions. We found that EP (50% of the sample) had significantly lower odds of AC presence (odds ratio (OR): 0.62, 95% confidence interval (CI): 0.39, 0.98) compared to non-EP. This association was independent of CVD risk factors. For the dose-response association, compared to non-EP, subjects with low and high levels of equol had ORs of 0.51 (95% CI 0.30, 0.84) and 0.67 (95% CI 0.39, 1.14) after adjusting for major CVD risk factors (p for trend = 0.06). ISFs concentrations were not significantly associated with AC presence (OR: 1.18, 95% CI: 0.82, 1.69). In conclusion, EP had a significantly lower burden of AC than non-EP, while ISFs were not associated with AC presence in Japanese men aged 40-79 years.

DOI： 10.1038/s41598-022-24659-8

PubMed

researchmap

　前のページ - 次のページ　

<久松 隆史>

論文 - 久松 隆史

<久松　隆史>

論文 - 久松　隆史